Cluster of systemic lupus erythematosus (SLE) associated with an oil field waste site: a cross sectional study

BackgroundThis is a community comparison study that examines persons living in a subdivision exposed to petroleum products and mercury.MethodsWe compared their health status and questionnaire responses to those living in another community with no known exposures of this type.ResultsPristane house dust among the exposed homes was higher than in the comparison communities. The exposed subdivision has higher ambient air mercury levels compared to the control community. The prevalence of rheumatic diseases (OR = 10.78; CI = 4.14, 28.12) and lupus (OR = 19.33; CI = 1.96, 190.72) was greater in the exposed population compared to the unexposed. A higher prevalence of neurological symptoms, respiratory symptoms and several cardiovascular problems including stroke (OR = 15.41; CI = 0.78, 304.68) and angina (OR = 5.72; CI = 1.68, 19.43) was seen.ConclusionThere were statistically significant differences in B cells, Natural Killer Cells, gamma glutamyl transferase, globulin and serum calcium levels between control and exposed subjects.

• Publication year

  2007

• Venue

  Environmental Health

• Publication date

  2007-02-22

• Fields of study

  Medicine, Environmental Science

• Identifiers
  DOI 10.1186/1476-069X-6-8PMID 17316448PMCID 1821321
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The website census

  2009cited by this paper
• A CLINICAL STUDY

  2007cited by this paper
• Occupational risk factors for the development of systemic lupus erythematosus.

  2004cited by this paper
• Experimental mercury-induced glomerulonephritis

  2004cited by this paper
• Autoimmunity induced by adjuvant hydrocarbon oil components of vaccine.

  2004cited by this paper
• Ecotropic murine leukemia viruses and exogenous mouse mammary tumor viruses are not essential for pristane-induced lupus.

  2003cited by this paper
• The epidemiology of systemic lupus erythematosus

  2003cited by this paper
• Health effects on nearby residents of a wood treatment plant.

  2003cited by this paper
• Induction of lupus autoantibodies by adjuvants.

  2003cited by this paper
• Low-dose exposure to inorganic mercury accelerates disease and mortality in acquired murine lupus.

  2003cited by this paper
• Immunoregulatory Role of CD1d in the Hydrocarbon Oil-Induced Model of Lupus Nephritis1

  2003cited by this paper
• Impaired T Cell Death and Lupus-like Autoimmunity in T Cell–specific Adapter Protein–deficient Mice

  2003cited by this paper
• Calcium hypochlorite removal of mercury and petroleum hydrocarbons from co-contaminated soils

  2002cited by this paper
• Estimate of mercury emissions to the atmosphere from petroleum.

  2001cited by this paper
• Investigation of systemic lupus erythematosus in Nogales, Arizona.

  2001cited by this paper
• Myeloma proteins that bind Hsp65 (GroEL) are polyreactive and are found in high incidence in pristine induced plasmacytomas.

  2000cited by this paper
• Immunotoxicology of Environmental and Occupational Metals

  2000cited by this paper
• Widespread susceptibility among inbred mouse strains to the induction of lupus autoantibodies by pristane

  2000cited by this paper
• Analysis and stability of mercury speciation in petroleum hydrocarbons

  2000cited by this paper
• B cell subsets in pristane-induced autoimmunity.

  2000cited by this paper
• Pristane‐induced arthritis in mice selected for maximal or minimal acute inflammatory reaction

  2000cited by this paper
• Epidemiologic studies of environmental agents and systemic autoimmune diseases.

  1999cited by this paper
• Activated human T lymphocytes exhibit reduced susceptibility to methylmercury chloride-induced apoptosis.

  1999cited by this paper
• Inhibition of pristane-induced peritoneal plasmacytoma formation.

  1999cited by this paper
• Guidelines for referral and management of systemic lupus erythematosus in adults. American College of Rheumatology Ad Hoc Committee on Systemic Lupus Erythematosus Guidelines.

  1999cited by this paper
• Lupus-prone mice as models to study xenobiotic-induced acceleration of systemic autoimmunity.

  1999cited by this paper
• Murine mercury-induced autoimmunity

  1999influential reference
• IL-2 may be a limiting factor precluding lymphocytes from genetically resistant mice from responding to HgCl2.

  1999cited by this paper
• Experimental studies on genetically determined susceptibility to mercury-induced autoimmune response.

  1999cited by this paper
• Induction of B cell autoimmunity by pristane.

  1999cited by this paper
• Disparate T cell requirements of two subsets of lupus‐specific autoantibodies in pristane‐treated mice

  1999cited by this paper
• Pristane-induced arthritis in mice. V. Susceptibility to pristane-induced arthritis is determined by the genetic regulation of the T cell repertoire.

  1998cited by this paper
• Interleukin 6 Dependence of Anti-DNA Antibody Production: Evidence for Two Pathways of Autoantibody Formation in Pristane-induced Lupus

  1998cited by this paper
• Immunotoxicology Of Environmental And Occupational Metals

  1998cited by this paper
• Influence of microbial stimulation on hypergammaglobulinemia and autoantibody production in pristane-induced lupus.

  1998cited by this paper
• Pristane‐induced arthritis is CD4+ T‐cell dependent

  1997cited by this paper
• Minimal immunological effects on workers with prolonged low exposure to inorganic mercury.

  1997cited by this paper
• Thiol compounds inhibit mercury‐induced immunological and immunopathological alterations in susceptible mice

  1997cited by this paper
• Systemic lupus erythematosus in relation to environmental pollution: an investigation in an African-American community in North Georgia.

  1997influential reference
• Immune system alteration in the rat after indirect exposure to methyl mercury chloride or methyl mercury sulfide.

  1997cited by this paper
• Mercuric compounds inhibit human monocyte function by inducing apoptosis: evidence for formation of reactive oxygen species, development of mitochondrial membrane permeability transition and loss of reductive reserve.

  1997cited by this paper
• Autoantibodies to ribosomal P antigens with immune complex glomerulonephritis in SJL mice treated with pristane.

  1996cited by this paper
• Toxicology of metals

  1996cited by this paper
• Expression of mammalian 60-kD heat shock protein in the joints of mice with pristane-induced arthritis.

  1996cited by this paper
• Immunotoxicology of Metals

  1995cited by this paper
• Environmental Personal Injury Litigation as One Source of Response Effects: Findings From the National Exposure Registry

  1995cited by this paper
• Systemic autoimmunity due to mercury vapor exposure in genetically susceptible mice: dose-response studies.

  1995cited by this paper
• Pristane induces high titers of anti-Su and anti-nRNP/Sm autoantibodies in BALB/c mice. Quantitation by antigen capture ELISAs based on monospecific human autoimmune sera.

  1995cited by this paper
• 12 – Immune Modulation by Toxic Metals

  1995cited by this paper
• Case in point. Pseudohyperkalemia secondary to thrombocytosis.

  1995cited by this paper
• Anti-nuclear antibody production and immune-complex glomerulonephritis in BALB/c mice treated with pristane.

  1995cited by this paper
• Environmental lupus syndromes.

  1995cited by this paper
• Autoimmunity and Heavy Metals

  1994cited by this paper
• Adverse immunological effects and autoimmunity induced by dental amalgam and alloy in mice

  1994cited by this paper
• Induction of lupus-associated autoantibodies in BALB/c mice by intraperitoneal injection of pristane

  1994cited by this paper
• Contact stomatitis to mercury associated with spontaneous mononuclear cell infiltrates in brown Norway (BN) rats with HgCl2-induced autoimmunity.

  1994cited by this paper
• Immunoglobulin levels in workers exposed to inorganic mercury.

  1994cited by this paper
• Minor effects of low exposure to inorganic mercury on the human immune system.

  1993cited by this paper
• Murine susceptibility to mercury. II. autoantibody profiles and renal immune deposits in hybrid, backcross, and H-2d congenic mice.

  1993cited by this paper
• Autoimmunity and selected environmental factors of disease induction.

  1993influential reference
• Role of drugs and environmental agents in lupus syndromes

  1992cited by this paper
• Drug-induced lupus.

  1992cited by this paper
• Pathology of the Kidney

  1992cited by this paper
• Medication-induced systemic lupus erythematosus.

  1992cited by this paper
• The in vitro effects of mercury on peritoneal leukocytes (PMN and macrophages) from inbred brown Norway and Lewis rats.

  1992cited by this paper
• Epidemiology of systemic lupus erythematosus.

  1992cited by this paper
• Dose-response studies in murine mercury-induced autoimmunity and immune-complex disease.

  1992cited by this paper
• Effects of occupational exposure to mercury vapor on lymphocyte micronuclei.

  1991cited by this paper
• Strain differences in the effect of mercury on murine cell-mediated immune reactions.

  1991cited by this paper
• Connective tissue disease in southeastern Georgia: a case-control study of etiologic factors.

  1989cited by this paper
• Epidemiology of systemic lupus erythematosus.

  1987cited by this paper
• Mercury-induced autoimmune glomerulonephritis in inbred rats. I. Kinetics and species specificity of autoimmune responses.

  1985cited by this paper
• Epidemiology of systemic lupus erythematosus and other connective tissue diseases in Rochester, Minnesota, 1950 through 1979.

  1985cited by this paper
• Mercury-Induced Autoimmune Glomerulonephritis in Inbred Rats

  1985cited by this paper
• Aromatic amines and the pathogenesis of lupus erythematosus.

  1983cited by this paper
• Drug-induced lupus

  1982cited by this paper
• Immune dysregulation and auto-immunity induced by toxic agents.

  1982cited by this paper
• Immunoregulation and anti-nuclear antibodies in mercury-induced glomerulopathy in the rat.

  1981cited by this paper
• Genetics of susceptibility to pristane-induced plasmacytomas in BALB/cAn: reduced susceptibility in BALB/cJ with a brief description of pristane-induced arthritis.

  1981cited by this paper
• ACUTE METHYL MERCURY INTOXICATION IN MICE — Effect on the Immune System —

  1980cited by this paper
• The requirement of an adherent cell substratum for the growth of developing plasmacytoma cells in vivo

  1976cited by this paper
• Systemic lupus erythematosus in the community. Incidence, prevalence, outcome, and first symptoms; the high prevalence in black women.

  1974cited by this paper
• Preliminary criteria for the classification of systemic lupus erythematosus (SLE). Evaluation in early diagnosed SLE and rheumatoid arthritis.

  1974cited by this paper
• The epidemiology of systemic lupus erythematosus.

  1973cited by this paper
• Occupational acroosteolysis.

  1972cited by this paper
• Occupational acroosteolysis. 3. A clinical study.

  1971cited by this paper
• Epidemiologic studies on systemic lupus erythematosus. Comparative data for New York City and Jefferson County, Alabama, 1956-1965.

  1970cited by this paper
• The association of progressive systemic sclerosis (scleroderma) with coal miners' pneumoconiosis and other forms of silicosis.

  1967cited by this paper

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• Environmental and occupational contributors to autoimmune, inflammatory, and musculoskeletal rheumatic disease: a review of emerging evidence and clinical implications

  2025cites this paper
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  2024cites this paper
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  2024cites this paper
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  2024cites this paper
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  2023cites this paper
• Regeneration of waste hydraulic oils as a recycling method in relation to the environment

  2023cites this paper
• Dysregulated balance in Th17/Treg axis of Pristane-induced lupus mouse model, are mesenchymal stem cells therapeutic?

  2023cites this paper
• Metal Exposures in Residents Living Near an Urban Oil Drilling Site in Los Angeles, California

  2022cites this paper
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  2022cites this paper
• Oil and its influence on the creation of a sustainable society: A systematic literature review

  2022cites this paper
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  2022cites this paper
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  2021cites this paper
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  2021cites this paper
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  2021cites this paper
• Assessment of hazards and risks associated with dietary exposure to mineral oil for the Belgian population.

  2021cites this paper
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  2020cites this paper
• A benzimidazole inhibitor attenuates sterile inflammation induced in a model of systemic autoinflammation in female mice

  2020cites this paper
• Interplay and roles of oxidative stress, toll-like receptor 4 and Nrf2 in trichloroethene-mediated autoimmunity.

  2020cites this paper
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  2019cites this paper
• Impact of upstream oil extraction and environmental public health: A review of the evidence.

  2019cites this paper
• A review of exposure assessment methods for epidemiological studies of health effects related to industrially contaminated sites.

  2018cites this paper
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  2018cites this paper
• DNA methylation 101: what is important to know about DNA methylation and its role in SLE risk and disease heterogeneity

  2018cites this paper
• Delayed‐type hypersensitivity to metals in connective tissue diseases and fibromyalgia

  2018cites this paper
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  2018cites this paper
• Experimental lupus is aggravated in mouse strains with impaired induction of neutrophil extracellular traps.

  2017cites this paper
• Mercury as an environmental stimulus in the development of autoimmunity - A systematic review.

  2017cites this paper
• Environmental triggers in systemic lupus erythematosus.

  2017cites this paper
• Low level exposure to inorganic mercury interferes with B cell receptor signaling in transitional type 1 B cells

  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
• Pristane-induced lupus: considerations on this experimental model

  2017cites this paper
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  2017cites this paper
• The global burden of SLE: prevalence, health disparities and socioeconomic impact

  2016cites this paper
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  2016cites this paper
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  2016cites this paper
• Environmental Basis of Autoimmunity

  2016cites this paper
• Mercury concentrations in urine of amerindian populations near oil fields in the peruvian and ecuadorian amazon.

  2016cites this paper
• Hazardous waste and health impact: a systematic review of the scientific literature

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  2015cites this paper
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  2015cites this paper
• Animal models of lupus and lupus nephritis.

  2015cites this paper
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  2015cites this paper
• Alpha‐melanocyte stimulating hormone ameliorates disease activity in an induced murine lupus‐like model

  2014cites this paper
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  2014cites this paper
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  2014cites this paper
• Association of Systemic Lupus Erythematosus With Uranium Exposure in a Community Living Near a Uranium‐Processing Plant: A Nested Case–Control Study

  2014cites this paper
• Wolves in Sheepâs Clothing: How Chemically Inert Hydrocarbon Oils Induce Autoimmunity

  2014influential citation
• Environmental exposures, epigenetic changes and the risk of lupus

  2014cites this paper
• Autoimmunity Induced by Hydrocarbon Oils in Mice

  2014influential citation
• Mercury alters B-cell protein phosphorylation profiles.

  2014cites this paper
• Pristane-Induced Lupus Disease and Renal Pathology in Ligand (CD95L) Exacerbates Autoimmune Overexpression of Membrane-Bound Fas

  2013cites this paper
• Pristane-induced lupus as a model of human lupus arthritis: evolvement of autoantibodies, internal organ and joint inflammation

  2013cites this paper
• Sex-specific environmental influences on the development of autoimmune diseases.

  2013cites this paper
• Exposure to lipophilic chemicals as a cause of neurological impairments, neurodevelopmental disorders and neurodegenerative diseases

  2013cites this paper
• Studies on metals in motor neuron disease

  2013cites this paper
• Wolves in Sheep's Clothing: How Chemically Inert Hydrocarbon Oils Induce

  2013cites this paper
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  2013cites this paper
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  2012cites this paper
• The Buffalo Lupus Project: A Community-Based Participatory Research Investigation of Toxic Waste Exposure and Lupus

  2012cites this paper
• Cell death and cytokine production induced by autoimmunogenic hydrocarbon oils

  2012cites this paper
• Air pollution in autoimmune rheumatic diseases: a review.

  2011cites this paper
• A geographic information assessment of exposure to a toxic waste site and development of systemic lupus erythematosus (SLE): Findings from the buffalo lupus project

  2011cites this paper
• Molecular Mimicry as a Mechanism of Autoimmune Disease

  2011cites this paper
• Nutritional supplementation and dietary restriction in the resolution of enthesitis-related arthritis

  2011cites this paper
• Risks of Hazardous Wastes

  2011cites this paper
• Epigenetics in lupus

  2011cites this paper
• Regulatory Effect of Melatonin on Cytokine Disturbances in the Pristane-Induced Lupus Mice

  2010cites this paper
• Sensitivity-related illness: the escalating pandemic of allergy, food intolerance and chemical sensitivity.

  2010cites this paper
• The Antigen Presenting Cell Lectin-like Receptor gene Complex, APLEC, regulates susceptibility to oil induced arthritis

  2010cites this paper
• Behind the Fence Forum Theater: An Arts Performance Partnership to Address Lupus and Environmental Justice

  2010cites this paper
• Association of GSTT1, GSTM1 and CYP1A1 polymorphisms with susceptibility to systemic lupus erythematosus in the Chinese population.

  2010cites this paper
• of patients with systemic lupus erythematosus Disease activity and damage accrual during the early disease course in a multinational inception cohort

  2010cites this paper
• Air pollution as a potential contributor to the 'epidemic' of autoimmune disease.

  2010cites this paper
• The Petroleum Industry

  2010cites this paper
• The Santa Maria oil sumps

  2010cites this paper
• The immune effects of naturally occurring and synthetic nanoparticles.

  2010cites this paper
• Clinical and Serologic Correlations and Autoantibody Clusters in Systemic Lupus Erythematosus: A Retrospective Review of 917 Patients in South China

  2010cites this paper
• Disease activity and damage accrual during the early disease course in a multinational inception cohort of patients with systemic lupus erythematosus

  2010cites this paper
• Induction of autoimmunity by pristane and other naturally occurring hydrocarbons.

  2009cites this paper
• Immmunopathogenesis of Rheumatoid Arthritis

  2009cites this paper
• Reflections on Lupus and the Environment in an Urban African American Community

  2009cites this paper
• A Common Pathway for All Autoimmune Diseases? The Unholy Alliance of Environment, Cell Death and Nucleic Acids

  2009cites this paper
• Lipid peroxidation-derived aldehyde-protein adducts contribute to trichloroethene-mediated autoimmunity via activation of CD4+ T cells.

  2008cites this paper
• Community and environmental factors and arthritis outcomes.

  2007cites this paper
• Correction: Cluster of systemic lupus erythematosus (SLE) associated with an oil field waste site: a cross sectional study

  2007cites this paper