Kinetic control of nucleosome displacement by ISWI/ACF chromatin remodelers

Chromatin structure is dynamically organized by chromatin remodelers, motor protein complexes which move and remove nucleosomes. The regulation of remodeler action has recently been proposed to underlie a kinetic proofreading scheme which combines the recognition of histone-tail states and the ATP-dependent loosening of DNA around nucleosomes. Members of the ISWI-family of remodelers additionally recognize linker length between nucleosomes. Here, we show that the additional proofreading step involving linker length alone is sufficient to promote the formation of regular arrays of nucleosomes. ATP-dependent remodeling by bidirectional motors is shown to reinforce positioning as compared to statistical positioning.

• Publication year

  2012

• Venue

  Epigenetics & Chromatin

• Publication date

  2012-09-13

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1186/1756-8935-6-S1-P7PMID 23005680PMCID 3600836
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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