Synergism between thapsigargin and the phorbol ester 12-O-tetradecanoylphorbol 13-acetate on the release of [14C]arachidonic acid and histamine from rat peritoneal mast cells.

No abstract is available for this paper.

• Publication year

  1987

• Venue

  Biochemical Pharmacology

• Publication date

  1987-03-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/0006-2952(87)90711-8PMID 2435291
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Synergistic stimulation of histamine release from rat peritoneal mast cells by 12-O-tetradecanoylphorbol 13-acetate (TPA)-type and non-TPA-type tumor promoters.

  1986cited by this paper
• Simultaneous inhibitions of inositol phospholipid breakdown, arachidonic acid release, and histamine secretion in mast cells by islet-activating protein, pertussis toxin. A possible involvement of the toxin-specific substrate in the Ca2+-mobilizing receptor-mediated biosignaling system.

  1985cited by this paper
• The ability of thapsigargin and thapsigargicin to activate cells involved in the inflammatory response

  1985cited by this paper
• Arachidonic acid release in rat peritoneal mast cells stimulated with antigen, ionophore A23187, and compound 48/80.

  1985cited by this paper
• Characterization of the effects of phorbol esters on rat mast cell secretion.

  1985cited by this paper
• Absolute configurations of the histamine liberating sesquiterpene lactones thapsigargin and trilobolide

  1985cited by this paper
• The role of protein kinase C in cell surface signal transduction and tumour promotion

  1984cited by this paper
• Synergistic action of protein kinase C and calcium for histamine release from rat peritoneal mast cells.

  1984cited by this paper
• Differential activation of membrane phospholipid turnover by compound 48/80 and ionophore A23187 in rat mast cells.

  1984cited by this paper
• Purification of PGD2 11-ketoreductase from rabbit liver.

  1982cited by this paper
• Augmentation of IgE-mediated release of histamine by 5-hydroxyeicosatetraenoic acid and 12-hydroxyeicosatetraenoic acid.

  1980cited by this paper
• Prostaglandin thromboxane, and 12-hydroxy-5,8,10,14-eicosatetraenoic acid production by ionophore-stimulated rat serosal mast cells.

  1979cited by this paper
• On the mechanism of histamine release induced by thapsigargin fromThapsia garganica L.

  1979cited by this paper
• Thapsigargine and thapsigargicine, two new histamine liberators from Thapsia garganica L.

  1978cited by this paper
• Calcium Ionophores and Movement of Calcium Ions following the Physiological Stimulus to a Secretory Process

  1973cited by this paper
• A method for the fluorometric assay of histamine in tissues.

  1959cited by this paper
• Isolation of "biologically intact" mast cells.

  1959cited by this paper

• From Plant to Patient: Thapsigargin, a Tool for Understanding Natural Product Chemistry, Total Syntheses, Biosynthesis, Taxonomy, ATPases, Cell Death, and Drug Development.

  2021cites this paper
• Role of endoplasmic reticulum stress in drug‐induced toxicity

  2016cites this paper
• Flow cytometric calcium flux assay: evaluation of cytoplasmic calcium kinetics in whole blood leukocytes.

  2009cites this paper
• Attenuation of human lung mast cell degranulation by bronchial epithelium

  2006cites this paper
• Thapsia garganica L: a poisonous plant of North Africa.

  2001cites this paper
• Signal Transduction Pathways Regulating Arachidonic Acid Metabolite Generation Following FcεRI Aggregation

  1997cites this paper
• IgE Receptor (FcεRI) Function in Mast Cells and Basophils

  1997cites this paper
• Ca2+‐Atpase inhibitor, cyclopiazonic acid, releases Ca2+ from intracellular stores in rbl‐2h3 mast cells and activates a Ca2+ influx pathway that is permeable to sodium and manganese

  1995cites this paper
• Effect of ion composition on the changes in membrane potential induced with several stimuli in rat mast cells

  1994cites this paper
• Effect of signal transduction pathways on the action of thapsigargin on rat mast cells. Crosstalks between cellular signalling and cytosolic pH.

  1994cites this paper
• Indirect actions of thapsigargin on human platelets: activation of eicosanoid biosynthesis and cellular signaling pathways.

  1992cites this paper
• Effect of thapsigargin on cytosolic Ca2+ level and amylase release in rat parotid acinar cells.

  1992cites this paper
• Stimulatory effect of thapsigargin, a non-TPA-type tumor promoter, on arachidonic acid metabolism in the murine keratinocyte line HEL30 and on epidermal cell proliferation in vivo as compared to the effects of phorbol ester TPA.

  1991cites this paper
• Amplification of prostaglandin I2 production by thapsigargin.

  1991cites this paper
• The effects of the protein kinase C inhibitors staurosporine and H7 on the IgE dependent mediator release from RBL 2H3 cells

  1990cites this paper
• Effects of the protein kinase inhibitors, staurosporine and K-252a, on PGI2 production by rat liver cells (the C-9 cell line).

  1990cites this paper
• Role of phosphoinositides in transmembrane signaling.

  1990cites this paper
• Effect of amiloride on arachidonic acid and histamine release from rat mast cells

  1989cites this paper
• Activation of calcium entry by the tumor promoter thapsigargin in parotid acinar cells. Evidence that an intracellular calcium pool and not an inositol phosphate regulates calcium fluxes at the plasma membrane.

  1989cites this paper
• Inhibition by amiloride and by Na+‐depletion of A23187‐stimulated arachidonic acid and histamine release from rat mast cells

  1988cites this paper
• Neural function: metabolism and actions of inositol metabolites in mammalian brain.

  1988cites this paper
• A novel tumour promoter, thapsigargin, transiently increases cytoplasmic free Ca2+ without generation of inositol phosphates in NG115-401L neuronal cells.

  1988cites this paper
• The interaction of natural products with cellular signalling mechanisms

  1987cites this paper