Concise Reviews: Regeneration in Mammalian Cochlea Hair Cells: Help from Supporting Cells Transdifferentiation.

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Stem Cells

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/STEM.2554
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Dual role for Sox2 in specification of sensory competence and regulation of Atoh1 function

  2017cited by this paper
• Characterization of Lgr5+ progenitor cell transcriptomes in the apical and basal turns of the mouse cochlea

  2016cited by this paper
• Role of Wnt and Notch signaling in regulating hair cell regeneration in the cochlea

  2016cited by this paper
• Extensive Supporting Cell Proliferation and Mitotic Hair Cell Generation by In Vivo Genetic Reprogramming in the Neonatal Mouse Cochlea

  2016cited by this paper
• Wnt activation followed by Notch inhibition promotes mitotic hair cell regeneration in the postnatal mouse cochlea

  2016cited by this paper
• Canonical Notch signaling plays an instructive role in auditory supporting cell development

  2016cited by this paper
• Cochlear supporting cell transdifferentiation and integration into hair cell layers by inhibition of ephrin-B2 signalling

  2015cited by this paper
• Changes in the regulation of the Notch signaling pathway are temporally correlated with regenerative failure in the mouse cochlea

  2015cited by this paper
• Cooperative and independent functions of FGF and Wnt signaling during early inner ear development

  2015cited by this paper
• MicroRNA-124 Regulates Cell Specification in the Cochlea through Modulation of Sfrp4/5.

  2015cited by this paper
• The Wnt and Notch signalling pathways in the developing cochlea: Formation of hair cells and induction of regenerative potential

  2015cited by this paper
• Cell cycle reactivation of cochlear progenitor cells in neonatal FUCCI mice by a GSK3 small molecule inhibitor

  2015cited by this paper
• Opportunities and limits of the one gene approach: the ability of Atoh1 to differentiate and maintain hair cells depends on the molecular context

  2015cited by this paper
• Changes in Regenerative Capacity through Lifespan

  2015cited by this paper
• In Vivo Cochlear Hair Cell Generation and Survival by Coactivation of β-Catenin and Atoh1

  2015cited by this paper
• Therapeutic potential of a gamma-secretase inhibitor for hearing restoration in a guinea pig model with noise-induced hearing loss

  2014cited by this paper
• Notch inhibition induces mitotically generated hair cells in mammalian cochleae via activating the Wnt pathway

  2014cited by this paper
• β-Catenin Is Required for Hair-Cell Differentiation in the Cochlea

  2014cited by this paper
• Spontaneous hair cell regeneration in the neonatal mouse cochlea in vivo

  2014cited by this paper
• A BMP regulatory network controls ectodermal cell fate decisions at the neural plate border

  2013cited by this paper
• Conditional Deletion of Atoh1 Reveals Distinct Critical Periods for Survival and Function of Hair Cells in the Organ of Corti

  2013cited by this paper
• Induction of the inner ear: stepwise specification of otic fate from multipotent progenitors.

  2013cited by this paper
• Notch inhibition induces cochlear hair cell regeneration and recovery of hearing after acoustic trauma.

  2013cited by this paper
• Generation of hair cells in neonatal mice by β-catenin overexpression in Lgr5-positive cochlear progenitors

  2013cited by this paper
• Postnatal development, maturation and aging in the mouse cochlea and their effects on hair cell regeneration.

  2013cited by this paper
• Atoh1 directs hair cell differentiation and survival in the late embryonic mouse inner ear.

  2013cited by this paper
• Atoh1 Directs the Formation of Sensory Mosaics and Induces Cell Proliferation in the Postnatal Mammalian Cochlea In Vivo

  2012cited by this paper
• Differential distribution of competence for panplacodal and neural crest induction to non-neural and neural ectoderm

  2012cited by this paper
• Wnt signaling induces proliferation of sensory precursors in the postnatal mouse cochlea

  2012cited by this paper
• A dual function for canonical Wnt/β-catenin signaling in the developing mammalian cochlea

  2012cited by this paper
• Regulation of p27Kip1 by Sox2 Maintains Quiescence of Inner Pillar Cells in the Murine Auditory Sensory Epithelium

  2012cited by this paper
• Age-Dependent In Vivo Conversion of Mouse Cochlear Pillar and Deiters' Cells to Immature Hair Cells by Atoh1 Ectopic Expression

  2012cited by this paper
• p27Kip1 Directly Represses Sox2 during Embryonic Stem Cell Differentiation

  2012cited by this paper
• Wnt-Responsive Lgr5-Expressing Stem Cells Are Hair Cell Progenitors in the Cochlea

  2012cited by this paper
• Conditional deletion of Atoh1 using Pax2-Cre results in viable mice without differentiated cochlear hair cells that have lost most of the organ of Corti.

  2011cited by this paper
• Intrinsic regenerative potential of murine cochlear supporting cells

  2011cited by this paper
• A novel mutation within the MIR96 gene causes non-syndromic inherited hearing loss in an Italian family by altering pre-miRNA processing

  2011cited by this paper
• Sox2 Induces Neuronal Formation in the Developing Mammalian Cochlea

  2010cited by this paper
• Notch signaling specifies prosensory domains via lateral induction in the developing mammalian inner ear

  2010cited by this paper
• MicroRNA-183 Family Members Regulate Sensorineural Fates in the Inner Ear

  2010cited by this paper
• FGF signaling regulates otic placode induction and refinement by controlling both ectodermal target genes and hindbrain Wnt8a.

  2010cited by this paper
• Supporting Cell Division Is Not Required for Regeneration of Auditory Hair Cells After Ototoxic Injury In Vitro

  2010cited by this paper
• From shared lineage to distinct functions: the development of the inner ear and epibranchial placodes

  2010cited by this paper
• BMP Signaling Is Necessary for Patterning the Sensory and Nonsensory Regions of the Developing Mammalian Cochlea

  2010cited by this paper
• Cochlear supporting cells

  2010cited by this paper
• β-Catenin Up-regulates Atoh1 Expression in Neural Progenitor Cells by Interaction with an Atoh1 3′ Enhancer*

  2009cited by this paper
• Mutations in the seed region of human miR-96 are responsible for nonsyndromic progressive hearing loss

  2009cited by this paper
• Feathers and fins: non-mammalian models for hair cell regeneration.

  2009cited by this paper
• Sox2 signaling in prosensory domain specification and subsequent hair cell differentiation in the developing cochlea

  2008cited by this paper
• Functional auditory hair cells produced in the mammalian cochlea by in utero gene transfer

  2008cited by this paper
• Notch signaling is essential for ventricular chamber development.

  2007cited by this paper
• The first steps towards hearing: mechanisms of otic placode induction.

  2007cited by this paper
• Differential Distribution of Stem Cells in the Auditory and Vestibular Organs of the Inner Ear

  2007cited by this paper
• Expression and functions of FGF ligands during early otic development.

  2007cited by this paper
• Fgf8 induces pillar cell fate and regulates cellular patterning in the mammalian cochlea

  2007cited by this paper
• Loss of Fgfr3 leads to excess hair cell development in the mouse organ of Corti

  2007cited by this paper
• Wnt signals mediate a fate decision between otic placode and epidermis

  2006cited by this paper
• Induction and specification of cranial placodes.

  2006cited by this paper
• Differential expression of unconventional myosins in apoptotic and regenerating chick hair cells confirms two regeneration mechanisms

  2006cited by this paper
• Mammalian cochlear supporting cells can divide and trans-differentiate into hair cells

  2006cited by this paper
• MicroRNA gene expression in the mouse inner ear.

  2006cited by this paper
• Auditory hair cell replacement and hearing improvement by Atoh1 gene therapy in deaf mammals

  2005cited by this paper
• Auditory hair cell replacement and hearing improvement by Atoh1 gene therapy in deaf mammals

  2005cited by this paper
• Wnt-dependent regulation of inner ear morphogenesis is balanced by the opposing and supporting roles of Shh.

  2005cited by this paper
• Direct transdifferentiation gives rise to the earliest new hair cells in regenerating avian auditory epithelium

  2004cited by this paper
• Requirements for FGF3 and FGF10 during inner ear formation

  2003cited by this paper
• Fgf3 and Fgf10 are required for mouse otic placode induction

  2003cited by this paper
• Proliferative generation of mammalian auditory hair cells in culture.

  2002cited by this paper
• The role of Math1 in inner ear development: Uncoupling the establishment of the sensory primordium from hair cell fate determination.

  2002cited by this paper
• Extensive cell movements accompany formation of the otic placode.

  2002cited by this paper
• Sensory organ development in the inner ear: molecular and cellular mechanisms.

  2002cited by this paper
• Notch signaling regulates the pattern of auditory hair cell differentiation in mammals.

  2000cited by this paper
• p27(Kip1) links cell proliferation to morphogenesis in the developing organ of Corti.

  1999cited by this paper
• Notch signalling pathway mediates hair cell development in mammalian cochlea

  1999cited by this paper
• Math1: an essential gene for the generation of inner ear hair cells.

  1999cited by this paper
• New hair cells arise from supporting cell conversion in the acoustically damaged chick inner ear.

  1996cited by this paper
• Developmental morphology of the mouse inner ear. A scanning electron microscopic observation.

  1985cited by this paper
• The embryonic and postnatal development of the inner ear of the mouse.

  1971cited by this paper

• The mTOR Pathway in Hearing Disorders: Mechanistic Links to Aging, Regeneration, and Neurodegeneration

  2026cites this paper
• Wnt/PKC Signaling Inhibits Sensory Hair Cell Formation in the Developing Mammalian Cochlea

  2025cites this paper
• Development of otic organoids and their current status

  2023cites this paper
• Stem Cell-Based Therapies for Auditory Hair Cell Regeneration in the Treatment of Hearing Loss

  2023cites this paper
• Transcriptomic and epigenomic analyses explore the potential role of H3K4me3 in neomycin-induced cochlear Lgr5+ progenitor cell regeneration of hair cells

  2022cites this paper
• Gradients in cellular metabolism regulate development of tonotopy along the chick cochlea

  2022cites this paper
• Advances and challenges in adeno-associated viral inner-ear gene therapy for sensorineural hearing loss

  2021cites this paper
• The pericyte progenitors and the pericytes are the ancestors of the inner ear structures

  2020cites this paper
• Recent development of AAV-based gene therapies for inner ear disorders

  2020cites this paper
• Usher Syndrome: Genetics and Molecular Links of Hearing Loss and Directions for Therapy

  2020cites this paper
• Emerging approaches for restoration of hearing and vision.

  2020cites this paper
• Gene therapy for hair cell regeneration: Review and new data.

  2020cites this paper
• Cell-Specific Transcriptional Responses to Heat Shock in the Mouse Utricle Epithelium

  2020cites this paper
• Recent development of AAV-based gene therapies for inner ear disorders

  2020cites this paper
• Invited contribution to the volume: "Stem cells & cancer stem cells, regenerative medicine & cancer" (VSI stem cells) reprogramming and transdifferentiation - two key processes for regenerative medicine.

  2020cites this paper
• Hair cell regeneration from inner ear progenitors in the mammalian cochlea.

  2020cites this paper
• Cellular mechanisms of epithelial stem cell self‐renewal and differentiation during homeostasis and repair

  2019cites this paper
• Influence of 24-diamino-5-phenylthiazole on neomycin ototoxicity in cultured organ of Corti explants

  2018cites this paper
• Characterization of the Transcriptome of Hair Cell Regeneration in the Neonatal Mouse Utricle

  2018cites this paper
• An evidence-base and implementation framework for promoting best practices in pharmaceutical interventions for hearing loss (PIHL) research

  2017cites this paper