Injectable peramivir mitigates disease and promotes survival in ferrets and mice infected with the highly virulent influenza virus, A/Vietnam/1203/04 (H5N1).

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Virology

• Publication date

  2008-04-25

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1016/j.virol.2007.12.029PMID 18234269PMCID PMC2680697
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Avian Influenza Virus (H5N1): a Threat to Human Health

  2007cited by this paper
• Avian and pandemic influenza: an overview.

  2007cited by this paper
• Review of human infections with avian influenza H5N1 and proposed local clinical management guideline.

  2007cited by this paper
• The threat of avian influenza A (H5N1). Part I: epidemiologic concerns and virulence determinants

  2007cited by this paper
• Susceptibility of highly pathogenic A(H5N1) avian influenza viruses to the neuraminidase inhibitors and adamantanes.

  2007influential reference
• Efficacy of Oseltamivir Therapy in Ferrets Inoculated with Different Clades of H5N1 Influenza Virus

  2007influential reference
• Characterization of drug-resistant recombinant influenza A/H1N1 viruses selected in vitro with peramivir and zanamivir.

  2007cited by this paper
• The threat of avian influenza A (H5N1). Part III: antiviral therapy

  2007cited by this paper
• Host Species Barriers to Influenza Virus Infections

  2006cited by this paper
• H5N1 Virus Attachment to Lower Respiratory Tract

  2006cited by this paper
• Host Range Restriction and Pathogenicity in the Context of Influenza Pandemic

  2006cited by this paper
• Ferrets and the challenges of H5N1 vaccine formulation.

  2006cited by this paper
• Antigenic and genetic characteristics of H5N1 viruses and candidate H5N1 vaccine viruses developed for potential use as pre-pandemic vaccines.

  2006cited by this paper
• Epidemiology of WHO-confirmed human cases of avian influenza A(H5N1) infection.

  2006cited by this paper
• Feline friend or potential foe?

  2006cited by this paper
• Pandemic influenza: clinical issues

  2006cited by this paper
• Resistance to anti-influenza drugs: adamantanes and neuraminidase inhibitors

  2006influential reference
• Wild Birds Only Partly to Blame in Spreading H5N1

  2006cited by this paper
• Anti-influenza virus activity of peramivir in mice with single intramuscular injection.

  2006cited by this paper
• Influenza and the pandemic threat.

  2006cited by this paper
• Antivirals for influenza in healthy adults: systematic review.

  2006cited by this paper
• Oseltamivir resistance during treatment of influenza A (H5N1) infection.

  2005cited by this paper
• Avian flu: Isolation of drug-resistant H5N1 virus

  2005cited by this paper
• Avian Influenza (H5N1) Viruses Isolated from Humans in Asia in 2004 Exhibit Increased Virulence in Mammals

  2005influential reference
• Cell-based protein vaccines for influenza.

  2005cited by this paper
• Immunopathology and Infectious Diseases Influenza A Virus ( H 5 N 1 ) Infection in Cats Causes Systemic Disease with Potential Novel Routes of Virus Spread within and between Hosts

  2005cited by this paper
• Characterization of a Human H5N1 Influenza A Virus Isolated in 2003

  2005cited by this paper
• Lethality to Ferrets of H5N1 Influenza Viruses Isolated from Humans and Poultry in 2004

  2005cited by this paper
• Virulence may determine the necessary duration and dosage of oseltamivir treatment for highly pathogenic A/Vietnam/1203/04 influenza virus in mice.

  2005influential reference
• Fatal avian influenza A (H5N1) in a child presenting with diarrhea followed by coma.

  2005cited by this paper
• Efficacy and Tolerability of the Oral Neuraminidase Inhibitor Peramivir in Experimental Human Influenza: Randomized, Controlled Trials for Prophylaxis and Treatment

  2005cited by this paper
• Avian influenza A (H5N1) infection in humans.

  2005influential reference
• Avian H5N1 Influenza in Cats

  2004cited by this paper
• Confronting the avian influenza threat: vaccine development for a potential pandemic

  2004cited by this paper
• Reemerging H5N1 Influenza Viruses in Hong Kong in 2002 Are Highly Pathogenic to Ducks

  2004cited by this paper
• Investigation of outbreaks of highly pathogenic H5N1 avian influenza in waterfowl and wild birds in Hong Kong in late 2002

  2004cited by this paper
• Susceptibility of human influenza viruses from Australasia and South East Asia to the neuraminidase inhibitors zanamivir and oseltamivir.

  2004cited by this paper
• The Ferret: An Animal Model to Study Influenza Virus

  2004cited by this paper
• The annual production cycle for influenza vaccine.

  2003cited by this paper
• Pathology of Human Influenza A (H5N1) Virus Infection in Cynomolgus Macaques (Macaca fascicularis)

  2003cited by this paper
• Neurological Manifestations of Avian Influenza Viruses in Mammals

  2003influential reference
• Neurovirulence in Mice of H5N1 Influenza Virus Genotypes Isolated from Hong Kong Poultry in 2001

  2003cited by this paper
• Mechanisms of Pathogenicity of Influenza A (H5N1) Viruses in Mice

  2003influential reference
• Pathogenesis of Avian Influenza A (H5N1) Viruses in Ferrets

  2002influential reference
• WHO Manual on Animal Influenza Diagnosis and Surveillance

  2002cited by this paper
• Characterization of 2 influenza A(H3N2) clinical isolates with reduced susceptibility to neuraminidase inhibitors due to mutations in the hemagglutinin gene.

  2002cited by this paper
• In vivo influenza virus-inhibitory effects of the cyclopentaneneuraminidase inhibitor RJW-270201

  2001cited by this paper
• Comparison of Efficacies of RWJ-270201, Zanamivir, and Oseltamivir against H5N1, H9N2, and Other Avian Influenza Viruses

  2001influential reference
• Cyclopentane Neuraminidase Inhibitors with Potent In Vitro Anti-Influenza Virus Activities

  2001cited by this paper
• In Vivo Influenza Virus-Inhibitory Effects of the Cyclopentane Neuraminidase Inhibitor RWJ-270201

  2001cited by this paper
• Pharmacodynamic Evaluation of RWJ-270201, a Novel Neuraminidase Inhibitor, in a Lethal Murine Model of Influenza Predicts Efficacy for Once-Daily Dosing

  2001cited by this paper
• Comparison of the Anti-Influenza Virus Activity of RWJ-270201 with Those of Oseltamivir and Zanamivir

  2001cited by this paper
• Avian influenza viruses infecting humans

  2000cited by this paper
• RWJ-270201 BioCryst Pharmaceuticals/Johnson & Johnson.

  2000cited by this paper
• The neuraminidase inhibitor GS4104 (oseltamivir phosphate) is efficacious against A/Hong Kong/156/97 (H5N1) and A/Hong Kong/1074/99 (H9N2) influenza viruses.

  2000cited by this paper
• In vitro and in vivo assay systems for study of influenza virus inhibitors.

  2000cited by this paper
• Distinct Pathogenesis of Hong Kong-Origin H5N1 Viruses in Mice Compared to That of Other Highly Pathogenic H5 Avian Influenza Viruses

  2000influential reference
• Influenza virus neuraminidase inhibitors.

  2000cited by this paper
• BCX-1812 (RWJ-270201): discovery of a novel, highly potent, orally active, and selective influenza neuraminidase inhibitor through structure-based drug design.

  2000cited by this paper
• Pathogenesis of and immunity to avian influenza A H5 viruses.

  2000cited by this paper
• A Mouse Model for the Evaluation of Pathogenesis and Immunity to Influenza A (H5N1) Viruses Isolated from Humans

  1999cited by this paper
• Biological Heterogeneity, Including Systemic Replication in Mice, of H5N1 Influenza A Virus Isolates from Humans in Hong Kong

  1999influential reference
• Oral Administration of a Prodrug of the Influenza Virus Neuraminidase Inhibitor GS 4071 Protects Mice and Ferrets against Influenza Infection

  1998cited by this paper
• Influenza neuraminidase inhibitors possessing a novel hydrophobic interaction in the enzyme active site: design, synthesis, and structural analysis of carbocyclic sialic acid analogues with potent anti-influenza activity.

  1997cited by this paper
• In £ uenza : interspecies transmission and emergence of new pandemics

  1997cited by this paper
• Severity of fever in influenza: differential pyrogenicity in ferrets exhibited by H1N1 and H3N2 strains of differing virulence.

  1986cited by this paper
• Severity of fever in influenza: studies on the relation between viral surface antigens, pyrexia, level of nasal virus and inflammatory response in the ferret.

  1985cited by this paper

• Antivirals for Novel Influenza A Virus Infections.

  2025cites this paper
• The Synergistic Effect of Baloxavir and Neuraminidase Inhibitors against Influenza Viruses In Vitro

  2024cites this paper
• Influenza antivirals and animal models

  2022cites this paper
• Evaluation of Baloxavir Marboxil and Peramivir for the Treatment of High Pathogenicity Avian Influenza in Chickens

  2020cites this paper
• Infection and Drug Resistance Dovepress

  2019cites this paper
• Central nervous system laboratory-confirmed influenza meningo-encephalitis treated with peramivir.

  2018cites this paper
• Systemic and mucosal humoral immune responses induced by the JY-adjuvanted nasal spray H7N9 vaccine in mice

  2018cites this paper
• Peramivir: A Review in Uncomplicated Influenza

  2018cites this paper
• 9 Ferret TNF-α and IFN-γ Immunoassays Alyson

  2018cites this paper
• Animal models used to assess influenza antivirals

  2018cites this paper
• Pathogenicity and peramivir efficacy in immunocompromised murine models of influenza B virus infection

  2017cites this paper
• Therapeutic efficacy of peramivir against H5N1 highly pathogenic avian influenza viruses harboring the neuraminidase H275Y mutation

  2017cites this paper
• Using the Ferret as an Animal Model for Investigating Influenza Antiviral Effectiveness

  2016cites this paper
• Efficacy of a specific polyclonal equine F(ab')2 against avian influenza (H5N1) in ferrets: synergy with oseltamivir.

  2016cites this paper
• Peramivir: A Novel Intravenous Neuraminidase Inhibitor for Treatment of Acute Influenza Infections

  2016cites this paper
• In Vitro Evaluation of Absorption Characteristics of Peramivir for Oral Delivery

  2016cites this paper
• The Effect of Intravenous Peramivir, Compared with Oral Oseltamivir, on the Outcome of Post-Influenza Pneumococcal Pneumonia in Mice

  2015cites this paper
• Peramivir: an intravenous neuraminidase inhibitor

  2015influential citation
• Introduce Indian gray mongoose (Herpestes edwardsii): as a successful animal model for influenza virus infection (a preliminary study)

  2015cites this paper
• Mechanisms of resistance to neuraminidase inhibitors in influenza A viruses and evaluation of combined antiviral therapy

  2015cites this paper
• 3 Guangdong Provincial Key Laboratory of Infectious Diseases and Molecular Immunopathology

  2015cites this paper
• Assessment of Antiviral Properties of Peramivir against H7N9 Avian Influenza Virus in an Experimental Mouse Model

  2015cites this paper
• Modeling human influenza infection in the laboratory

  2015cites this paper
• Combination Effects of Peramivir and Favipiravir against Oseltamivir-Resistant 2009 Pandemic Influenza A(H1N1) Infection in Mice

  2014cites this paper
• Preclinical Activity of VX-787, a First-in-Class, Orally Bioavailable Inhibitor of the Influenza Virus Polymerase PB2 Subunit

  2014cites this paper
• Efficacy of Repeated Intravenous Administration of Peramivir against Highly Pathogenic Avian Influenza A (H5N1) Virus in Cynomolgus Macaques

  2014cites this paper
• A Review of the Antiviral Susceptibility of Human and Avian Influenza Viruses over the Last Decade

  2014cites this paper
• Viral Diseases of Ferrets

  2014cites this paper
• DBA/2 mouse as an animal model for anti-influenza drug efficacy evaluation

  2013cites this paper
• Drugs to cure avian influenza infection – multiple ways to prevent cell death

  2013cites this paper
• Influenza virus resistance to neuraminidase inhibitors.

  2013cites this paper
• Clinical Experience with Influenza Virus Sialidase Inhibitors

  2012cites this paper
• Multiple routes of invasion of wild-type Clade 1 highly pathogenic avian influenza H5N1 virus into the central nervous system (CNS) after intranasal exposure in ferrets

  2012cites this paper
• Combinations of favipiravir and peramivir for the treatment of pandemic influenza A/California/04/2009 (H1N1) virus infections in mice.

  2012cites this paper
• Ferret TNF-α and IFN-γ Immunoassays

  2012cites this paper
• Cloned Defective Interfering Influenza Virus Protects Ferrets from Pandemic 2009 Influenza A Virus and Allows Protective Immunity to Be Established

  2012cites this paper
• The current state of H5N1 vaccines and the use of the ferret model for influenza therapeutic and prophylactic development.

  2012cites this paper
• Therapeutic Activity of Intramuscular Peramivir in Mice Infected with a Recombinant Influenza A/WSN/33 (H1N1) Virus Containing the H275Y Neuraminidase Mutation

  2012cites this paper
• Neuropathology of H5N1 virus infection in ferrets.

  2012cites this paper
• Peramivir for the treatment of influenza

  2012cites this paper
• Élaboration de nouvelles stratégies thérapeutiques à l'encontre du virus de la grippe

  2011cites this paper
• The medicinal potential of influenza virus surface proteins: hemagglutinin and neuraminidase.

  2011cites this paper
• Prevention of influenza virus shedding and protection from lethal H1N1 challenge using a consensus 2009 H1N1 HA and NA adenovirus vector vaccine.

  2011cites this paper
• Antiviral agents for the treatment and chemoprophylaxis of influenza --- recommendations of the Advisory Committee on Immunization Practices (ACIP).

  2011cites this paper
• A single intramuscular injection of neuraminidase inhibitor peramivir demonstrates antiviral activity against novel pandemic A/California/04/2009 (H1N1) influenza virus infection in mice.

  2011cites this paper
• Efficacy of Single Intravenous Injection of Peramivir against Influenza B Virus Infection in Ferrets and Cynomolgus Macaques (cid:1)

  2011cites this paper
• Efficacy of Single Intravenous Injection of Peramivir against Influenza B Virus Infection in Ferrets and Cynomolgus Macaques

  2011cites this paper
• Other antiviral agents

  2011cites this paper
• Neuraminidase inhibitors for treatment of human and avian strain influenza: A comparative modeling study.

  2011cites this paper
• Peramivir: A New Drug for Influenza

  2011cites this paper
• The next ten stories on antiviral drug discovery (part E): advents, advances, and adventures.

  2011cites this paper
• 1. New Anti-influenza Drugs

  2010cites this paper
• Drugs in Development for Influenza

  2010cites this paper
• Molecular simulation study of the binding mechanism of [α-PTi2W10O40]7− for its promising broad-spectrum inhibitory activity to FluV-A neuraminidase

  2010cites this paper
• Comprehensive assessment of 2009 Pandemic Influenza a (H1N1) Virus Drug Susceptibility in vitro

  2010cites this paper
• The next ten stories on antiviral drug discovery (part E): advents, advances, and adventures

  2010cites this paper
• Influenza pathogenesis: lessons learned from animal studies with H5N1, H1N1 Spanish, and pandemic H1N1 2009 influenza.

  2010cites this paper
• Animal Models for Influenza Virus Pathogenesis and Transmission

  2010cites this paper
• Combinations of oseltamivir and peramivir for the treatment of influenza A (H1N1) virus infections in cell culture and in mice.

  2010cites this paper
• Prophylactic Activity of Intramuscular Peramivir in Mice Infected with a Recombinant Influenza A/WSN/33 (H1N1) Virus Containing the H274Y Neuraminidase Mutation

  2010cites this paper
• Efficacy and Safety of Intravenous Peramivir for Treatment of Seasonal Influenza Virus Infection

  2010cites this paper
• Peramivir and its use in H1N1 influenza.

  2010cites this paper
• Antiviral Resistance in Influenza Viruses: Clinical and Epidemiological Aspects

  2009cites this paper
• Animal models for the study of influenza pathogenesis and therapy

  2009cites this paper
• T-705 (favipiravir) activity against lethal H5N1 influenza A viruses

  2009cites this paper
• Quantification of peramivir (a novel anti-influenza drug) in human plasma by hydrophilic interaction chromatography/tandem mass spectrometry.

  2009cites this paper
• Superior efficacy of a recombinant flagellin:H5N1 HA globular head vaccine is determined by the placement of the globular head within flagellin.

  2009cites this paper
• Mechanisms of the action of povidone-iodine against human and avian influenza A viruses: its effects on hemagglutination and sialidase activities

  2009cites this paper
• Evaluation of Recombinant Influenza Virus-Simian Immunodeficiency Virus Vaccines in Macaques

  2009cites this paper
• Antiviral therapy in patients with hematologic malignancies, transplantation, and aplastic anemia.

  2009cites this paper
• Influenza Virus Antiviral Targets

  2009cites this paper
• Efficacy of the novel parainfluenza virus haemagglutinin-neuraminidase inhibitor BCX 2798 in mice – further evaluation

  2009cites this paper
• Developing new antiviral agents for influenza treatment: what does the future hold?

  2009cites this paper
• Emerging antiviral drugs

  2008cites this paper
• Intramuscularly administered neuraminidase inhibitor peramivir is effective against lethal H5N1 influenza virus in mice.

  2008cites this paper
• Novel linear DNA vaccines induce protective immune responses against lethal infection with influenza virus type A/H5N1

  2008cites this paper