IL17A and IL17F gene polymorphisms in patients with rheumatoid arthritis

BackgroundInterleukin-17 plays important role in the pathogenesis of rheumatoid arthritis (RA). The aim of this study was to examine the associations between polymorphisms in the IL17A and IL17F genes and RA.MethodsWe examined 422 RA patients and 337 subjects as a control group. Single nucleotide polymorphism (SNP) in the IL17A (rs2275913) and IL17F (rs763780, rs11465553, rs2397084) genes were genotyped using TaqMan genotyping assays from Life Technologies Genomic.ResultsThere were no significant differences in distribution of IL17A and IL17F genotypes and alleles between RA patients and control group. There were no significant associations between IL17A and IL17F genotypes and age of disease diagnosis rheumatoid factor, erosive disease as well as extra-articular manifestations.ConclusionsThe results of this study suggest, that IL17A and IL17F gene polymorphism are not the important factors associated with susceptibility and some clinical parameters of RA in a Polish population.

• Publication year

  2016

• Venue

  BMC Musculoskeletal Disorders

• Publication date

  2016-05-11

• Fields of study

  Medicine

• Identifiers
  DOI 10.1186/s12891-016-1064-1PMID 27169372PMCID 4864924
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• IL-17 in the Rheumatologist's Line of Sight

  2013cited by this paper
• IL-17A and Th17 Cells in Lung Inflammation: An Update on the Role of Th17 Cell Differentiation and IL-17R Signaling in Host Defense against Infection

  2013influential reference
• Dynamic visualization of RANKL and Th17-mediated osteoclast function.

  2013cited by this paper
• Th17 Cells in Immunopathogenesis and treatment of rheumatoid arthritis

  2013cited by this paper
• Pathologic finding of increased expression of interleukin-17 in the synovial tissue of rheumatoid arthritis patients.

  2013cited by this paper
• Genetics of rheumatoid arthritis contributes to biology and drug discovery

  2013cited by this paper
• Genetics of rheumatoid arthritis contributes to biology and drug discovery

  2013cited by this paper
• IL-17 patterns in synovium, serum and synovial fluid from treatment-naïve, early rheumatoid arthritis patients.

  2012cited by this paper
• UvA-DARE (Digital Academic Repository) 2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative Aletaha,

  2010influential reference
• Association between IL‐17F Gene Polymorphisms and Susceptibility to and Severity of Rheumatoid Arthritis (RA)

  2010cited by this paper
• 2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative.

  2010cited by this paper
• IL-17 and Th17 Cells.

  2009cited by this paper
• Association analysis of the interleukin 17A gene in Caucasian rheumatoid arthritis patients from Norway and New Zealand.

  2009influential reference
• Human rheumatoid arthritis tissue production of IL-17A drives matrix and cartilage degradation: synergy with tumour necrosis factor-α, Oncostatin M and response to biologic therapies

  2009cited by this paper
• Structural basis of receptor sharing by interleukin 17 cytokines

  2009cited by this paper
• Synergism between tumor necrosis factor alpha and interleukin-17 to induce IL-23 p19 expression in fibroblast-like synoviocytes.

  2009influential reference
• Structure and signalling in the IL-17 receptor family

  2009cited by this paper
• Associations between HLA-DRB1, RANK, RANKL, OPG, and IL-17 genotypes and disease severity phenotypes in Japanese patients with early rheumatoid arthritis

  2007cited by this paper
• Th17: the third member of the effector T cell trilogy.

  2007cited by this paper
• IL-17 increased the production of vascular endothelial growth factor in rheumatoid arthritis synoviocytes

  2006cited by this paper
• Blocking of interleukin-17 during reactivation of experimental arthritis prevents joint inflammation and bone erosion by decreasing RANKL and interleukin-1.

  2005cited by this paper
• IL-17 Promotes Bone Erosion in Murine Collagen-Induced Arthritis Through Loss of the Receptor Activator of NF-κB Ligand/Osteoprotegerin Balance 1

  2003cited by this paper
• Suppression of Immune Induction of Collagen-Induced Arthritis in IL-17-Deficient Mice 1

  2003cited by this paper
• Reduction of joint inflammation and bone erosion in rat adjuvant arthritis by treatment with interleukin-17 receptor IgG1 Fc fusion protein.

  2002cited by this paper
• IL-1-Independent Role of IL-17 in Synovial Inflammation and Joint Destruction During Collagen-Induced Arthritis1

  2001cited by this paper
• Human interleukin-17: A T cell-derived proinflammatory cytokine produced by the rheumatoid synovium.

  1999cited by this paper
• IL-17 stimulates the production and expression of proinflammatory cytokines, IL-beta and TNF-alpha, by human macrophages.

  1998cited by this paper
• T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines

  1996cited by this paper

• The relationship between interleukin 17A rs2275913 gene polymorphism and circulating IL17A levels and disease activity and severity in Egyptian rheumatoid arthritis patients

  2025cites this paper
• Association of IL-17A gene polymorphism rs2275913 with rheumatoid arthritis susceptibility in Iranian patients

  2025cites this paper
• Innovative peptide therapeutics targeting IL17RA to regulate inflammatory responses

  2025cites this paper
• Gene polymorphisms of an interleukin‐23 receptor associated with susceptibility to rheumatoid arthritis in the Western Chinese Han population

  2024cites this paper
• Association of Interleukins 17A and 17F Gene Polymorphism with Asthma: A Case Control Study in North Indian Population

  2024cites this paper
• Tumor necrosis factor alpha induced protein 3, interleukin 10, tumor necrosis factor alpha, and interleukin 17 F genes polymorphisms in Algerian patients with rheumatoid arthritis

  2024cites this paper
• Single nucleotide polymorphism of IL-17F as a possible biomarker of rheumatoid arthritis in the Russian population of the Chelyabinsk Region and its non-equilium linkage with IL-17A

  2024cites this paper
• Genetic polymorphism of IL-17F rs763780 contributes to the susceptibility to bipolar disorder but not to schizophrenia in the Turkish population

  2023cites this paper
• Association of IL-17F rs2397084 (E126G), rs11465553 (V155I) and rs763780 (H161R) variants with rheumatoid arthritis and their effects on the stability of protein

  2023cites this paper
• IL12B and IL17 genes polymorphisms associated with differential susceptibility to juvenile idiopathic arthritis and juvenile-onset systemic lupus erythematosus in Chinese children

  2023cites this paper
• Investigation of the relationship between IL17A, IL17F and ILR1N polymorphisms and COVID‐19 severity: The predictive role of IL17A rs2275913 polymorphism in the clinical course of COVID‐19

  2023cites this paper
• Systems biology approach delineates critical pathways associated with disease progression in rheumatoid arthritis

  2022cites this paper
• IL-17F gene polymorphism (7488T/C, rs763780) in Egyptian patients with SLE

  2022cites this paper
• IL17F rs763780 polymorphism is associated with unhealthy BMI and diabetes mellitus in patients with acute myocardial infarction

  2022cites this paper
• Pharmacogenomics of Monoclonal Antibodies for the Treatment of Rheumatoid Arthritis

  2022cites this paper
• The role of heterodimer IL-17-A/F in atopic dermatitis

  2022cites this paper
• Association between Interleukin-17F 7488A/G and 7383A/G polymorphisms and susceptibility to juvenile idiopathic arthritis

  2022cites this paper
• Polymorphisms within Genes Coding for IL-17A and F and Their Receptor as Clinical Hallmarks in Ankylosing Spondylitis

  2021cites this paper
• Association between the interleukin (IL)-17A rs2275913 polymorphism and rheumatoid arthritis susceptibility: a meta-analysis and trial sequential analysis

  2021cites this paper
• Association of interleukin-17A rs2275913 polymorphism with rheumatoid arthritis susceptibility in Sudanese population

  2021cites this paper
• IL-23/Th17 pathway and IL-17A gene polymorphism in Egyptian children with immune thrombocbytopenic purpura

  2021cites this paper
• Association of Rs763780 Polymorphism of Gene IL17F with the Risk of Developing Rheumatoid Arthritis in Uzbekistan

  2021influential citation
• Association of IL-17A -197G/A (rs2275913) Single Nucleotide Polymorphism and Rheumatoid Arthritis in Sudanese Patients

  2020cites this paper
• IL-17, IL-21 and IL-22 polymorphisms in rheumatoid arthritis: A systematic review and meta-analysis.

  2020cites this paper
• Association between IL-17A and IL-17F gene polymorphism and susceptibility in inflammatory arthritis: A meta-analysis.

  2020cites this paper
• Interleukin-17 Gene Polymorphism (Rs2275913 G/A, Rs763780 C/T) in Rheumatoid arthritis：Meta-analysis Based on Ethnicity

  2020cites this paper
• Frequency distribution of IL-17A G197A (rs2275913) and IL-17F A7488G (rs763780) polymorphisms among healthy Sudanese population

  2020cites this paper
• IL-17 and IL-21 polymorphisms in relation to HBV related hepatocellular carcinoma in Chinese Han population.

  2020cites this paper
• Interleukin 17A gene polymorphism in patients with rheumatoid arthritis

  2020cites this paper
• Interleukin-17: Functional and Structural Features, Application as a Therapeutic Target

  2019cites this paper
• Are genetic variations in IL‐21–IL‐23R–IL‐17A cytokine axis involved in a pathogenic pathway of rheumatoid arthritis? Bayesian hierarchical meta‐analysis

  2019cites this paper
• Association of Interleukin-17F 7488A/G and 7383A/G Polymorphisms With Rheumatoid Arthritis: A Meta-Analysis.

  2019cites this paper
• Genetic analysis of the relation between IL2RA/IL2RB and rheumatoid arthritis risk

  2019cites this paper
• IL-17A, IL-17RC polymorphisms and IL17 plasma levels in Tunisian patients with rheumatoid arthritis

  2018cites this paper
• Association between interleukin-17 gene polymorphism and rheumatoid arthritis among Egyptians

  2018cites this paper
• IL‐17A haplotype confers susceptibility to systemic lupus erythematosus but not to rheumatoid arthritis in Mexican patients

  2018cites this paper
• Impact of Interleukin-17F Gene Polymorphisms in Outcome of Kidney Transplantation in Tunisian Recipients.

  2018cites this paper
• IL1F7 Gene Polymorphism Is not Associated with Rheumatoid Arthritis Susceptibility in the Northern Chinese Han Population: A Case–Control Study

  2018cites this paper
• Polymorphism rs 2275913 of Interleukin-17 A is related to more intensive therapy with disease-modifying anti rheumatic drugs in Rheumatoid Arthritis Mexican patients

  2017cites this paper
• How to manage rheumatoid arthritis according to classic biomarkers and polymorphisms?

  2017influential citation
• Associations between circulating IL-17 levels and rheumatoid arthritis and between IL-17 gene polymorphisms and disease susceptibility: a meta-analysis

  2017cites this paper
• Interleukin (IL)-23 Receptor, IL-17A and IL-17F Gene Polymorphisms in Brazilian Patients with Rheumatoid Arthritis

  2017cites this paper
• Interleukin 17 A rs 2275913 G > A polymorphism is associated with the decreased risk of rheumatoid arthritis : a meta-analysis involving 6 , 266 subjects

  2016influential citation
• Association between Interleukin-17 rs2275913 G/A Gene Polymorphism and Susceptibility and Severity of Rheumatoid Arthritis in a sample of Iraqi patients

  year unknowncites this paper