Stereocilia morphogenesis and maintenance through regulation of actin stability.

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Seminars in Cell and Developmental Biology

• Publication date

  2017-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.semcdb.2016.08.017PMID 27565685PMCID PMC5323431
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Murine Fam65b forms ring-like structures at the base of stereocilia critical for mechanosensory hair cell function

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• The GPSM2/LGN GoLoco motifs are essential for hearing

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• The acquisition of mechano‐electrical transducer current adaptation in auditory hair cells requires myosin VI

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• Class III myosins shape the auditory hair bundles by limiting microvilli and stereocilia growth

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• Actin and Actin-Binding Proteins.

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  2015influential reference
• Characterization and regulation of an additional actin-filament-binding site in large isoforms of the stereocilia actin-bundling protein espin

  2015cited by this paper
• The Rho GTPase Cdc42 regulates hair cell planar polarity and cellular patterning in the developing cochlea

  2015cited by this paper
• A Short Splice Form of Xin-Actin Binding Repeat Containing 2 (XIRP2) Lacking the Xin Repeats Is Required for Maintenance of Stereocilia Morphology and Hearing Function

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• The 133-kDa N-terminal domain enables myosin 15 to maintain mechanotransducing stereocilia and is essential for hearing

  2015influential reference
• Ciliary proteins Bbs8 and Ift20 promote planar cell polarity in the cochlea

  2015cited by this paper
• The Stereociliary Paracrystal Is a Dynamic Cytoskeletal Scaffold In Vivo.

  2015cited by this paper
• XIRP2, an actin-binding protein essential for inner ear hair-cell stereocilia.

  2015cited by this paper
• Ciliary proteins Bbs8 and Ift20 promote planar cell polarity in the cochlea

  2015cited by this paper
• Live-cell imaging of actin dynamics reveals mechanisms of stereocilia length regulation in the inner ear

  2015cited by this paper
• CLIC5 stabilizes membrane‐actin filament linkages at the base of hair cell stereocilia in a molecular complex with radixin, taperin, and myosin VI

  2014cited by this paper
• The Actin-Binding Proteins Eps8 and Gelsolin Have Complementary Roles in Regulating the Growth and Stability of Mechanosensory Hair Bundles of Mammalian Cochlear Outer Hair Cells

  2014cited by this paper
• Characterization and regulation of an additional actin-filament-binding site in large isoforms of the stereocilia actin-bundling protein espin

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• Absence of plastin 1 causes abnormal maintenance of hair cell stereocilia and a moderate form of hearing loss in mice

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• TMIE is an essential component of the mechanotransduction machinery of cochlear hair cells.

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• Compound Heterozygosity of the Functionally Null Cdh23v-ngt and Hypomorphic Cdh23ahl Alleles Leads to Early-onset Progressive Hearing Loss in Mice

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  2013influential reference
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  2011cited by this paper
• Myosin VIIa and sans localization at stereocilia upper tip-link density implicates these Usher syndrome proteins in mechanotransduction

  2011cited by this paper
• Eps8 Regulates Hair Bundle Length and Functional Maturation of Mammalian Auditory Hair Cells

  2011cited by this paper
• Coupling of the mechanotransduction machinery and F-actin polymerization in the cochlear hair bundles.

  2011cited by this paper
• Coupling of the mechanotransduction machinery and stereocilia F-actin polymerization in the cochlear hair bundles

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• Usher type 1G protein sans is a critical component of the tip-link complex, a structure controlling actin polymerization in stereocilia

  2011cited by this paper
• Regulation of PCDH15 function in mechanosensory hair cells by alternative splicing of the cytoplasmic domain

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• Roles of the Espin Actin-Bundling Proteins in the Morphogenesis and Stabilization of Hair Cell Stereocilia Revealed in CBA/CaJ Congenic Jerker Mice

  2011cited by this paper
• Multi-isotope imaging mass spectrometry (MIMS) reveals slow protein turnover in hair-cell stereocilia

  2011influential reference
• Regulation of stereocilia length by myosin XVa and whirlin depends on the actin-regulatory protein Eps8.

  2011cited by this paper
• Mutations in Protocadherin 15 and Cadherin 23 Affect Tip Links and Mechanotransduction in Mammalian Sensory Hair Cells

  2011cited by this paper
• The R109H Variant of Fascin-2, a Developmentally Regulated Actin Crosslinker in Hair-Cell Stereocilia, Underlies Early-Onset Hearing Loss of DBA/2J Mice

  2010cited by this paper
• Asymmetric Distribution of Cadherin 23 and Protocadherin 15 in the Kinocilial Links of Avian Sensory Hair Cells

  2010influential reference
• β-Actin and γ-Actin Are Each Dispensable for Auditory Hair Cell Development But Required for Stereocilia Maintenance

  2010cited by this paper
• Actin-bundling protein TRIOBP forms resilient rootlets of hair cell stereocilia essential for hearing.

  2010cited by this paper
• Gelsolin Plays a Role in the Actin Polymerization Complex of Hair Cell Stereocilia

  2010cited by this paper
• Targeted capture and next-generation sequencing identifies C9orf75, encoding taperin, as the mutated gene in nonsyndromic deafness DFNB79.

  2010cited by this paper
• γ-Actin is required for cytoskeletal maintenance but not development

  2009cited by this paper
• The Small GTPase Rac1 Regulates Auditory Hair Cell Morphogenesis

  2009cited by this paper
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  2009influential reference
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  2009cited by this paper
• MyosinVIIa Interacts with Twinfilin-2 at the Tips of Mechanosensory Stereocilia in the Inner Ear

  2009influential reference
• Harmonin mutations cause mechanotransduction defects in cochlear hair cells.

  2009influential reference
• Twinfilin 2 Regulates Actin Filament Lengths in Cochlear Stereocilia

  2009influential reference
• The Dimensions and Composition of Stereociliary Rootlets in Mammalian Cochlear Hair Cells: Comparison between High- and Low-Frequency Cells and Evidence for a Connection to the Lateral Membrane

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  2007influential reference
• The sensory and motor roles of auditory hair cells

  2006influential reference
• Differential expression of espin isoforms during epithelial morphogenesis, stereociliogenesis and postnatal maturation in the developing inner ear.

  2006cited by this paper
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  2005cited by this paper
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  2005cited by this paper
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  1996cited by this paper
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  1994cited by this paper
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  1992cited by this paper
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  1985cited by this paper
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  1983cited by this paper
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  1980cited by this paper
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  1977cited by this paper

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