Src, chemoresistance and epithelial to mesenchymal transition: are they related?

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Anti-Cancer Drugs

• Publication date

  2007-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1097/CAD.0B013E32801265D7PMID 17351389
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Activated Src and Ras induce gefitinib resistance by activation of signaling pathways downstream of epidermal growth factor receptor in human gallbladder adenocarcinoma cells

  2006cited by this paper
• Chronic Oxaliplatin Resistance Induces Epithelial-to-Mesenchymal Transition in Colorectal Cancer Cell Lines

  2006cited by this paper
• Inhibition of SRC expression and activity inhibits tumor progression and metastasis of human pancreatic adenocarcinoma cells in an orthotopic nude mouse model.

  2006cited by this paper
• SKI-606 decreases growth and motility of colorectal cancer cells by preventing pp60(c-Src)-dependent tyrosine phosphorylation of beta-catenin and its nuclear signaling.

  2006cited by this paper
• Elevated Src activity promotes cellular invasion and motility in tamoxifen resistant breast cancer cells

  2006cited by this paper
• Different pattern of expression of cellular oncogenes in human non-small-cell lung cancer cell lines

  2005cited by this paper
• Expression of E-cadherin and uPA and their association with the prognosis of pancreatic cancer.

  2005cited by this paper
• The origin of vimentin expression in invasive breast cancer: epithelial–mesenchymal transition, myoepithelial histogenesis or histogenesis from progenitor cells with bilinear differentiation potential?

  2005cited by this paper
• Prognostic significance of cell infiltrations of immunosurveillance in colorectal cancer.

  2005cited by this paper
• Expression and activity of SRC regulate interleukin-8 expression in pancreatic adenocarcinoma cells: implications for angiogenesis.

  2005cited by this paper
• HIF-1α, STAT3, CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas

  2005cited by this paper
• AP23846, a novel and highly potent Src family kinase inhibitor, reduces vascular endothelial growth factor and interleukin-8 expression in human solid tumor cell lines and abrogates downstream angiogenic processes

  2005cited by this paper
• c-src activating mutation analysis in Chinese patients with colorectal cancer.

  2005cited by this paper
• Active Src Elevates the Expression of β-Catenin by Enhancement of Cap-Dependent Translation

  2005cited by this paper
• The fallacy of epithelial mesenchymal transition in neoplasia.

  2005cited by this paper
• Src inhibition enhances paclitaxel cytotoxicity in ovarian cancer cells by caspase-9-independent activation of caspase-3.

  2005cited by this paper
• siRNA directed against c-Src enhances pancreatic adenocarcinoma cell gemcitabine chemosensitivity.

  2004cited by this paper
• Inhibition of Src Tyrosine Kinase Impairs Inherent and Acquired Gemcitabine Resistance in Human Pancreatic Adenocarcinoma Cells

  2004cited by this paper
• Expression of Kinase-defective Mutants of c-Src in Human Metastatic Colon Cancer Cells Decreases Bcl-xL and Increases Oxaliplatin- and Fas-induced Apoptosis*

  2004cited by this paper
• BCR-ABL independence and LYN kinase overexpression in chronic myelogenous leukemia cells selected for resistance to STI571.

  2003cited by this paper
• Requirement of different signaling pathways mediated by insulin-like growth factor-I receptor for proliferation, invasion, and VPF/VEGF expression in a pancreatic carcinoma cell line.

  2003cited by this paper
• SRC family kinases: potential targets for the treatment of human cancer and leukemia.

  2003cited by this paper
• Activated SRC protein tyrosine kinase is overexpressed in late-stage human ovarian cancers.

  2003cited by this paper
• Src family kinases in tumor progression and metastasis

  2003cited by this paper
• Inhibition of tyrosine kinase Src suppresses pancreatic cancer invasiveness.

  2003cited by this paper
• Epithelial–mesenchymal transitions in tumour progression

  2002cited by this paper
• Activation of Src kinase in primary colorectal carcinoma

  2002cited by this paper
• Increased Src activity disrupts cadherin/catenin-mediated homotypic adhesion in human colon cancer and transformed rodent cells.

  2002cited by this paper
• Src-induced de-regulation of E-cadherin in colon cancer cells requires integrin signalling

  2002cited by this paper
• Src family kinase inhibitor PP2 restores the E-cadherin/catenin cell adhesion system in human cancer cells and reduces cancer metastasis.

  2002cited by this paper
• Restoration of E-cadherin/beta-catenin expression in pancreatic cancer cells inhibits growth by induction of apoptosis.

  2002cited by this paper
• Establishment of two new human bladder carcinoma cell lines, CAL 29 and CAL 185. Comparative study of cell scattering and epithelial to mesenchyme transition induced by growth factors

  2001cited by this paper
• Down-regulation of E-cadherin gene expression by collagen type I and type III in pancreatic cancer cell lines.

  2001cited by this paper
• Lack of mutation at codon 531 of SRC in advanced colorectal cancers from Italian patients

  2001cited by this paper
• Tyrosine nitration of c-SRC tyrosine kinase in human pancreatic ductal adenocarcinoma.

  2000cited by this paper
• Selected glimpses into the activation and function of Src kinase

  2000cited by this paper
• v‐src induces cisplatin resistance by increasing the repair of cisplatin–DNA interstrand cross‐links in human gallbladder adenocarcinoma cells

  1999cited by this paper
• Activating SRC mutation in a subset of advanced human colon cancers

  1999cited by this paper
• Extracellular signal-regulated kinase activation is required for up-regulation of vascular endothelial growth factor by serum starvation in human colon carcinoma cells.

  1999cited by this paper
• Advances in Brief Extracellular Signal-regulated Kinase Activation Is Required for Up-Regulation of Vascular Endothelial Growth Factor by Serum Starvation in Human Colon Carcinoma Cells 1

  1999cited by this paper
• Overexpression and activation of the tyrosine kinase Src in human pancreatic carcinoma.

  1998cited by this paper
• Down-regulation of Vascular Endothelial Growth Factor in a Human Colon Carcinoma Cell Line Transfected with an Antisense Expression Vector Specific for c-src *

  1998cited by this paper
• Activation of c-Src by receptor tyrosine kinases in human colon cancer cells with high metastatic potential

  1997cited by this paper
• Ovarian cancer: screening, treatment, and followup.

  1995cited by this paper
• NIH consensus conference. Ovarian cancer. Screening, treatment, and follow-up. NIH Consensus Development Panel on Ovarian Cancer.

  1995cited by this paper
• pp60c-src is a positive regulator of growth factor-induced cell scattering in a rat bladder carcinoma cell line

  1995cited by this paper
• Increase in activity and level of pp60c-src in progressive stages of human colorectal cancer.

  1993cited by this paper
• Site-specific differences in pp60c-src activity in human colorectal metastases.

  1993cited by this paper
• Elevated expression of pp60c-src in low grade human bladder carcinoma.

  1992cited by this paper
• CSK: a protein-tyrosine kinase involved in regulation of src family kinases.

  1991cited by this paper
• pp60c‐src protein kinase activity in human gastric carcinomas

  1990cited by this paper
• Expression of pp60c-src protein kinase in adult and fetal human tissue: high activities in some sarcomas and mammary carcinomas.

  1983cited by this paper
• Epithelia suspended in collagen gels can lose polarity and express characteristics of migrating mesenchymal cells

  1982cited by this paper
• DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA

  1976cited by this paper
• A SARCOMA OF THE FOWL TRANSMISSIBLE BY AN AGENT SEPARABLE FROM THE TUMOR CELLS

  1911cited by this paper

• Targeting STAT3 by SH-4-54 suppresses the occurrence and inactivates oxidative phosphorylation in small-cell lung cancer via the SRC signaling.

  2026cites this paper
• FDA-approved antivirals ledipasvir and daclatasvir downregulate the Src-EPHA2-Akt oncogenic pathway in colorectal and triple-negative breast cancer cells.

  2024cites this paper
• Expressions and clinical significance of CCN5 and E-cadherin in primary and recurrent lesions of breast cancer

  2024cites this paper
• Drivergene.net: A Cytoscape app for the identification of driver nodes of large-scale complex networks and case studies in discovery of drug target genes

  2024cites this paper
• Pan-cancer chemoresistance-associated genes, affected pathways and potential therapeutic targets

  2023cites this paper
• Utility of CYP2D6 copy number variants as prognostic biomarker in localized anal squamous cell carcinoma

  2023cites this paper
• Resistance to Gemcitabine in Pancreatic Ductal Adenocarcinoma: A Physiopathologic and Pharmacologic Review

  2022cites this paper
• The Effect of Lidocaine and Bosutinib on 4T1 Murine Breast Cancer Cell Behaviour In Vitro

  2021cites this paper
• Combinatorial Strategies to Target Molecular and Signaling Pathways to Disarm Cancer Stem Cells

  2021cites this paper
• Src family kinases, adaptor proteins and the actin cytoskeleton in epithelial-to-mesenchymal transition

  2021cites this paper
• Non-Genomic Actions of Estrogens on the DNA Repair Pathways Are Associated With Chemotherapy Resistance in Breast Cancer

  2021cites this paper
• Effects of Lidocaine and Src Inhibition on Metastasis in a Murine Model of Breast Cancer Surgery

  2019cites this paper
• Pharmacogenomic analysis of patient-derived tumor cells in gynecologic cancers

  2019cites this paper
• On an Interpolation Problem for Generalized Schur Functions

  2019cites this paper
• EMT and Treatment Resistance in Pancreatic Cancer

  2017cites this paper
• Signaling and Antiestrogen Resistance and BCAR 3 Scaffolding Proteins in Cell ( BCAR 1 ) Antiestrogen Resistance Protein 1 Association of the Breast Cancer Signal Transduction

  2014cites this paper
• Pre-clinical evaluation of novel anti-metastatic targets

  2014cites this paper
• Association of the Breast Cancer Antiestrogen Resistance Protein 1 (BCAR1) and BCAR3 Scaffolding Proteins in Cell Signaling and Antiestrogen Resistance*

  2014cites this paper
• Epithelial-to-mesenchymal transition rewires the molecular path to PI3K-dependent proliferation.

  2014cites this paper
• Molecular Mechanism of BCAR 3p 130 Cas in Breast Cancer

  2013cites this paper
• Aberrant glycogen synthase kinase 3β in the development of pancreatic cancer

  2012cites this paper
• Src-mediated regulation of E-cadherin and EMT in pancreatic cancer.

  2012influential citation
• SRC points the way to biomarkers and chemotherapeutic targets.

  2012cites this paper
• CCN5/WISP-2: A micromanager of breast cancer progression

  2012cites this paper
• Why do targeted agents not work in the adjuvant setting in colon cancer?

  2012cites this paper
• New Targets for Therapy in Pancreatic Cancer

  2012cites this paper
• NSP-CAS Protein Complexes: Emerging Signaling Modules in Cancer.

  2012cites this paper
• Nonreceptor Tyrosine Kinases and Their Roles in Cancer

  2012cites this paper
• Gene profiling v-Src transformation in primary avian cells and the identification of the novel Src-responsive gene DAPK1 as a mediator of apoptosis in Src-transformed cells with repressed AP-1 activity

  2012influential citation
• CHEMOSENSITIZATION OF HEPATOCELLULAR CARCINOMA TO GEMCITABINE BY NON-INVASIVE RADIOFREQUENCY FIELD-INDUCED HYPERTHERMIA

  2012cites this paper
• Pancreatic Cancer Cells Resistant to Chemoradiotherapy Rich in “Stem-Cell-Like” Tumor Cells

  2011cites this paper
• MicroRNA-205 inhibits Src-mediated oncogenic pathways in renal cancer.

  2011cites this paper
• Clinical and molecular evidences of epithelial to mesenchymal transition in acquired resistance to EGFR-TKIs.

  2011cites this paper
• The dual kinase complex FAK-Src as a promising therapeutic target in cancer

  2010cites this paper
• Cellular processes of v-Src transformation revealed by gene profiling of primary cells - Implications for human cancer

  2010cites this paper
• The dual kinase complex FAK-Src as a promising therapeutic target in cancer

  2010cites this paper
• Src signaling in cancer invasion

  2010cites this paper
• Genomic-directed targeted therapy increases endometrial cancer cell sensitivity to doxorubicin.

  2010cites this paper
• The SRC family of protein tyrosine kinases: a new and promising target for colorectal cancer therapy.

  2010cites this paper
• The dual kinase complex FAK-Src as a promising therapeutic target in cancer

  2010cites this paper
• Src inhibitors in lung cancer: current status and future directions.

  2010cites this paper
• The Src Inhibitor AZD0530 Blocks Invasion and May Act as a Radiosensitizer in Lung Cancer Cells

  2009cites this paper
• Chemoresistance acquisition induces a global shift of expression of aniogenesis-associated genes and increased pro-angogenic activity in neuroblastoma cells

  2009cites this paper
• A gene expression signature associated with "K-Ras addiction" reveals regulators of EMT and tumor cell survival.

  2009cites this paper
• BCAR3 Regulates Src/p130Cas Association, Src Kinase Activity, and Breast Cancer Adhesion Signaling*

  2009cites this paper
• Involvement of members of the cadherin superfamily in cancer.

  2009cites this paper
• The role of Src in solid tumors.

  2009cites this paper
• Medical Management of Pancreatic Adenocarcinoma

  2009cites this paper
• Targeting Transcription Factors with Decoy Oligonucleotides: Modulation of the Expression of Genes Involved in Chemotherapy Resistance of Tumor Cells

  2008cites this paper
• Short interfering RNA directed against TWIST, a novel zinc finger transcription factor, increases A549 cell sensitivity to cisplatin via MAPK/mitochondrial pathway.

  2008cites this paper
• Targeting SRC family kinases inhibits growth and lymph node metastases of prostate cancer in an orthotopic nude mouse model.

  2008cites this paper
• PRL PTPs: mediators and markers of cancer progression

  2008cites this paper
• Current Advances in the Development of Anticancer Drugs Targeting Tyrosine Kinases of the Src Family

  2008cites this paper
• Gemcitabine Resistance in Pancreatic Cancer: Picking the Key Players

  2008cites this paper
• Src Continues Aging: Current and Future Clinical Directions

  2007cites this paper
• Development and Characterization of Gemcitabine-Resistant Pancreatic Tumor Cells

  2007cites this paper
• Clinical Development of Src Family Kinase Inhibitors in Malignant Melanoma

  2007cites this paper
• Epithelial-mesenchymal transition and tumour invasion.

  2007cites this paper
• Regulation of angiogenesis and vascular permeability by Src family kinases: opportunities for therapeutic treatment of solid tumors

  2007cites this paper