Neutron and X-ray scattering studies on the human complement protein properdin provide an analysis of the thrombospondin repeat.

No abstract is available for this paper.

• Publication year

  1991

• Venue

  Biochemistry

• Publication date

  1991-08-13

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1021/BI00246A018PMID 1868073
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Molecular cloning of the cDNA coding for properdin, a positive regulator of the alternative pathway of human complement

  1991cited by this paper
• Properdin binds to sulfatide [Gal(3-SO4)beta 1-1 Cer] and has a sequence homology with other proteins that bind sulfated glycoconjugates.

  1990cited by this paper
• Molecular modelling strategies in application to complement.

  1990cited by this paper
• Structural comparisons of the native and reactive-centre-cleaved forms of alpha 1-antitrypsin by neutron- and X-ray-scattering in solution.

  1990cited by this paper
• Molecular modeling of human complement component C4 and its fragments by X-ray and neutron solution scattering.

  1990cited by this paper
• Characterization of the mouse thrombospondin gene and evaluation of the role of the first intron in human gene expression.

  1990cited by this paper
• A new cytokine receptor superfamily.

  1990cited by this paper
• Structure and chromosomal localization of the human thrombospondin gene.

  1990cited by this paper
• Hierarchical method to align large numbers of biological sequences.

  1990cited by this paper
• Complete primary structure of human properdin: a positive regulator of the alternative pathway of the serum complement system.

  1990cited by this paper
• Electron microscopic demonstration of a common structural motif in human complement factor C3 and rat α1 ‐inhibitor 3 (murinoglobulin)

  1990cited by this paper
• Participation of C3 and its ligands in complement activation.

  1990cited by this paper
• Complete primary structure and functional characterization of the sixth component of the human complement system. Identification of the C5b-binding domain in complement C6.

  1989cited by this paper
• Secondary structure in properdin of the complement cascade and related proteins: a study by Fourier transform infrared spectroscopy.

  1989cited by this paper
• Analysis of the natural polymeric forms of human properdin and their functions in complement activation.

  1989cited by this paper
• Biosynthesis of properdin.

  1989cited by this paper
• Structural homology of complement protein C6 with other channel-forming proteins of complement.

  1989cited by this paper
• The molecular architecture of human complement component C6.

  1989cited by this paper
• Time‐resolved x‐ray diffraction station: X‐ray optics, detectors, and data acquisition

  1989cited by this paper
• Fibronectins: structure, functions and receptors.

  1989cited by this paper
• Detecting distant homologies of mosaic proteins. Analysis of the sequences of thrombomodulin, thrombospondin complement components C9, C8 alpha and C8 beta, vitronectin and plasma cell membrane glycoprotein PC-1.

  1988cited by this paper
• A 34-amino acid peptide of the third component of complement mediates properdin binding.

  1988cited by this paper
• A highly conserved amino-acid sequence in thrombospondin, properdin and in proteins from sporozoites and blood stages of a human malaria parasite

  1988cited by this paper
• Properdin, the terminal complement components, thrombospondin and the circumsporozoite protein of malaria parasites contain similar sequence motifs

  1988cited by this paper
• Structural studies of proteins by high-flux X-ray and neutron solution scattering.

  1988cited by this paper
• A study of the structure of human complement component factor H by Fourier transform infrared spectroscopy and secondary structure averaging methods.

  1988cited by this paper
• Analysis of the interactions between properdin, the third component of complement (C3), and its physiological activation products.

  1988cited by this paper
• Analysis of the interaction between properdin and factor B, components of the alternative-pathway C3 convertase of complement.

  1988cited by this paper
• Do exons code for structural or functional units in proteins?

  1988cited by this paper
• The structure of human complement component C7 and the C5b-7 complex.

  1988cited by this paper
• Complementary DNA and derived amino acid sequence of the beta subunit of human complement protein C8: identification of a close structural and ancestral relationship to the alpha subunit and C9.

  1987cited by this paper
• Complementary DNA cloning of complement C8 beta and its sequence homology to C9.

  1987cited by this paper
• Complementary DNA and derived amino acid sequence of the alpha subunit of human complement protein C8: evidence for the existence of a separate alpha subunit messenger RNA.

  1987cited by this paper
• Topological mapping of complement component C9 by recombinant DNA techniques suggests a novel mechanism for its insertion into target membranes.

  1987cited by this paper
• Resolution and analysis of 'native' and 'activated' properdin.

  1987cited by this paper
• Protein volumes and hydration effects

  1986cited by this paper
• Molecular modelling of human complement component C3 and its fragments by solution scattering.

  1986cited by this paper
• Protein volumes and hydration effects. The calculations of partial specific volumes, neutron scattering matchpoints and 280-nm absorption coefficients for proteins and glycoproteins from amino acid sequences.

  1986cited by this paper
• Identification of protein sequence homology by consensus template alignment.

  1986cited by this paper
• Molecular modelling of human complement subcomponent C1q and its complex with C1r2C1s2 derived from neutron-scattering curves and hydrodynamic properties.

  1985cited by this paper
• Incorporation of thrombospondin into fibrin clots.

  1985cited by this paper
• The sequence and topology of human complement component C9.

  1985cited by this paper
• Nucleotide sequence of cDNA and derived amino acid sequence of human complement component C9.

  1984cited by this paper
• Molecular architecture of human properdin, a positive regulator of the alternative pathway of complement.

  1984cited by this paper
• Mapping of the properdin-binding site in the third component of complement.

  1984cited by this paper
• Low-resolution structural studies of mitochondrial ubiquinol:cytochrome c reductase in detergent solutions by neutron scattering.

  1983cited by this paper
• Properdin is a trimer.

  1982cited by this paper
• Intron–exon splice junctions map at protein surfaces

  1982cited by this paper
• Instrumental effects on the scattering curves.

  1981cited by this paper
• Determination of molecular weight by neutron scattering

  1981cited by this paper
• [12] Preparation of human properdin

  1981cited by this paper
• Prediction of the secondary structure of proteins from their amino acid sequence.

  1978cited by this paper
• Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins.

  1978cited by this paper
• Hydrodynamics of macromolecular complexes. III. Bacterial viruses

  1977cited by this paper
• Hydrodynamic properties of macromolecular complexes. I. Translation

  1977cited by this paper
• Alternative pathway of complement: recruitment of precursor properdin by the labile C3/C5 convertase and the potentiation of the pathway

  1976cited by this paper
• The neutron small‐angle camera D11 at the high‐flux reactor, Grenoble

  1976cited by this paper
• Effect of proteolytic digestion on the structure and function of human properdin.

  1976cited by this paper
• Characteristics of a channel plate as an image intensifier for X-ray topography

  1976cited by this paper
• Properdin: binding to C3b and stabilization of the C3b-dependent C3 convertase

  1975cited by this paper
• Structural invariants in protein folding

  1975cited by this paper
• Studies on the sub-unit structure of human properdin.

  1974cited by this paper
• Solid phase radioimmunoassay of properdin.

  1973cited by this paper
• Properties of highly purified human properdin.

  1968cited by this paper
• X-RAY SMALL ANGLE SCATTERING WITH SUBSTANCES OF BIOLOGICAL INTEREST IN DILUTED SOLUTIONS.

  1963cited by this paper

• The role of properdin and Factor H in disease.

  2022cites this paper
• Complement Proteins as Soluble Pattern Recognition Receptors for Pathogenic Viruses

  2021cites this paper
• Human Properdin Released By Infiltrating Neutrophils Can Modulate Influenza A Virus Infection

  2021cites this paper
• Chapter 27 – Properdin

  2018cites this paper
• Properdin: a tightly regulated critical inflammatory modulator

  2016cites this paper
• Local release of properdin in the cellular microenvironment: role in pattern recognition and amplification of the alternative pathway of complement

  2013cites this paper
• A new effector of lipid metabolism: complement factor properdin.

  2012cites this paper
• Protein ultrastructure and the nanoscience of complement activation.

  2011cites this paper
• Emerging roles of brain-specific angiogenesis inhibitor 1.

  2010cites this paper
• Native polymeric forms of properdin selectively bind to targets and promote activation of the alternative pathway of complement.

  2010influential citation
• Properdin in immunity : in vitro and in vivo investigations

  2009cites this paper
• Variability and Action Mechanism of a Family of Anticomplement Proteins in Ixodes ricinus

  2008cites this paper
• Complement and immunoglobulin protein structures by X-ray and neutron solution scattering and analytical ultracentrifugation

  2005cites this paper
• The dimeric and trimeric solution structures of the multidomain complement protein properdin by X-ray scattering, analytical ultracentrifugation and constrained modelling.

  2004cites this paper
• Structural characterization of the second TSP1-module of human thrombospondin.

  2002cites this paper
• Bovine floor plate explants secrete SCO-spondin

  2002cites this paper
• Biophysical characterization, including disulfide bond assignments, of the anti-angiogenic type 1 domains of human thrombospondin-1.

  2002cites this paper
• Thrombospondins: multifunctional regulators of cell interactions.

  2001cites this paper
• The characterisation of the murine gene for properdin

  2000cites this paper
• Physical Characterization of the Procollagen Module of Human Thrombospondin 1 Expressed in Insect Cells*

  2000cites this paper
• The thrombospondin type 1 repeat (TSR) superfamily: Diverse proteins with related roles in neuronal development

  2000cites this paper
• Properdin: Native properdin1

  2000cites this paper
• Thrombospondins and Angiogenesis

  2000cites this paper
• Three distinct D-amino acid substitutions confer potent antiangiogenic activity on an inactive peptide derived from a thrombospondin-1 type 1 repeat.

  1999cites this paper
• The Four Terminal Components of the Complement System AreC-Mannosylated on Multiple Tryptophan Residues*

  1999cites this paper
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  1998cites this paper
• Interaction between complement proteins C5b-7 and erythrocyte membrane sialic acid

  1996cites this paper
• Control of the complement system.

  1996cites this paper
• Characterization of mutant forms of recombinant human properdin lacking single thrombospondin type I repeats. Identification of modules important for function.

  1995cites this paper
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  1994cites this paper
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  1994cites this paper
• Structural and functional properties of region II-plus of the malaria circumsporozoite protein

  1994cites this paper
• Domain structure, functional activity, and polymerization of trout complement protein C9.

  1993cites this paper
• Complement System Genes and the Structures of the Proteins They Encode

  1993cites this paper
• The modular architecture of a new family of growth regulators related to connective tissue growth factor

  1993cites this paper
• Peptides derived from two separate domains of the matrix protein thrombospondin-1 have anti-angiogenic activity

  1993cites this paper
• Molecular modelling of the domain structure of factor I of human complement by X-ray and neutron solution scattering.

  1993cites this paper
• Properdin.

  1993cites this paper
• Molecular modeling of the domain structure of C9 of human complement by neutron and X-ray solution scattering.

  1992cites this paper
• Thrombospondins: structure and regulation of expression

  1992cites this paper
• F-spondin: a gene expressed at high levels in the floor plate encodes a secreted protein that promotes neural cell adhesion and neurite extension.

  1992cites this paper
• Characterization of the human properdin gene.

  1992cites this paper
• Nucleic acids

  1964cites this paper