Hemorrhagic necrotizing enterocolitis associated with Clostridium difficile infection in four foals.

Severe hemorrhagic necrotizing enterocolitis was determined to be the cause of death for 4 foals. Toxigenic Clostridium difficile was isolated form the intestine of each foal, and large, gram-positive, rod-shaped bacteria lined the surface of necrotic villi. This finding of toxigenic C difficile associated with enteritis in foals adds another possible cause to the list of infectious agents that should be considered when evaluating foals with enteritis. Definitive diagnosis requires a thorough diagnostic evaluation, including procedures that will identify the organism and demonstrate its toxigenicity.

• Publication year

  1988

• Venue

  Journal of the American Veterinary Medical Association

• Publication date

  1988-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.2460/javma.1988.193.01.76PMID 3262102
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Isolation of Clostridium difficile and detection of cytotoxin in the feces of diarrheic foals in the absence of antimicrobial treatment

  1987cited by this paper
• Evaluation of a commercial kit for the routine detection of Clostridium difficile cytotoxin by tissue culture

  1986cited by this paper
• Evaluation of a commercial cytotoxicity assay for detection of Clostridium difficile toxin

  1986cited by this paper
• Hemorrhagic enteritis caused by Clostridium perfringens type C in a foal.

  1986cited by this paper
• Clostridium perfringens type C enterotoxemia in a newborn foal.

  1986cited by this paper
• Effect of toxin A and B of Clostridium difficile on rabbit ileum and colon.

  1986cited by this paper
• Infectious diarrhoea in foals

  1985cited by this paper
• Effects of Clostridium difficile toxins given intragastrically to animals

  1985cited by this paper
• Haemorrhagic necrotising enteritis in foals associated with Clostridium perfringens.

  1985cited by this paper
• Acute diarrhea in horses of the Potomac River area: examination for clostridial toxins.

  1984cited by this paper
• Antimicrobial agent-associated colitis and diarrhea: historical background and clinical aspects.

  1984cited by this paper
• Clostridium difficile colitis unassociated with antibiotic therapy

  1983cited by this paper
• Hemorrhagic Enterotoxemia Caused by Clostridium perfringens Type C in a Foal.

  1982cited by this paper
• Nonantibiotic-associated enterocolitis caused by Clostridium difficile in an infant.

  1981cited by this paper
• Negative contrast electron microscopic techniques for diagnosis of viruses of veterinary importance.

  1980cited by this paper
• Selective and differential medium for isolation of Clostridium difficile

  1979cited by this paper
• Antibiotic-associated pseudomembranous colitis due to toxin-producing clostridia.

  1978cited by this paper
• Enterotoxemia in two foals.

  1978cited by this paper
• Clostridium sordellii isolated from foals.

  1977cited by this paper
• Clostridium difficile: isolation and characteristics.

  1976cited by this paper

• Anesthetic Management of Foals

  2022cites this paper
• Clostridioides difficile on dairy farms and potential risk to dairy farm workers.

  2021cites this paper
• Detection of pathogens in blood or feces of adult horses with enteric disease and association with outcome of colitis

  2021cites this paper
• Clostridium difficile Infections in Adult Horses and Foals: Prevalence and Associated Risk Factors

  2020influential citation
• The Equine Peripartum Period

  2020cites this paper
• Collapse and Sudden Death

  2020cites this paper
• Mortality, clinical findings, predisposing factors and treatment of Clostridioides difficile colitis in Japanese thoroughbred racehorses

  2020cites this paper
• Gut microbiome features associated with Clostridium difficile colonization in puppies

  2019cites this paper
• Jejunum and Ileum

  2019cites this paper
• Clostridioides (Clostridium) Difficile in Food-Producing Animals, Horses and Household Pets: A Comprehensive Review

  2019cites this paper
• Gut microbiota features associated with Clostridioides difficile colonization in puppies

  2019cites this paper
• Disorders of the Gastrointestinal System

  2017cites this paper
• Disorders of Foals

  2017cites this paper
• Epidemiology and Antimicrobial Resistance in Clostridium difficile With Special Reference to the Horse

  2016cites this paper
• The Role of Clostridium Perfringens in Camel Calf Diarrhoea with Special Reference to the Pathogenesis and Pathology in the Sudan

  2015cites this paper
• Kotwasser beim Pferd – ein ungelöstes Problem

  2015cites this paper
• Clostridium Difficile Infection in Horses

  2014cites this paper
• Chapter 41 – Enteric Clostridial Infections

  2014cites this paper
• Author ' s personal copy Clostridium difficile infection in horses : A review

  2013influential citation
• Clostridium difficile infection in horses: a review.

  2013cites this paper
• Immunisation of mares with binding domains of toxins A and B of Clostridium difficile elicits serum and colostral antibodies that block toxin binding.

  2013cites this paper
• Postoperative Clostridium difficile infection with PCR ribotype 078 strain identified at necropsy in five Thoroughbred racehorses

  2013cites this paper
• Pathology and Diagnostic Criteria of Clostridium difficile Enteric Infection in Horses

  2013cites this paper
• Man and pigs: sharing the same C. difficile

  2013cites this paper
• Incomplete longitudinal fractures and fatigue injury of the proximopalmar medial aspect of the third metacarpal bone in 55 horses.

  2012cites this paper
• The importance of ultrasonographic pneumatosis intestinalis in equine neonatal gastrointestinal disease

  2012cites this paper
• Mesenteric Lymphangitis and Sepsis Due to RTX Toxin-Producing Actinobacillus spp in 2 Foals With Hypothyroidism–Dysmaturity Syndrome

  2012cites this paper
• The importance of ultrasonographic pneumatosis intestinalis in equine neonatal gastrointestinal disease.

  2012cites this paper
• Clostridium difficile infection in humans and animals, differences and similarities.

  2011cites this paper
• Clostridium difficile associated diarrhoea in horses within the community: predictors, clinical presentation and outcome

  2010cites this paper
• A prospective study of the roles of clostridium difficile and enterotoxigenic Clostridium perfringens in equine diarrhoea.

  2010cites this paper
• Clostridium difficile: its potential as a source of foodborne disease.

  2010cites this paper
• Clostridium difficile: prevalence in horses and environment, and antimicrobial susceptibility.

  2010cites this paper
• Infectious foal diarrhoea: Pathophysiology, prevalence and diagnosis

  2010cites this paper
• Disorders of Foals

  2009cites this paper
• Gastrointestinal Disease

  2009influential citation
• Disorders of the Gastrointestinal System

  2009cites this paper
• Surgical diseases of the small intestine.

  2008cites this paper
• Porcine Enteric Disease Caused by Clostridium difficile and Clostridium perfringens: Epidemiology, Pathogenesis and Immunity

  2008cites this paper
• Diagnosis and treatment of non-infectious and infectious foal diarrhoea

  2008cites this paper
• Chapter 14 – Clostridial Species

  2007cites this paper
• Equine amyloid A in the peripartum and neonatal period

  2006cites this paper
• The Comparative Pathology of Clostridium difficile-associated Disease

  2006cites this paper
• Clostridium difficile associated diarrhoea in horses within the community: predictors, clinical presentation and outcome.

  2006cites this paper
• Intestinal surgery of adult cattle.

  2005cites this paper
• Clostridial Diseases in Domestic Animals

  2005cites this paper
• Antibiotic Associated Diarrhea in Horses With special reference to Clostridium difficile

  2004cites this paper
• THE PATHOGENESIS OF CLOSTRIDIUMDIFFICILE-AS>S0CIA.1ED DISEASE IN NEONATAL PIGS

  2004cites this paper
• Clostridium difficile diarrhea: infection control in horses.

  2004cites this paper
• Antibiotic associated diarrhea in horses

  2004cites this paper
• Antimicrobial susceptibility of Clostridium difficile isolated from neonatal pigs with enteritis.

  2004cites this paper
• Bacterial-associated diarrhea in the dog: a critical appraisal.

  2003cites this paper
• Hepatitis associated with Clostridium difficile in an ostrich chick

  2003cites this paper
• Evaluation of a Test for Clostridium Difficile Toxins A and B for the Diagnosis of Neonatal Swine Enteritis

  2002cites this paper
• Evaluation of the Ability of Di-tri-octahedral Smectite to Adhere to Clostridium difficile Toxins and Clostridium perfringens Enterotoxin In Vitro

  2002cites this paper
• Clostridium difficile infections in animals with special reference to the horse. A review

  2002cites this paper
• Characterization of Clostridium difficile isolates from foals with diarrhea: 28 cases (1993-1997).

  2002cites this paper
• Partial Parenteral Nutrition in Equine Neonatal Clostridial Enterocolitis

  2002cites this paper
• Equine Neonatal Clostridiosis: Treatment and Prevention UPDATE ON EQUINE THERAPEUTICS

  2001cites this paper
• Clostridial enterocolitis.

  2000cites this paper
• Prevalence of Clostridium perfringens enterotoxin and Clostridium difficile toxin A in feces of horses with diarrhea and colic.

  1999cites this paper
• The Prevalence of Aeromonas Species in Feces of Horses with Diarrhea

  1999cites this paper
• Association of Clostridium difficile with enterocolitis and lactose intolerance in a foal.

  1999cites this paper
• Enterocolitis associated with Clostridium perfringens infection in neonatal foals: 54 cases (1988-1997).

  1998cites this paper
• Clostridium difficile infection in a horse.

  1998cites this paper
• Clostridium difficile associated with acute colitis in mares when their foals are treated with erythromycin and rifampicin for Rhodococcus equi pneumonia.

  1998cites this paper
• Acute colitis in adult horses. A review with emphasis on aetiology and pathogenesis.

  1997cites this paper
• Clostridial Diseases of Animals

  1997cites this paper
• Antimicrobial susceptibilities of equine isolates of Clostridium difficile and molecular characterization of metronidazole-resistant strains.

  1997cites this paper
• Clostridium difficile associated with acute colitis in mature horses treated with antibiotics.

  1997cites this paper
• The use of animal models in the study of necrotizing enterocolitis in the newborn

  1997cites this paper
• Clostridial enteric diseases of domestic animals

  1996cites this paper
• Apparent Outbreaks of Clostridium Difficile-Associated Diarrhea in Horses in a Veterinary Medical Teaching Hospital

  1995cites this paper
• Diagnosis of Enteritis and Enterotoxemia due to Clostridium Difficile in Captive Ostriches (Struthio Camelus)

  1993cites this paper
• Clostridium Difficile Associated with Typhlocolitis in an Adult Horse

  1993cites this paper
• Clostridia-associated enterocolitis in adult horses and foals.

  1993cites this paper
• From the Director

  1992cites this paper
• The prevalence of enteric pathogens in diarrhoeic Thoroughbred foals in Britain and Ireland

  1991cites this paper
• Necrohemorrhagic enterocolitis caused by Clostridium perfringens type C in a foal.

  1990cites this paper
• Diagnostic Procedures for Isolation and Characterization of Clostridium Difficile Associated with Enterocolitis in Foals

  1989cites this paper
• Upper gastrointestinal surgery for ulcer disease in foals.

  1989cites this paper
• Zoonoses and communicable diseases common to man and animals, 2nd edn. by Pedro N. Acha and Boris Szyfres. Pan American Health Organization, Washington, D.C., 1987, iii–xx, 963 pp., price US$20.00, ISBN: 92-75-11503-6

  1989cites this paper
• REVIEW ARTICLE Diagnostic procedures for isolation and characterization of Clostridium difficile associated with enterocolitis in foals

  1989cites this paper