Astroglial 5-HT2B receptor in mood disorders

No abstract is available for this paper.

• Publication year

  2018

• Venue

  Expert Review of Neurotherapeutics

• Publication date

  2018-03-30

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1080/14737175.2018.1458612PMID 29600729
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Physiology of Astroglia.

  2018influential reference
• Bi-phasic regulation of glycogen content in astrocytes via Cav-1/PTEN/PI3K/AKT/GSK-3β pathway by fluoxetine

  2017influential reference
• Astrocyte pathology in a human neural stem cell model of frontotemporal dementia caused by mutant TAU protein

  2017cited by this paper
• Aberrant iPSC-derived human astrocytes in Alzheimer's disease

  2017cited by this paper
• Stratification of astrocytes in healthy and diseased brain

  2017cited by this paper
• Targeting astrocytes in bipolar disorder

  2016cited by this paper
• Astrocytes: a central element in neurological diseases

  2016cited by this paper
• Principles of sodium homeostasis and sodium signalling in astroglia

  2016cited by this paper
• The PI3K/Akt Pathway in Tumors of Endocrine Tissues

  2016influential reference
• Chronic SSRI stimulation of astrocytic 5-HT2B receptors change multiple gene expressions/editings and metabolism of glutamate, glucose and glycogen: a potential paradigm shift

  2015cited by this paper
• Physiology of Astroglia: Channels, Receptors, Transporters, Ion Signaling and Gliotransmission

  2015cited by this paper
• Targeting astrocytes in major depression

  2015cited by this paper
• Decrease of gene expression of astrocytic 5-HT2B receptors parallels development of depressive phenotype in a mouse model of Parkinson’s disease

  2015influential reference
• Cell type-specific in vivo expression of genes encoding signalling molecules in the brain in response to chronic mild stress and chronic treatment with fluoxetine

  2015cited by this paper
• The glial perspective of autism spectrum disorders.

  2014cited by this paper
• Phenotypic Heterogeneity and Plasticity of Isocortical and Hippocampal Astrocytes in the Human Brain

  2014cited by this paper
• EDITORIAL Neuroglia as a Central Element of Neurological Diseases: An Underappreciated Target for Therapeutic Intervention

  2014cited by this paper
• Astrogliopathology

  2014cited by this paper
• Fluoxetine and all other SSRIs are 5-HT2B Agonists - Importance for their Therapeutic Effects

  2014cited by this paper
• Continuous GSK-3β overexpression in the hippocampal dentate gyrus induces prodepressant-like effects and increases sensitivity to chronic mild stress in mice.

  2013cited by this paper
• Glial physiology and pathophysiology

  2013cited by this paper
• α1-Adrenergic receptors mediate coordinated Ca2+ signaling of cortical astrocytes in awake, behaving mice.

  2013cited by this paper
• The Pro-inflammatory Cytokine TNF-α Regulates the Activity and Expression of the Serotonin Transporter (SERT) in Astrocytes

  2013cited by this paper
• Glial Physiology and Pathophysiology: Verkhratsky/Glial Physiology and Pathophysiology

  2013cited by this paper
• Astrocyte pathology in major depressive disorder: insights from human postmortem brain tissue.

  2013cited by this paper
• Sodium dynamics: another key to astroglial excitability?

  2012cited by this paper
• Cell Type-Specific Gene Expression and Editing Responses to Chronic Fluoxetine Treatment in the In Vivo Mouse Brain and Their Relevance for Stress-Induced Anhedonia

  2012influential reference
• Depression in Parkinson's disease: diagnosis and treatment.

  2012cited by this paper
• Caveolins: targeting pro-survival signaling in the heart and brain

  2012cited by this paper
• Astrocytes as a 5-HT2B-Mediated SERT-Independent SSRI Target, Slowly Altering Depression-Associated Genes and Function

  2012cited by this paper
• Protein levels of β-catenin and activation state of glycogen synthase kinase-3β in major depression. A study with postmortem prefrontal cortex.

  2012cited by this paper
• Novel Insights into the Role of Caveolin-2 in Cell- and Tissue-Specific Signaling and Function

  2011cited by this paper
• Antidepressants act on glial cells: SSRIs and serotonin elicit astrocyte calcium signaling in the mouse prefrontal cortex.

  2011cited by this paper
• A review on animal models for screening potential anti-stress agents

  2011cited by this paper
• Pathologic caveolin-1 regulation of PTEN in idiopathic pulmonary fibrosis.

  2010cited by this paper
• Serotonin increases ERK1/2 phosphorylation in astrocytes by stimulation of 5-HT2B and 5-HT2C receptors.

  2010influential reference
• 5-HT2B receptors are expressed on astrocytes from brain and in culture and are a chronic target for all five conventional 'serotonin-specific reuptake inhibitors'.

  2010influential reference
• Adrenoceptors in brain: cellular gene expression and effects on astrocytic metabolism and [Ca(2+)]i.

  2010cited by this paper
• Light and Electron Microscopy Study of Glycogen Synthase Kinase-3β in the Mouse Brain

  2010cited by this paper
• Uniquely Hominid Features of Adult Human Astrocytes

  2009cited by this paper
• Fluoxetine-mediated 5-HT2B receptor stimulation in astrocytes causes EGF receptor transactivation and ERK phosphorylation

  2008influential reference
• Oestrogen Regulates the Expression and Function of Dopamine Transporters in Astrocytes of the Nigrostriatal System

  2007cited by this paper
• Glycogen Synthase Kinase-3: a Putative Molecular Target for Lithium Mimetic Drugs

  2005cited by this paper
• Expression of caveolin-1, -2, and -3 in the spinal cords of Lewis rats with experimental autoimmune encephalomyelitis.

  2005cited by this paper
• Astrocytic adrenoceptors: a major drug target in neurological and psychiatric disorders?

  2004cited by this paper
• Functional expression of the norepinephrine transporter in cultured rat astrocytes

  2002cited by this paper
• Establishment of a novel enzyme-linked immunosorbent assay for Thy-1; quantitative assessment of neuronal degeneration.

  2002cited by this paper
• RNA editing by adenosine deaminases that act on RNA.

  2002cited by this paper
• Serotonin 2A receptor-like immunoreactivity is detected in astrocytes but not in oligodendrocytes of rat spinal cord.

  2001cited by this paper
• Pharmacological characterisation of human 5-HT2 receptor subtypes.

  2001influential reference
• Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A.

  2000cited by this paper
• Imaging neuronal subsets in transgenic mice expressing multiple spectral variants of GFP.

  2000cited by this paper
• 5-Hydroxytryptamine2B receptors stimulate Ca2+ increases in cultured astrocytes from three different brain regions.

  2000cited by this paper
• Multiple Microvascular and Astroglial 5-Hydroxytryptamine Receptor Subtypes in Human Brain: Molecular and Pharmacologic Characterization

  1999cited by this paper
• Activated astrocytes display increased 5-HT2a receptor expression in pathological states.

  1999cited by this paper
• Caveolins, Liquid-Ordered Domains, and Signal Transduction

  1999cited by this paper
• Cultured astrocytes express messenger RNA for multiple serotonin receptor subtypes, without functional coupling of 5-HT1 receptor subtypes to adenylyl cyclase.

  1998cited by this paper
• 5-Hydroxytryptamine2-family receptors (5-hydroxytryptamine2A, 5-hydroxytryptamine2B, 5-hydroxytryptamine2C): where structure meets function.

  1998cited by this paper
• Calcium Signalling in Mouse Bergmann Glial Cells Mediated by α1‐adrenoreceptors and H1 Histamine ‐ Receptors

  1996cited by this paper
• The 5‐HT5A serotonin receptor is expressed predominantly by astrocytes in which it inhibits cAMP accumulation: A mechanism for neuronal suppression of reactive astrocytes

  1996cited by this paper
• Immunohistochemical localisation of the serotonin 5‐HT2B receptor in mouse gut, cardiovascular system, and brain

  1996cited by this paper
• Molecular biology of serotonin receptors.

  1995cited by this paper
• Molecular cloning, functional expression, and mRNA tissue distribution of the human 5-hydroxytryptamine2B receptor.

  1994influential reference
• Molecular cloning, functional expression, and pharmacological characterization of a novel serotonin receptor (5-hydroxytryptamine2F) from rat stomach fundus.

  1992cited by this paper
• Quantitative enzyme radioautography with 3H-Ro 41-1049 and 3H-Ro 19- 6327 in vitro: localization and abundance of MAO-A and MAO-B in rat CNS, peripheral organs, and human brain

  1992cited by this paper
• Molecular biology of serotonin receptors.

  1992cited by this paper
• Expression cloning of a cocaine-and antidepressant-sensitive human noradrenaline transporter

  1991cited by this paper
• Serotonin Metabolism by Monoamine Oxidase in Rat Primary Astrocyte Cultures

  1990cited by this paper
• Biochemical pathophysiology of Parkinson's disease.

  1987cited by this paper
• Receptors for dopamine and serotonin on astrocytes of cultured rat central nervous system.

  1987cited by this paper
• Functional receptors for vasoactive intestinal polypeptide in cultured astroglia from neonatal rat brain.

  1983cited by this paper
• Some Properties of an Astrocytic Protein Fraction That Binds Serotonin

  1981cited by this paper
• Serotonin receptors on astrocytes in primary cultures: effects of methysergide and fluoxetine.

  1979cited by this paper
• Estrogen Receptor (cid:1) -mediated Silencing of Caveolin Gene Expression in Neuronal Cells*

  year unknowncited by this paper

• Effects of astrocytes in the dorsal hippocampus on anxiety-like and depressive-like behaviors in hemiparkinsonian rats.

  2025cites this paper
• Bibliometric insights into astrocytic roles in depression and treatment

  2025cites this paper
• The Highly Selective 5-HT2B Receptor Antagonist MW073 Mitigates Aggressive Behavior in an Alzheimer’s Disease Mouse Model

  2025cites this paper
• A Comprehensive Review on Major Depressive Disorder: Exploring Etiology, Pathogenesis and Clinical Approaches

  2025cites this paper
• The unique role of fluoxetine in alleviating depression and anxiety by regulating gut microbiota and the expression of vagus nerve-mediated serotonin and melanocortin-4 receptors.

  2024cites this paper
• Fluoxetine inhibited the activation of A1 reactive astrocyte in a mouse model of major depressive disorder through astrocytic 5-HT2BR/β-arrestin2 pathway

  2022influential citation
• Astrocytes in Post-traumatic Stress Disorder

  2022cites this paper
• Crosstalk between neurons and glia through G-protein coupled receptors: Insights from Caenorhabditis elegans.

  2022cites this paper
• The Implication of 5-HT Receptor Family Members in Aggression, Depression and Suicide: Similarity and Difference

  2022cites this paper
• Astroglial Serotonin Receptors as the Central Target of Classic Antidepressants.

  2021cites this paper
• Structure, Function, and Pharmaceutical Ligands of 5-Hydroxytryptamine 2B Receptor

  2021cites this paper
• The Association Between Antidepressant Effect of SSRIs and Astrocytes: Conceptual Overview and Meta‐analysis of the Literature

  2021cites this paper
• Serotonergic neurons in the treatment of mood disorders: The dialogue with astrocytes.

  2021cites this paper
• Ketamine Alters Functional Plasticity of Astroglia: An Implication for Antidepressant Effect

  2021cites this paper
• Ketamine Action on Astrocytes Provides New Insights into Rapid Antidepressant Mechanisms.

  2021cites this paper
• Sleep Deprivation Selectively Down-Regulates Astrocytic 5-HT2B Receptors and Triggers Depressive-Like Behaviors via Stimulating P2X7 Receptors in Mice

  2020cites this paper
• Distribution of 5-HT receptors in the central nervous system: an update

  2020cites this paper
• Astrocytes in rapid ketamine antidepressant action.

  2020cites this paper
• Sleep Disturbance in Bipolar Disorder: Neuroglia and Circadian Rhythms

  2019cites this paper
• Insufficient sleep and suicidal ideation: a survey of 12,046 female adolescents.

  2019cites this paper
• Leptin Increases Expression of 5-HT2B Receptors in Astrocytes Thus Enhancing Action of Fluoxetine on the Depressive Behavior Induced by Sleep Deprivation

  2019cites this paper
• Sleep deprivation selectively down-regulates astrocytic 5-HT2B receptors and triggers depressive-like behaviors via stimulating P2X7 receptors

  2019cites this paper
• Astrocyte Specific Remodeling of Plasmalemmal Cholesterol Composition by Ketamine Indicates a New Mechanism of Antidepressant Action

  2019cites this paper