A new flavonoid from the leaves of Atalantia monophylla (L.) DC

Abstract A new flavonoid, atalantraflavone (1) as well as eight known compounds including atalantoflavone (2), racemoflavone (3), 5,4′-dihydroxy-(3″,4″-dihydro-3″,4″-dihydroxy)-2″,2″-dimethylpyrano-(5″,6″:7,8)-flavone (4), lupalbigenin (5), anabellamide (6), citrusinine I (7), p-hydroxybenzaldehyde (8), and frideline (9), were isolated from the leaves of Atalantia monophylla (L.) DC. Focusing on Alzheimer’s disease, acetylcholine esterase (AChE) inhibition and antioxidant activity were evaluated using the modified Ellman’s method and the ABTS scavenging assay, respectively. It was found that isoflavonoid 5, lupalbigenin, showed 79% inhibition to AChE and was 1.4-fold stronger than the tacrine standard. In addition, acridone 7, citrusinine I, displayed 90.68% antioxidant activity.

• Publication year

  2019

• Venue

  Natural Product Research

• Publication date

  2019-04-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1080/14786419.2018.1457667PMID 29600742
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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