Improving immunogenicity and effectiveness of influenza vaccine in older adults

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Expert Review of Vaccines

• Publication date

  2011-11-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1586/erv.11.137PMID 22043953
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Dysregulation of human Toll-like receptor function in aging.

  2011cited by this paper
• EFFECTIVENESS OF INFLUENZA VACCINE IN THE COMMUNITY-DWELLING ELDERLY

  2011cited by this paper
• Inactivated Influenza Vaccines

  2011cited by this paper
• B cell immunosenescence: different features of naive and memory B cells in elderly

  2011cited by this paper
• MF59 adjuvant: the best insurance against influenza strain diversity

  2011cited by this paper
• Immunogenicity Profile of a 3.75-μg Hemagglutinin Pandemic rH5N1 Split Virion AS03A-Adjuvanted Vaccine in Elderly Persons: A Randomized Trial

  2011cited by this paper
• Antibody and Th1-type cell-mediated immune responses in elderly and young adults immunized with the standard or a high dose influenza vaccine.

  2011cited by this paper
• Licensure of a high-dose inactivated influenza vaccine for persons aged >or=65 years (Fluzone High-Dose) and guidance for use - United States, 2010.

  2010cited by this paper
• Advances in the vaccination of the elderly against influenza: role of a high-dose vaccine

  2010cited by this paper
• Age-Associated Decrease in TLR Function in Primary Human Dendritic Cells Predicts Influenza Vaccine Response

  2010cited by this paper
• Use of a reduced (4-dose) vaccine schedule for postexposure prophylaxis to prevent human rabies-recommendations of the Advisory Committee on Immunization Practice.

  2010cited by this paper
• AS03(A)-Adjuvanted influenza A (H1N1) 2009 vaccine for adults up to 85 years of age.

  2010cited by this paper
• The Role of Epigenetics in Aging and Autoimmunity

  2010cited by this paper
• A Heterologous MF59-Adjuvanted H5N1 Prepandemic Influenza Booster Vaccine Induces a Robust, Cross-Reactive Immune Response in Adults and the Elderly

  2010cited by this paper
• H5N1 Influenza Vaccine Formulated with AS03A Induces Strong Cross-Reactive and Polyfunctional CD4 T-Cell Responses

  2010cited by this paper
• Japanese encephalitis vaccines: recommendations of the Advisory Committee on Immunization Practices (ACIP).

  2010cited by this paper
• Prevention and control of influenza with vaccines: recommendations of the Advisory Committee on Immunization Practices (ACIP), 2010.

  2010cited by this paper
• Use of a reduced (4-dose) vaccine schedule for postexposure prophylaxis to prevent human rabies: recommendations of the advisory committee on immunization practices.

  2010cited by this paper
• Priming with AS03 A-adjuvanted H5N1 influenza vaccine improves the kinetics, magnitude and durability of the immune response after a heterologous booster vaccination: an open non-randomised extension of a double-blind randomised primary study.

  2010cited by this paper
• [Oxidative stress as an universal cause of aging--from human somatic cells to the unicellular yeast and bacteria].

  2010cited by this paper
• B-cell diversity decreases in old age and is correlated with poor health status

  2009cited by this paper
• Fast rise of broadly cross-reactive antibodies after boosting long-lived human memory B cells primed by an MF59 adjuvanted prepandemic vaccine

  2009cited by this paper
• Adjuvanted H5N1 vaccine induces early CD4+ T cell response that predicts long-term persistence of protective antibody levels

  2009cited by this paper
• Seasonal influenza vaccines.

  2009cited by this paper
• Aging is associated with a numerical and functional decline in plasmacytoid dendritic cells, whereas myeloid dendritic cells are relatively unaltered in human peripheral blood.

  2009cited by this paper
• A vaccine manufacturer’s approach to address medical needs related to seasonal and pandemic influenza viruses

  2008cited by this paper
• Age-associated decline in T cell repertoire diversity leads to holes in the repertoire and impaired immunity to influenza virus

  2008cited by this paper
• Influenza vaccination and risk of community-acquired pneumonia in immunocompetent elderly people: a population-based, nested case-control study.

  2008cited by this paper
• Safety of MF59 adjuvant.

  2008cited by this paper
• Combination adjuvants for the induction of potent, long-lasting antibody and T-cell responses to influenza vaccine in mice.

  2008cited by this paper
• Antigen sparing and cross-reactive immunity with an adjuvanted rH5N1 prototype pandemic influenza vaccine: a randomised controlled trial.

  2007cited by this paper
• Age-Associated Defect in Human TLR-1/2 Function1

  2007cited by this paper
• Mortality benefits of influenza vaccination in elderly people: an ongoing controversy.

  2007cited by this paper
• Effectiveness of influenza vaccine in the community-dwelling elderly.

  2007cited by this paper
• Prevaccine determination of the expression of costimulatory B7 molecules in activated monocytes predicts influenza vaccine responses in young and older adults.

  2007cited by this paper
• Altered Innate Immune Functioning of Dendritic Cells in Elderly Humans: A Role of Phosphoinositide 3-Kinase-Signaling Pathway1

  2007cited by this paper
• MF59 Is a Safe and Potent Vaccine Adjuvant for Flu Vaccines in Humans: What Did We Learn During Its Development?

  2007cited by this paper
• Changes of CD4+CD25+Foxp3+ regulatory T cells in aged Balb/c mice

  2007cited by this paper
• Safety and immunogenicity of a high dosage trivalent influenza vaccine among elderly subjects.

  2007cited by this paper
• Peripheral blood dendritic cells and monocytes are differently regulated in the elderly.

  2007cited by this paper
• Higher frequency of regulatory T cells in the elderly and increased suppressive activity in neurodegeneration.

  2007cited by this paper
• IL-7 Administration to Humans Leads to Expansion of CD8+ and CD4+ Cells but a Relative Decrease of CD4+ T-Regulatory Cells

  2006cited by this paper
• The influenza viruses

  2006cited by this paper
• Antibody response to influenza vaccination in the elderly: a quantitative review.

  2006cited by this paper
• Safety of high doses of influenza vaccine and effect on antibody responses in elderly persons.

  2006cited by this paper
• The Influence of Age on T Cell Generation and TCR Diversity1

  2005cited by this paper
• The number of human peripheral blood CD4+ CD25high regulatory T cells increases with age

  2005cited by this paper
• Intrinsic versus environmental influences on T‐cell responses in aging

  2005cited by this paper
• Age-related changes in lymphocyte development and function

  2004cited by this paper
• Increased immunogenicity of the MF59-adjuvanted influenza vaccine compared to a conventional subunit vaccine in elderly subjects

  2004cited by this paper
• Age effects on macrophage function vary by tissue site, nature of stimulant, and exercise behavior.

  2004cited by this paper
• Impaired antigen-induced CD8+ T cell clonal expansion in aging is due to defects in antigen presenting cell function.

  2004cited by this paper
• Innate immunity in aging: impact on macrophage function

  2004cited by this paper
• Influenza: historical aspects of epidemics and pandemics.

  2004cited by this paper
• Efficacy trial of live, cold-adapted and inactivated influenza virus vaccines in older adults with chronic obstructive pulmonary disease: a VA cooperative study.

  2003cited by this paper
• Enhanced Differentiation of Splenic Plasma Cells but Diminished Long-Lived High-Affinity Bone Marrow Plasma Cells in Aged Mice 1

  2003cited by this paper
• Influenza vaccination and reduction in hospitalizations for cardiac disease and stroke among the elderly.

  2003cited by this paper
• Phagocytosis of microbes: complexity in action.

  2002cited by this paper
• Cutting Edge: Impaired Toll-Like Receptor Expression and Function in Aging

  2002cited by this paper
• Review: inactivated vaccines provide the greatest protection against influenza in healthy persons.

  2002cited by this paper
• Severe impairment of primary but not memory responses to influenza viral antigens in aged mice: costimulation in vivo partially reverses impaired primary immune responses.

  2001cited by this paper
• Value of Immunological Markers in Predicting Responsiveness to Influenza Vaccination in Elderly Individuals

  2001cited by this paper
• The adjuvanted influenza vaccines with novel adjuvants: experience with the MF59-adjuvanted vaccine.

  2001cited by this paper
• Thymic Involution in Aging

  2000cited by this paper
• Analysis of the human thymic perivascular space during aging.

  1999cited by this paper
• Increased activity of caspase 3 and caspase 8 in anti‐Fas‐induced apoptosis in lymphocytes from ageing humans

  1999cited by this paper
• Maturation of CD4+ lymphocytes in the aged microenvironment results in a memory-enriched population.

  1999cited by this paper
• Age-Related Decrease in Accessory Cell Function of Human Alveolar Macrophages

  1999cited by this paper
• Safety and immunogenicity of MF59-adjuvanted influenza vaccine in the elderly.

  1999cited by this paper
• Safety and immunogenicity of an inactivated subunit influenza virus vaccine combined with MF59 adjuvant emulsion in elderly subjects, immunized for three consecutive influenza seasons.

  1999cited by this paper
• Increased apoptosis of T cell subsets in aging humans: altered expression of Fas (CD95), Fas ligand, Bcl-2, and Bax.

  1998cited by this paper
• Enhanced immune responses and resistance against infection in aged mice conferred by Flu-ISCOMs vaccine correlate with up-regulation of costimulatory molecule CD86.

  1998cited by this paper
• Natural killer cells in the late decades of human life.

  1997cited by this paper
• [Oxidative stress and aging].

  1997cited by this paper
• MF59 adjuvant enhances the immunogenicity of influenza vaccine in both young and old mice.

  1996cited by this paper
• Antibody response after influenza immunization with various vaccine doses: a double-blind, placebo-controlled, multi-centre, dose-response study in elderly nursing-home residents and young volunteers.

  1993cited by this paper
• Lymphocyte subsets and natural killer cell activity in healthy old people and centenarians.

  1993cited by this paper
• The impairment of natural killer function in the healthy aged is due to a postbinding deficient mechanism.

  1992cited by this paper
• Responses

  1991cited by this paper
• Granzymes, a Family of Serine Proteases Released from Granules of Cytolytic T Lymphocytes upon T Cell Receptor Stimulation

  1988cited by this paper
• Recognition of noninfectious influenza virus by class I-restricted murine cytotoxic T lymphocytes.

  1988cited by this paper
• A novel serine esterase expressed by cytotoxic T lymphocytes

  1985cited by this paper
• HLA restricted virus-specific cytotoxic T-lymphocyte responses to live and inactivated influenza vaccines.

  1981cited by this paper
• [Vaccination against influenza].

  1981cited by this paper
• ANTIBODY RESPONSES TO ANTIGENIC DETERMINANTS OF INFLUENZA VIRUS HEMAGGLUTININ

  1974cited by this paper
• ANTIBODY RESPONSES TO ANTIGENIC DETERMINANTS OF INFLUENZA VIRUS HEMAGGLUTININ

  1974cited by this paper
• THE IMMUNOLOGIC THEORY OF AGING

  1969cited by this paper
• Vaccination Against Influenza

  1961cited by this paper
• Vaccination against influenza.

  1953cited by this paper
• INFLUENZA viruses.

  1952cited by this paper

• First clinical experiences with the tetravalent live vaccine against dengue (Qdenga ®) in travellers: a multicentric TravelMedVac study in Germany.

  2025cites this paper
• Nanomedicine Therapies for Pediatric Diseases

  2024cites this paper
• Revisiting the dimensions of universal vaccine with special focus on COVID-19: Efficacy versus methods of designing.

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• COVID-19 Pandemic and Physical Exercise: Lessons Learnt for Confined Communities

  2021cites this paper
• Benefits of Exercise on Influenza or Pneumonia in Older Adults: A Systematic Review

  2020influential citation
• Vacuna antigripal trivalente de alta dosis: seguridad e inmunogenicidad

  2020cites this paper
• EXamining the knowledge, Attitudes and experiences of Canadian seniors Towards influenza (the EXACT survey)

  2019cites this paper
• Research progress on immune aging and its mechanisms affecting geriatric diseases

  2019cites this paper
• Immunogenicity of high-dose trivalent inactivated influenza vaccine: a systematic review and meta-analysis

  2019cites this paper
• Canadian older adults’ perceptions of effectiveness and value of regular and high-dose influenza vaccines

  2018cites this paper
• [Seasonal flu vaccination for older people: Evaluation of the adjuvanted vaccine. Positioning report].

  2017cites this paper
• PROPHYLAXIS OF INFLUENZA IN THE ELDERY. IS THERE ANY ALTERNATIVE?

  2017cites this paper
• Fluzone® High-Dose Influenza Vaccine

  2016cites this paper
• Hajj vaccinations-facts, challenges, and hope.

  2016cites this paper
• Seasonal influenza vaccination of high-risk adults

  2016cites this paper
• Intranasal Inactivated Influenza Vaccines: a Reasonable Approach to Improve the Efficacy of Influenza Vaccine?

  2016cites this paper
• Age, serum 25-hydroxyvitamin D and vitamin D receptor (VDR) expression and function in peripheral blood mononuclear cells

  2016cites this paper
• Immunization in Canada: Update for 2015.

  2016cites this paper
• Suboptimal Effectiveness of the 2011–2012 Seasonal Influenza Vaccine in Adult Korean Populations

  2015cites this paper
• Immunosenescence: implications for vaccination programs in the elderly

  2015cites this paper
• Waning vaccine protection against influenza A (H3N2) illness in children and older adults during a single season.

  2015cites this paper
• Safety and immunogenicity of high-dose trivalent inactivated influenza vaccine in adults 50-64 years of age.

  2015cites this paper
• Multifaceted Strategies Needed for Influenza Prevention in Long-term Care.

  2015cites this paper
• Comparative effectiveness of high-dose versus standard-dose influenza vaccines in US residents aged 65 years and older from 2012 to 2013 using Medicare data: a retrospective cohort analysis.

  2015cites this paper
• Immunogenicity and safety of Fluzone(®) intradermal and high-dose influenza vaccines in older adults ≥65 years of age: a randomized, controlled, phase II trial.

  2014cites this paper
• A dose-ranging study in older adults to compare the safety and immunogenicity profiles of MF59®-adjuvanted and non-adjuvanted seasonal influenza vaccines following intradermal and intramuscular administration

  2014cites this paper
• Adult Population Influenza Virus Infection in the Korean for Prevention of Laboratory-Confirmed the 2010-2011 Seasonal Influenza Vaccine Case-Control Study of the Effectiveness of

  2014cites this paper
• Case-Control Study of the Effectiveness of the 2010-2011 Seasonal Influenza Vaccine for Prevention of Laboratory-Confirmed Influenza Virus Infection in the Korean Adult Population

  2013cites this paper
• Effectiveness of 2010–2011 seasonal influenza vaccine for preventing laboratory- 1 confirmed influenza infection in Korean adult population: Case-control study 2

  2013cites this paper
• TLR7 Recognition Is Dispensable for Influenza Virus A Infection but Important for the Induction of Hemagglutinin-Specific Antibodies in Response to the 2009 Pandemic Split Vaccine in Mice

  2012cites this paper
• [Present state and the future direction of HBV vaccine].

  2012cites this paper
• Antibody responses against influenza A(H1N1)pdm09 virus after sequential vaccination with pandemic and seasonal influenza vaccines in Finnish healthcare professionals

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• Expert Review of Vaccines 10-year anniversary issue

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