The effect of exposure to nanoparticles and nanomaterials on the mammalian epigenome

Human exposure to nanomaterials and nanoparticles is increasing rapidly, but their effects on human health are still largely unknown. Epigenetic modifications are attracting ever more interest as possible underlying molecular mechanisms of gene–environment interactions, highlighting them as potential molecular targets following exposure to nanomaterials and nanoparticles. Interestingly, recent research has identified changes in DNA methylation, histone post-translational modifications, and noncoding RNAs in mammalian cells exposed to nanomaterials and nanoparticles. However, the challenge for the future will be to determine the molecular pathways driving these epigenetic alterations, the possible functional consequences, and the potential effects on health.

• Publication year

  2016

• Venue

  International Journal of Nanomedicine

• Publication date

  2016-11-25

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.2147/IJN.S120104PMID 27932878PMCID 5135284
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Prolonged Effects of Silver Nanoparticles on p53/p21 Pathway-Mediated Proliferation, DNA Damage Response, and Methylation Parameters in HT22 Hippocampal Neuronal Cells

  2016cited by this paper
• Maintaining memory of silencing at imprinted differentially methylated regions

  2016cited by this paper
• Long noncoding RNAs in DNA methylation: new players stepping into the old game

  2016cited by this paper
• Effects of intratracheally instilled laser printer-emitted engineered nanoparticles in a mouse model: A case study of toxicological implications from nanomaterials released during consumer use.

  2016cited by this paper
• Low-dose carbon-based nanoparticle-induced effects in A549 lung cells determined by biospectroscopy are associated with increases in genomic methylation

  2016cited by this paper
• Epigenetic modulation upon exposure of lung fibroblasts to TiO2 and ZnO nanoparticles: alterations in DNA methylation

  2016cited by this paper
• Alterations in DNA methylation corresponding with lung inflammation and as a biomarker for disease development after MWCNT exposure

  2016influential reference
• In vivo epigenetic effects induced by engineered nanomaterials: A case study of copper oxide and laser printer-emitted engineered nanoparticles

  2016cited by this paper
• Application of biomaterials to advance induced pluripotent stem cell research and therapy

  2015cited by this paper
• Silver nanoparticle-induced hemoglobin decrease involves alteration of histone 3 methylation status.

  2015cited by this paper
• Nano-hydroxyapatite modulates osteoblast lineage commitment by stimulation of DNA methylation and regulation of gene expression.

  2015cited by this paper
• Perturbation of cellular mechanistic system by silver nanoparticle toxicity: Cytotoxic, genotoxic and epigenetic potentials.

  2015cited by this paper
• Short-term exposure to engineered nanomaterials affects cellular epigenome

  2015cited by this paper
• Evaluating the effect of ambient particulate pollution on DNA methylation in Alaskan sled dogs: potential applications for a sentinel model of human health.

  2015cited by this paper
• RecQ helicases and PARP1 team up in maintaining genome integrity.

  2015cited by this paper
• Of drug administration, war and oïkos: mediating cancer with nanomedicines.

  2015cited by this paper
• MicroRNAs as Potential Signatures of Environmental Exposure or Effect: A Systematic Review

  2015cited by this paper
• Effects of Laser Printer–Emitted Engineered Nanoparticles on Cytotoxicity, Chemokine Expression, Reactive Oxygen Species, DNA Methylation, and DNA Damage: A Comprehensive in Vitro Analysis in Human Small Airway Epithelial Cells, Macrophages, and Lymphoblasts

  2015cited by this paper
• Silver nanoparticles cause complications in pregnant mice

  2015cited by this paper
• Cross talk between poly(ADP-ribose) polymerase 1 methylation and oxidative stress involved in the toxic effect of anatase titanium dioxide nanoparticles

  2015cited by this paper
• Epigenetics of Aging

  2015cited by this paper
• Integrated mRNA and micro RNA profiling reveals epigenetic mechanism of differential sensitivity of Jurkat T cells to AgNPs and Ag ions.

  2014cited by this paper
• Non-coding RNAs as direct and indirect modulators of epigenetic regulation

  2014cited by this paper
• Harnessing the potential of lipid-based nanomedicines for type-specific ovarian cancer treatments.

  2014cited by this paper
• Epigenetic effects of nano-sized materials.

  2013cited by this paper
• Metabolic effects of TiO2 nanoparticles, a common component of sunscreens and cosmetics, on human keratinocytes

  2013cited by this paper
• Evolutionary age of repetitive element subfamilies and sensitivity of DNA methylation to airborne pollutants

  2013cited by this paper
• Biophysical regulation of epigenetic state and cell reprogramming.

  2013cited by this paper
• Liver-specific microRNAs as biomarkers of nanomaterial-induced liver damage

  2013cited by this paper
• Transplacental clastogenic and epigenetic effects of gold nanoparticles in mice.

  2013cited by this paper
• Influence of ambient air pollution on global DNA methylation in healthy adults: a seasonal follow-up.

  2013cited by this paper
• Nanoparticle Technology as a Double-Edged Sword: Cytotoxic, Genotoxic and Epigenetic Effects on Living Cells

  2013cited by this paper
• Genetic and Epigenetic Effects of Nanoparticles

  2013cited by this paper
• TET enzymes, TDG and the dynamics of DNA demethylation

  2013cited by this paper
• Novel Mesoporous Hydroxyapatite/Chitosan Composite for Bone Repair

  2012cited by this paper
• Epigenetics and the environment: emerging patterns and implications

  2012cited by this paper
• Methylation of PARP-1 promoter involved in the regulation of nano-SiO2-induced decrease of PARP-1 mRNA expression.

  2012cited by this paper
• Assessment of nanomaterial cytotoxicity with SOLiD sequencing-based microRNA expression profiling.

  2011cited by this paper
• Child health, developmental plasticity, and epigenetic programming.

  2011cited by this paper
• The induction of epigenetic regulation of PROS1 gene in lung fibroblasts by gold nanoparticles and implications for potential lung injury.

  2011cited by this paper
• DNA Methylation and Demethylation in Mammals*

  2011cited by this paper
• Prolonged Exposure to Particulate Pollution, Genes Associated with Glutathione Pathways, and DNA Methylation in a Cohort of Older Men

  2011cited by this paper
• Nanoscale hydroxyapatite particles for bone tissue engineering.

  2011cited by this paper
• SiO(2) nanoparticles induce global genomic hypomethylation in HaCaT cells.

  2010cited by this paper
• Silver nanoparticles disrupt GDNF/Fyn kinase signaling in spermatogonial stem cells.

  2010cited by this paper
• Repetitive element DNA methylation and circulating endothelial and inflammation markers in the VA normative aging study

  2010cited by this paper
• Corrigendum: Targeted and genome-scale strategies reveal gene-body methylation signatures in human cells

  2009cited by this paper
• Targeted and genome-scale methylomics reveals gene body signatures in human cell lines

  2009cited by this paper
• Stem cell differentiation by functionalized micro- and nanostructured surfaces.

  2009cited by this paper
• Quantum dot-induced epigenetic and genotoxic changes in human breast cancer cells

  2008cited by this paper
• CdTe nanoparticles display tropism to core histones and histone-rich cell organelles.

  2008cited by this paper
• The SRA protein Np95 mediates epigenetic inheritance by recruiting Dnmt1 to methylated DNA

  2007cited by this paper
• A simple method for estimating global DNA methylation using bisulfite PCR of repetitive DNA elements.

  2004cited by this paper
• The potential environmental impact of engineered nanomaterials

  2003cited by this paper
• Environmental and Molecular Mutagenesis 52:425^439 (2011) Research Article Pulmonary Response to Surface-Coated Nanotitanium Dioxide Particles Includes Induction of Acute Phase Response Genes, Inflammatory Cascades, and Changes in MicroRNAs: A Toxicogenom

  year unknowncited by this paper
• submit your manuscript | www.dovepress.com

  year unknowncited by this paper

• Green Synthesized Silver Nanoparticles: Genotoxic/Epigenetic Alterations in Human Peripheral Lymphocytes and Cytotoxicity in Human Colon Cell Lines.

  2026cites this paper
• Histone modification changes upon exposure of human lung adenocarcinoma cells to nanoparticles

  2025cites this paper
• Galleria mellonella as a Simple Yet Reliable In Vivo Model for Nanotoxicology: Techniques and Applications

  2025cites this paper
• The potential effects of nanoparticles in gene regulation and expression in mammalian, bacterial and plant cells- A comprehensive review

  2025cites this paper
• The Epigenomic Impact of Quantum Dots: Emerging Biosensors and Potential Disruptors

  2025cites this paper
• Implications of environmental nanoparticles on neurodegeneration

  2024cites this paper
• Mechanistic insights into zinc oxide nanoparticles induced embryotoxicity via H3K9me3 modulation.

  2024cites this paper
• Revealing molecular dynamics of nanoparticles antimicrobial activity, toxicities and cope up strategies

  2024cites this paper
• Investigating the ecological implications of nanomaterials: Unveiling plants' notable responses to nano-pollution.

  2023cites this paper
• Multiple RNA Profiling Reveal Epigenetic Toxicity Effects of Oxidative Stress by Graphene Oxide Silver Nanoparticles in-vitro

  2023cites this paper
• Study of the Embryonic Toxicity of TiO2 and ZrO2 Nanoparticles

  2023cites this paper
• Epigenetic reprogramming of cancer stem cells to tumor cells using ultrasmall gold nanoparticle

  2023cites this paper
• ZnO nanoparticles and SWCNT induced general stress response pathway in HepG2 cells at non-cytotoxic doses revealed by RNA sequencing

  2022cites this paper
• Long Non-Coding RNA Expression Profile Alteration Induced by Titanium Dioxide Nanoparticles in HepG2 Cells

  2022cites this paper
• Dental implant material related changes in molecular signatures in peri-implantitis - A systematic review and integrative analysis of omics in-vitro studies.

  2022cites this paper
• Environmental Implications Associated with the Development of Nanotechnology: From Synthesis to Disposal

  2022cites this paper
• Effect of titanium dioxide nanoparticles on histone modifications and histone modifying enzymes expression in human cell lines

  2022cites this paper
• Proteomic Response of Aedes aegypti Larvae to Silver/Silver Chloride Nanoparticles Synthesized Using Bacillus thuringiensis subsp. israelensis Metabolites

  2022cites this paper
• Particle release from dental implants immediately after placement - An ex vivo comparison of different implant systems.

  2022cites this paper
• Epigenetic Regulation in Exposome-Induced Tumorigenesis: Emerging Roles of ncRNAs

  2022cites this paper
• Nanomaterial-Augmented Formulation of Disinfectants and Antiseptics in Controlling SARS CoV-2

  2022cites this paper
• Nanoparticle-Induced m6A RNA Modification: Detection Methods, Mechanisms and Applications

  2022cites this paper
• CRISPR/Cas9 in epigenetics studies of health and disease.

  2021cites this paper
• MicroRNAs as a Suitable Biomarker to Detect the Effects of Long-Term Exposures to Nanomaterials. Studies on TiO2NP and MWCNT

  2021cites this paper
• Nanomaterials exposure to human

  2021cites this paper
• Epigenetics in toxicology and drug development

  2021cites this paper
• Epigenetic Effects of Nanomaterials and Nanoparticles

  2021cites this paper
• Possible health risks associated with nanostructures in food

  2021cites this paper
• How can exposure to engineered nanomaterials influence our epigenetic code? A review of the mechanisms and molecular targets.

  2021cites this paper
• Cellular Mechanisms Involved in the Combined Toxic Effects of Diesel Exhaust and Metal Oxide Nanoparticles

  2021cites this paper
• Multi-walled carbon nanotubes elicit concordant changes in DNA methylation and gene expression following long-term pulmonary exposure in mice

  2021cites this paper
• Effects of Silver Nanoparticles and Silver Nitrate on mRNA and microRNA Expression in Human Hepatocellular Carcinoma Cells (HepG2).

  2021cites this paper
• Engineered nanoparticle-induced epigenetic changes: An important consideration in nanomedicine.

  2020cites this paper
• No genome-wide DNA methylation changes found associated with medium-term reduced graphene oxide exposure in human lung epithelial cells

  2020cites this paper
• Les hautes dilutions homéopathiques vues par la physique : arguments en faveur d’une nanomédecine

  2020cites this paper
• Preclinical Evaluation of Antimicrobial Nanodrugs

  2020cites this paper
• In Vitro Nanotoxicity: Toward the Development of Safe and Effective Treatments

  2020cites this paper
• Characteristics of iron status, oxidation response, and DNA methylation profile in response to occupational iron oxide nanoparticles exposure

  2020cites this paper
• The genotoxic effects in the leukocytes of workers handling nanocomposite materials.

  2020cites this paper
• Particle release from implantoplasty of dental implants and impact on cells

  2020cites this paper
• Induction of Innate Immune Memory by Engineered Nanoparticles in Monocytes/Macrophages: From Hypothesis to Reality

  2020cites this paper
• Industrially produced PET nanocomposites with enhaced properties for food packaging applications

  2020cites this paper
• The Cytotoxicity of Metal Nanoparticles Depends on Their Synergistic Interactions

  2020cites this paper
• Effect of Silver Nanoparticles (AgNPs) Exposure on microRNA Expression and Global DNA Methylation in Endothelial Cells EA.hy926.

  2020cites this paper
• Silver Nanoparticles Induce DNA Hypomethylation through Proteasome-Mediated Degradation of DNA Methyltransferase 1.

  2020cites this paper
• Safe Nanoparticles: Are We There Yet?

  2020cites this paper
• Silver, Gold, and Iron Oxide Nanoparticles Alter miRNA Expression but Do Not Affect DNA Methylation in HepG2 Cells

  2019cites this paper
• Common Gene Expression Patterns in Environmental Model Organisms Exposed to Engineered Nanomaterials: A Meta-Analysis

  2019cites this paper
• Comprehensive In Vitro Testing of Calcium Phosphate-Based Bioceramics with Orthopedic and Dentistry Applications

  2019cites this paper
• Bio-Inspired Silver Nanoparticles Impose Metabolic and Epigenetic Toxicity to Saccharomyces cerevisiae

  2019cites this paper
• Silver nanoparticles alter epithelial basement membrane integrity, cell adhesion molecule expression, and TGF-β1 secretion.

  2019cites this paper
• N-acetylcysteine reverses the decrease of DNA methylation status caused by engineered gold, silicon, and chitosan nanoparticles

  2019cites this paper
• The repeated cytogenetic analysis of subjects occupationally exposed to nanoparticles: a pilot study.

  2019cites this paper
• Epigenetics in cancer therapy and nanomedicine

  2019cites this paper
• Adverse Effects of Fine-Particle Exposure on Joints and Their Surrounding Cells and Microenvironment.

  2019cites this paper
• Impact of nanoparticles on the Bacillus subtilis (3610) competence

  2018cites this paper
• Interaction of engineered nanomaterials with the immune system: Health-related safety and possible benefits

  2018cites this paper
• Towards a Rational Insight into the Paradox of Homeopathy

  2018cites this paper
• Regulation of cellular gene expression by nanomaterials

  2018cites this paper
• Towards the development of a high throughput screening approach for Mytilus edulis hemocytes: A case study on silicon-based nanomaterials.

  2018cites this paper
• Evaluation of immunoresponses and cytotoxicity from skin exposure to metallic nanoparticles

  2018cites this paper
• Toxicological status of nanoparticles: What we know and what we don't know.

  2018cites this paper
• The current understanding of the interactions between nanoparticles and cytochrome P450 enzymes – a literature-based review

  2018cites this paper
• Biological monitoring of workers exposed to engineered nanomaterials.

  2018cites this paper
• Could the Olfactory System Be a Target for Homeopathic Remedies as Nanomedicines?

  2018cites this paper
• Toxicological assessment of nanomaterials: the role of in vitro Raman microspectroscopic analysis

  2018cites this paper
• Clavanin A-bioconjugated Fe3O4/Silane core-shell nanoparticles for thermal ablation of bacterial biofilms.

  2018cites this paper
• Advancing Vibrational Spectroscopy for Cellular and Sub Cellular Analysis: Raman Spectroscopy as a Novel In Vitro Nanotoxicological Assessment Protocol

  2017cites this paper
• In vitro studies of nanosilver-doped titanium implants for oral and maxillofacial surgery

  2017cites this paper
• Label-free, high content screening using Raman microspectroscopy: the toxicological response of different cell lines to amine-modified polystyrene nanoparticles (PS-NH2).

  2017cites this paper
• Safety issues associated with the use of nanoparticles in human body.

  2017cites this paper
• Induction of Innate Immune Memory by Engineered Nanoparticles: A Hypothesis That May Become True

  2017cites this paper
• Nanoparticles and innate immunity: new perspectives on host defence.

  2017cites this paper
• DNA Methylation and the Potential Role of Methyl-Containing Nutrients in Cardiovascular Diseases

  2017cites this paper
• Determination of spectral markers of cytotoxicity and genotoxicity using in vitro Raman microspectroscopy: cellular responses to polyamidoamine dendrimer exposure.

  2017cites this paper
• A Tox21 Approach to Altered Epigenetic Landscapes: Assessing Epigenetic Toxicity Pathways Leading to Altered Gene Expression and Oncogenic Transformation In Vitro

  2017cites this paper
• DNA methylation changes in human lung epithelia cells exposed to multi-walled carbon nanotubes

  2017cites this paper
• Nanomedicine and epigenome. Possible health risks.

  2017cites this paper