Development of a partially automated solubility screening (PASS) assay for early drug development.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Journal of Pharmacy and Science

• Publication date

  2007-07-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1002/JPS.20814PMID 17238197
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Rapid, small-scale determination of organic solvent solubility using a thermogravimetric analyzer.

  2005cited by this paper
• Role of the solvent in the adsorption-desorption equilibrium of cinchona alkaloids between solution and a platinum surface: correlations among solvent polarity, cinchona solubility, and catalytic performance.

  2005cited by this paper
• The Influence of Water Content of Triglyceride Oils on the Solubility of Steroids

  2005cited by this paper
• Peak Seeker: An Algorithm for Rapid Determination of Solubility

  2005cited by this paper
• In vivo in vitro correlations for a poorly soluble drug, danazol, using the flow-through dissolution method with biorelevant dissolution media.

  2005cited by this paper
• Solubility of ( ± )-Ibuprofen and S ( + )-Ibuprofen in the Presence of Cosolvents and Cyclodextrins

  2005cited by this paper
• Evaluation of cyclodextrin solubilization of drugs.

  2005cited by this paper
• Impact of the Amount of Excess Solids on Apparent Solubility

  2005cited by this paper
• Comparison of a miniaturized shake-flask solubility method with automated potentiometric acid/base titrations and calculated solubilities.

  2005cited by this paper
• Trends in solubility of polymorphs.

  2005cited by this paper
• Molecular properties of WHO essential drugs and provisional biopharmaceutical classification.

  2004cited by this paper
• Accuracy of calculated pH-dependent aqueous drug solubility.

  2004cited by this paper
• Biopharmaceutics Classification by High Throughput Solubility Assay and PAMPA

  2004cited by this paper
• Miniature Device for Aqueous and Non-aqueous Solubility Measurements During Drug Discovery

  2004cited by this paper
• pH-Metric Solubility. 2: Correlation Between the Acid-Base Titration and the Saturation Shake-Flask Solubility-pH Methods

  2004cited by this paper
• The effect of solubilization on the oral bioavailability of three benzimidazole carbamate drugs.

  2004cited by this paper
• Effect of Hydroxypropyl β‐Cyclodextrin on Drug Solubility in Water‐Propylene Glycol Mixtures

  2004cited by this paper
• Impact of solid state properties on developability assessment of drug candidates.

  2004cited by this paper
• The “High Solubility” Definition of the Current FDA Guidance on Biopharmaceutical Classification System May Be Too Strict for Acidic Drugs

  2004cited by this paper
• The emulsification and solubilisation properties of polyglycolysed oils in self‐emulsifying formulations

  2004cited by this paper
• Drug Solubilization Behavior During in Vitro Digestion of Simple Triglyceride Lipid Solution Formulations

  2004cited by this paper
• Pharmaceutical profiling in drug discovery.

  2003cited by this paper
• Solubilization of flurbiprofen in pH-surfactant solutions.

  2003cited by this paper
• Optimized conditions for MDCK permeability and turbidimetric solubility studies using compounds representative of BCS classes I-IV.

  2002cited by this paper
• Prediction of drug solubility from structure.

  2002cited by this paper
• Evaluation of a method for high throughput solubility determination using a multi-wavelength UV plate reader.

  2002cited by this paper
• Solubility measurement using differential scanning calorimetry

  2002cited by this paper
• Examination of the solubilization of drugs by bile salt micelles.

  2002cited by this paper
• Development of an automated in-line microfiltration system coupled to an HPLC for the determination of solubility.

  2001cited by this paper
• Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings.

  2001cited by this paper
• Determination of the Aqueous Solubility of Drugs Using a Convenient 96-Well Plate-Based Assay

  2001cited by this paper
• Solubility of drugs in the presence of gelatin: effect of drug lipophilicity and degree of ionization.

  2001cited by this paper
• Revisiting the Solubility Concept of Pharmaceutical Compounds

  2001cited by this paper
• Crystallization of hydrocortisone acetate: influence of polymers.

  2001cited by this paper
• A high-throughput screening method for the determination of aqueous drug solubility using laser nephelometry in microtiter plates.

  2000cited by this paper
• A Comparison of the Solubility of Danazol in Human and Simulated Gastrointestinal Fluids

  2000cited by this paper
• Solubility behavior of polymorphs I and II of mefenamic acid in solvent mixtures.

  1999cited by this paper
• The Influence of β-Cyclodextrins on the Solubility of Furosemide

  1998cited by this paper
• Evaluation of Various Dissolution Media for Predicting In Vivo Performance of Class I and II Drugs

  1998cited by this paper
• Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

  1997cited by this paper
• Analysis of the solubilization of steroids by bile salt micelles.

  1997cited by this paper
• Development of digoxin dry elixir as a novel dosage form using a spray-drying technique.

  1995cited by this paper
• PREDICTION OF SOLUBILITY OF SULFONAMIDES IN WATER AND ORGANIC SOLVENTS BASED ON THE EXTENDED REGULAR SOLUTION THEORY

  1992cited by this paper
• Effect of cholic and deoxycholic acid conjugates on solubility and dissolution of indomethacin and phenylbutazone

  1991cited by this paper
• Thermodynamics of paracetamol solubility in sugar-water cosolvent systems

  1990cited by this paper
• Digitalis

  1988cited by this paper
• [Biopharmaceutical evaluation of the intrarectal use of mefenamic acid. III. Effect of solubilizers on the biological availability of mefenamic acid from witepsol H15].

  1986cited by this paper
• Preclinical safety evaluation of intravenously administered mixed micelles.

  1984cited by this paper
• THE UNITED STATES PHARMACOPEIA.

  1908cited by this paper

• Laser Microinterferometry for API Solubility and Phase Equilibria: Darunavir as a Case Example

  2025cites this paper
• Highly Active Oligoethylene Glycol Pleuromutilins via Systematic Linker Synthesis/One-Pot Attachment and a Microscale Solubility Method

  2024cites this paper
• Phase behaviour and pH-solubility profile prediction of aqueous buffered solutions of ibuprofen and ketoprofen

  2022cites this paper
• Application of UV dissolution imaging to pharmaceutical systems.

  2021cites this paper
• Machine Vision for Enhanced Understanding of Solid-State Impact on Solubility of Drug Compounds

  2021cites this paper
• UNGAP best practice for improving solubility data quality of orally administered drugs.

  2021cites this paper
• Impact on Drug Development and Drug Product Processing

  2021cites this paper
• An investigation of drug compact topography as relates to intrinsic dissolution rates determined by dissolution imaging

  2020cites this paper
• Automated solubility screening platform using computer vision

  2020cites this paper
• In Vitro Assessment of Supersaturation/Precipitation and Biological Membrane Permeation of Poorly Water-Soluble Drugs: A Case Study With Albendazole and Ketoconazole.

  2019cites this paper
• A review of methods for solubility determination in biopharmaceutical drug characterization

  2019influential citation
• Location of Solvated Probe Molecules Within Nonionic Surfactant Micelles Using Molecular Dynamics.

  2019cites this paper
• Design und Synthese neuer TGFβ-Inhibitoren zur Regeneration von Herzmuskelgewebe

  2019cites this paper
• PBPK Models for CYP3A4 and P‐gp DDI Prediction: A Modeling Network of Rifampicin, Itraconazole, Clarithromycin, Midazolam, Alfentanil, and Digoxin

  2018cites this paper
• In vitro methods to assess drug precipitation in the fasted small intestine – a PEARRL review

  2018cites this paper
• Improved Molecular Understanding of Lipid-Based Formulations : for Enabling Oral Delivery of Poorly Water-Soluble Drugs

  2018cites this paper
• Automated assays for thermodynamic (equilibrium) solubility determination.

  2018cites this paper
• Translational physiologically-based pharmacokinetic (PBPK) modeling and simulation to support drug development and pharmacotherapy

  2018cites this paper
• Brief overview of solubility methods: Recent trends in equilibrium solubility measurement and predictive models.

  2018cites this paper
• Solubility and Dissolution

  2017cites this paper
• Computational Models of the Gastrointestinal Environment. 2. Phase Behavior and Drug Solubilization Capacity of a Type I Lipid-Based Drug Formulation after Digestion.

  2017cites this paper
• Study of drug-excipient interactions regarding solubility enhancement in diluted aqueous media and solid state transformations

  2017cites this paper
• Chapter 2 Solubility Determinations for Pharmaceutical API

  2017cites this paper
• Abraham model correlations for describing solute transfer into anhydrous 1,2-propylene glycol for neutral and ionic species

  2016cites this paper
• Pharmaceutical excipients - quality, regulatory and biopharmaceutical considerations.

  2016cites this paper
• Semiautomated Sample Preparation for Protein Stability and Formulation Screening via Buffer Exchange

  2016cites this paper
• Clarithromycin, Midazolam, and Digoxin: Application of PBPK Modeling to Gain New Insights into Drug–Drug Interactions and Co-medication Regimens

  2016cites this paper
• Miniaturized INtrinsic DISsolution Screening (MINDISS) assay for preformulation.

  2016cites this paper
• Medicinal Chemistry and Lead Optimization of Marine Natural Products

  2015cites this paper
• Amorphous Solid Dispersion Screening

  2015cites this paper
• Analytical technologies for real‐time drug dissolution and precipitation testing on a small scale

  2015cites this paper
• Amorphous solid dispersions: a robust platform to address bioavailability challenges.

  2015cites this paper
• Leveraging Solid State Form and Physiochemical Properties for Early Clinical Formulation Efforts: Opportunities and Challenges During Telcagepant Liquid Capsule Development

  2015cites this paper
• PHYSICOCHEMICAL PROFILING IN DRUG RESEARCH AND DEVELOPMENT

  2014cites this paper
• A combination turbidity and supernatant microplate assay to rank-order the supersaturation limits of early drug candidates.

  2014cites this paper
• Glyceride Lipid Formulations: Molecular Dynamics Modeling of Phase Behavior During Dispersion and Molecular Interactions Between Drugs and Excipients

  2013cites this paper
• A Perspective on the Prediction of Drug Pharmacokinetics and Disposition in Drug Research and Development

  2013cites this paper
• Evaluation of the structural determinants of polymeric precipitation inhibitors using solvent shift methods and principle component analysis.

  2013cites this paper
• DMD054031 1975..1993

  2013cites this paper
• pH-Dependent solubility and permeability criteria for provisional biopharmaceutics classification (BCS and BDDCS) in early drug discovery.

  2012cites this paper
• Optimizing solubility: kinetic versus thermodynamic solubility temptations and risks.

  2012cites this paper
• The Impact of Solubility and Dissolution Assessment on Formulation Strategy and Implications for Oral Drug Disposition

  2012cites this paper
• PowderPicking: An inexpensive, manual, medium-throughput method for powder dispensing

  2011cites this paper
• The apparent solubilizing capacity of simulated intestinal fluids for poorly water-soluble drugs

  2011cites this paper
• Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, part 1: oral solutions.

  2011cites this paper
• A Highly Automated Assay for Determining the Aqueous Equilibrium Solubility of Drug Discovery Compounds

  2011cites this paper
• Solubility of simvastatin: A theoretical and experimental study

  2011cites this paper
• The developability classification system: application of biopharmaceutics concepts to formulation development.

  2010cites this paper
• Miniaturization of Drug Solubility and Dissolution Testings

  2010cites this paper
• Using polymeric precipitation inhibitors to improve the absorption of poorly water-soluble drugs: A mechanistic basis for utility

  2010cites this paper
• Emerging analytical separation techniques with high throughput potential for pharmaceutical analysis, part I: Stationary phase and instrumental developments in LC.

  2010cites this paper
• In vitro methods to assess drug precipitation.

  2010cites this paper
• High throughput screening of physicochemical properties and in vitro ADME profiling in drug discovery.

  2009cites this paper
• Comparison of nephelometric, UV-spectroscopic, and HPLC methods for high-throughput determination of aqueous drug solubility in microtiter plates.

  2009cites this paper
• Solubility Data in Organic Solvents

  2009cites this paper
• Handbook of Solubility Data for Pharmaceuticals

  2009influential citation
• Applying automation in early drug discovery: lessons learnt and future perspectives An issue that the drug discovery industry has faced over the past

  2008cites this paper
• Advanced screening assays to rapidly identify solubility-enhancing formulations: high-throughput, miniaturization and automation.

  2008cites this paper
• Applications of physiologically based absorption models in drug discovery and development.

  2008cites this paper
• Aqueous Solubility in Drug Discovery Chemistry, DMPK, and Biological Assays

  2008cites this paper
• Solubility of lovastatin in a family of six alcohols: Ethanol, 1-propanol, 1-butanol, 1-pentanol, 1-hexanol, and 1-octanol.

  2008cites this paper
• High-speed solubility screening assay using ultra-performance liquid chromatography/mass spectrometry in drug discovery.

  2008cites this paper
• Solubility of sparingly-soluble ionizable drugs.

  2007cites this paper
• Miniaturized Assay for Solubility and Residual Solid Screening (SORESOS) in Early Drug Development

  2007cites this paper
• High throughput solubility measurement in drug discovery and development.

  2007cites this paper