RNA adenosine deaminase ADAR1 deficiency leads to increased activation of protein kinase PKR and reduced vesicular stomatitis virus growth following interferon treatment.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Virology

• Publication date

  2010-01-20

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.virol.2009.10.026PMID 19913273PMCID PMC2789878
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• RNA-specific Adenosine Deaminase ADAR1 Suppresses Measles Virus-induced Apoptosis and Activation of Protein Kinase PKR*

  2009cited by this paper
• The RNA-activated Protein Kinase Enhances the Induction of Interferon-β and Apoptosis Mediated by Cytoplasmic RNA Sensors*

  2009cited by this paper
• ADAR1 Interacts with PKR during Human Immunodeficiency Virus Infection of Lymphocytes and Contributes to Viral Replication

  2009cited by this paper
• Editing of HIV-1 RNA by the double-stranded RNA deaminase ADAR1 stimulates viral infection

  2009cited by this paper
• ADAR1 is essential for maintenance of hematopoiesis and suppression of interferon signaling

  2008influential reference
• Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures.

  2008cited by this paper
• Organization of the mouse RNA-specific adenosine deaminase Adar1 gene 5'-region and demonstration of STAT1-independent, STAT2-dependent transcriptional activation by interferon.

  2008cited by this paper
• Interferon-inducible antiviral effectors

  2008cited by this paper
• Protein Kinase PKR Plays a Stimulus- and Virus-Dependent Role in Apoptotic Death and Virus Multiplication in Human Cells

  2007cited by this paper
• ADENOSINE DEAMINASE ACTING ON RNA 1 ACCELERATES CELL CYCLE THROUGH INCREASED TRANSLATION AND ACTIVITY OF CYCLIN-DEPENDENT KINASE 2

  2007cited by this paper
• Loss of Protein Kinase PKR Expression in Human HeLa Cells Complements the Vaccinia Virus E3L Deletion Mutant Phenotype by Restoration of Viral Protein Synthesis

  2007cited by this paper
• The p110 Isoform of the CDP/Cux Transcription Factor Accelerates Entry into S Phase

  2006cited by this paper
• Double-Stranded RNA Deaminase ADAR1 Increases Host Susceptibility to Virus Infection

  2006cited by this paper
• Interferon action and the double-stranded RNA-dependent enzymes ADAR1 adenosine deaminase and PKR protein kinase.

  2006cited by this paper
• Activation of the RNA-dependent Protein Kinase PKR Promoter in the Absence of Interferon Is Dependent Upon Sp Proteins*

  2006cited by this paper
• Impact of Protein Kinase PKR in Cell Biology: from Antiviral to Antiproliferative Action

  2006cited by this paper
• The interferon response circuit: Induction and suppression by pathogenic viruses

  2005cited by this paper
• Expression of Interferon-inducible RNA Adenosine Deaminase ADAR1 during Pathogen Infection and Mouse Embryo Development Involves Tissue-selective Promoter Utilization and Alternative Splicing*

  2005cited by this paper
• ADAR gene family and A-to-I RNA editing: diverse roles in posttranscriptional gene regulation.

  2005influential reference
• The crystal structure of the Zbeta domain of the RNA-editing enzyme ADAR1 reveals distinct conserved surfaces among Z-domains.

  2005cited by this paper
• PIKE/nuclear PI 3‐kinase signaling mediates the antiapoptotic actions of NGF in the nucleus

  2004cited by this paper
• Stress-induced Apoptosis Associated with Null Mutation of ADAR1 RNA Editing Deaminase Gene*

  2004influential reference
• Liver Disintegration in the Mouse Embryo Caused by Deficiency in the RNA-editing Enzyme ADAR1*

  2004influential reference
• Regulation of ion channel/neurotransmitter receptor function by RNA editing.

  2003cited by this paper
• Inhibition of Hepatitis Delta Virus RNA Editing by Short Inhibitory RNA-Mediated Knockdown of ADAR1 but Not ADAR2 Expression

  2002cited by this paper
• RNA editing by adenosine deaminases that act on RNA.

  2002cited by this paper
• Mechanism of Interferon Action : Inhibition of Vesicular Stomatitis Virus Replication in Human Amnion U Cells by Cloned Human Leukocyte Interferon 11

  2001cited by this paper
• Underediting of glutamate receptor GluR-B mRNA in malignant gliomas

  2001influential reference
• Vaccinia virus E3L interferon resistance protein inhibits the interferon-induced adenosine deaminase A-to-I editing activity.

  2001cited by this paper
• Antiviral Actions of Interferons

  2001cited by this paper
• Essential role for the dsRNA-dependent protein kinase PKR in innate immunity to viral infection.

  2000cited by this paper
• The Murine Double-Stranded RNA-Dependent Protein Kinase PKR Is Required for Resistance to Vesicular Stomatitis Virus

  2000cited by this paper
• Chimeric double-stranded RNA-specific adenosine deaminase ADAR1 proteins reveal functional selectivity of double-stranded RNA-binding domains from ADAR1 and protein kinase PKR.

  2000cited by this paper
• Human RNA-specific adenosine deaminase (ADAR1) gene specifies transcripts that initiate from a constitutively active alternative promoter.

  2000cited by this paper
• Serotonin-2C Receptor Pre-mRNA Editing in Rat Brain andin Vitro by Splice Site Variants of the Interferon-inducible Double-stranded RNA-specific Adenosine Deaminase ADAR1*

  1999cited by this paper
• Editing of Glutamate Receptor Subunit B Pre-mRNA by Splice-site Variants of Interferon-inducible Double-stranded RNA-specific Adenosine Deaminase ADAR1*

  1999cited by this paper
• Human RNA-specific adenosine deaminase ADAR1 transcripts possess alternative exon 1 structures that initiate from different promoters, one constitutively active and the other interferon inducible.

  1999cited by this paper
• Adenovirus VAI RNA antagonizes the RNA-editing activity of the ADAR adenosine deaminase.

  1998cited by this paper
• Isolation of the interferon-inducible RNA-dependent protein kinase Pkr promoter and identification of a novel DNA element within the 5'-flanking region of human and mouse Pkr genes.

  1997cited by this paper
• Functionally Distinct Double-stranded RNA-binding Domains Associated with Alternative Splice Site Variants of the Interferon-inducible Double-stranded RNA-specific Adenosine Deaminase*

  1997cited by this paper
• Nuclear antisense RNA induces extensive adenosine modifications and nuclear retention of target transcripts.

  1997cited by this paper
• Map location, genomic organization and expression patterns of the human RED1 RNA editase

  1997cited by this paper
• Mechanism of interferon action: functionally distinct RNA-binding and catalytic domains in the interferon-inducible, double-stranded RNA-specific adenosine deaminase

  1996cited by this paper
• A mammalian RNA editing enzyme

  1996cited by this paper
• Mechanism of interferon action: double-stranded RNA-specific adenosine deaminase from human cells is inducible by alpha and gamma interferons.

  1995cited by this paper
• Cloning of cDNAs encoding mammalian double-stranded RNA-specific adenosine deaminase

  1995cited by this paper
• The interferon-inducible, double-stranded RNA-specific adenosine deaminase gene (DSRAD) maps to human chromosome 1q21.1-21.2.

  1995cited by this paper
• Expression and regulation by interferon of a double-stranded-RNA-specific adenosine deaminase from human cells: evidence for two forms of the deaminase

  1995cited by this paper
• Molecular cloning of cDNA for double-stranded RNA adenosine deaminase, a candidate enzyme for nuclear RNA editing.

  1994cited by this paper
• Mechanism of interferon action: structure of the mouse PKR gene encoding the interferon-inducible RNA-dependent protein kinase.

  1994cited by this paper
• The eIF-2 alpha protein kinases, regulators of translation in eukaryotes from yeasts to humans.

  1993cited by this paper
• Mechanism of interferon action: evidence for intermolecular autophosphorylation and autoactivation of the interferon-induced, RNA-dependent protein kinase PKR

  1993cited by this paper
• Identification of a conserved motif that is necessary for binding of the vaccinia virus E3L gene products to double-stranded RNA.

  1993cited by this paper
• RNA editing of AMPA receptor subunit GluR-B: a base-paired intron-exon structure determines position and efficiency.

  1993cited by this paper
• A specific base transition occurs on replicating hepatitis delta virus RNA

  1990cited by this paper
• A double-stranded RNA unwinding activity introduces structural alterations by means of adenosine to inosine conversions in mammalian cells and Xenopus eggs.

  1989cited by this paper
• An unwinding activity that covalently modifies its double-stranded RNA substrate.

  1988cited by this paper
• Antisense RNA injections in fertilized frog eggs reveal an RNA duplex unwinding activity.

  1987cited by this paper
• Adenovirus VAI RNA antagonizes the antiviral action of interferon by preventing activation of the interferon-induced eIF-2α kinase

  1986cited by this paper
• Adenovirus VAI RNA antagonizes the antiviral action of interferon by preventing activation of the interferon-induced eIF-2 alpha kinase.

  1986cited by this paper
• Mechanism of interferon action: inhibition of vesicular stomatitis virus replication in human amnion U cells by cloned human leukocyte interferon. II. Effect on viral macromolecular synthesis.

  1983cited by this paper
• Mechanism of interferon action: cloned human leukocyte interferons induce protein kinase and inhibit vesicular stomatitis virus but not reovirus replication in human amnion cells.

  1981cited by this paper
• Mechanism of interferon action: phosphorylation of protein synthesis initiation factor eIF-2 in interferon-treated human cells by a ribosome-associated kinase processing site specificity similar to hemin-regulated rabbit reticulocyte kinase.

  1979cited by this paper
• Cyclic production of vesicular stomatitis virus caused by defective interfering particles.

  1974cited by this paper
• Defective Viral Particles and Viral Disease Processes

  1970cited by this paper

• The role of ADAR1 in human pathophysiology

  2025cites this paper
• ADAR1: from basic mechanisms to inhibitors

  2024cites this paper
• ADAR1 p150 prevents HSV-1 from triggering PKR/eIF2α-mediated translational arrest and is required for efficient viral replication

  2024cites this paper
• Ubiquitination network in the type I IFN‐induced antiviral signaling pathway

  2023cites this paper
• ADAR1p150 Prevents MDA5 and PKR Activation via Distinct Mechanisms to Avert Fatal Autoinflammation

  2023cites this paper
• ADAR1p150 prevents MDA5 and PKR activation via distinct mechanisms to avert fatal autoinflammation.

  2023cites this paper
• Generation of a new Adar1p150−/− mouse demonstrates isoform-specific roles in embryonic development and adult homeostasis

  2022cites this paper
• Inosine and its methyl derivatives: Occurrence, biogenesis, and function in RNA.

  2022cites this paper
• Z‐nucleic acids: Uncovering the functions from past to present

  2022cites this paper
• RNA adenosine deaminase (ADAR1) alleviates high-fat diet-induced nonalcoholic fatty liver disease by inhibiting NLRP3 inflammasome

  2022cites this paper
• Adenosine-to-inosine editing of endogenous Z-form RNA by the deaminase ADAR1 prevents spontaneous MAVS-dependent type I interferon responses

  2021cites this paper
• Deciphering the Biological Significance of ADAR1–Z-RNA Interactions

  2021cites this paper
• ADAR Editing in Viruses: An Evolutionary Force to Reckon with

  2021cites this paper
• Inhibition of PKR by Viruses

  2021cites this paper
• ADAR1 restricts ZBP1-mediated immune response and PANoptosis to promote tumorigenesis.

  2021influential citation
• Marburg and Ebola Virus mRNA 3′ Untranslated Regions Contain Negative Regulators of Translation That Are Modulated by ADAR1 Editing

  2021influential citation
• Protein kinase R and the integrated stress response drive immunopathology caused by mutations in the RNA deaminase ADAR1.

  2021cites this paper
• Adenosine Deaminases Acting on RNA (ADARs) and Viral Infections.

  2021cites this paper
• RNA Editing: Methods and Protocols

  2021cites this paper
• Human Dicer helicase domain recruits PKR and dsRNA binding proteins during viral infection

  2020influential citation
• Human DICER helicase domain recruits PKR and modulates its antiviral activity

  2020influential citation
• PKR and the Integrated Stress Response drive immunopathology caused by ADAR1 mutation

  2020cites this paper
• Recognition of Z-RNA by ADAR1 limits interferon responses

  2020cites this paper
• The Role of RNA Editing in the Immune Response.

  2020cites this paper
• Perversely expressed long noncoding RNAs can alter host response and viral proliferation in SARS-CoV-2 infection

  2020cites this paper
• Adenosine deaminase acting on RNA (ADAR1), a suppressor of double-stranded RNA–triggered innate immune responses

  2019cites this paper
• ADAR1: “Editor-in-Chief” of Cytoplasmic Innate Immunity

  2019influential citation
• Double-stranded RNA deaminase ADAR1 promotes the Zika virus replication by inhibiting the activation of protein kinase PKR

  2019cites this paper
• Current strategies for Site-Directed RNA Editing using ADARs.

  2019cites this paper
• Retrovectors packaged in CHO cells to generate GLP-1-Fc stable expression CHO cell lines

  2019cites this paper
• ADAR1 and PKR, interferon stimulated genes with clashing effects on HIV-1 replication.

  2018cites this paper
• Rotavirus Induces Formation of Remodeled Stress Granules and P Bodies and Their Sequestration in Viroplasms To Promote Progeny Virus Production

  2018cites this paper
• ADAR1 and MicroRNA; A Hidden Crosstalk in Cancer

  2017cites this paper
• Adenosine Deaminases That Act on RNA (ADARs).

  2017cites this paper
• ADAR1 and PACT contribute to efficient translation of transcripts containing HIV-1 trans-activating response (TAR) element

  2017cites this paper
• RNA editing by ADAR1 regulates innate and antiviral immune functions in primary macrophages

  2017cites this paper
• Upon Infection, Cellular WD Repeat-Containing Protein 5 (WDR5) Localizes to Cytoplasmic Inclusion Bodies and Enhances Measles Virus Replication

  2017cites this paper
• Modulation Of PKR Activity During HIV Infection And Cellular Stress By PACT And TRBP

  2017cites this paper
• Janus effects of ADAR1 on CVB3-induced viral myocarditis at different infection stages.

  2016cites this paper
• Identification and characterization of a constitutively expressed Ctenopharyngodon idella ADAR1 splicing isoform (CiADAR1a).

  2016cites this paper
• Inhibition of PKR protects against H2O2-induced injury on neonatal cardiac myocytes by attenuating apoptosis and inflammation

  2016cites this paper
• Ubiquitin-dependent Turnover of Adenosine Deaminase Acting on RNA 1 (ADAR1) Is Required for Efficient Antiviral Activity of Type I Interferon*

  2016cites this paper
• Editing of Cellular Self-RNAs by Adenosine Deaminase ADAR1 Suppresses Innate Immune Stress Responses*

  2016cites this paper
• ADAR1, inosine and the immune sensing system: distinguishing self from non‐self

  2016cites this paper
• ADAR1 restricts LINE-1 retrotransposition

  2016cites this paper
• Novel antiviral mechanism of IFN-stimulated gene 20(ISG20) via translational suppression

  2016cites this paper
• Phenotypic Variation in Aicardi–Goutières Syndrome Explained by Cell-Specific IFN-Stimulated Gene Response and Cytokine Release

  2015cites this paper
• ADARs and the Balance Game between Virus Infection and Innate Immune Cell Response.

  2015cites this paper
• Double-stranded RNA-specific adenosine deaminase 1 (ADAR1) promotes EIAV replication and infectivity.

  2015cites this paper
• A splicing isoform of Ctenopharyngodon idella ADAR1 (CiADAR1-like): Genome organization, tissue specific expression and transcriptional regulation.

  2015cites this paper
• Programa de Pós-Graduação em Microbiologia

  2014cites this paper
• Induction of stress granules by interferon and down-regulation by the cellular RNA adenosine deaminase ADAR1.

  2014cites this paper
• ADAR1 enhances HTLV-1 and HTLV-2 replication through inhibition of PKR activity

  2014cites this paper
• Elevated signal transducers and activators of transcription 1 correlates with increased C-C motif chemokine ligand 2 and C-X-C motif chemokine 10 levels in peripheral blood of patients with systemic lupus erythematosus

  2014cites this paper
• An RNA Editor, Adenosine Deaminase Acting on Double-Stranded RNA (ADAR1)

  2014cites this paper
• HIV-1 translation and its regulation by cellular factors PKR and PACT.

  2014cites this paper
• Transcriptome-Wide Characterization of APOBEC1-Catalyzed RNA Editing Events in Macrophages

  2014influential citation
• Learning from the Messengers: Innate Sensing of Viruses and Cytokine Regulation of Immunity—Clues for Treatments and Vaccines

  2013influential citation
• Impact of interferon β and interferon stimulated gene induction on Bunyamwera virus replication

  2012influential citation
• ADARs: viruses and innate immunity.

  2012cites this paper
• Zalpha-domains: at the intersection between RNA editing and innate immunity.

  2012influential citation
• Viperin, MTAP44, and Protein Kinase R Contribute to the Interferon-Induced Inhibition of Bunyamwera Orthobunyavirus Replication

  2012cites this paper
• dsRNA-Dependent Protein Kinase PKR and its Role in Stress, Signaling and HCV Infection

  2012cites this paper
• Adenosine Deaminase Acting on RNA 1 (ADAR1) Suppresses the Induction of Interferon by Measles Virus

  2012cites this paper
• Multi-level regulation of cellular recognition of viral dsRNA

  2012cites this paper
• Stress Granule Formation Induced by Measles Virus Is Protein Kinase PKR Dependent and Impaired by RNA Adenosine Deaminase ADAR1

  2012cites this paper
• The Role of Protein Kinase R in the Interferon Response

  2011cites this paper
• Multiple levels of HIV-1 replication

  2011cites this paper
• Multiple levels of PKR inhibition during HIV‐1 replication

  2011cites this paper
• Recombinant Chicken Interferon-α Inhibits H9N2 Avian Influenza Virus Replication In Vivo by Oral Administration

  2011cites this paper
• Enhancement of Replication of RNA Viruses by ADAR1 via RNA Editing and Inhibition of RNA-Activated Protein Kinase

  2011influential citation
• Adenosine deaminases acting on RNA (ADARs) are both antiviral and proviral.

  2011cites this paper
• Protein kinase PKR and RNA adenosine deaminase ADAR1: new roles for old players as modulators of the interferon response.

  2011cites this paper
• Regulation of innate immunity through RNA structure and the protein kinase PKR.

  2011cites this paper
• Host Response to Polyomavirus Infection Is Modulated by RNA Adenosine Deaminase ADAR1 but Not by ADAR2

  2011cites this paper
• Adenosine Deaminases Acting on RNA, RNA Editing, and Interferon Action

  2011cites this paper
• RNA editing catalyzed by ADAR1 and its function in mammalian cells

  2011cites this paper
• RNA editing enzyme adenosine deaminase is a restriction factor for controlling measles virus replication that also is required for embryogenesis

  2010cites this paper
• Orchestration of the Activation of Protein Kinase R by the RNA-Binding Motif

  2010cites this paper
• Diverse functions for DNA and RNA editing in the immune system

  2010cites this paper
• Type I Interferon Modulates the Battle of Host Immune System Against Viruses

  2010cites this paper
• Gedruckt mit Genehmigung des Fachbereichs Veterinärmedizin der Freien Universität Berlin

  2009cites this paper
• Release Ifn-stimulated Gene Response and Cytokine Syndrome Explained by Cell-specific Goutières − Phenotypic Variation in Aicardi Phenotypic Variation in Aicardi–goutières Syndrome Explained by Cell-specific Ifn-stimulated Gene Response and Cytokine Release Materials and Methods Lv Production and Kn

  year unknowncites this paper
• Release Ifn-stimulated Gene Response and Cytokine Syndrome Explained by Cell-specific Goutières − Phenotypic Variation in Aicardi

  year unknowncites this paper