Estradiol Negatively Modulates the Pleiotropic Actions of Orphanin FQ/Nociceptin at Proopiomelanocortin Synapses

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Neuroendocrinology

• Publication date

  2013-07-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1159/000351868PMID 23735696PMCID PMC4170741
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2011cited by this paper
• Membrane Estrogen Receptors Stimulate Intracellular Calcium Release and Progesterone Synthesis in Hypothalamic Astrocytes

  2010cited by this paper
• The role of the NOP receptor in regulating food intake, meal pattern, and the excitability of proopiomelanocortin neurons.

  2010cited by this paper
• Chronic intracerebroventricular infusion of nociceptin/orphanin FQ produces body weight gain by affecting both feeding and energy metabolism in mice.

  2009cited by this paper
• Estrogen rapidly attenuates cannabinoid-induced changes in energy homeostasis.

  2009cited by this paper
• Estradiol induces hypothalamic dendritic spines by enhancing glutamate release: a mechanism for organizational sex differences.

  2008cited by this paper
• PI3K signaling effects in hypothalamic neurons mediated by estrogen

  2008cited by this paper
• Protein kinase C signaling in the hypothalamic arcuate nucleus regulates sexual receptivity in female rats.

  2008cited by this paper
• Anorectic estrogen mimics leptin's effect on the rewiring of melanocortin cells and Stat3 signaling in obese animals

  2007cited by this paper
• Cannabinoid-induced hyperphagia: correlation with inhibition of proopiomelanocortin neurons?

  2007cited by this paper
• Role of hypothalamus nociceptin/orphanin FQ in pre-ovulatory luteinizing hormone surge of estrogen and progesterone-primed, ovariectomized rats

  2007cited by this paper
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  2007cited by this paper
• Estradiol Targets Synaptic Proteins to Induce Glutamatergic Synapse Formation in Cultured Hippocampal Neurons: Critical Role of Estrogen Receptor-α

  2007cited by this paper
• Estrogen Differentially Modulates the Cannabinoid- Induced Presynaptic Inhibition of Amino Acid Neurotransmission in Proopiomelanocortin Neurons of the Arcuate Nucleus

  2006cited by this paper
• Functional interaction between nociceptin/orphanin FQ and alpha-melanocyte-stimulating hormone in the regulation of feeding.

  2006cited by this paper
• Site‐specific estrogen and progestin regulation of orphanin FQ/nociceptin and nociceptin opioid receptor mRNA expression in the female rat limbic hypothalamic system

  2006cited by this paper
• Estrogen Upregulates T-Type Calcium Channels in the Hypothalamus and Pituitary

  2006cited by this paper
• Nociceptin/orphanin FQ (N/OFQ) inhibits excitatory and inhibitory synaptic signaling in the suprachiasmatic nucleus (SCN).

  2005influential reference
• Sex differences in the cannabinoid modulation of an A-type K+ current in neurons of the mammalian hypothalamus.

  2005cited by this paper
• Estradiol Activates Group I and II Metabotropic Glutamate Receptor Signaling, Leading to Opposing Influences on cAMP Response Element-Binding Protein

  2005cited by this paper
• Involvement of nociceptin/orphanin FQ in release of hypothalamic GnRH mediated by ORL1 receptor in ovariectomized rats

  2005cited by this paper
• Sexual receptivity is reduced in the female mu-opioid receptor knockout mouse

  2005cited by this paper
• Dissociated histaminergic neuron cultures from the tuberomammillary nucleus of rats: culture methods and ghrelin effects.

  2004cited by this paper
• Estrogen-Induced μ-Opioid Receptor Internalization in the Medial Preoptic Nucleus Is Mediated via Neuropeptide Y-Y1 Receptor Activation in the Arcuate Nucleus of Female Rats

  2004cited by this paper
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  2003cited by this paper
• Cyclic estradiol treatment normalizes body weight and restores physiological patterns of spontaneous feeding and sexual receptivity in ovariectomized rats.

  2002cited by this paper
• Episodic Bursting Activity and Response to Excitatory Amino Acids in Acutely Dissociated Gonadotropin-Releasing Hormone Neurons Genetically Targeted with Green Fluorescent Protein

  2002cited by this paper
• Progesterone Blockade of Estrogen Activation of μ-Opioid Receptors Regulates Reproductive Behavior

  2001influential reference
• Control of glutamate and GABA release by nociceptin/orphanin FQ in the rat lateral amygdala

  2001cited by this paper
• Effects of orphanin FQ on central dopaminergic neuronal activities and prolactin secretion.

  2001cited by this paper
• Pharmacological characterization of the nociceptin receptor mediating hyperphagia: identification of a selective antagonist

  2000cited by this paper
• A cellular mechanism for the bidirectional pain-modulating actions of orphanin FQ/nociceptin.

  2000cited by this paper
• Cyclic estradiol treatment normalizes body weight and test meal size in ovariectomized rats.

  1999cited by this paper
• Orphanin-FQ/Nociceptin (OFQ/N) Modulates the Activity of Suprachiasmatic Nucleus Neurons

  1999cited by this paper
• Pre‐ and postsynaptic actions of opioid and orphan opioid agonists in the rat arcuate nucleus and ventromedial hypothalamus in vitro

  1999influential reference
• Orphan opioid receptor antisense probes block orphanin FQ-induced hyperphagia.

  1998cited by this paper
• Estrogen-Induced Alteration of μ-Opioid Receptor Immunoreactivity in the Medial Preoptic Nucleus and Medial Amygdala

  1998influential reference
• The Peptide Orphanin FQ Inhibits β-Endorphin Neurons and Neurosecretory Cells in the Hypothalamic Arcuate Nucleus by Activating an Inwardly-Rectifying K+ Conductance

  1998cited by this paper
• Estradiol Increases Dendritic Spine Density by Reducing GABA Neurotransmission in Hippocampal Neurons

  1998cited by this paper
• Gonadal steroids target AMPA glutamate receptor-containing neurons in the rat hypothalamus, septum and amygdala: a morphological and biochemical study.

  1997cited by this paper
• Actions of the ORL1 Receptor Ligand Nociceptin on Membrane Properties of Rat Periaqueductal Gray Neurons In Vitro

  1997cited by this paper
• Modulation of G protein-coupled receptors by an estrogen receptor that activates protein kinase A.

  1997cited by this paper
• ACTIONS OF AMINO‐ACIDS ON THE ISOLATED HEMISECTED SPINAL CORD OF THE TOAD

  1997cited by this paper
• Actions of amino‐acids on the isolated hemisected spinal cord of the toad

  1997cited by this paper
• Nociceptin Inhibits T-Type Ca2+ Channel Current in Rat Sensory Neurons by a G-Protein-Independent Mechanism

  1997cited by this paper
• Rise in intracellular calcium via a nongenomic effect of allopregnanolone in fetal rat hypothalamic neurons

  1996cited by this paper
• Identification of opioid receptor-like (ORL1) peptide-stimulated [35S]GTP gamma S binding in rat brain.

  1996cited by this paper
• Identification of opioid receptor‐like (ORL1) peptide‐stimulated [35S]GTPγS binding in rat brain

  1996cited by this paper
• Modulation of Voltage-Gated Calcium Channels by Orphanin FQ in Freshly Dissociated Hippocampal Neurons

  1996cited by this paper
• Sensitivity of Opioid Receptor-like Receptor ORL1 for Chemical Modification on Nociceptin, a Naturally Occurring Nociceptive Peptide*

  1996cited by this paper
• Nociceptin receptor coupling to a potassium conductance in rat locus coeruleus neurones in vitro

  1996cited by this paper
• Orphanin FQ, agonist of orphan opioid receptor ORL1, stimulates feeding in rats

  1996cited by this paper
• Naloxone and initial estrogen action to induce lordosis in ovariectomized rats: the effect of a cut between the septum and preoptic area.

  1995cited by this paper
• Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor

  1995cited by this paper
• Gonadal steroid hormone regulation of proopiomelanocortin gene expression in arcuate neurons that innervate the medial preoptic area of the rat.

  1995cited by this paper
• Orphanin FQ: A Neuropeptide That Activates an Opioidlike G Protein-Coupled Receptor

  1995cited by this paper
• Temporal regulation by estrogen of beta-preprotachykinin mRNA expression in the rat ventromedial nucleus of the hypothalamus.

  1995cited by this paper
• Effects of estrogen on the number of neurons expressing β‐endorphin in the medial basal hypothalamus of the female guinea pig

  1994cited by this paper
• Molecular cloning and tissue distribution of a putative member of the rat opioid receptor gene family that is not a μ, δ or κ opioid receptor type

  1994cited by this paper
• Energy regulation over the menstrual cycle.

  1994cited by this paper
• Molecular cloning and tissue distribution of a putative member of the rat opioid receptor gene family that is not a mu, delta or kappa opioid receptor type.

  1994cited by this paper
• The potency of mu-opioid hyperpolarization of hypothalamic arcuate neurons is rapidly attenuated by 17 beta-estradiol

  1994cited by this paper
• Estrogen suppresses mu-opioid- and GABAB-mediated hyperpolarization of hypothalamic arcuate neurons

  1992cited by this paper
• NMDA receptor‐mediated rhythmic bursting activity in rat supraoptic nucleus neurones in vitro.

  1992cited by this paper
• Psychopharmacology: The Third Generation of Progress

  1989cited by this paper
• Psychopharmacology: The third generation of progress

  1988cited by this paper
• Diversity and ubiquity of K channels.

  1988cited by this paper
• Central vs. peripheral effects of estrogen on food intake and lipoprotein lipase activity in ovariectomized rats.

  1986cited by this paper
• Effects of Estrogen on Food Intake, Body Weight, and Temperature of Male and Female Obese Mice 1

  1985cited by this paper
• Intracranial estradiol in ovariectomized guinea pigs: effects on ingestive behaviors and body weight.

  1984cited by this paper
• The hypothalamic control of the menstrual cycle and the role of endogenous opioid peptides.

  1984cited by this paper
• Acidic amino acids with strong excitatory actions on mammalian neurones

  1963cited by this paper
• Printed in U.S.A. Copyright © 2004 by The Endocrine Society doi: 10.1210/en.2004-0016 Minireview: Characterization of Influence of Central Nociceptin/Orphanin FQ on Consummatory Behavior

  year unknowncited by this paper

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  2023influential citation
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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• Estradiol Membrane-Initiated Signaling in the Brain Mediates Reproduction.

  2017cites this paper
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  2014cites this paper
• Endogenous opiates and behavior: 2013.

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