The efficacy of p.o. semisynthetic glycolipid LIGA20 (II3Neu5-AcGgOse4-2-d-erythro-1,3-dihydroxy-2-dichloro-aceta mide-4-trans- octadecene) treatment in stroke was studied in a permanent left middle cerebral artery occlusion model in the rat. A dose-dependent increase of plasma LIGA20 and its presence in the brain were documented after p.o. drug application. Oral administration of 50 to 200 mg/kg of LIGA20, initiated 24 hr before middle cerebral artery occlusion and continued for 7 days, reduced the motor and cognitive impairment after the stroke, measured by the rotarod and the passive avoidance test, respectively. The 10-mg/kg dose was effective when given i.v. but not p.o. Oral treatment with 100 mg/kg of LIGA20 reduced the infarct size in the cortex but not in the ischemic core (the striatum). No biochemical or behavioral adverse effects of LIGA20 treatment were observed. Further studies are needed to evaluate the full therapeutic potential of this compound.
Orally administered glycolipid derivative LIGA20 reduces infarct volume and behavioral impairment after focal cerebral ischemia.
M. S. Seren,A. Lazzaro,C. L. Yang,R. Canella,M. Bassan,R. Zanoni,H. Manev
Published 1994 in Journal of Pharmacology and Experimental Therapeutics
ABSTRACT
PUBLICATION RECORD
- Publication year
1994
- Venue
Journal of Pharmacology and Experimental Therapeutics
- Publication date
1994-01-01
- Fields of study
Medicine
- Identifiers
- External record
- Source metadata
Semantic Scholar, PubMed
CITATION MAP
EXTRACTION MAP
CLAIMS
CONCEPTS
- brain presence
Detection of LIGA20 in brain tissue after dosing.
Aliases: presence in the brain, brain detection, brain penetration
- infarct size
The extent of ischemic tissue damage measured in brain regions after middle cerebral artery occlusion.
Aliases: infarct volume
- intravenous administration
Delivery of LIGA20 by the i.v. route used for the single-dose comparison.
Aliases: i.v. administration, i.v.
- liga20
A semisynthetic glycolipid derivative evaluated as the treatment candidate in the rat stroke experiments.
Aliases: II3Neu5-AcGgOse4-2-d-erythro-1,3-dihydroxy-2-dichloro-aceta mide-4-trans-octadecene
- oral administration
Delivery of LIGA20 by the p.o. route used for repeated treatment in the animal model.
Aliases: p.o. administration, p.o.
- passive avoidance test
A memory-based behavioral task used to assess cognitive performance after stroke.
Aliases: passive avoidance
- plasma liga20
LIGA20 measured in blood plasma as an indicator of systemic exposure after dosing.
Aliases: plasma concentration of LIGA20
- rotarod test
A motor coordination assay used to evaluate post-stroke motor function in the rats.
Aliases: rotarod
REFERENCES
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