Therapeutic Hypothesis Testing With Rodent Brain Tumor Models

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Neurotherapeutics

• Publication date

  2017-03-20

• Fields of study

  Medicine

• Identifiers
  DOI 10.1007/s13311-017-0523-1PMID 28321824PMCID PMC5398994
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Childhood Medulloblastoma.

  2020cited by this paper
• Predictive In Vivo Models for Oncology.

  2016cited by this paper
• Childhood medulloblastoma.

  2016cited by this paper
• Generation of Immunodeficient Mice Bearing Human Immune Systems by the Engraftment of Hematopoietic Stem Cells.

  2016cited by this paper
• A luciferin analogue generating near-infrared bioluminescence achieves highly sensitive deep-tissue imaging

  2016cited by this paper
• Patient-Derived Tumor Xenografts Are Susceptible to Formation of Human Lymphocytic Tumors1

  2015cited by this paper
• Noninvasive imaging of tumor burden and molecular pathways in mouse models of cancer.

  2015cited by this paper
• Brain metastasis: clinical characteristics, pathological findings and molecular subtyping for therapeutic implications

  2015cited by this paper
• Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma

  2014cited by this paper
• Focal Radiation Therapy Combined with 4-1BB Activation and CTLA-4 Blockade Yields Long-Term Survival and a Protective Antigen-Specific Memory Response in a Murine Glioma Model

  2014cited by this paper
• Establishment of genetically diverse patient-derived xenografts of colorectal cancer.

  2014cited by this paper
• Human cancer growth and therapy in immunodeficient mouse models.

  2014cited by this paper
• Immunodeficient mouse model for human hematopoietic stem cell engraftment and immune system development.

  2014cited by this paper
• A synthetic luciferin improves bioluminescence imaging in live mice

  2014cited by this paper
• Integrated Next-Generation Sequencing and Avatar Mouse Models for Personalized Cancer Treatment

  2014cited by this paper
• Immunocompetent murine models for the study of glioblastoma immunotherapy

  2014cited by this paper
• Durable Therapeutic Efficacy Utilizing Combinatorial Blockade against IDO, CTLA-4, and PD-L1 in Mice with Brain Tumors

  2014cited by this paper
• A Novel, Diffusely Infiltrative Xenograft Model of Human Anaplastic Oligodendroglioma with Mutations in FUBP1, CIC, and IDH1

  2013cited by this paper
• Patient-specific orthotopic glioblastoma xenograft models recapitulate the histopathology and biology of human glioblastomas in situ.

  2013cited by this paper
• Vertebrate animal models of glioma: understanding the mechanisms and developing new therapies.

  2013cited by this paper
• Meningioma

  2013cited by this paper
• An in vivo patient-derived model of endogenous IDH1-mutant glioma.

  2012cited by this paper
• Effect of Low Doses of Low-Let Radiation on the Innate Anti-Tumor Reactions in Radioresistant and Radiosensitive Mice

  2012cited by this paper
• Targeted Therapy for BRAFV600E Malignant Astrocytoma

  2011cited by this paper
• Report from the fifth National Cancer Institute Mouse Models of Human Cancers Consortium Nervous System Tumors Workshop.

  2011cited by this paper
• Establishment, Maintenance, and In Vitro and In Vivo Applications of Primary Human Glioblastoma Multiforme (GBM) Xenograft Models for Translational Biology Studies and Drug Discovery

  2011cited by this paper
• Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma

  2011cited by this paper
• Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1.

  2010cited by this paper
• Comparative analyses of gene copy number and mRNA expression in glioblastoma multiforme tumors and xenografts.

  2009cited by this paper
• A reproducible brain tumour model established from human glioblastoma biopsies

  2009cited by this paper
• Glioma stem cell lines expanded in adherent culture have tumor-specific phenotypes and are suitable for chemical and genetic screens.

  2009cited by this paper
• Cytogenetical studies with G‐band technique of established cell lines of human malignant gliomas

  2009cited by this paper
• Rat brain tumor models in experimental neuro-oncology: the C6, 9L, T9, RG2, F98, BT4C, RT-2 and CNS-1 gliomas

  2009cited by this paper
• Pten haploinsufficiency accelerates formation of high-grade astrocytomas.

  2008cited by this paper
• Genomic Changes and Gene Expression Profiles Reveal That Established Glioma Cell Lines Are Poorly Representative of Primary Human Gliomas

  2008cited by this paper
• A comparison of the cell lines used in meningioma research.

  2008cited by this paper
• Comprehensive genomic characterization defines human glioblastoma genes and core pathways

  2008cited by this paper
• Systemic CTLA-4 Blockade Ameliorates Glioma-Induced Changes to the CD4+ T Cell Compartment without Affecting Regulatory T-Cell Function

  2007cited by this paper
• Bioluminescence monitoring of intracranial glioblastoma xenograft: response to primary and salvage temozolomide therapy.

  2007cited by this paper
• Genetically engineered models have advantages over xenografts for preclinical studies.

  2006cited by this paper
• Use of an Orthotopic Xenograft Model for Assessing the Effect of Epidermal Growth Factor Receptor Amplification on Glioblastoma Radiation Response

  2006cited by this paper
• Glioma stem cells promote radioresistance by preferential activation of the DNA damage response

  2006cited by this paper
• Noninvasive Bioluminescence Imaging of Luciferase Expressing Intracranial U87 Xenografts: Correlation with Magnetic Resonance Imaging Determined Tumor Volume and Longitudinal Use in Assessing Tumor Growth and Antiangiogenic Treatment Effect

  2006cited by this paper
• Patient tumor EGFR and PDGFRA gene amplifications retained in an invasive intracranial xenograft model of glioblastoma multiforme.

  2005cited by this paper
• Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma.

  2005influential reference
• ''Of mice and men'': values and liabilities of the athymic nude mouse model in anticancer drug development

  2004cited by this paper
• Of mice and men: values and liabilities of the athymic nude mouse model in anticancer drug development.

  2004cited by this paper
• Identification of human brain tumour initiating cells

  2004cited by this paper
• The role of xenografting in pediatric brain tumor research with specific emphasis on medulloblastoma/primitive neuroectodermal tumors of childhood.

  2003cited by this paper
• Alterations of the tumor suppressor genes CDKN2A (p16(INK4a)), p14(ARF), CDKN2B (p15(INK4b)), and CDKN2C (p18(INK4c)) in atypical and anaplastic meningiomas.

  2001cited by this paper
• Astrocyte-specific expression of activated p21-ras results in malignant astrocytoma formation in a transgenic mouse model of human gliomas.

  2001cited by this paper
• Analysis of Tissue Chimerism in Nude Mouse Brain and Abdominal Xenograft Models of Human Glioblastoma Multiforme: What Does It Tell Us About the Models and About Glioblastoma Biology and Therapy?

  2000cited by this paper
• Frequent Co‐Alterations of TP53, p16/CDKN2A, p14ARF, PTEN Tumor Suppressor Genes in Human Glioma Cell Lines.

  1999cited by this paper
• Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

  1992cited by this paper
• Amplification of the c-myc gene in human medulloblastoma cell lines and xenografts.

  1990cited by this paper
• Characterization of a newly established malignant meningioma cell line of the human brain: IOMM-Lee.

  1990cited by this paper
• Phenotypic Analysis of Four Human Medulloblastoma Cell Lines and Transplantable Xenografts

  1989cited by this paper
• Relationship of in Vitro Morphologic and Growth Characteristics of Established Human Glioma‐derived Cell Lines to Their Tumorigenicity in Athymic Nude Mice

  1981cited by this paper
• Cytogentical studies with G-band technique of established cell lines of human malignant glomas.

  1974cited by this paper

• Brief results of heterotopic xenotransplantation of meningioma into the peritoneum of Wistar rats: an experimental study.

  2026cites this paper
• Efficacy of Oncolytic Virus VV-GMCSF-Lact Against Immunocompetent Glioma

  2025cites this paper
• Preclinical Models and Technologies in Glioblastoma Research: Evolution, Current State, and Future Avenues

  2023influential citation
• Nanomedicine for Brain Cancer.

  2022cites this paper
• Patient-Derived Orthotopic Xenograft Models of Pediatric Brain Tumors: In a Mature Phase or Still in Its Infancy?

  2020cites this paper
• Phase 0 Clinical Trial Strategies for the Neurosurgical Oncologist

  2019influential citation
• Animal models of primary brain tumors

  2019cites this paper
• Overcoming the Blood–Brain Barrier. Challenges and Tricks for CNS Drug Delivery

  2019cites this paper
• Genetic Abnormalities, Clonal Evolution, and Cancer Stem Cells of Brain Tumors

  2018cites this paper
• Current trends in mouse models of glioblastoma

  2017cites this paper