Do spin traps also act as classical chain-breaking antioxidants? A quantitative kinetic study of phenyl tert-butylnitrone (PBN) in solution and in liposomes.

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Free Radical Biology & Medicine

• Publication date

  2000-04-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/S0891-5849(00)00197-0PMID 10832069
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• MPTP-induced deficits in motor activity: Neuroprotective effects of the spintrapping agent, α-phenyl-tert-butyl-nitrone (PBN)

  2005cited by this paper
• Reactivity of Substituted Phenols Toward Alkyl Radicals

  1999cited by this paper
• Media Effects on Antioxidant Activities of Phenols and Catechols

  1999cited by this paper
• Reassignment of organic peroxyl radical adducts.

  1999cited by this paper
• On the antioxidant activity of melatonin.

  1999cited by this paper
• Issues Pertinent to the in vivo in situ Spin Trapping of Free Radicals

  1999cited by this paper
• Spin-trapping: Recent developmetns and applications

  1998cited by this paper
• Blood gas measurement during exercise: a comparative study between arterialized earlobe sampling and direct arterial puncture in adults.

  1998cited by this paper
• A spin trap, N-tert-butyl-alpha-phenylnitrone extends the life span of mice.

  1998cited by this paper
• A spin trap, N-tert-butyl-α-phenylnitrone extends the life span of mice

  1998cited by this paper
• The efficiency of antioxidants delivered by liposomal transfer.

  1997cited by this paper
• Radical Trapping and Inhibition of Iron‐Dependent CNS Damage by Cyclic Nitrone Spin Traps

  1997cited by this paper
• Alpha‐phenyl-tert‐butyl-nitrone (PBN) reverses age‐related maze learning performance and motor activity deficits in C57 BL/6 mice

  1996cited by this paper
• Antioxidant treatment with phenyl-α-tert-butyl nitrone (PBN) improves the cognitive performance and survival of aging rats

  1996cited by this paper
• Alpha-phenyl N-tert-butylnitrone as antioxidant for low density lipoproteins.

  1994cited by this paper
• Brain antioxidant activity of spin traps in Mongolian gerbils.

  1994cited by this paper
• Comparison of antioxidant properties of nifedipine and illuminated nifedipine with nitroso spin traps in low density lipoproteins and phosphatidylcholine liposomes.

  1994cited by this paper
• Biological spin trapping

  1994cited by this paper
• Spin Trapping Organic Radicals

  1994cited by this paper
• ESR Spin-Trapping Artifacts in Biological Model Systems

  1993cited by this paper
• Effect of theophylline on brain tissue oxygenation during normoxia and hypoxia in humans.

  1993cited by this paper
• Detection of lipid radicals by electron paramagnetic resonance spin trapping using intact cells enriched with polyunsaturated fatty acid.

  1992cited by this paper
• Absolute kinetics of hydrogen abstraction from .alpha.-tocopherol by several reactive species including an alkyl radical

  1992cited by this paper
• Detection of Alkyl, Alkoxyl, and Alkyperoxyl Radicals from the Thermolysis of Azobis(isobutyronitrile) by ESR/Spin Trapping. Evidence for Double Spin Adducts from Liquid-Phase Chromatography and Mass Spectroscopy.

  1991cited by this paper
• Oxygenation of human tumors: evaluation of tissue oxygen distribution in breast cancers by computerized O2 tension measurements.

  1991cited by this paper
• Protective effects of spin-trapping agents on adriamycin-induced cardiotoxicity in isolated rat atria.

  1991cited by this paper
• The spin trap, α‐phenyl N‐tert‐butylnitrone, inhibits the oxidative modification of low density lipoprotein

  1991cited by this paper
• The spin trap, alpha-phenyl N-tert-butylnitrone, inhibits the oxidative modification of low density lipoprotein.

  1991cited by this paper
• The antioxidant activities of phenolic antioxidants in free radical peroxidation of phospholipid membranes

  1990cited by this paper
• Biokinetics of dietary RRR-alpha-tocopherol in the male guinea pig at three dietary levels of vitamin C and two levels of vitamin E. Evidence that vitamin C does not "spare" vitamin E in vivo.

  1990cited by this paper
• Protection from cerebral ischemic injury in gerbils with the spin trap agent N-tert-butyl-alpha-phenylnitrone (PBN).

  1990cited by this paper
• HPLC procedure for the pharmacokinetic study of the spin-trapping agent, alpha-phenyl-N-tert-butyl nitrone (PBN).

  1990cited by this paper
• Detection of alkyl, alkoxyl, and alkyperoxyl radicals from the thermolysis of azobis(isobutyronitrile) by ESR/spin trapping. Evidence for double spin adducts from liquid-phase chromatography and mass spectroscopy

  1990cited by this paper
• Electron spin resonance spin-trapping study of peroxidation of human low density lipoprotein

  1988cited by this paper
• Spin trapping of oxygen and carbon-centered free radicals in ischemic canine myocardium.

  1987cited by this paper
• Applications of electron spin resonance spectroscopy to the identification of radicals produced during lipid peroxidation.

  1987cited by this paper
• Mechanisms for the autoxidation of polyunsaturated lipids

  1986cited by this paper
• Facile one-step synthesis of phenyl-tert-butylnitrone (PBN) and its derivatives

  1985cited by this paper
• Autoxidation of biological molecules. 4. Maximizing the antioxidant activity of phenols

  1985cited by this paper
• Autoxidation in micelles. Synergism of vitamin C with lipid-soluble vitamin E and water-soluble Trolox

  1985cited by this paper
• beta-Carotene: an unusual type of lipid antioxidant.

  1984cited by this paper
• Oxidation of lipids. XI. Spin trapping and identification of peroxy and alkoxy radicals of methyl linoleate

  1984cited by this paper
• Tissue oxygen tension in normal and ischaemic human skin.

  1984cited by this paper
• Oxygen radicals in biological systems.

  1984cited by this paper
• Concentration of oxygen in lipid bilayers using a spin-label method.

  1983cited by this paper
• Rate constants for the reactions of free radicals with oxygen in solution

  1983cited by this paper
• Spin trapping of peroxy radicals by phenyl N-(tert-butyl) nitrone and methyl N-duryl nitrone

  1983cited by this paper
• The lewis acid catalyzed reaction of trans-hyponitrite ion with alkyl halides

  1983cited by this paper
• First proof that vitamin E is major lipid-soluble, chain-breaking antioxidant in human blood plasma.

  1982cited by this paper
• Spin Trapping of Radical Species Involved in the Propagation of Lipid Peroxidation

  1980cited by this paper
• KINETIC APPLICATIONS OF ELECTRON PARAMAGNETIC RESONANCE SPECTROSCOPY. 34. RATE CONSTANTS FOR SPIN TRAPPING. 2. SECONDARY ALKYL RADICALS

  1978cited by this paper
• Solvent effects on the spin-trapping of primary alkyl radicals

  1978cited by this paper
• Electron paramagnetic resonance spectra of the tert-butylperoxy and tert-butoxy adducts to phenyl tert-butyl nitrone and 2-methyl-2-nitrosopropane. Oxygen-17 hyperfine coupling constants

  1978cited by this paper
• Study of autoxidation by spin trapping. Spin trapping of peroxyl radicals by phenyl N-t-butyl nitrone

  1977cited by this paper
• Spin trapping alkylperoxy radicals, and superoxide-alkyl halide reactions

  1977cited by this paper
• A probe for homolytic reactions in solution. Part VII. Hindered phenols as spin traps

  1972cited by this paper
• .alpha.-(3,5-Di-tert-butyl-4-hydroxyphenyl)-N-tert-butylnitrone. Novel probe for radical detection and identification

  1970cited by this paper
• THE KINETICS OF THE INHIBITED AUTOXIDATION OF TETRALIN

  1964cited by this paper
• Azo-bis-nitriles. III.1The Preparation and Decomposition of Azo-nitriles. Steric Factors

  1951cited by this paper
• The Preparation of Some Aliphatic Azo Nitriles and their Decomposition in Solution

  1949cited by this paper
• THE CHEMISTRY OF VITAMIN E. VI. THE ADDITION OF DIENES TO PHENOLS AND HYDROQUINONES1

  1939cited by this paper

• Mitochondrial Quality Control in Health and Disease

  2025cites this paper
• Monocyclic Nitro-heteroaryl Nitrones with Dual Mechanism of Activation: Synthesis and Antileishmanial Activity.

  2021cites this paper
• Influence of antioxidants in biodiesel degradation: Electronic paramagnetic resonance tracking of free radicals

  2020cites this paper
• Cytoprotective effects of antioxidant supplementation on mesenchymal stem cell therapy

  2020cites this paper
• Liver-targeted Nano-MitoPBN normalizes glucose metabolism by improving mitochondrial redox balance.

  2019cites this paper
• Nitrone-Trolox conjugate as an inhibitor of lipid oxidation: Towards synergistic antioxidant effects

  2018cites this paper
• Why Have Clinical Trials of Antioxidants to Prevent Neurodegeneration Failed? - A Cellular Investigation of Novel Phenothiazine-Type Antioxidants Reveals Competing Objectives for Pharmaceutical Neuroprotection

  2017cites this paper
• Cholesterol-nitrone conjugates as protective agents against lipid oxidation: A model membrane study.

  2017cites this paper
• Divalent Amino-Acid-Based Amphiphilic Antioxidants: Synthesis, Self-Assembling Properties, and Biological Evaluation.

  2016cites this paper
• On the vasoprotective mechanisms underlying novel β-phosphorylated nitrones: Focus on free radical characterization, scavenging and NO-donation in a biological model of oxidative stress.

  2016cites this paper
• Synthesis of N-methylarylnitrones derived from alkyloxybenzaldehydes and antineoplastic effect on human cancer cell lines.

  2015cites this paper
• PBN derived amphiphilic spin-traps. II/Study of their antioxidant properties in biomimetic membranes.

  2014cites this paper
• Evidence for transfer of radicals between oil-in-water emulsion droplets as detected by the probe (E,E)-3,5-bis(4-phenyl-1,3-butadienyl)-4,4-difluoro-4-bora-3a,4a-diaza-s-indacene, BODIPY(665/676.).

  2014cites this paper
• Conception de nitrones amphiphiles aux propriétés de piégeage et antioxydantes supérieure

  2014cites this paper
• 15. Synthetic Antioxidants

  2013cites this paper
• Benzoxazinic nitrones and nitroxides as possible antioxidants in biological systems

  2013cites this paper
• Identification of isomeric spin adducts of Leu-Tyr and Tyr-Leu free radicals using liquid chromatography-tandem mass spectrometry.

  2012cites this paper
• Is the chromanol head group of vitamin E nature's final truth on chain‐breaking antioxidants?

  2012cites this paper
• Translational research involving oxidative stress and diseases of aging.

  2011cites this paper
• Modulation of ethoxyquin genotoxicity by free radical scavengers and DNA damage repair in human lymphocytes.

  2010cites this paper
• N-tert-butyl and N-methyl nitrones derived from aromatic aldehydes inhibit macromolecular permeability increase induced by ischemia/reperfusion in hamsters.

  2009cites this paper
• Phenols as Antioxidants

  2009cites this paper
• Synthesis and antioxidant activity of [60]fullerene–flavonoid conjugates

  2009cites this paper
• Nitrones as therapeutics.

  2008cites this paper
• Antioxidant activity of the new thiosulfinate derivative, S-benzyl phenylmethanethiosulfinate, from Petiveria alliacea L.

  2008cites this paper
• Mitochondrial uncoupling proteins--what is their physiological role?

  2007cites this paper
• Alpha-phenyl-N-tert-butyl nitrone (PBN) derivatives: synthesis and protective action against microvascular damages induced by ischemia/reperfusion.

  2007cites this paper
• Bilirubin as an antioxidant in micelles and lipid bilayers: its contribution to the total antioxidant capacity of human blood plasma.

  2007cites this paper
• Identification of free radicals of glycerophosphatidylcholines containing ω-6 fatty acids using spin trapping coupled with tandem mass spectrometry

  2007cites this paper
• Activity and thermal stability of antioxidants by differential scanning calorimetry and electron spin resonance spectroscopy

  2007cites this paper
• Pharmacological properties of BN82451: a novel multitargeting neuroprotective agent.

  2007cites this paper
• Multi-frequency ESR study of the polycrystalline phenoxyl radical of alpha-(3,5-di-tert-butyl-4-hydroxyphenyl)-N-tert-butylnitrone in the diamagnetic matrix.

  2006cites this paper
• Targeting antioxidants to mitochondria: a new therapeutic direction.

  2006cites this paper
• Nitrone derivatives of trolox as neuroprotective agents.

  2005cites this paper
• Analysis of Lipid Oxidation by ESR Spectroscopy

  2005cites this paper
• Electron spin resonance spin trapping for analysis of lipid oxidation in oils: inhibiting effect of the spin trap alpha-phenyl-N-tert-butylnitrone on lipid oxidation.

  2005cites this paper
• Evaluation of oxidative stability of vegetable oils by monitoring the tendency to radical formation. A comparison of electron spin resonance spectroscopy with the Rancimat method and differential scanning calorimetry

  2004cites this paper
• Kinetic studies on stilbazulenyl-bis-nitrone (STAZN), a nonphenolic chain-breaking antioxidant in solution, micelles, and lipid membranes.

  2004cites this paper
• The role of superoxide dismutase and alpha-tocopherol in the development of seizures and kindling induced by pentylenetetrazol - influence of the radical scavenger alpha-phenyl-N-tert-butyl nitrone.

  2004cites this paper
• Mitochondrial superoxide and aging: uncoupling-protein activity and superoxide production.

  2004cites this paper
• The role of superoxide dismutase and α-tocopherol in the development of seizures and kindling induced by pentylenetetrazol - influence of the radical scavenger α-phenyl-N-tert-butyl nitrone

  2004cites this paper
• Brain Regional Heterogeneity and Toxicological Mechanisms of Organophosphates and Carbamates

  2004cites this paper
• Superoxide Activates Uncoupling Proteins by Generating Carbon-centered Radicals and Initiating Lipid Peroxidation

  2003cites this paper
• Stilbazulenyl nitrone (STAZN): a nitronyl-substituted hydrocarbon with the potency of classical phenolic chain-breaking antioxidants.

  2002cites this paper
• Naphthalene diols: a new class of antioxidants intramolecular hydrogen bonding in catechols, naphthalene diols, and their aryloxyl radicals.

  2002cites this paper
• Genetic damage and ageing T cells

  2002cites this paper
• Oxidative Stress and Antioxidant Intervention

  2002cites this paper
• Isolated perfused rat hearts release secondary free radicals during ischemia reperfusion injury: Cardiovascular effects of the spin trap α-phenyl N-tert-butylnitrone

  2001cites this paper
• Kinetics of peroxidation of linoleic acid incorporated into DPPC vesicles initiated by the thermal decomposition of 2,2'-azobis(2-amidinopropane) dihydrochloride.

  2001cites this paper
• Depletion of energy metabolites following acetylcholinesterase inhibitor-induced status epilepticus: protection by antioxidants.

  2001cites this paper
• Nitric oxide modulates high-energy phosphates in brain regions of rats intoxicated with diisopropylphosphorofluoridate or carbofuran: prevention by N-tert-butyl-α-phenylnitrone or vitamin E

  2001cites this paper
• Spin trapping agents (Tempol and POBN) protect HepG2 cells overexpressing CYP2E1 against arachidonic acid toxicity.

  2001cites this paper