Involvement of Epigenetics and EMT-Related miRNA in Arsenic-Induced Neoplastic Transformation and Their Potential Clinical Use

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Cancer Prevention Research

• Publication date

  2015-01-13

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1158/1940-6207.CAPR-14-0251PMID 25586904PMCID PMC4355280
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Targeting the genetic alterations of the PI3K-AKT-mTOR pathway: its potential use in the treatment of bladder cancers.

  2015cited by this paper
• The effects of environmental chemical carcinogens on the microRNA machinery.

  2014cited by this paper
• Association between arsenic exposure from drinking water and hematuria: results from the Health Effects of Arsenic Longitudinal Study.

  2014cited by this paper
• The role of PTEN tumor suppressor pathway staining in carcinoma in situ of the bladder.

  2014cited by this paper
• The microRNAs as potential biomarkers for predicting the onset of aflatoxin exposure in human beings: a review

  2014cited by this paper
• Expression of miRNAs and ZEB1 and ZEB2 correlates with histopathological grade in papillary urothelial tumors of the urinary bladder

  2014cited by this paper
• S100A9 and EGFR gene signatures predict disease progression in muscle invasive bladder cancer patients after chemotherapy.

  2014cited by this paper
• The Inhibitory Effect of Intravesical Fisetin against Bladder Cancer by Induction of p53 and Down‐Regulation of NF‐kappa B Pathways in a Rat Bladder Carcinogenesis Model

  2014cited by this paper
• Arsenic and Lung Disease Mortality in Bangladeshi Adults

  2014cited by this paper
• Genome-wide methylation profiling and the PI3K-AKT pathway analysis associated with smoking in urothelial cell carcinoma

  2013cited by this paper
• Fluorescence in situ hybridization analysis of CCND3 gene as marker of progression in bladder carcinoma.

  2013cited by this paper
• Case-control study of arsenic in drinking water and kidney cancer in uniquely exposed Northern Chile.

  2013cited by this paper
• Roxarsone, Inorganic Arsenic, and Other Arsenic Species in Chicken: A U.S.-Based Market Basket Sample

  2013cited by this paper
• The shaping and functional consequences of the microRNA landscape in breast cancer

  2013cited by this paper
• Bladder cancer, a review of the environmental risk factors

  2012cited by this paper
• Transcriptional Modulation of the ERK1/2 MAPK and NF-κB Pathways in Human Urothelial Cells After Trivalent Arsenical Exposure: Implications for Urinary Bladder Cancer.

  2012cited by this paper
• Bladder cancer risk from occupational and environmental exposures.

  2012cited by this paper
• Interleukin-20 Promotes Migration of Bladder Cancer Cells through Extracellular Signal-regulated Kinase (ERK)-mediated MMP-9 Protein Expression Leading to Nuclear Factor (NF-κB) Activation by Inducing the Up-regulation of p21WAF1 Protein Expression*

  2012cited by this paper
• Advanced Urothelial Carcinoma: Overcoming Treatment Resistance through Novel Treatment Approaches

  2012cited by this paper
• Differential expression of microRNAs during melanoma progression: miR-200c, miR-205 and miR-211 are downregulated in melanoma and act as tumour suppressors

  2012cited by this paper
• Expression of microRNAs in the urine of patients with bladder cancer.

  2012cited by this paper
• OGDHL Is a Modifier of AKT-Dependent Signaling and NF-κB Function

  2012cited by this paper
• Overabundance of putative cancer stem cells in human skin keratinocyte cells malignantly transformed by arsenic.

  2012cited by this paper
• Reversal and prevention of arsenic-induced human bronchial epithelial cell malignant transformation by microRNA-200b.

  2011influential reference
• MicroRNA‐200c attenuates tumour growth and metastasis of presumptive head and neck squamous cell carcinoma stem cells

  2011cited by this paper
• miRNA-205 Suppresses Melanoma Cell Proliferation and Induces Senescence via Regulation of E2F1 Protein*

  2011cited by this paper
• Arsenic Exposure and the Induction of Human Cancers

  2011cited by this paper
• Arsenic, stem cells, and the developmental basis of adult cancer.

  2011cited by this paper
• Mechanisms Pertaining to Arsenic Toxicity

  2011cited by this paper
• A MicroRNA expression profile defining the invasive bladder tumor phenotype.

  2011cited by this paper
• Discovery pipeline for epigenetically deregulated miRNAs in cancer: integration of primary miRNA transcription

  2011cited by this paper
• Coordinated epigenetic repression of the miR‐200 family and miR‐205 in invasive bladder cancer

  2011cited by this paper
• Integrated, Genome-Wide Screening for Hypomethylated Oncogenes in Salivary Gland Adenoid Cystic Carcinoma

  2011cited by this paper
• MicroRNA let-7a represses chemoresistance and tumourigenicity in head and neck cancer via stem-like properties ablation.

  2011cited by this paper
• Signatures of microRNAs and selected microRNA target genes in human melanoma.

  2010cited by this paper
• Risk of transitional-cell carcinoma of the bladder in first- and second-generation immigrants to Sweden

  2010cited by this paper
• Bladder cancer or bladder cancers? Genetically distinct malignant conditions of the urothelium.

  2010cited by this paper
• The ups and downs of miR-205: Identifying the roles of miR-205 in mammary gland development and breast cancer

  2010cited by this paper
• Diagnostic assay based on hsa-miR-205 expression distinguishes squamous from nonsquamous non-small-cell lung carcinoma.

  2009cited by this paper
• Dysregulated microRNAs and their predicted targets associated with endometrioid endometrial adenocarcinoma in Hong Kong women

  2009cited by this paper
• microRNA-205 regulates HER3 in human breast cancer.

  2009cited by this paper
• MicroRNAs — the micro steering wheel of tumour metastases

  2009cited by this paper
• The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs

  2009cited by this paper
• Association between Lifestyle Factors and CpG Island Methylation in a Cancer-Free Population

  2009cited by this paper
• Arsenic Activates EGFR Pathway Signaling in the Lung

  2009cited by this paper
• Genomic profiling of microRNAs in bladder cancer: miR-129 is associated with poor outcome and promotes cell death in vitro.

  2009cited by this paper
• Targeting miR-205 in breast cancer

  2009cited by this paper
• Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits

  2009cited by this paper
• Epigenetic remodeling during arsenical-induced malignant transformation.

  2008cited by this paper
• Direct regulation of TWIST by HIF-1α promotes metastasis

  2008cited by this paper
• Genome-wide promoter analysis uncovers portions of the cancer methylome.

  2008cited by this paper
• The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1

  2008cited by this paper
• Suppression of cell growth and invasion by miR-205 in breast cancer

  2008cited by this paper
• Prognostic value of mature microRNA-21 and microRNA-205 overexpression in non-small cell lung cancer by quantitative real-time RT-PCR.

  2008cited by this paper
• MicroRNA signature predicts survival and relapse in lung cancer.

  2008cited by this paper
• Nicotine promotes colon tumor growth and angiogenesis through beta-adrenergic activation.

  2007cited by this paper
• Arsenic Metabolism, Genetic Susceptibility, and Risk of Premalignant Skin Lesions in Bangladesh

  2007cited by this paper
• Micro-RNA profiling in kidney and bladder cancers.

  2007cited by this paper
• Transplacental arsenic carcinogenesis in mice.

  2007cited by this paper
• Health Effects of Arsenic Longitudinal Study (HEALS): Description of a multidisciplinary epidemiologic investigation

  2006cited by this paper
• Arsenic exposure from drinking water, dietary intakes of B vitamins and folate, and risk of high blood pressure in Bangladesh: a population-based, cross-sectional study.

  2006cited by this paper
• A microRNA expression signature of human solid tumors defines cancer gene targets

  2006cited by this paper
• Comprehensive DNA methylation profiling in a human cancer genome identifies novel epigenetic targets.

  2006cited by this paper
• Enhanced urinary bladder and liver carcinogenesis in male CD1 mice exposed to transplacental inorganic arsenic and postnatal diethylstilbestrol or tamoxifen.

  2006cited by this paper
• Arsenic exposure from drinking water and risk of premalignant skin lesions in Bangladesh: baseline results from the Health Effects of Arsenic Longitudinal Study.

  2006cited by this paper
• Urogenital carcinogenesis in female CD1 mice induced by in utero arsenic exposure is exacerbated by postnatal diethylstilbestrol treatment.

  2006cited by this paper
• MicroRNA expression profiles classify human cancers

  2005cited by this paper
• Some drinking-water disinfectants and contaminants, including arsenic.

  2004cited by this paper
• Immunohistochemical analysis of oxidative DNA damage in arsenic-related human skin samples from arsenic-contaminated area of China.

  2004cited by this paper
• Chronic inorganic arsenic exposure induces hepatic global and individual gene hypomethylation: implications for arsenic hepatocarcinogenesis.

  2004influential reference
• Transplacental carcinogenicity of inorganic arsenic in the drinking water: induction of hepatic, ovarian, pulmonary, and adrenal tumors in mice.

  2003cited by this paper
• DNA repair gene XPD and susceptibility to arsenic-induced hyperkeratosis.

  2003cited by this paper
• Arsenite and arsenate activate extracellular signal‐regulated kinases 1/2 by an epidermal growth factor receptor‐mediated pathway in normal human keratinocytes

  2003cited by this paper
• Induction of tumors of the liver, lung, ovary and adrenal in adult mice after brief maternal gestational exposure to inorganic arsenic: promotional effects of postnatal phorbol ester exposure on hepatic and pulmonary, but not dermal cancers.

  2003cited by this paper
• Arsenic carcinogenicity: Relevance of c-Src activation

  2002cited by this paper
• c-Src-dependent Activation of the Epidermal Growth Factor Receptor and Mitogen-activated Protein Kinase Pathway by Arsenic

  2002cited by this paper
• Arsenic in drinking water.

  2001cited by this paper
• Associations Between Drinking Water and Urinary Arsenic Levels and Skin Lesions in Bangladesh

  2000cited by this paper
• The Stress Inducer Arsenite Activates Mitogen-activated Protein Kinases Extracellular Signal-regulated Kinases 1 and 2 via a MAPK Kinase 6/p38-dependent Pathway*

  1998cited by this paper
• Characterization of two urothelium cancer cell lines derived from a blackfoot disease endemic area in Taiwan.

  1996cited by this paper
• ARSENIC AND CANCERS

  1988cited by this paper
• Arsenic and cancers.

  1988cited by this paper

• The Role of microRNAs in Arsenic-Induced Human Diseases: A Review.

  2023cites this paper
• Arsenic in Drinking Water and Diabetes

  2023cites this paper
• miRNAs and arsenic-induced carcinogenesis.

  2023cites this paper
• Epigenomic reprogramming in iAs-mediated carcinogenesis.

  2023cites this paper
• In Vitro Approaches to Determine the Potential Carcinogenic Risk of Environmental Pollutants

  2023cites this paper
• Biological implications and clinical potential of invasion and migration related miRNAs in glioma

  2022cites this paper
• MicroRNA–Gene Interactions Impacted by Toxic Metal(oid)s during EMT and Carcinogenesis

  2022cites this paper
• Dysregulation of microRNAs in metal-induced angiogenesis and carcinogenesis.

  2021cites this paper
• MiR-379-5p targets microsomal glutathione transferase 1 (MGST1) to regulate human glioma in cell proliferation, migration and invasion and epithelial-mesenchymal transition (EMT).

  2021cites this paper
• Epigenetic modifications from arsenic exposure: A comprehensive review.

  2021cites this paper
• Arsenic-Induced Epigenetic Changes in Cancer Development.

  2021cites this paper
• Modulatory role of tea in arsenic induced epigenetic alterations in carcinogenesis

  2021cites this paper
• Epigenetic effects of low-level sodium arsenite exposure on human liver HepaRG cells

  2020cites this paper
• Arsenic-induced changes in miRNA expression in cancer and other diseases.

  2020influential citation
• GULP1 regulates the NRF2-KEAP1 signaling axis in urothelial carcinoma

  2020cites this paper
• The expression of microRNAs and exposure to environmental contaminants related to human health: a review

  2020cites this paper
• Urinary MicroRNAs as Potential Markers for Non-Invasive Diagnosis of Bladder Cancer

  2020cites this paper
• Metals and Molecular Carcinogenesis.

  2020cites this paper
• Toxic-Metal-Induced Alteration in miRNA Expression Profile as a Proposed Mechanism for Disease Development

  2020cites this paper
• A Review of Urine Ancillary Tests in the Era of the Paris System

  2019cites this paper
• Arsenic and microRNA Expression

  2019cites this paper
• Metal carcinogen exposure induces cancer stem cell-like property through epigenetic reprograming: A novel mechanism of metal carcinogenesis.

  2019cites this paper
• Deregulation of small non-coding RNAs in response to environmental carcinogens and during human development

  2019cites this paper
• Oncogenetics of Lung Cancer Induced by Environmental Carcinogens

  2018cites this paper
• Effects of microRNA-135a on the epithelial–mesenchymal transition, migration and invasion of bladder cancer cells by targeting GSK3β through the Wnt/β-catenin signaling pathway

  2018cites this paper
• Increased O-GlcNAcylation of SNAP29 Drives Arsenic-Induced Autophagic Dysfunction

  2018cites this paper
• Acetarsol Suppositories: Effective Treatment for Refractory Proctitis in a Cohort of Patients with Inflammatory Bowel Disease

  2018cites this paper
• Arsenic promotes the COX2/PGE2–SOX2 axis to increase the malignant stemness properties of urothelial cells

  2018influential citation
• PI3K/Akt/mTOR Signaling Pathway and the Biphasic Effect of Arsenic in Carcinogenesis

  2018influential citation
• miR‐21a negatively modulates tumor suppressor genes PTEN and miR‐200c and further promotes the transformation of M2 macrophages

  2018cites this paper
• YAP1 and COX2 Coordinately Regulate Urothelial Cancer Stem-like Cells.

  2018cites this paper
• Arsenic-Induced Carcinogenesis: The Impact of miRNA Dysregulation.

  2018cites this paper
• Malignant Transformation of Human Bronchial Epithelial Cells Induced by Arsenic through STAT3/miR-301a/SMAD4 Loop

  2018cites this paper
• MiR-218-5p targets LHFPL3 to regulate proliferation, migration, and epithelial–mesenchymal transitions of human glioma cells

  2018cites this paper
• Epigenetic Alterations in Bladder Cancer

  2018cites this paper
• Differential metallothionein isoform expression as biomarkers of cadmium exposure in human urothelium

  2017cites this paper
• Role of epigenetics in tumor induction by non-genotoxic carcinogens

  2017cites this paper
• MiRNA expression changes in arsenic-induced skin cancer in vitro and in vivo.

  2017cites this paper
• Expression of GULP1 in bronchial epithelium is associated with the progression of emphysema in chronic obstructive pulmonary disease.

  2017cites this paper
• Mirna Expression in Bladder Cancer and Their Potential Role in Clinical Practice.

  2017cites this paper
• Arsenic Exposure and Type 2 Diabetes: MicroRNAs as Mechanistic Links?

  2017cites this paper
• Genetic and epigenetic mechanisms underlying arsenic-associated diabetes mellitus: a perspective of the current evidence.

  2017cites this paper
• Long-term exposure of immortalized keratinocytes to arsenic induces EMT, impairs differentiation in organotypic skin models and mimics aspects of human skin derangements

  2017cites this paper
• Oncogenomic disruptions in arsenic-induced carcinogenesis

  2017influential citation
• MiR-375 suppresses invasion and metastasis by direct targeting of SHOX2 in esophageal squamous cell carcinoma

  2017cites this paper
• Upregulation of MiR-205 under hypoxia promotes epithelial–mesenchymal transition by targeting ASPP2

  2016cites this paper
• The role of microRNAs in metal carcinogen-induced cell malignant transformation and tumorigenesis.

  2016influential citation
• Loss of N-Cadherin Expression in Tumor Transplants Produced From As+3- and Cd+2-Transformed Human Urothelial (UROtsa) Cell Lines

  2016influential citation
• Differences in the Molecular Characteristics of Bladder Cancer between Smokers and Nonsmokers.

  2016cites this paper
• Oxidative Stress, Epigenetics, and Cancer Stem Cells in Arsenic Carcinogenesis and Prevention

  2016cites this paper
• The role of microRNAs in the development and progression of chemical-associated cancers.

  2016cites this paper