Hypoxia and kinase activity regulate lung epithelial cell glutathione

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Experimental Lung Research

• Publication date

  2010-02-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.3109/01902140903061795PMID 20128681
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Regulation of glutathione synthesis.

  2009cited by this paper
• KINASE ACTIVITY, HEAT SHOCK PROTEIN 27 PHOSPHORYLATION, AND LUNG EPITHELIAL CELL GLUTATHIONE

  2008cited by this paper
• Systemic Deficiency of the MAP Kinase-Activated Protein Kinase 2 Reduces Atherosclerosis in Hypercholesterolemic Mice

  2007cited by this paper
• Lack of MK2 inhibits myofibroblast formation and exacerbates pulmonary fibrosis.

  2007cited by this paper
• The Qo site of the mitochondrial complex III is required for the transduction of hypoxic signaling via reactive oxygen species production

  2007cited by this paper
• Hydrogen peroxide increases the activity of γ-glutamylcysteine synthetase in cultured Chinese hamster V79 cells

  2007cited by this paper
• Submicromolar concentrations of 4-hydroxynonenal induce glutamate cysteine ligase expression in HBE1 cells

  2007cited by this paper
• Overexpression of human Hsp27 inhibits serum-induced proliferation in airway smooth muscle myocytes and confers resistance to hydrogen peroxide cytotoxicity.

  2007cited by this paper
• Heat shock protects cardiac cells from doxorubicin-induced toxicity by activating p38 MAPK and phosphorylation of small heat shock protein 27.

  2006cited by this paper
• Biological Significance of Decreased HSP27 in Human Atherosclerosis

  2006cited by this paper
• Characterization of the Bifunctional γ-Glutamate-cysteine Ligase/Glutathione Synthetase (GshF) of Pasteurella multocida*

  2006influential reference
• Hypoxic reduction in cellular glutathione levels requires mitochondrial reactive oxygen species.

  2004cited by this paper
• p38mapk and MEK1/2 inhibition contribute to cellular oxidant injury after hypoxia.

  2004cited by this paper
• Mitochondrial complex I, aconitase, and succinate dehydrogenase during hypoxia-reoxygenation: modulation of enzyme activities by MnSOD.

  2003cited by this paper
• Cellular glutathione and thiols metabolism.

  2002cited by this paper
• Reactive nitrogen species and cell signaling: implications for death or survival of lung epithelium.

  2002influential reference
• A549 subclones demonstrate heterogeneity in toxicological sensitivity and antioxidant profile.

  2002cited by this paper
• Role of AP-1 in the Coordinate Induction of Rat Glutamate-cysteine Ligase and Glutathione Synthetase bytert-Butylhydroquinone*

  2002cited by this paper
• Adenovirus-mediated overexpression of catalase in the cytosolic or mitochondrial compartment protects against toxicity caused by glutathione depletion in HepG2 cells expressing CYP2E1.

  2002influential reference
• Cytoskeletal Changes in Hypoxic Pulmonary Endothelial Cells Are Dependent on MAPK-activated Protein Kinase MK2*

  2002cited by this paper
• Adenovirus-mediated Overexpression of Catalase in the Cytosolic or Mitochondrial Compartment Protects against Cytochrome P450 2E1-dependent Toxicity in HepG2 Cells*

  2001cited by this paper
• Ethanol ingestion via glutathione depletion impairs alveolar epithelial barrier function in rats.

  2000cited by this paper
• Biophysical properties and molecular characterization of amiloride-sensitive sodium channels in A549 cells.

  2000cited by this paper
• MAPKAP kinase 2 is essential for LPS-induced TNF-alpha biosynthesis.

  1999cited by this paper
• MAPKAP kinase 2 is essential for LPS-induced TNF-α biosynthesis

  1999cited by this paper
• Expression and characterization of human glutamate-cysteine ligase.

  1998cited by this paper
• MULTIPLE COMPARISON PROCEDURES UPDATED

  1998cited by this paper
• Large unphosphorylated aggregates as the active form of hsp27 which controls intracellular reactive oxygen species and glutathione levels and generates a protection against TNFalpha in NIH-3T3-ras cells.

  1997cited by this paper
• Regulation of c -glutamylcysteine synthetase by protein phosphorylation

  1996cited by this paper
• Regulation of gamma-glutamylcysteine synthetase by protein phosphorylation.

  1996cited by this paper
• Intracellular reactive oxygen species as apparent modulators of heat-shock protein 27 (hsp27) structural organization and phosphorylation in basal and tumour necrosis factor alpha-treated T47D human carcinoma cells.

  1995cited by this paper
• Normal alveolar epithelial lining fluid contains high levels of glutathione.

  1987cited by this paper
• High-performance liquid chromatography of thiols and disulfides: dinitrophenol derivatives.

  1987cited by this paper
• Synthesis of lung surfactant-associated glycoproteins by A549 cells: description of an in vitro model for human type II cell dysfunction.

  1984cited by this paper
• Reversible dissociation of gamma-glutamylcysteine synthetase into two subunits.

  1984cited by this paper
• "Western blotting": electrophoretic transfer of proteins from sodium dodecyl sulfate--polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A.

  1981cited by this paper
• Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues.

  1969cited by this paper

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  2017cites this paper
• HIF‐1α triggers long‐lasting glutamate excitotoxicity via system xc− in cerebral ischaemia–reperfusion

  2017cites this paper
• Mitogen-activated protein kinase-activated protein kinase 2 mediates resistance to hydrogen peroxide-induced oxidative stress in human hepatobiliary cancer cells.

  2015cites this paper
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  2014cites this paper
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  2012cites this paper