Dynamic metabolic flux analysis using a convex analysis approach: Application to hybridoma cell cultures in perfusion

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Biotechnology and Bioengineering

• Publication date

  2016-05-01

• Fields of study

  Medicine, Mathematics, Engineering

• Identifiers
  DOI 10.1002/bit.25879PMID 26551676
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Metabolic Engineering Principles And Methodologies

  2016cited by this paper
• Methods and advances in metabolic flux analysis: a mini-review

  2015cited by this paper
• Dynamic estimation of specific fluxes in metabolic networks using non-linear dynamic optimization

  2014cited by this paper
• Analyzing Clonal Variation of Monoclonal Antibody-Producing CHO Cell Lines Using an In Silico Metabolomic Platform

  2014cited by this paper
• Dynamic metabolic flux analysis--tools for probing transient states of metabolic networks.

  2013cited by this paper
• Metabolic Pathway Analysis and Reduction for Mammalian Cell Cultures-Towards Macroscopic Modeling

  2013influential reference
• Macroscopic modelling of overflow metabolism and model based optimization of hybridoma cell fed-batch cultures

  2013cited by this paper
• Dynamic estimations of metabolic fluxes with constraint-based models and possibility theory

  2012cited by this paper
• Marketed therapeutic antibodies compendium

  2012cited by this paper
• Metabolic Flux Analysis of CHO cell cultures

  2012cited by this paper
• Metabolic flux analysis in systems biology of mammalian cells.

  2012cited by this paper
• 13C metabolic flux analysis in complex systems.

  2011cited by this paper
• Dynamic metabolic flux analysis (DMFA): a framework for determining fluxes at metabolic non-steady state.

  2011cited by this paper
• Dynamic model of CHO cell metabolism.

  2011influential reference
• Quantitative characterization of metabolism and metabolic shifts during growth of the new human cell line AGE1.HN using time resolved metabolic flux analysis

  2010cited by this paper
• A detailed metabolic flux analysis of an underdetermined network of CHO cells.

  2010cited by this paper
• Cell culture processes for monoclonal antibody production

  2010cited by this paper
• Dynamic Metabolic Flux Analysis Demonstrated on Cultures Where the Limiting Substrate Is Changed from Carbon to Nitrogen and Vice Versa

  2010cited by this paper
• Metabolic flux-based modeling of mAb production during batch and fed-batch operations

  2009cited by this paper
• Elucidation of metabolism in hybridoma cells grown in fed‐batch culture by genome‐scale modeling

  2009cited by this paper
• An elementary metabolite unit (EMU) based method of isotopically nonstationary flux analysis

  2008cited by this paper
• Comparison of Metabolic Flux Distributions for MDCK Cell Growth in Glutamine‐ and Pyruvate‐Containing Media

  2008cited by this paper
• Metabolic flux analysis in a nonstationary system: fed-batch fermentation of a high yielding strain of E. coli producing 1,3-propanediol.

  2007cited by this paper
• Dynamic Metabolic Modeling for a MAB Bioprocess

  2007cited by this paper
• Metabolic flux analysis at ultra short time scale: isotopically non-stationary 13C labeling experiments.

  2007cited by this paper
• Metabolic design of dynamic bioreaction models

  2006cited by this paper
• Metabolic flux analysis of HEK-293 cells in perfusion cultures for the production of adenoviral vectors.

  2005cited by this paper
• Production of recombinant protein therapeutics in cultivated mammalian cells

  2004cited by this paper
• Understanding AIC and BIC in Model Selection

  2004cited by this paper
• Use of on-line gas analysis to monitor recombinant mammalian cell cultures

  2004cited by this paper
• Dynamic metabolic modelling under the balanced growth condition

  2004cited by this paper
• Analysis of cellular metabolism of hybridoma cells at distinct physiological states.

  2003cited by this paper
• Determination of dissolved CO(2) concentration and CO(2) production rate of mammalian cell suspension culture based on off-gas measurement.

  2002cited by this paper
• Dynamic flux balance analysis of diauxic growth in Escherichia coli.

  2002cited by this paper
• Industrial choices for protein production by large-scale cell culture.

  2001cited by this paper
• METATOOL: for studying metabolic networks

  1999cited by this paper
• Estimation of the intracellular fluxes for a hybridoma cell line by material balances

  1998cited by this paper
• CHAPTER 1 – The Essence of Metabolic Engineering

  1998cited by this paper
• Identification of key patterns in the metabolism of hybridoma cells in culture

  1997cited by this paper
• Metabolic flux analysis of hybridoma cells in different culture media using mass balances

  1996cited by this paper

• A Constructive Bottom-up Approach for the Elaboration of Metabolic Networks: Case Study of Photosynthetic Cyanobacteria Arthrospira Spirulina Platensis PCC 8005

  2025cites this paper
• Mathematical Modeling of Photosynthetic Eukaryotic Microorganisms Using Metabolic Networks

  2025cites this paper
• Metabolic Modeling of Arthrospira sp. PCC 8005 - Network Definition and Experimental Validation

  2025cites this paper
• A real-time Oxygen Uptake Rate monitoring approach suitable for the antibody production process

  2024cites this paper
• Practical data-driven modeling and robust predictive control of mammalian cell fed-batch process

  2023cites this paper
• A genome-scale dynamic constraint-based modelling (gDCBM) framework predicts growth dynamics, medium composition and intracellular flux distributions in CHO clonal variations.

  2023cites this paper
• Hybrid Dynamic Models of Bioprocesses Based on Elementary Flux Modes and Multilayer Perceptrons

  2022cites this paper
• Metabolic Reaction Network-Based Model Predictive Control of Bioprocesses

  2021cites this paper
• Selection of a Minimal Suboptimal Set of EFMs for Dynamic Metabolic Modelling

  2021cites this paper
• A new strategy for dynamic metabolic flux estimation by integrating transient metabolome data into genome-scale metabolic models

  2021cites this paper
• How to Tackle Underdeterminacy in Metabolic Flux Analysis? A Tutorial and Critical Review

  2021cites this paper
• Metabolic Flux Analysis of VERO Cells under Various Culture Conditions

  2021cites this paper
• Control of Continuous Manufacturing Processes for Production of Monoclonal Antibodies

  2021cites this paper
• Microbial Growth Dynamics

  2019cites this paper
• Determining a unique solution to underdetermined metabolic networks via a systematic path through the Most Accurate Fluxes

  2019influential citation
• Dynamic flux balance analysis for predicting biomass growth and ethanol production in yeast fed-batch cultures

  2018cites this paper
• Quantitative intracellular flux modeling and applications in biotherapeutic development and production using CHO cell cultures

  2017cites this paper
• Metabolomics and Dynamic Metabolic Flux Analysis in ABE (Acetone-Butanol-Ethanol) Fermentation

  2017cites this paper
• Dyna ic etabolic flux analysis of underdeter ined and ove deter ined etabolic networks

  2017cites this paper
• Dynamic metabolic flux analysis of underdetermined and overdetermined metabolic networks

  2016cites this paper