Anaerobic vs aerobic pathways of carbonyl and oxidant stress in human lens and skin during aging and in diabetes: A comparative analysis.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Free Radical Biology & Medicine

• Publication date

  2010-09-01

• Fields of study

  Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1016/j.freeradbiomed.2010.06.003PMID 20541005PMCID PMC2910832
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Transcutaneous pO2 imaging during tourniquet‐induced forearm ischemia using planar optical oxygen sensors

  2008cited by this paper
• Identification of glucose-derived cross-linking sites in ribonuclease A.

  2008cited by this paper
• Glycation by ascorbic acid oxidation products leads to the aggregation of lens proteins.

  2008cited by this paper
• Radiocarbon Dating of the Human Eye Lens Crystallines Reveal Proteins without Carbon Turnover throughout Life

  2008cited by this paper
• Methylglyoxal inhibits glycation-mediated loss in chaperone function and synthesis of pentosidine in alpha-crystallin.

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• Determination of malondialdehyde, reduced glutathione levels and APOE4 allele frequency in late-onset Alzheimer's disease in Denizli, Turkey.

  2007cited by this paper
• Increased Dicarbonyl Metabolism in Endothelial Cells in Hyperglycemia Induces Anoikis and Impairs Angiogenesis by RGD and GFOGER Motif Modification

  2006cited by this paper
• Oxygen distribution in the rabbit eye and oxygen consumption by the lens.

  2006cited by this paper
• Vitamin C mediates chemical aging of lens crystallins by the Maillard reaction in a humanized mouse model

  2006cited by this paper
• Advanced glycation end products in renal failure.

  2006cited by this paper
• Glycation Products as Markers and Predictors of the Progression of Diabetic Complications

  2005cited by this paper
• Ornithine Is a Novel Amino Acid and a Marker of Arginine Damage by Oxoaldehydes in Senescent Proteins

  2005cited by this paper
• Paradoxical effects of green tea (Camellia sinensis) and antioxidant vitamins in diabetic rats: improved retinopathy and renal mitochondrial defects but deterioration of collagen matrix glycoxidation and cross-linking.

  2005cited by this paper
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  2005cited by this paper
• Cross‐Linking of the Extracellular Matrix by the Maillard Reaction in Aging and Diabetes: An Update on “a Puzzle Nearing Resolution”

  2005cited by this paper
• Dicarbonyl Intermediates in the Maillard Reaction

  2005cited by this paper
• Conversion of Arginine into Ornithine by Advanced Glycation in Senescent Human Collagen and Lens Crystallins*

  2004cited by this paper
• Enhanced degradation and decreased stability of eye lens alpha-crystallin upon methylglyoxal modification.

  2004cited by this paper
• AGE-related cross-linking of collagen is associated with aortic wall matrix stiffness in the pathogenesis of drug-induced diabetes in rats.

  2004cited by this paper
• Characterization and detection of lysine-arginine cross-links derived from dehydroascorbic acid.

  2004cited by this paper
• Methylglyoxal-derived hydroimidazolone advanced glycation end-products of human lens proteins.

  2003cited by this paper
• Quantitative screening of protein biomarkers of early glycation, advanced glycation, oxidation and nitrosation in cellular and extracellular proteins by tandem mass spectrometry multiple reaction monitoring.

  2003cited by this paper
• Molecular motors

  2003cited by this paper
• Identification and Quantification of Major Maillard Cross-links in Human Serum Albumin and Lens Protein

  2002cited by this paper
• Argpyrimidine, a blue fluorophore in human lens proteins: high levels in brunescent cataractous lenses.

  2001cited by this paper
• Isotope dilution gas chromatography/mass spectrometry method for the determination of methionine sulfoxide in protein.

  2001influential reference
• Suppression of the accumulation of triosephosphates and increased formation of methylglyoxal in human red blood cells during hyperglycaemia by thiamine in vitro.

  2001cited by this paper
• Transition metal-catalyzed oxidation of ascorbate in human cataract extracts: possible role of advanced glycation end products.

  2000cited by this paper
• Identification, cloning, and heterologous expression of a mammalian fructosamine-3-kinase.

  2000cited by this paper
• Longitudinal determination of skin collagen glycation and glycoxidation rates predicts early death in C57BL/6NNIA mice

  2000cited by this paper
• Effect of Collagen Turnover on the Accumulation of Advanced Glycation End Products*

  2000cited by this paper
• Effects of advanced glycation end products on the proliferation and fibronectin production of smooth muscle cells.

  2000cited by this paper
• Structure and Mechanism of Formation of Human Lens Fluorophore LM-1

  1999cited by this paper
• Skin collagen glycation, glycoxidation, and crosslinking are lower in subjects with long-term intensive versus conventional therapy of type 1 diabetes: relevance of glycated collagen products versus HbA1c as markers of diabetic complications. DCCT Skin Collagen Ancillary Study Group. Diabetes Contro

  1999cited by this paper
• Immunochemical detection of oxalate monoalkylamide, an ascorbate‐derived Maillard reaction product in the human lens

  1999cited by this paper
• The relative ability of glucose and ascorbate to glycate and crosslink lens proteins in vitro. off.

  1998cited by this paper
• Diabetes-induced changes in lens antioxidant status, glucose utilization and energy metabolism: effect of DL-α-lipoic acid

  1998cited by this paper
• Role of the Maillard Reaction in Aging of Tissue Proteins

  1998cited by this paper
• Nonenzymatic glycation of type IV collagen and matrix metalloproteinase susceptibility.

  1997cited by this paper
• Photo-enhanced modification of human skin elastin in actinic elastosis by N(epsilon)-(carboxymethyl)lysine, one of the glycoxidation products of the Maillard reaction.

  1997cited by this paper
• Mechanism of Protein Modification by Glyoxal and Glycolaldehyde, Reactive Intermediates of the Maillard Reaction (*)

  1995cited by this paper
• Detection of fructose-3-phosphokinase activity in intact mammalian lenses by 31P NMR spectroscopy.

  1993cited by this paper
• Differential effects of type 2 (non-insulin-dependent) diabetes mellitus on pentosidine formation in skin and glomerular basement membrane

  1993cited by this paper
• Mechanism of formation of the Maillard protein cross-link pentosidine. Glucose, fructose, and ascorbate as pentosidine precursors.

  1991cited by this paper
• Formation of pentosidine during nonenzymatic browning of proteins by glucose. Identification of glucose and other carbohydrates as possible precursors of pentosidine in vivo.

  1991cited by this paper
• Nonenzymatic Glycation of Fibronectin and Alterations in the Molecular Association of Cell Matrix and Basement Membrane Components in Diabetes Mellitus

  1985cited by this paper
• STATISTICAL METHODS

  1967cited by this paper

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  2026cites this paper
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  2025cites this paper
• Synthetic and Natural Agents Targeting Advanced Glycation End-Products for Skin Anti-Aging: A Comprehensive Review of Experimental and Clinical Studies

  2025cites this paper
• A comprehensive review on the Advanced Glycation End Products detection: From conventional to advanced approaches.

  2025cites this paper
• Glycative stress as a cause of macular degeneration.

  2024cites this paper
• Role of the Glyoxalase System in Breast Cancer and Gynecological Cancer-Implications for Therapeutic Intervention: a Review

  2022cites this paper
• Decreased methylglyoxal-mediated protein glycation in the healthy aging mouse model of ectopic expression of UCP1 in skeletal muscle

  2022cites this paper
• The lens epithelium as a major determinant in the development, maintenance, and regeneration of the crystalline lens.

  2022cites this paper
• Plasma advanced glycation end products and the subsequent risk of microvascular complications in type 1 diabetes in the DCCT/EDIC

  2022cites this paper
• A review on prevention of glycation of proteins: Potential therapeutic substances to mitigate the severity of diabetes complications.

  2021cites this paper
• Protein posttranslational modification (PTM) by glycation: Role in lens aging and age-related cataractogenesis.

  2021cites this paper
• Protein glycation – biomarkers of metabolic dysfunction and early-stage decline in health in the era of precision medicine

  2021cites this paper
• Aging Lens Epithelium is Susceptible to Ferroptosis.

  2021cites this paper
• The M aillard Reaction: Protein Modification by Ascorbic Acid

  2021cites this paper
• Collagen Biosynthesis, Processing, and Maturation in Lung Ageing

  2021cites this paper
• Carbonylation of skin collagen induced by reaction with methylglyoxal.

  2021cites this paper
• Methylglyoxal, a highly reactive dicarbonyl compound, in diabetes, its vascular complications and other age-related diseases.

  2020cites this paper
• Mass spectrometric quantitation of AGEs and enzymatic crosslinks in human cancellous bone

  2020cites this paper
• Vitamin C is a source of oxoaldehyde and glycative stress in age‐related cataract and neurodegenerative diseases

  2020cites this paper
• Synthesis and Biological Evaluation of a Library of AGE‐Related Amino Acid Triazole Crosslinkers

  2020cites this paper
• Investigating the biophysical properties of ageing of collagenous tissue at the nanoscale

  2019cites this paper
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  2019cites this paper
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  2019cites this paper
• Clinical Applications of Metabolomics in Diabetes Research

  2018cites this paper
• Diabetes, Non-Enzymatic Glycation, and Aging

  2018cites this paper
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  2017cites this paper
• GLYCATION STRESS AND PHOTOAGING OF THE SKIN

  2017cites this paper
• Metabolic and microbial responses to the complexation of manuka honey with α-cyclodextrin after simulated gastrointestinal digestion and fermentation

  2017cites this paper
• Reduced Glutathione Level Promotes Epithelial-Mesenchymal Transition in Lens Epithelial Cells via a Wnt/β-Catenin-Mediated Pathway: Relevance for Cataract Therapy.

  2017cites this paper
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  2016cites this paper
• Dicarbonyls and glyoxalase in disease mechanisms and clinical therapeutics

  2016cites this paper
• Methylglyoxal-induced dicarbonyl stress in aging and disease: first steps towards glyoxalase 1-based treatments.

  2016cites this paper
• Mass spectrometric determination of early and advanced glycation in biology

  2016cites this paper
• Advanced glycation end-products inhibit mesenchymal-epidermal interaction by up-regulating proinflammatory cytokines in hair follicles

  2015cites this paper
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  2015cites this paper
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  2015cites this paper
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• Effect of chronic hypoxia on RAGE and its soluble forms in lungs and plasma of mice.

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