LPA1 receptors mediate stimulation, whereas LPA2 receptors mediate inhibition, of migration of pancreatic cancer cells in response to lysophosphatidic acid and malignant ascites.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Carcinogenesis

• Publication date

  2009-03-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1093/carcin/bgp011PMID 19129242
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• ROCK‐regulated cytoskeletal dynamics participate in the inhibitory effect of melatonin on cancer cell migration

  2009cited by this paper
• Biological roles of lysophospholipid receptors revealed by genetic null mice: an update.

  2008cited by this paper
• S1P(2) receptors mediate inhibition of glioma cell migration through Rho signaling pathways independent of PTEN.

  2008cited by this paper
• Sphingosine-1-phosphate signaling and biological activities in the cardiovascular system.

  2008cited by this paper
• G12/13 and Gq mediate S1P2-induced inhibition of Rac and migration in vascular smooth muscle in a manner dependent on Rho but not Rho kinase.

  2008cited by this paper
• Cyclooxygenase‐2 Expression and Prostaglandin E2 Production in Response to Acidic pH Through OGR1 in a Human Osteoblastic Cell Line

  2008cited by this paper
• Rho Inhibition Induces Migration of Mesenchymal Stromal Cells

  2007cited by this paper
• Oligodendrocyte Lineage Transcription Factor 2 Inhibits the Motility of a Human Glial Tumor Cell Line by Activating RhoA

  2007cited by this paper
• Previously postulated "ligand-independent" signaling of GPR4 is mediated through proton-sensing mechanisms.

  2007cited by this paper
• Lysophospholipid receptors: signalling, pharmacology and regulation by lysophospholipid metabolism.

  2007cited by this paper
• Role of the monomeric GTPase Rho in hematopoietic progenitor cell migration and transplantation

  2006cited by this paper
• Rho-dependent, Rho kinase-independent inhibitory regulation of Rac and cell migration by LPA1 receptor in Gi-inactivated CHO cells.

  2006cited by this paper
• Of Spiders and Crabs: The Emergence of Lysophospholipids and Their Metabolic Pathways as Targets for Therapy in Cancer

  2006cited by this paper
• Cyclin D1 Functions in Cell Migration

  2006cited by this paper
• Lysophosphatidic acid is constitutively produced by human peritoneal mesothelial cells and enhances adhesion, migration, and invasion of ovarian cancer cells.

  2006cited by this paper
• The type 1 lysophosphatidic acid receptor is a target for therapy in bone metastases.

  2006cited by this paper
• Cyclin D1 Regulates Cellular Migration through the Inhibition of Thrombospondin 1 and ROCK Signaling

  2006cited by this paper
• Role of p38 mitogen-activated kinase and c-Jun terminal kinase in migration response to lysophosphatidic acid and sphingosine-1-phosphate in glioma cells

  2005cited by this paper
• PTEN as an effector in the signaling of antimigratory G protein-coupled receptor.

  2005cited by this paper
• Inhibition of Rho-kinase affects astrocytoma morphology, motility, and invasion through activation of Rac1.

  2005cited by this paper
• Identification of autotaxin as a neurite retraction‐inducing factor of PC12 cells in cerebrospinal fluid and its possible sources

  2005cited by this paper
• The G protein-coupled receptor S1P2 regulates Rho/Rho kinase pathway to inhibit tumor cell migration.

  2005cited by this paper
• The ins and outs of lysophosphatidic acid signaling

  2004cited by this paper
• Development of gene therapy to target pancreatic cancer

  2004cited by this paper
• Lysophospholipid receptors: signaling and biology.

  2004cited by this paper
• Lysophosphatidic Acid (LPA) in Malignant Ascites Stimulates Motility of Human Pancreatic Cancer Cells through LPA1*

  2004cited by this paper
• Lysophosphatidic Acid and Autotaxin Stimulate Cell Motility of Neoplastic and Non-neoplastic Cells through LPA1*

  2004cited by this paper
• Cell migration: Rho GTPases lead the way.

  2004cited by this paper
• Differential requirement of G alpha12, G alpha13, G alphaq, and G beta gamma for endothelin-1-induced c-Jun NH2-terminal kinase and extracellular signal-regulated kinase activation.

  2003cited by this paper
• Ligand-dependent inhibition of B16 melanoma cell migration and invasion via endogenous S1P2 G protein-coupled receptor

  2003cited by this paper
• Differential Requirement of Gα12, Gα13, Gαq, and Gβγ for Endothelin-1-Induced c-Jun NH2-Terminal Kinase and Extracellular Signal-Regulated Kinase Activation

  2003cited by this paper
• Lysophosphatidic acid (LPA) enhances the metastatic potential of human colon carcinoma DLD1 cells through LPA1.

  2003cited by this paper
• Inhibitory and Stimulatory Regulation of Rac and Cell Motility by the G12/13-Rho and Gi Pathways Integrated Downstream of a Single G Protein-Coupled Sphingosine-1-Phosphate Receptor Isoform

  2003cited by this paper
• Fatty alcohol phosphates are subtype-selective agonists and antagonists of lysophosphatidic acid receptors.

  2003cited by this paper
• The emerging role of lysophosphatidic acid in cancer

  2003cited by this paper
• Ki16425, a subtype-selective antagonist for EDG-family lysophosphatidic acid receptors.

  2003cited by this paper
• Invasion and metastasis in pancreatic cancer

  2003cited by this paper
• Galpha12 and Galpha13 as key regulatory mediator in signal transduction.

  2003cited by this paper
• Ligand-dependent Inhibition of B16 Melanoma Cell Migration and Invasion via Endogenous S1P2 G Protein-coupled Receptor

  2003cited by this paper
• Gα12 and Gα13 as key regulatory mediator in signal transduction

  2003cited by this paper
• RHO–GTPases and cancer

  2002cited by this paper
• Lysophosphatidic Acid Receptor-Selective Effects on Jurkat T Cell Migration Through a Matrigel Model Basement Membrane1

  2001cited by this paper
• Disseminated tumour cells. Their detection and significance for prognosis of gastrointestinal and pancreatic carcinomas.

  2001cited by this paper
• Rho family proteins in cell adhesion and cell migration.

  2000cited by this paper
• Malignant effusions contain lysophosphatidic acid (LPA)-like activity.

  1998cited by this paper
• Tumor necrosis factor-alpha induces adhesion molecule expression through the sphingosine kinase pathway.

  1998cited by this paper

• Identification of Distinct Subtypes in Immune Tolerance after Hematopoietic Cell Transplantation Using the Prospective ABLE1.0 Pediatric Study Cohort.

  2025cites this paper
• Roles of lysophosphatidic acid (LPA) receptor-mediated signaling in cellular functions modulated by endothelial cells in pancreatic cancer cells under hypoxic conditions.

  2024cites this paper
• Roles of lysophosphatidic acid (LPA) receptor-mediated signaling in cancer cell biology

  2024cites this paper
• Lysophosphatidic Acid Signaling in the Gastrointestinal System

  2024cites this paper
• Alteration of chromosome structure impacts gene expressions implicated in pancreatic ductal adenocarcinoma cells

  2024cites this paper
• The lysophosphatidic acid-regulated signal transduction network in ovarian cancer cells and its role in actomyosin dynamics, cell migration and entosis

  2023cites this paper
• Roles of lysophosphatidic acid (LPA) receptor-2 (LPA2) in the regulation of cellular responses induced by X-ray irradiation and hydrogen peroxide in pancreatic cancer cells

  2023cites this paper
• Effects of LPA receptor-mediated signaling on the modulation of cellular functions of pancreatic cancer cells cultured in fibroblast supernatants under hypoxic conditions

  2023influential citation
• LPA receptor-mediated signaling regulates cell motility and survival to anticancer drug of pancreatic cancer cells under glucose-deprived and hypoxic conditions.

  2023cites this paper
• Pancreatic cancer cells upregulate LPAR4 in response to isolation stress to promote an ECM-enriched niche and support tumour initiation

  2023cites this paper
• LPAR1 and aberrantly expressed LPAR3 differentially promote the migration and proliferation of malignant peripheral nerve sheath tumor cells

  2022cites this paper
• Targeting lysophosphatidic acid receptor with Ki16425 impedes T cell lymphoma progression through apoptosis induction, glycolysis inhibition, and activation of antitumor immune response

  2022cites this paper
• Lysophosphatidic Acid Receptor Antagonists and Cancer: The Current Trends, Clinical Implications, and Trials

  2021cites this paper
• GPCRs in pancreatic adenocarcinoma: Contributors to tumour biology and novel therapeutic targets

  2020cites this paper
• CMTM8 as an LPA1-associated partner mediates lysophosphatidic acid-induced pancreatic cancer metastasis

  2020cites this paper
• Effects of stanniocalcin-1 overexpressing hepatocellular carcinoma cells on macrophage migration

  2020cites this paper
• Lysophosphatidic Acid Receptors: Biochemical and Clinical Implications in Different Diseases

  2020cites this paper
• microRNA‐501‐5p promotes cell proliferation and migration in gastric cancer by downregulating LPAR1

  2019cites this paper
• N-WASP Control of LPAR1 Trafficking Establishes Response to Self-Generated LPA Gradients to Promote Pancreatic Cancer Cell Metastasis

  2019cites this paper
• Lysophosphatidic acid regulates the motility of MCF10CA1a breast cancer cell sheets via two opposing signaling pathways.

  2018cites this paper
• Promotion of cell-invasive activity through the induction of LPA receptor-1 in pancreatic cancer cells

  2018cites this paper
• Cell type‐selective pathways and clinical associations of lysophosphatidic acid biosynthesis and signaling in the ovarian cancer microenvironment

  2018cites this paper
• Involvement of LPA signaling via LPA receptor‐2 in the promotion of malignant properties in osteosarcoma cells

  2018cites this paper
• GPCRs: Emerging anti-cancer drug targets.

  2018cites this paper
• In vitro effect of lysophosphatidic acid on proliferation, invasion and migration of human ovarian cancer cells

  2018cites this paper
• From the Glucose Metabolism to the Signal Transduction Study: - ATP, Sphingosine 1-phosphate, and Protons -@@@- ATP, スフィンゴシン1-リン酸, そしてプロトン -

  2017cites this paper
• Differential expression of lysophosphatidic acid receptors between benign and malignant tissues in humans

  2016cites this paper
• Lysophosphatidic acid induces both EGFR-dependent and EGFR-independent effects on DNA synthesis and migration in pancreatic and colorectal carcinoma cells

  2016cites this paper
• G-Protein-Coupled Lysophosphatidic Acid Receptors and Their Regulation of AKT Signaling

  2016cites this paper
• LPA receptor 1 mediates LPA-induced ovarian cancer metastasis: an in vitro and in vivo study

  2016cites this paper
• Angiogenic effect of lysophosphatidic acid receptors on cervical cancer cells

  2015cites this paper
• Expression and function of lysophosphatidic acid receptors (LPARs) 1 and 3 in human hepatic cancer progenitor cells

  2015cites this paper
• Opposing regulation of megakaryopoiesis by LPA receptors 2 and 3 in K562 human erythroleukemia cells.

  2015cites this paper
• Expression and Function of LPA1 in Bladder Cancer.

  2015cites this paper
• Characterisation of human airway smooth muscle cell lysophosphatidic acid receptors in asthma and health

  2014cites this paper
• Role of LPAR3, PKC and EGFR in LPA-induced cell migration in oral squamous carcinoma cells

  2014cites this paper
• The roles of miR-200c in colon cancer and associated molecular mechanisms

  2014cites this paper
• Identification of Novel Predictive Markers for the Prognosis of Pancreatic Ductal Adenocarcinoma

  2014cites this paper
• LPA receptor signaling: pharmacology, physiology, and pathophysiology

  2014cites this paper
• Lysophospholipid receptor nomenclature review: IUPHAR Review 8

  2014cites this paper
• Lysophosphatidic acid stimulates cell migration of satellite cells. A role for the sphingosine kinase/sphingosine 1‐phosphate axis

  2014cites this paper
• Design of anticancer lysophosphatidic acid agonists and antagonists.

  2014cites this paper
• Creating a Dead End for Cancer: The Role of LPA Receptors 1/3 and 2 in Ovarian Cancer Metastases

  2014cites this paper
• Understanding the Functions of Lysophosphatidic Acid Receptors in Cancer

  2013cites this paper
• Lysophosphatidic Acid (LPA) Receptor Signaling

  2013cites this paper
• Lysophosphatidic Acid Receptors in Cancer

  2013cites this paper
• Research progress on lysophosphatidic acid receptor 2

  2013influential citation
• GENDER DIFFERENCES IN CHEMICAL CARCINOGENESIS

  2013cites this paper
• Autotaxin as a novel, tissue‐remodeling‐related factor in regressing corpora lutea of cycling rats

  2013cites this paper
• Atlas of Genetics and Cytogenetics in Oncology and Haematology LPAR 2 ( lysophosphatidic acid receptor 2 )

  2013cites this paper
• The gep Proto-Oncogene G&agr;13 Mediates Lysophosphatidic Acid-Mediated Migration of Pancreatic Cancer Cells

  2013cites this paper
• Restoration of klotho expression induces apoptosis and autophagy in hepatocellular carcinoma cells

  2013cites this paper
• Identification of novel predictive markers for the prognosis of pancreatic ductal adenocarcinoma.

  2013cites this paper
• The regulatory mechanism of CCR7 gene expression and its involvement in the metastasis and progression of gastric cancer

  2013cites this paper
• Real-Time Motion Analysis Reveals Cell Directionality as an Indicator of Breast Cancer Progression

  2013cites this paper
• Lysophosphatidic Acid Stimulates Activation of Focal Adhesion Kinase and Paxillin and Promotes Cell Motility, via LPA1–3, in Human Pancreatic Cancer

  2013influential citation
• Effect of inhibition of the lysophosphatidic acid receptor 1 on metastasis and metastatic dormancy in breast cancer.

  2012cites this paper
• Targeted ovarian cancer treatment: the TRAILs of resistance.

  2012cites this paper
• Exocrine Pancreatic Carcinogenesis and Autotaxin Expression

  2012cites this paper
• Studier i adenokarsinomceller fra bukspyttkjertel: stimulering av cellemigrasjon og involverte signalveier

  2012cites this paper
• miR-143 inhibits the metastasis of pancreatic cancer and an associated signaling pathway

  2012cites this paper
• Orally active lysophosphatidic acid receptor antagonist attenuates pancreatic cancer invasion and metastasis in vivo

  2012cites this paper
• Pharmacokinetic and Pharmacodynamic Characterization of an Oral Lysophosphatidic Acid Type 1 Receptor-Selective Antagonist

  2011cites this paper
• MAGI-3 competes with NHERF-2 to negatively regulate LPA2 receptor signaling in colon cancer cells.

  2011cites this paper
• Progranulin Stimulated by LPA Promotes the Migration of Aggressive Breast Cancer Cells

  2011influential citation
• Lysophosphatidic acid (LPA) and endothelial differentiation gene (Edg) receptors in human pancreatic cancer

  2011cites this paper
• Regulatory effect of lysophosphatidic acid on lymphocyte migration.

  2010cites this paper
• Rôle de l’axe Autotaxine (ATX)- Acide Lysophosphatidique (LPA) et récepteur LPA1 dans la dissémination métastatique des cancers du sein

  2010cites this paper
• LPA induces osteoblast differentiation through interplay of two receptors: LPA1 and LPA4

  2010cites this paper
• LPA receptors: subtypes and biological actions.

  2010cites this paper
• Lysophosphatidic acid, vitamin D, and p53: a novel signaling axis in cell death and differentiation

  2009cites this paper