DEPTOR ubiquitination and destruction by SCF(β-TrCP).

No abstract is available for this paper.

• Publication year

  2012

• Venue

  American Journal of Physiology. Endocrinology and Metabolism

• Publication date

  2012-07-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1152/ajpendo.00105.2012PMID 22454292PMCID PMC3431131
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Rictor regulates FBXW7-dependent c-Myc and cyclin E degradation in colorectal cancer cells.

  2012cited by this paper
• BMK1 kinase suppresses epithelial-mesenchymal transition through the Akt/GSK3β signaling pathway.

  2012cited by this paper
• Control of mTORC1 signaling by the Opitz syndrome protein MID1

  2011cited by this paper
• Regulation of mammalian target of rapamycin complex 1 (mTORC1) by hypoxia: causes and consequences

  2011cited by this paper
• The dynamic nature of autophagy in cancer.

  2011cited by this paper
• Interplay Between pVHL and mTORC1 Pathways in Clear-Cell Renal Cell Carcinoma

  2011cited by this paper
• Role of AMPK-mTOR-Ulk1/2 in the Regulation of Autophagy: Cross Talk, Shortcuts, and Feedbacks

  2011cited by this paper
• Overexpression of DEP domain containing mTOR-interacting protein correlates with poor prognosis in differentiated thyroid carcinoma.

  2011cited by this paper
• Rapamycin passes the torch: a new generation of mTOR inhibitors

  2011cited by this paper
• DEPTOR, an mTOR inhibitor, is a physiological substrate of SCF(βTrCP) E3 ubiquitin ligase and regulates survival and autophagy.

  2011cited by this paper
• mTOR generates an auto-amplification loop by triggering the βTrCP- and CK1α-dependent degradation of DEPTOR.

  2011cited by this paper
• mTOR complex 2 signaling and functions

  2011cited by this paper
• mTOR drives its own activation via SCF(βTrCP)-dependent degradation of the mTOR inhibitor DEPTOR.

  2011cited by this paper
• Chemical genetics screen for enhancers of rapamycin identifies a specific inhibitor of an SCF family E3 ubiquitin ligase.

  2010cited by this paper
• Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase.

  2010cited by this paper
• mTOR: from growth signal integration to cancer, diabetes and ageing

  2010cited by this paper
• Differential expression of mTOR signalling components in drug resistance in ovarian cancer.

  2010cited by this paper
• Role of N‐end rule ubiquitin ligases UBR1 and UBR2 in regulating the leucine‐mTOR signaling pathway

  2010cited by this paper
• Role of CK1 in GSK3β-mediated phosphorylation and degradation of Snail

  2010cited by this paper
• Decreased Level of PDCD4 (Programmed Cell Death 4) Protein Activated Cell Proliferation in the Lung of A/J Mouse

  2010cited by this paper
• High expression levels of the mammalian target of rapamycin inhibitor DEPTOR are predictive of response to thalidomide in myeloma

  2010cited by this paper
• Targeting the PI3K/Akt/mTOR Pathway – Beyond Rapalogs

  2010cited by this paper
• Glycolytic Flux Signals to mTOR through Glyceraldehyde-3-Phosphate Dehydrogenase-Mediated Regulation of Rheb

  2009cited by this paper
• DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival.

  2009cited by this paper
• REDD1, an inhibitor of mTOR signalling, is regulated by the CUL4A–DDB1 ubiquitin ligase

  2009cited by this paper
• Control of cell growth by the SCF and APC/C ubiquitin ligases.

  2009cited by this paper
• Transfer-NMR and docking studies identify the binding of the peptide derived from activating transcription factor 4 to protein ubiquitin ligase beta-TrCP. Competition STD-NMR with beta-catenin.

  2008cited by this paper
• Hypoxia signalling through mTOR and the unfolded protein response in cancer

  2008cited by this paper
• Pam (Protein associated with Myc) functions as an E3 ubiquitin ligase and regulates TSC/mTOR signaling.

  2008cited by this paper
• Ribosomal protein S6 kinase 1 interacts with and is ubiquitinated by ubiquitin ligase ROC1.

  2008cited by this paper
• mTORC1 signaling requires proteasomal function and the involvement of CUL4-DDB1 ubiquitin E3 ligase

  2008cited by this paper
• The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

  2008cited by this paper
• Rapamycin Induces Transactivation of the EGFR and Increases Cell Survival

  2008cited by this paper
• FBXW7 Targets mTOR for Degradation and Cooperates with PTEN in Tumor Suppression

  2008cited by this paper
• Deregulated proteolysis by the F-box proteins SKP2 and β-TrCP: tipping the scales of cancer

  2008cited by this paper
• Role of autophagy in cancer

  2007cited by this paper
• PDGFRs are critical for PI3K/Akt activation and negatively regulated by mTOR.

  2007cited by this paper
• Regulation of survivin expression by IGF-1/mTOR signaling

  2007cited by this paper
• Identification of Protor as a novel Rictor-binding component of mTOR complex-2.

  2007cited by this paper
• SAG/ROC-SCF beta-TrCP E3 ubiquitin ligase promotes pro-caspase-3 degradation as a mechanism of apoptosis protection.

  2006cited by this paper
• Ubiquitin and ubiquitin-like proteins in cancer pathogenesis

  2006cited by this paper
• mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s.

  2006cited by this paper
• mTOR and cancer: insights into a complex relationship

  2006cited by this paper
• Ubiquitin ligases: cell-cycle control and cancer

  2006cited by this paper
• S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth.

  2006cited by this paper
• S6K1- and ßTRCP-Mediated Degradation of PDCD4 Promotes Protein Translation and Cell Growth

  2006cited by this paper
• Wnt, Hedgehog, and Snail: Sister Pathways That Control by GSK-3beta and beta-Trcp in the Regulation of Metastasis

  2005cited by this paper
• The role of autophagy in cancer development and response to therapy

  2005cited by this paper
• The eukaryotic initiation factor 4E-binding proteins and apoptosis

  2005cited by this paper
• Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2.

  2005cited by this paper
• Mechanism of processing of the NF-κB2 p100 precursor: identification of the specific polyubiquitin chain-anchoring lysine residue and analysis of the role of NEDD8-modification on the SCFβ-TrCP ubiquitin ligase

  2004cited by this paper
• Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome.

  2004cited by this paper
• Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

  2004cited by this paper
• The many faces of β-TrCP E3 ubiquitin ligases: reflections in the magic mirror of cancer

  2004cited by this paper
• The tor pathway: a target for cancer therapy

  2004cited by this paper
• Dysregulation of the TSC-mTOR pathway in human disease

  2004cited by this paper
• M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP.

  2004cited by this paper
• Control of meiotic and mitotic progression by the F box protein beta-Trcp1 in vivo.

  2003cited by this paper
• Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage.

  2003cited by this paper
• Degradation of Cdc25A by β-TrCP during S phase and in response to DNA damage

  2003cited by this paper
• SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase.

  2003cited by this paper
• Control of Meiotic and Mitotic Progression by the F Box Protein β-Trcp1 In Vivo

  2003cited by this paper
• Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase.

  2003cited by this paper
• A novel conditional Akt ‘survival switch’ reversibly protects cells from apoptosis

  2002cited by this paper
• mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery.

  2002cited by this paper
• Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action.

  2002cited by this paper
• Role of the phosphatidylinositol 3-kinase/Akt and mTOR/P70S6-kinase pathways in the proliferation and apoptosis in multiple myeloma

  2002cited by this paper
• Mechanisms of ubiquitin-mediated, limited processingof the NF-κB1 precursor protein p105

  2001cited by this paper
• Mechanisms of ubiquitin-mediated, limited processing of the NF-kappaB1 precursor protein p105.

  2001cited by this paper
• SCFβ-TRCP and phosphorylation dependent ubiquitination of IκBα catalyzed by Ubc3 and Ubc4

  2000cited by this paper
• SCF(beta-TRCP) and phosphorylation dependent ubiquitinationof I kappa B alpha catalyzed by Ubc3 and Ubc4.

  2000cited by this paper
• Cyclin D1 Expression Mediated by Phosphatidylinositol 3-Kinase through mTOR-p70S6K-Independent Signaling in Growth Factor-Stimulated NIH 3T3 Fibroblasts

  1999cited by this paper

• Regulatory mechanisms for Snail protein stability: ubiquitin-proteasome system and chaperone-mediated autophagy.

  2026cites this paper
• Normalization of trophoblast mTOR signaling rescues impaired function in primary human trophoblast cells isolated from pregnancies complicated by fetal growth restriction

  2025cites this paper
• MCF7 breast cancer anabolic capacity reduced with CRISPR/Cas9-mediated stable overexpression of DEPTOR.

  2025cites this paper
• New mode of action of curcumin on prostate cancer cells: Modulation of endoplasmic reticulum‐associated degradation mechanism and estrogenic signaling

  2024cites this paper
• A patent review of SCF E3 ligases inhibitors for cancer：Structural design, pharmacological activities and structure-activity relationship.

  2024cites this paper
• Elevating PLK1 overcomes BETi resistance in prostate cancer via triggering BRD4 phosphorylation-dependent degradation in mitosis

  2024cites this paper
• Inhibitors Targeting the F-BOX Proteins

  2023cites this paper
• The F-box Protein FBW7 Negatively Regulates the Stability of ERK3 Protein

  2022cites this paper
• Targeting matrix metalloproteinases by E3 ubiquitin ligases as a way to regulate the tumor microenvironment for cancer therapy.

  2022cites this paper
• Bipartite binding and partial inhibition links DEPTOR and mTOR in a mutually antagonistic embrace

  2021cites this paper
• β-TrCP1 facilitates cell cycle checkpoint activation, DNA repair, and cell survival through ablation of β-TrCP2 in response to genotoxic stress

  2021cites this paper
• Age-related copy number variations and expression levels of F-box protein FBXL20 predict ovarian cancer prognosis

  2020cites this paper
• Cross Talk Networks of Mammalian Target of Rapamycin Signaling With the Ubiquitin Proteasome System and Their Clinical Implications in Multiple Myeloma.

  2019cites this paper
• WNT pathway signaling is associated with microvascular injury and predicts kidney transplant failure

  2019cites this paper
• DEPTOR at the Nexus of Cancer, Metabolism, and Immunity.

  2018cites this paper
• Cardiac ubiquitin ligases: Their role in cardiac metabolism, autophagy, cardioprotection and therapeutic potential.

  2016cites this paper
• Deregulation of F-box proteins and its consequence on cancer development, progression and metastasis.

  2016cites this paper
• DNA Damage Regulates Translation through β-TRCP Targeting of CReP

  2015cites this paper
• The role of the ubiquitin proteasome system in cerebellar development and medulloblastoma

  2015cites this paper
• Hypothalamic mTOR: the rookie energy sensor.

  2014cites this paper
• DEPTOR Is a Stemness Factor That Regulates Pluripotency of Embryonic Stem Cells*

  2014cites this paper
• Abnormal protein turnover and anabolic resistance to exercise in sarcopenic obesity

  2013cites this paper
• Emerging roles of E3 ubiquitin ligases in autophagy.

  2013cites this paper