Combined treatment with a β3‐adrenergic receptor agonist and a muscarinic receptor antagonist inhibits detrusor overactivity induced by cold stress in spontaneously hypertensive rats

This study determined if combined treatment with the muscarinic receptor (MR) antagonist solifenacin and the β3‐adrenergic receptor (AR) agonist mirabegron could inhibit detrusor overactivity induced by cold stress in spontaneously hypertensive rats (SHRs).

• Publication year

  2017

• Venue

  Neurourology and Urodynamics

• Publication date

  2017-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/nau.23061PMID 27367573
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Acetylcholine and molecular components of its synthesis and release machinery in the urothelium.

  2007influential reference
• Non-neuronal cholinergic system in human bladder urothelium.

  2006influential reference
• Systemic oxybutynin decreases afferent activity of the pelvic nerve of the rat: New insights into the working mechanism of antimuscarinics

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• Nitric oxide synthase and the lower urinary tract: possible implications for physiology and pathophysiology.

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