Oral quercetin administration transiently protects respiratory function in dystrophin‐deficient mice

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Journal of Physiology

• Publication date

  2016-10-15

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1113/JP272057PMID 27094343PMCID PMC5063947
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Plethysmography measurements of respiratory function in conscious unrestrained mice

  2016cited by this paper
• Histological and biochemical outcomes of cardiac pathology in mdx mice with dietary quercetin enrichment

  2015cited by this paper
• PGC‐1α gene transfer improves muscle function in dystrophic muscle following prolonged disease progress

  2015influential reference
• AMPK-Dependent Phosphorylation of GAPDH Triggers Sirt1 Activation and Is Necessary for Autophagy upon Glucose Starvation.

  2015cited by this paper
• Long-term quercetin dietary enrichment decreases muscle injury in mdx mice.

  2015influential reference
• Resveratrol induces expression of the slow, oxidative phenotype in mdx mouse muscle together with enhanced activity of the SIRT1-PGC-1α axis.

  2014cited by this paper
• Histological and biochemical outcomes of cardiac pathology in mdx mice with dietary quercetin enrichment.

  2014cited by this paper
• Quercetin reduces obesity-associated ATM infiltration and inflammation in mice: a mechanism including AMPKα1/SIRT1[S]

  2014influential reference
• Dystrophin insufficiency causes selective muscle histopathology and loss of dystrophin‐glycoprotein complex assembly in pig skeletal muscle

  2014cited by this paper
• Quercetin protects against high glucose-induced damage in bone marrow-derived endothelial progenitor cells.

  2014influential reference
• Long-term wheel running compromises diaphragm function but improves cardiac and plantarflexor function in the mdx mouse.

  2013cited by this paper
• Rescue of dystrophic skeletal muscle by PGC-1α involves restored expression of dystrophin-associated protein complex components and satellite cell signaling.

  2013influential reference
• Resveratrol decreases inflammation and increases utrophin gene expression in the mdx mouse model of Duchenne muscular dystrophy.

  2013cited by this paper
• Lysine deacetylases and mitochondrial dynamics in neurodegeneration.

  2013cited by this paper
• Peroxisome proliferator‐activated receptor γ coactivator 1‐α gene transfer restores mitochondrial biomass and improves mitochondrial calcium handling in post‐necrotic mdx mouse skeletal muscle

  2012cited by this paper
• Rescue of Dystrophic Skeletal Muscle by PGC-1α Involves a Fast to Slow Fiber Type Shift in the mdx Mouse

  2012influential reference
• SIRT1 regulation-it ain't all NAD.

  2012cited by this paper
• Chronic AMPK activation evokes the slow, oxidative myogenic program and triggers beneficial adaptations in mdx mouse skeletal muscle.

  2011cited by this paper
• Impaired respiratory function in mdx and mdx/utrn+/− mice

  2011cited by this paper
• The cAMP/PKA pathway rapidly activates SIRT1 to promote fatty acid oxidation independently of changes in NAD(+).

  2011cited by this paper
• Quercetin reduces markers of oxidative stress and inflammation in sarcoidosis.

  2011cited by this paper
• Increased catalase expression improves muscle function in mdx mice

  2011cited by this paper
• Leupeptin-based inhibitors do not improve the mdx phenotype.

  2010cited by this paper
• Bowman-Birk inhibitor attenuates dystrophic pathology in mdx mice.

  2010cited by this paper
• Quercetin increases brain and muscle mitochondrial biogenesis and exercise tolerance.

  2009cited by this paper
• Concurrent regulation of AMP-activated protein kinase and SIRT1 in mammalian cells.

  2009cited by this paper
• p38γ Mitogen-Activated Protein Kinase Is a Key Regulator in Skeletal Muscle Metabolic Adaptation in Mice

  2009cited by this paper
• The anti-obesity effect of quercetin is mediated by the AMPK and MAPK signaling pathways.

  2008cited by this paper
• IRES-Mediated Translation of Utrophin A Is Enhanced by Glucocorticoid Treatment in Skeletal Muscle Cells

  2008cited by this paper
• Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC‐1α

  2007cited by this paper
• AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α

  2007influential reference
• PGC-1α regulates the neuromuscular junction program and ameliorates Duchenne muscular dystrophy

  2007influential reference
• AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha.

  2007cited by this paper
• Modulation of utrophin A mRNA stability in fast versus slow muscles via an AU-rich element and calcineurin signaling

  2007cited by this paper
• PGC-1alpha regulates the neuromuscular junction program and ameliorates Duchenne muscular dystrophy.

  2007cited by this paper
• SIRT1 Functionally Interacts with the Metabolic Regulator and Transcriptional Coactivator PGC-1α*

  2005influential reference
• The Utrophin A 5′-Untranslated Region Confers Internal Ribosome Entry Site-mediated Translational Control during Regeneration of Skeletal Muscle Fibers*

  2005cited by this paper
• Systemic administration of L‐arginine benefits mdx skeletal muscle function

  2005cited by this paper
• Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: modulation by p38 MAPK.

  2004cited by this paper
• Dystrophic phenotype of canine X-linked muscular dystrophy is mitigated by adenovirus-mediated utrophin gene transfer

  2003cited by this paper
• A quantitative study of bioenergetics in skeletal muscle lacking utrophin and dystrophin.

  2002influential reference
• Force and power output of fast and slow skeletal muscles from mdx mice 6‐28 months old

  2001cited by this paper
• Distinct regions in the 3′ untranslated region are responsible for targeting and stabilizing utrophin transcripts in skeletal muscle cells

  2001cited by this paper
• Prevention of the dystrophic phenotype in dystrophin/utrophin-deficient muscle following adenovirus-mediated transfer of a utrophin minigene

  2000cited by this paper
• Discordant expression of utrophin and its transcript in human and mouse skeletal muscles.

  1999cited by this paper
• Muscle fibers of mdx mice are more vulnerable to exercise than those of normal mice.

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• Effect of voluntary wheel-running exercise on muscles of the mdx mouse.

  1995cited by this paper
• α‐Dystroglycan deficiency correlates with elevated serum creatine kinase and decreased muscle contraction tension in golden retriever muscular dystrophy

  1994cited by this paper
• Adaptations in myosin heavy chain expression and contractile function in dystrophic mouse diaphragm.

  1993cited by this paper
• Dystrophin protects the sarcolemma from stresses developed during muscle contraction.

  1993cited by this paper
• The mdx mouse diaphragm reproduces the degenerative changes of Duchenne muscular dystrophy

  1991cited by this paper
• Deficiency of a glycoprotein component of the dystrophin complex in dystrophic muscle

  1990cited by this paper
• Contractile properties of skeletal muscles from young, adult and aged mice.

  1988cited by this paper
• A role for collagen in the pathogenesis of muscular dystrophy?

  1980cited by this paper

• Respiratory performance in Duchenne muscular dystrophy: Clinical manifestations and lessons from animal models

  2024cites this paper
• Molecular pathways involved in the control of contractile and metabolic properties of skeletal muscle fibers as potential therapeutic targets for Duchenne muscular dystrophy

  2024cites this paper
• Histone Deacetylases: Molecular Mechanisms and Therapeutic Implications for Muscular Dystrophies

  2023cites this paper
• Quercetin supplementation and muscular atrophy in animal models: A systematic review and meta-analysis

  2022influential citation
• Dietary Plant Extracts in Improving Skeletal Muscle Development and Metabolic Function

  2022influential citation
• A Systematic Review on the Role of SIRT1 in Duchenne Muscular Dystrophy

  2021influential citation
• Lifelong quercetin enrichment and cardioprotection in Mdx/ Lifelong quercetin enrichment and cardioprotection in Mdx/ Utrn+/− mice Utrn+/− mice

  2021cites this paper
• An anti-ADAMTS1 treatment relieved muscle dysfunction and fibrosis in dystrophic mice.

  2021cites this paper
• Natural products and skeletal muscle health.

  2021cites this paper
• Nutraceutical and pharmaceutical cocktails did not preserve diaphragm muscle function or reduce muscle damage in D2‐mdx mice

  2020influential citation
• PGC‐1α overexpression increases transcription factor EB nuclear localization and lysosome abundance in dystrophin‐deficient skeletal muscle

  2020cites this paper
• Flavonoids: nutraceutical potential for counteracting muscle atrophy

  2020cites this paper
• The regulatory role of dietary factors in skeletal muscle development, regeneration and function

  2020cites this paper
• The protective role of desmin in duchenne muscular dystrophy: Therapeutic insights

  2020cites this paper
• Utrophin A Upregulation by FDA-Approved Drugs for the Treatment of Duchenne Muscular Dystrophy

  2019cites this paper
• Nutraceutical and pharmaceutical cocktails did not improve muscle function or reduce histological damage in d2-mdx mice.

  2019cites this paper
• Inspiratory pressure‐generating capacity is preserved during ventilatory and non‐ventilatory behaviours in young dystrophic mdx mice despite profound diaphragm muscle weakness

  2019cites this paper
• Autophagy in the heart is enhanced and independent of disease progression in mus musculus dystrophinopathy models

  2019cites this paper
• Polyphenols and their potential role in preventing skeletal muscle atrophy.

  2019cites this paper
• Autophagic dysfunction and autophagosome escape in the mdx mus musculus model of Duchenne muscular dystrophy

  2018cites this paper
• Is Exercise the Right Medicine for Dystrophic Muscle?

  2018cites this paper
• Long‐term dietary quercetin enrichment as a cardioprotective countermeasure in mdx mice

  2017influential citation
• Designing translationally relevant preclinical studies of new therapeutics

  2017influential citation
• Tempol Supplementation Restores Diaphragm Force and Metabolic Enzyme Activities in mdx Mice

  2017cites this paper
• Lifelong quercetin enrichment and cardioprotection in Mdx/Utrn+/- mice.

  2017cites this paper
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  2016cites this paper
• 1 Lifelong quercetin enrichment and cardioprotection in Mdx / Utrn + /-mice 1 2 3 4

  2016cites this paper