Antidepressant-like effects of 3,6'-disinapoyl sucrose on hippocampal neuronal plasticity and neurotrophic signal pathway in chronically mild stressed rats.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Neurochemistry International

• Publication date

  2010-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.neuint.2009.12.004PMID 20018220
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Pharmacopoeia of the People's Republic of China

  2010cited by this paper
• Desipramine prevents stress-induced changes in depressive-like behavior and hippocampal markers of neuroprotection

  2009cited by this paper
• A bioactive compound from Polygala tenuifolia regulates efficiency of chronic stress on hypothalamic-pituitary-adrenal axis.

  2009cited by this paper
• [Study on antidepressant components of sucrose ester from Polygala tenuifolia].

  2008cited by this paper
• Antidepressant Effect of 3′,6-Disinapoyl Sucrose from Polygala tenuifolia Willd in Pharmacological Depression Model

  2008cited by this paper
• Regulation of adult hippocampal neurogenesis: relevance to depression

  2007cited by this paper
• Hippocampal neurogenesis: Opposing effects of stress and antidepressant treatment

  2006cited by this paper
• BDNF function in adult synaptic plasticity: the synaptic consolidation hypothesis.

  2005cited by this paper
• Antidepressants and prolonged stress in rats modulate CAM-L1, laminin, and pCREB, implicated in neuronal plasticity.

  2005cited by this paper
• Neurotrophin-mediated rapid signaling in the central nervous system: mechanisms and functions.

  2005cited by this paper
• From monoamines to genomic targets: a paradigm shift for drug discovery in depression

  2004cited by this paper
• Activation of cAMP Signaling Facilitates the Morphological Maturation of Newborn Neurons in Adult Hippocampus

  2004cited by this paper
• Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant

  2004cited by this paper
• Requirement of Hippocampal Neurogenesis for the Behavioral Effects of Antidepressants

  2003cited by this paper
• Regulation of Neurogenesis in Adult Mouse Hippocampus by cAMP and the cAMP Response Element-Binding Protein

  2002cited by this paper
• The antidepressant tianeptine persistently modulates glutamate receptor currents of the hippocampal CA3 commissural associational synapse in chronically stressed rats

  2002cited by this paper
• Norepinephrine alters the expression of genes involved in neuronal sprouting and differentiation: relevance for major depression and antidepressant mechanisms

  2002cited by this paper
• Stress-induced changes in cerebral metabolites, hippocampal volume, and cell proliferation are prevented by antidepressant treatment with tianeptine

  2001cited by this paper
• Chronic imipramine treatment partially reverses the long-term changes of hippocampal synaptic plasticity in socially stressed rats.

  2001cited by this paper
• Trimerization of Cell Adhesion Molecule L1 Mimics Clustered L1 Expression on the Cell Surface

  2000cited by this paper
• Cellular signaling by neural cell adhesion molecules of the immunoglobulin superfamily

  2000cited by this paper
• A molecular and cellular theory of depression.

  1997cited by this paper
• Role of laminin-nidogen complexes in basement membrane formation during embryonic development

  1995cited by this paper

• Unveiling the ‘Eating Poison’ of Polygala tenuifolia xylem: Mood changes and myocardial injury

  2025cites this paper
• Targeting neurodegenerative diseases with bioactive oligosaccharides: Mechanisms and prospects.

  2025cites this paper
• Jiawei Kongsheng Zhenzhong Pill: marker compounds, absorption into the serum (rat), and Q-markers identified by UPLC-Q-TOF-MS/MS

  2024cites this paper
• Polygalae Radix: review of metabolites, pharmacological activities and toxicology

  2024cites this paper
• The dose-dependent neuroprotective effect of norepinephrine in improving memory retrieval in an experimental model of multiple sclerosis, experimental autoimmune encephalomyelitis.

  2024cites this paper
• Efficacy of Chinese herbal formula Kai-Xin-San on rodent models of depression: A systematic review and meta-analysis.

  2023cites this paper
• The useful biological properties of sucrose esters: Opportunities for the development of new functional foods

  2023cites this paper
• Pharmacology of Polygala tenuifolia and Its Significance in Traditional Chinese Medicine

  2023cites this paper
• The beneficial effect of 3,6'-Disinapoyl sucrose on the cognitive decline via CREB/BDNF signal pathway in APP/PS1 transgenic mice.

  2023cites this paper
• Optimization of Ultrasonic-Assisted Extraction of Active Components and Antioxidant Activity from Polygala tenuifolia: A Comparative Study of the Response Surface Methodology and Least Squares Support Vector Machine

  2022cites this paper
• 3,6'‐disinapoyl sucrose attenuates Aβ1‐42‐ induced neurotoxicity in Caenorhabditis elegans by enhancing antioxidation and regulating autophagy

  2022cites this paper
• 3,6'-Disinapoylsucrose alleviates the amyloid precursor protein and lipopolysaccharide induced cognitive dysfunction through upregulation of the TrkB/BDNF pathway

  2022cites this paper
• Anxiolytic effects, metabolism and plasma pharmacokinetics of 3, 6' -disinapoylsucrose.

  2022cites this paper
• Comprehensive Quality Assessment of Kaixin Powder by HPLC–DAD Quantification and HPLC–QTOF-MS/MS Confirmation

  2021cites this paper
• Comparative Study on the Chemical Components and Gastrointestinal Function on Rats of the Raw Product and Licorice-Simmered Product of Polygala tenuifolia

  2021cites this paper
• Rapid Identification of 3,6′-Disinapoyl Sucrose Metabolites in Alzheimer’s Disease Model Mice Using UHPLC–Orbitrap Mass Spectrometry

  2021cites this paper
• Active constituent of Polygala tenuifolia attenuates cognitive deficits by rescuing hippocampal neurogenesis in APP/PS1 transgenic mice

  2021cites this paper
• Effects of Radix Polygalae on Cognitive Decline and Depression in Estradiol Depletion Mouse Model of Menopause

  2021cites this paper
• Network pharmacology study on the mechanism of Qiangzhifang in the treatment of panic disorder

  2021cites this paper
• Neuroplasticity: A Key Player in the Antidepressant Action of Chinese Herbal Medicine.

  2021cites this paper
• A validated UHPLC-MS/MS method for pharmacokinetic and brain distribution studies of twenty constituents in rat after oral administration of Jia-Wei-Qi-Fu-Yin.

  2021cites this paper
• Involvement of 5‐HT‐BDNF signaling axis in mediating synergistic antidepressant‐like effects after combined administration of two oligosaccharide esters

  2021cites this paper
• Natural sucrose esters: Perspectives on the chemical and physiological use of an under investigated chemical class of compounds.

  2020cites this paper
• Neuropathic Pain Causes Memory Deficits and Dendrite Tree Morphology Changes in Mouse Hippocampus

  2020cites this paper
• Polygalae Radix: A review of its traditional uses, phytochemistry, pharmacology, toxicology, and pharmacokinetics.

  2020cites this paper
• UHPLC-MS/MS method for pharmacokinetic and bioavailability determination of five bioactive components in raw and various processed products of Polygala tenuifolia in rat plasma

  2020cites this paper
• Study on myelin injury of AD mice treated with Shenzhiling oral liquid in the PI3K/Akt–mTOR pathway

  2020cites this paper
• Identification of protein targets for the antidepressant effects of Kai-Xin-San in Chinese medicine using isobaric tags for relative and absolute quantitation

  2019cites this paper
• Promoting neurogenesis in hippocampal dentate gyrus of chronic unpredictable stress-induced depressive-like rats with paeoniflorin.

  2019cites this paper
• The Protective Effect of Ethanol Extract of Polygalae Radix against Oxidative Stress-Induced DNA Damage and Apoptosis in Chang Liver Cells

  2019cites this paper
• A Chinese Herbal Preparation, Xiao-Er-An-Shen Decoction, Exerts Neuron Protection by Modulation of Differentiation and Antioxidant Activity in Cultured PC12 Cells

  2018cites this paper
• 1,3,7-Trihydroxyxanthone, derived from Polygalae Radix, a herbal medicine, stimulates the expression of neurotrophic factors in rat astrocyte primary cultures via cAMP- and ERK-dependent pathways.

  2018cites this paper
• UHPLC-MS/MS method for simultaneous determination of Radix Polygalae glycolipids and organic acids in rat plasma and application in a pharmacokinetic study.

  2018cites this paper
• Polygalae radix extract ameliorates behavioral and neuromorphological abnormalities in chronic corticosterone‐treated mice

  2018cites this paper
• Illumination on “Reserving Phloem and Discarding Xylem” and Quality Evaluation of Radix polygalae by Determining Oligosaccharide Esters, Saponins, and Xanthones

  2018cites this paper
• Microglia Loss Contributes to the Development of Major Depression Induced by Different Types of Chronic Stresses

  2017cites this paper
• A Modified Chinese Herbal Decoction (Kai-Xin-San) Promotes NGF-Induced Neuronal Differentiation in PC12 Cells via Up-Regulating Trk A Signaling

  2017cites this paper
• Determination of the phytochemical composition of Jingning fang and the in vivo pharmacokinetics of its metabolites in rat plasma by UPLC-MS/MS.

  2017cites this paper
• The Genus Alnus, A Comprehensive Outline of Its Chemical Constituents and Biological Activities

  2017cites this paper
• Antidepressant effects of Kai-Xin-San in fluoxetine-resistant depression rats

  2017cites this paper
• Reduced Consolidation, Reinstatement, and Renewal of Conditioned Fear Memory by Repetitive Treatment of Radix Polygalae in Mice

  2017cites this paper
• Ultra high performance liquid chromatography with mass spectrometry for the rapid analysis and global characterization of multiple constituents from Zibu Piyin Recipe.

  2016cites this paper
• Piromelatine ameliorates memory deficits associated with chronic mild stress-induced anhedonia in rats

  2016cites this paper
• Naturally Occurring Cinnamic Acid Sugar Ester Derivatives

  2016cites this paper
• A Chinese herbal decoction, reformulated from Kai-Xin-San, relieves the depression-like symptoms in stressed rats and induces neurogenesis in cultured neurons

  2016cites this paper
• Synergistic Neuroprotective Effects of Two Herbal Ingredients via CREB-Dependent Pathway

  2016cites this paper
• Tenuifoliside A promotes neurite outgrowth in PC12 cells via the PI3K/AKT and MEK/ERK/CREB signaling pathways.

  2015influential citation
• Optimizing the compatibility of paired-herb in an ancient Chinese herbal decoction Kai-Xin-San in activating neurofilament expression in cultured PC12 cells.

  2015cites this paper
• Polygala tenuifolia prevents anxiety-like behaviors in mice exposed to repeated restraint stress

  2015cites this paper
• An Update on Oligosaccharides and Their Esters from Traditional Chinese Medicines: Chemical Structures and Biological Activities

  2015cites this paper
• An efficient procedure for preparing main acylated pentasaccharides from Polygalae Radix using integrated extraction–adsorption method followed by semi-preparative high performance liquid chromatography

  2015cites this paper
• Antidepressant-like effects of oleoylethanolamide in a mouse model of chronic unpredictable mild stress.

  2015cites this paper
• Indirect identification of antioxidants in Polygalae Radix through their reaction with 2,2-diphenyl-1-picrylhydrazyl and subsequent HPLC-ESI-Q-TOF-MS/MS.

  2015cites this paper
• Preclinical Evidence of Rapid-Onset Antidepressant-Like Effect in Radix Polygalae Extract

  2014cites this paper
• Neuroprotective Effects of 3,6′-Disinapoyl Sucrose Through Increased BDNF Levels and CREB Phosphorylation via the CaMKII and ERK1/2 Pathway

  2014cites this paper
• Simple and efficient preparation of 3,6′-disinapoylsucrose from Polygalae Radix via column chromatographic extraction and reversed-phase flash chromatography

  2014cites this paper
• Quality analysis of Polygala tenuifolia root by ultrahigh performance liquid chromatography–tandem mass spectrometry and gas chromatography–mass spectrometry

  2014cites this paper
• Effect of Tenuifoliside A isolated from Polygala tenuifolia on the ERK and PI3K pathways in C6 glioma cells.

  2014cites this paper
• Antidepressant and Neuroprotective Effect of the Chinese Herb Kaixinsan against Lentiviral shRNA Knockdown Brain-Derived Neurotrophic Factor-Induced Injury in vitro and in vivo

  2014cites this paper
• Intestinal Transport of 3,6′-Disinapoylsucrose, A Major Active Component of Polygala tenuifolia, Using Caco-2 Cell Monolayer and In Situ Rat Intestinal Perfusion Models

  2013cites this paper
• Analysis and detection of the chemical constituents of Radix Polygalae and their metabolites in rats after oral administration by ultra high-performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry.

  2013cites this paper
• Antidepressant-like effects and memory enhancement of a herbal formula in mice exposed to chronic mild stress

  2013cites this paper
• Effect of Kai Xin San on Learning and Memory in a Rat Model of Paradoxical Sleep Deprivation

  2013cites this paper
• Antidepressant-like effect of the extracted of Kai Xin San, a traditional Chinese herbal prescription, is explained by modulation of the central monoaminergic neurotransmitter system in mouse.

  2012cites this paper
• Advances in Relationship Between Brain-derived Neurotrophic Factor and Depressive Disorder*: Advances in Relationship Between Brain-derived Neurotrophic Factor and Depressive Disorder*

  2012cites this paper
• Ethnobotanical treatment strategies against Alzheimer's disease.

  2012cites this paper
• A Pharmacognostic Approach to the Polygala Genus: Phytochemical and Pharmacological Aspects

  2012cites this paper
• Effects of a Chinese traditional formula Kai Xin San (KXS) on chronic fatigue syndrome mice induced by forced wheel running.

  2012cites this paper
• Application of Complementary and Alternative Medicine on Neurodegenerative Disorders: Current Status and Future Prospects

  2012cites this paper
• Neurobiology of chronic mild stress: parallels to major depression.

  2012cites this paper
• Lamotrigine treatment reverses depressive-like behavior and alters BDNF levels in the brains of maternally deprived adult rats.

  2012cites this paper
• The Effects of CREB-mediated BDNF Expression on Memory- and Anxiety-related Behaviours in the Adult Mouse

  2012cites this paper
• A Standardized Chinese Herbal Decoction, Kai-Xin-San, Restores Decreased Levels of Neurotransmitters and Neurotrophic Factors in the Brain of Chronic Stress-Induced Depressive Rats

  2012cites this paper
• In animal models, psychosocial stress-induced (neuro)inflammation, apoptosis and reduced neurogenesis are associated to the onset of depression.

  2011cites this paper
• Neurotrophins Role in Depression Neurobiology: A Review of Basic and Clinical Evidence

  2011cites this paper
• Protection of SH-SY5Y Neuronal Cells from Glutamate-Induced Apoptosis by 3,6′-Disinapoyl Sucrose, a Bioactive Compound Isolated from Radix Polygala

  2011cites this paper
• Chronic dizocilpine or apomorphine and development of neuropathy in two animal models II: effects on brain cytokines and neurotrophins.

  2011cites this paper
• Agomelatine reverses the decrease in hippocampal cell survival induced by chronic mild stress.

  2011cites this paper
• Quality assessment of a formulated Chinese herbal decoction, Kaixinsan, by using rapid resolution liquid chromatography coupled with mass spectrometry: A chemical evaluation of different historical formulae.

  2010cites this paper
• TMR Modern Herbal Medicine

  year unknowncites this paper
• University of Groningen The stressed brain

  year unknowncites this paper