Could MYC Induction of Mitochondrial Biogenesis be linked to ROS Production and Genomic Instability?

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Cell Cycle

• Publication date

  2005-08-22

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4161/cc.4.11.2121PMID 16205115
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• sQUIZ your knowledge! A case with unusual Nikolski sign: a diagnostic challenge!

  2023cited by this paper
• Antioxidants prevent oxidative DNA damage and cellular transformation elicited by the over-expression of c-MYC.

  2006cited by this paper
• Transcriptional regulation and transformation by Myc proteins

  2005cited by this paper
• Myc Stimulates Nuclearly Encoded Mitochondrial Genes and Mitochondrial Biogenesis

  2005cited by this paper
• Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation.

  2005cited by this paper
• Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing.

  2005cited by this paper
• Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-alpha activation.

  2005cited by this paper
• Peroxiredoxin III, a Mitochondrion-specific Peroxidase, Regulates Apoptotic Signaling by Mitochondria*

  2004cited by this paper
• In silico identification of transcriptional regulators associated with c-Myc.

  2004cited by this paper
• A switch in metabolism precedes increased mitochondrial biogenesis in respiratory chain-deficient mouse hearts.

  2004cited by this paper
• A common set of gene regulatory networks links metabolism and growth inhibition.

  2004cited by this paper
• Mitochondrial proteome: Altered cytochrome c oxidase subunit levels in prostate cancer

  2003cited by this paper
• c-MYC apoptotic function is mediated by NRF-1 target genes.

  2003cited by this paper
• Myc's Mastery of Mitochondrial Mischief

  2003cited by this paper
• Increased expression of mitochondrial peroxiredoxin-3 (thioredoxin peroxidase-2) protects cancer cells against hypoxia and drug-induced hydrogen peroxide-dependent apoptosis.

  2003cited by this paper
• The myc oncogene: MarvelouslY Complex.

  2002cited by this paper
• The c-Myc target gene PRDX3 is required for mitochondrial homeostasis and neoplastic transformation

  2002cited by this paper
• E2F1 and c-Myc potentiate apoptosis through inhibition of NF-kappaB activity that facilitates MnSOD-mediated ROS elimination.

  2002cited by this paper
• c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instability.

  2002cited by this paper
• The Myc/Max/Mad network and the transcriptional control of cell behavior.

  2000cited by this paper
• MYC oncogenes and human neoplastic disease

  1999cited by this paper
• c-Myc Target Genes Involved in Cell Growth, Apoptosis, and Metabolism

  1999cited by this paper
• Decreased ability of cells overexpressing MYC proteins to reduce peroxide and hydroperoxides.

  1996cited by this paper

• c-Myc: Central Regulator of Autophagy and Senescence in Cancer.

  2026cites this paper
• The oncogenic role of TIMM8A in cancer and the mechanistic insights into the function in breast cancer cells

  2025cites this paper
• Multifaceted roles of microbiota-derived deoxycholic acid in gastrointestinal cancers: from barrier disruption to therapeutic implications

  2025cites this paper
• The role of redox signaling in mitochondria and endoplasmic reticulum regulation in kidney diseases

  2025cites this paper
• F-ATP synthase inhibitory factor 1 and mitochondria-organelle interactions: new insight and implications.

  2024cites this paper
• ONC201 Suppresses Neuroblastoma Growth by Interrupting Mitochondrial Function and Reactivating Nuclear ATRX Expression While Decreasing MYCN

  2023cites this paper
• F-ATP synthase inhibitory factor 1 regulates metabolic reprogramming involving its interaction with c-Myc and PGC1α

  2023cites this paper
• Deoxycholic Acid Modulates Cell-Junction Gene Expression and Increases Intestinal Barrier Dysfunction

  2022cites this paper
• Regulation of Normal and Neoplastic Proliferation and Metabolism by the Extended Myc Network

  2022cites this paper
• MTBP and MYC: A Dynamic Duo in Proliferation, Cancer, and Aging

  2022cites this paper
• The MYC oncogene — the grand orchestrator of cancer growth and immune evasion

  2021cites this paper
• The Role of Non-Coding RNAs in the Regulation of the Proto-Oncogene MYC in Different Types of Cancer

  2021cites this paper
• MYC: a multipurpose oncogene with prognostic and therapeutic implications in blood malignancies

  2021cites this paper
• The Significance of Mitochondrial Dysfunction in Cancer

  2020cites this paper
• Regulation of Tolerogenic Features on Dexamethasone-Modulated MPLA-Activated Dendritic Cells by MYC

  2019cites this paper
• Camptothecin enhances c-Myc-mediated endoplasmic reticulum stress and leads to autophagy by activating Ca2+-mediated AMPK.

  2018cites this paper
• C-Myc misregulation triggers complex process of genomic instability

  2018cites this paper
• MYC-induced metabolic stress and tumorigenesis.

  2018cites this paper
• Altered Mitochondrial Signalling and Metabolism in Cancer

  2017cites this paper
• Mitochondrial Dysfunction and Biogenesis in Neurodegenerative diseases: Pathogenesis and Treatment

  2017cites this paper
• Essential roles of Caspase-3 in facilitating Myc-induced genetic instability and carcinogenesis

  2017cites this paper
• Targeting Myc-driven tumours - BETing on ATR

  2016cites this paper
• ' Liver let die '

  2014cites this paper
• c-MYC-induced genomic instability.

  2014cites this paper
• Inhibition of human mitochondrial peptide deformylase causes apoptosis in c-myc-overexpressing hematopoietic cancers

  2014cites this paper
• 'Liver let die': oxidative DNA damage and hepatotropic viruses.

  2014cites this paper
• Mitochondria: The Anti- cancer Target for the Third Millennium

  2014cites this paper
• The effects of bioactive compounds from plant foods on mitochondrial function: a focus on apoptotic mechanisms.

  2014cites this paper
• Targeting Mitochondria of Cancer Cells: Mechanisms and Compounds

  2014cites this paper
• Mad1 mediates hypoxia-induced doxorubicin resistance in colon cancer cells by inhibiting mitochondrial function.

  2013cites this paper
• Mitochondrial alterations during carcinogenesis: a review of metabolic transformation and targets for anticancer treatments.

  2013cites this paper
• Hepatitis C virus-induced activation of β-catenin promotes c-Myc expression and a cascade of pro-carcinogenetic events

  2013cites this paper
• Crosstalk between mitochondrial (dys)function and mitochondrial abundance

  2012cites this paper
• TUFM is a potential new prognostic indicator for colorectal carcinoma

  2012cites this paper
• Delineating the Role of c-Myc in Development and Propagation of Hypertrophic Cardiomyopathy

  2012cites this paper
• Transcriptional control of mitochondrial biogenesis and its interface with inflammatory processes.

  2012cites this paper
• Redox regulation of mitochondrial biogenesis.

  2012cites this paper
• Rôles des récepteurs à l'hormone thyroïdienne, TRα1 et p43, dans le contrôle de la prolifération des cellules de Sertoli chez la souris

  2011influential citation
• Reactive Oxygen Species Regulate Nucleostemin Oligomerization and Protein Degradation*

  2011cites this paper
• Oxidative stress and therapeutic opportunities: focus on the Ewing’s sarcoma family of tumors

  2011cites this paper
• Therapeutic potential of c-Myc inhibition in the treatment of hypertrophic cardiomyopathy

  2011influential citation
• The causes of cancer revisited: "mitochondrial malignancy" and ROS-induced oncogenic transformation - why mitochondria are targets for cancer therapy.

  2010cites this paper
• Anti-tumor effects by a synthetic chalcone compound is mediated by c-Myc-mediated reactive oxygen species production.

  2010cites this paper
• Glycolytic Pathway as a Target for Tumor Inhibition

  2010cites this paper
• Oxidative Stress Promotes Transcriptional Up-regulation of Fyn in BCR-ABL1-expressing Cells*

  2009cites this paper
• Prognostic relevance of c-MYC gene amplification and polysomy for chromosome 8 in suboptimally-resected, advanced stage epithelial ovarian cancers: a Gynecologic Oncology Group study.

  2009cites this paper
• Facilitating replication under stress: an oncogenic function of MYC?

  2009cites this paper
• Regulation of Reactive Oxygen Species Homeostasis by Peroxiredoxins and c-Myc*

  2009cites this paper
• Increase in mitochondrial biogenesis, oxidative stress, and glycolysis in murine lymphomas.

  2009cites this paper
• C-Myc et lymphomagenèse dans les cellules B infectées par le virus d’Epstein-Barr

  2009influential citation
• Finding an “Achilles’ heel” of cancer: The role of glucose and glutamine metabolism in the survival of transformed cells

  2008cites this paper
• Characterization of the acute temporal changes in excisional murine cutaneous wound inflammation by screening of the wound-edge transcriptome.

  2008cites this paper
• Reflecting on 25 years with MYC

  2008cites this paper
• The Cell Biology of Rad54: Implications for homologous recombination

  2008cites this paper
• The interplay between MYC and HIF in the Warburg effect.

  2007cites this paper
• Genome instability and oncogenesis

  2007cites this paper
• MYC can induce DNA breaks in vivo and in vitro independent of reactive oxygen species.

  2006cites this paper
• DNA double-strand break repair and chromosome translocations.

  2006cites this paper
• Regulation of Late G1/S Phase Transition and APCCdh1 by Reactive Oxygen Species

  2006cites this paper
• c-Myc-induced genomic instability.

  2003cites this paper