Chemistry in a vesicle

Slow fusion pore expansion could retain molecules within vesicles, enabling a chemical reaction that modifies secreted products.

• Publication year

  2017

• Venue

  The Journal of General Physiology

• Publication date

  2017-10-02

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1085/jgp.201711894PMID 28899933PMCID 5694936
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Synaptotagmin isoforms confer distinct activation kinetics and dynamics to chromaffin cell granules

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• Slow fusion pore expansion creates a unique reaction chamber for co-packaged cargo

  2017influential reference
• The Functional Significance of Synaptotagmin Diversity in Neuroendocrine Secretion

  2013cited by this paper
• Amperometric measurements at cells support a role for dynamin in the dilation of the fusion pore during exocytosis.

  2013cited by this paper
• Dynamin-2 Regulates Fusion Pore Expansion and Quantal Release through a Mechanism that Involves Actin Dynamics in Neuroendocrine Chromaffin Cells

  2013cited by this paper
• The Plasminogen Activation System and the Regulation of Catecholaminergic Function

  2012cited by this paper
• A new role for the dynamin GTPase in the regulation of fusion pore expansion

  2011cited by this paper
• Release mode of large and small dense-core vesicles specified by different synaptotagmin isoforms in PC12 cells

  2011cited by this paper
• Proteomics of dense core secretory vesicles reveal distinct protein categories for secretion of neuroeffectors for cell-cell communication.

  2010cited by this paper
• The Association of Dynamin with Synaptophysin Regulates Quantal Size and Duration of Exocytotic Events in Chromaffin Cells

  2010cited by this paper
• Three distinct kinetic groupings of the synaptotagmin family: candidate sensors for rapid and delayed exocytosis.

  2005cited by this paper
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  2005cited by this paper
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  2002cited by this paper
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  1999cited by this paper
• Direct Interaction of a Ca2+-binding Loop of Synaptotagmin with Lipid Bilayers*

  1998cited by this paper
• Tissue Plasminogen Activator (t-PA) Is Targeted to the Regulated Secretory Pathway

  1997cited by this paper

• No citing papers are available for this paper.