NGF promotes microglial migration through the activation of its high affinity receptor: modulation by TGF-beta.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Journal of Neuroimmunology

• Publication date

  2007-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/J.JNEUROIM.2007.07.020PMID 17868907
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Neurotrophin signalling in health and disease.

  2006influential reference
• Neurotrophin signaling: many exciting surprises!

  2006cited by this paper
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  2005cited by this paper
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  2004cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1997cited by this paper
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  1996cited by this paper
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  1996cited by this paper
• Cytokines in cerebral ischemia: expression of transforming growth factor beta-1 (TGF-beta 1) mRNA in the postischemic adult rat hippocampus.

  1995cited by this paper
• Cytokines in cerebral ischemia: Expression of transforming growth factor beta-1 (TGF-β1) mRNA in the postischemic adult rat hippocampus

  1995cited by this paper
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  1994cited by this paper
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  1993cited by this paper
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  1993cited by this paper
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  1993cited by this paper
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  1993cited by this paper
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  1992cited by this paper
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  1991cited by this paper
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  1989cited by this paper
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  1987cited by this paper
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  1987cited by this paper
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  1979cited by this paper
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  1969cited by this paper

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