A new lumazine peptide penilumamide E from the fungus Aspergillus terreus

Abstract A new rare lumazine peptide, penilumamide E (1), together with 13 known compounds (2–14) were isolated from the fungus Aspergillus terreus. Their structures were identified by spectroscopic techniques. The relative configuration of 1 was confirmed by single-crystal X-ray diffraction analysis. Compound 10 exhibited antimalarial activity against Plasmodium falciparum with IC50 values of 2.83 μg/mL. Compounds 4 and 6 showed weak cytotoxicity against cholangiocarcinoma (CCA) cell lines. In addition, 4 and 11 exhibited weak cytotoxicity against human hepatoma cell line. Graphical abstract

• Publication year

  2016

• Venue

  Natural Product Research

• Publication date

  2016-05-02

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1080/14786419.2015.1101107PMID 26518160
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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