Noradrenergic Activity in the Human Brain: A Mechanism Supporting the Defense Against Hypoglycemia

No abstract is available for this paper.

• Publication year

  2018

• Venue

  Journal of Clinical Endocrinology and Metabolism

• Publication date

  2018-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1210/jc.2017-02717PMID 29590401PMCID PMC6456998
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Evaluation of the agonist PET radioligand [11C]GR103545 to image kappa opioid receptor in humans: Kinetic model selection, test-retest reproducibility and receptor occupancy by the antagonist PF-04455242

  2014cited by this paper
• Functional neuroanatomy of the central noradrenergic system

  2013cited by this paper
• Influence of VMH fuel sensing on hypoglycemic responses.

  2013cited by this paper
• Ex vivo and in vivo evaluation of the norepinephrine transporter ligand [11C]MRB for brown adipose tissue imaging.

  2012cited by this paper
• Gray's Clinical Neuroanatomy: The Anatomic Basis for Clinical Neuroscience

  2011cited by this paper
• Evaluation of [11C]MRB for assessment of occupancy of norepinephrine transporters: Studies with atomoxetine in non-human primates

  2011cited by this paper
• Clinically relevant doses of methylphenidate significantly occupy norepinephrine transporters in humans in vivo.

  2010cited by this paper
• PET imaging of the effects of age and cocaine on the norepinephrine transporter in the human brain using (S,S)‐[11C]O‐methylreboxetine and HRRT

  2010cited by this paper
• Small Decrements in Systemic Glucose Provoke Increases in Hypothalamic Blood Flow Prior to the Release of Counterregulatory Hormones

  2009cited by this paper
• Effects of a Selective Serotonin Reuptake Inhibitor, Fluoxetine, on Counterregulatory Responses to Hypoglycemia in Healthy Individuals

  2008cited by this paper
• Effects of the Selective Serotonin Reuptake Inhibitor Fluoxetine on Counterregulatory Responses to Hypoglycemia in Individuals With Type 1 Diabetes

  2008cited by this paper
• Reciprocal connections between the suprachiasmatic nucleus and the midbrain raphe nuclei: A putative role in the circadian control of behavioral states

  2008cited by this paper
• Consensus Nomenclature for in vivo Imaging of Reversibly Binding Radioligands

  2007cited by this paper
• Imaging the norepinephrine transporter in humans with (S,S)-[11C]O-methyl reboxetine and PET: problems and progress.

  2007cited by this paper
• The norepinephrine transporter and its regulation

  2006cited by this paper
• Hypoglycemia-induced noradrenergic activation in the VMH is a result of decreased ambient glucose.

  2005cited by this paper
• Differential role of the hippocampus, amygdala, and dorsal raphe nucleus in regulating feeding, memory, and anxiety-like behavioral responses to ghrelin.

  2004cited by this paper
• Design of a motion-compensation OSEM list-mode algorithm for resolution-recovery reconstruction for the HRRT

  2003cited by this paper
• Linearized Reference Tissue Parametric Imaging Methods: Application to [11C]DASB Positron Emission Tomography Studies of the Serotonin Transporter in Human Brain

  2003cited by this paper
• The human raphe nuclei and the serotonergic system.

  2003cited by this paper
• Evaluation of a new norepinephrine transporter PET ligand in baboons, both in brain and peripheral organs

  2003cited by this paper
• Automated Anatomical Labeling of Activations in SPM Using a Macroscopic Anatomical Parcellation of the MNI MRI Single-Subject Brain

  2002cited by this paper
• Effects of Repetitive Hypoglycemia on Neuroendocrine Response and Brain Tyrosine Hydroxylase Activity in the Rat

  2002cited by this paper
• Insulin‐induced hypoglycemia decreases single‐unit activity of serotonergic medullary raphe neurons in freely moving cats: relationship to sympathetic and motor output

  2002cited by this paper
• Noradrenergic and GABAergic systems in the medial hypothalamus are activated during hypoglycemia.

  2001cited by this paper
• Norepinephrine mediates glucoprivic-induced increase in GABA in the ventromedial hypothalamus of rats.

  2000cited by this paper
• Design and construction of a realistic digital brain phantom

  1998cited by this paper
• Hypoglycemia in the Diabetes Control and Complications Trial

  1997cited by this paper
• Pharmacology and Distribution of Norepinephrine Transporters in the Human Locus Coeruleus and Raphe Nuclei

  1997cited by this paper
• Local ventromedial hypothalamus glucose perfusion blocks counterregulation during systemic hypoglycemia in awake rats.

  1997cited by this paper
• Hypoglycemia in the Diabetes Control and Complications Trial. The Diabetes Control and Complications Trial Research Group.

  1997cited by this paper
• Local Ventromedial Hypothalamus Glucopenia Triggers Counterregulatory Hormone Release

  1995cited by this paper
• Ventromedial hypothalamic lesions in rats suppress counterregulatory responses to hypoglycemia.

  1994cited by this paper
• Insulin reduces norepinephrine transporter mRNA in vivo in rat locus coeruleus.

  1993cited by this paper
• Hierarchy of glycemic thresholds for counterregulatory hormone secretion, symptoms, and cerebral dysfunction.

  1991cited by this paper
• Distribution of catecholamine uptake sites in human brain as determined by quantitative [3H] mazindol autoradiography

  1991cited by this paper
• Role of Brain in Counterregulation of Insulin-Induced Hypoglycemia in Dogs

  1989cited by this paper
• Single-unit responses of serotonergic neurons to glucose and insulin administration in behaving cats.

  1989cited by this paper
• Autoradiographic analysis of [3H]desmethylimipramine binding in the human brain postmortem.

  1988cited by this paper
• Effects of physiological manipulations on locus coeruleus neuronal activity in freely moving cats. II. Cardiovascular challenge.

  1987cited by this paper
• Effects of physiological manipulations on locus coeruleus neuronal activity in freely moving cats. III. Glucoregulatory challenge.

  1987cited by this paper
• Effects of physiological manipulations on locus coeruleus neuronal activity in freely moving cats. I. Thermoregulatory challenge.

  1987cited by this paper
• Relationship between medial hypothalamic α2-receptor binding, norepinephrine, and circulating glucose

  1986cited by this paper
• Relationships between medial hypothalamic alpha 2-receptor binding, norepinephrine, and circulating glucose.

  1986cited by this paper
• Histochemical visualization of peripheral and central adrenergic neurones.

  1973cited by this paper

• A head-to-head comparison of gray matter morphological differences between early-onset and middle-to-late-onset depression in a large-scale multi-site cohort.

  2026cites this paper
• Impaired LC-NE System—A Novel Molecular Mechanism Underlying Health Disparity and Increased Prevalence of Alzheimer’s Disease Among African Americans

  2026cites this paper
• Integrating [11C]methylreboxetine PET and MRI to map in vivo norepinephrine transporter distribution: A proof-of-concept study of noradrenergic vulnerability in neurodegeneration.

  2025cites this paper
• Mapping neurophysiological and molecular profiles of heterogeneity and homogeneity in schizophrenia-bipolar disorder

  2025cites this paper
• Neural correlates of abnormal regional functional efficiency in major depressive disorder: a large, multi-scale study.

  2025cites this paper
• Two subtypes of major depressive disorder are identified from individualized gray matter morphological abnormalities in a large multi-site dataset

  2025cites this paper
• Benchmarking methods for mapping functional connectivity in the brain

  2025cites this paper
• Locus coeruleus-related insula activation supports implicit learning

  2025cites this paper
• Disrupted intersubject variability architecture in structural and functional brain connectomes in major depressive disorder

  2025cites this paper
• Common neuroanatomical differential factors underlying heterogeneous gray matter volume variations in five common psychiatric disorders

  2025cites this paper
• Individualized gray matter morphological abnormalities unveil two neuroanatomical obsessive-compulsive disorder subtypes

  2025cites this paper
• Mapping Neurochemical Signatures onto Brain Structure for Neurotransmitter-Informed Discrimination of Schizophrenia Patients from Healthy Controls

  2025cites this paper
• Individualized gray matter morphological abnormalities uncover two robust transdiagnostic biotypes.

  2024cites this paper
• Norepinephrine mediates heart block during severe hypoglycemia in male rats

  2024cites this paper
• Network spreading and local biological vulnerability in amyotrophic lateral sclerosis

  2024cites this paper
• Contributions of network structure, chemoarchitecture and diagnostic categories to transitions between cognitive topographies

  2024cites this paper
• Enhanced detection of catecholamines in human urine using Cis-diol-microporous organic networks with PT-SPE and HPLC-MS/MS.

  2024cites this paper
• Shared differential factors underlying individual spontaneous neural activity abnormalities in major depressive disorder

  2024cites this paper
• Convergent functional effects of antidepressants in major depressive disorder: a neuroimaging meta-analysis

  2024cites this paper
• Mapping the microstructure of human cerebral cortex in vivo with diffusion MRI

  2024cites this paper
• Transcriptional expression patterns of the cortical morphometric similarity network in progressive supranuclear palsy

  2024cites this paper
• Convergent functional effects of antidepressants in major depressive disorder: a neuroimaging meta-analysis

  2023cites this paper
• Human pancreatic capillaries and nerve fibers persist in type 1 diabetes despite beta cell loss.

  2023cites this paper
• Transitions between cognitive topographies: contributions of network structure, neuromodulation, and disease

  2023cites this paper
• The Historical Progression of Positron Emission Tomography Research in Neuroendocrinology.

  2023cites this paper
• Integrating brainstem and cortical functional architectures

  2023cites this paper
• Molecular and connectomic vulnerability shape cross-disorder cortical abnormalities

  2022cites this paper
• Multimodal, multiscale connectivity blueprints of the cerebral cortex

  2022cites this paper
• Boronate affinity paper spray mass spectrometry for determination of elevated levels of catecholamines in urine.

  2022cites this paper
• Pathophysiology and management of hypoglycemia in diabetes

  2022cites this paper
• Effect of whole body cryotherapy on low back pain and release of endorphins and stress hormones in patients with lumbar spine osteoarthritis

  2022cites this paper
• NEUROTRANSMITTER TRANSPORTER/RECEPTOR CO-EXPRESSION SHARES ORGANIZATIONAL TRAITS WITH BRAIN STRUCTURE AND FUNCTION

  2022cites this paper
• Local molecular and global connectomic contributions to cross-disorder cortical abnormalities

  2022cites this paper
• Mapping Pharmacologically-induced Functional Reorganisation onto the Brain’s Neurotransmitter Landscape

  2022cites this paper
• Beta Blockers can mask not only Hypoglycemia, but also Hypotension.

  2022cites this paper
• Mapping neurotransmitter systems to the structural and functional organization of the human neocortex

  2021cites this paper
• Correspondence between gene expression and neurotransmitter receptor and transporter density in the human brain

  2021cites this paper
• Differential abnormalities of cerebrospinal fluid dopaminergic versus noradrenergic indices in synucleinopathies

  2021cites this paper
• Recent advances in radiotracers targeting norepinephrine transporter: structural development and radiolabeling improvements

  2020cites this paper
• Glycopenia - induced sympathoadrenal activation in diabetes mellitus and uncontrolled arterial hypertension: an observational study

  2020cites this paper
• Highly sensitive LC-MS/MS analysis of catecholamines in plasma.

  2020cites this paper
• Central Mechanisms of Glucose Sensing and Counterregulation in Defense of Hypoglycemia.

  2019cites this paper
• Molecular imaging of diabetes and diabetic complications: Beyond pancreatic β-cell targeting.

  2019cites this paper