Ferulic Acid Inhibits the Transition of Amyloid-β42 Monomers to Oligomers but Accelerates the Transition from Oligomers to Fibrils

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Journal of Alzheimer's Disease

• Publication date

  2013-08-20

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.3233/JAD-130164PMID 23727899
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• C-terminal turn stability determines assembly differences between Aβ40 and Aβ42.

  2013cited by this paper
• Protective effects of ferulic acid in amyloid precursor protein plus presenilin-1 transgenic mouse model of Alzheimer disease.

  2013cited by this paper
• Alzheimer mechanisms and therapeutic strategies.

  2012cited by this paper
• Alzheimer's disease.

  2011cited by this paper
• Biflavonoids are superior to monoflavonoids in inhibiting amyloid-β toxicity and fibrillogenesis via accumulation of nontoxic oligomer-like structures.

  2011cited by this paper
• Effect of curcumin-associated and lipid ligand-functionalized nanoliposomes on aggregation of the Alzheimer's Aβ peptide.

  2011cited by this paper
• Tramiprosate in mild-to-moderate Alzheimer’s disease – a randomized, double-blind, placebo-controlled, multi-centre study (the Alphase Study)

  2011cited by this paper
• Specific and efficient anti-Aβ42 antibodies induced by sixteen tandem repeats of Aβ9.

  2010cited by this paper
• α-Tocopherol quinone inhibits β-amyloid aggregation and cytotoxicity, disaggregates preformed fibrils and decreases the production of reactive oxygen species, NO and inflammatory cytokines.

  2010cited by this paper
• 9,10‐Anthraquinone hinders β‐aggregation: How does a small molecule interfere with Aβ‐peptide amyloid fibrillation?

  2009cited by this paper
• Silibinin prevents amyloid β peptide‐induced memory impairment and oxidative stress in mice

  2009cited by this paper
• Ellagic acid promotes Abeta42 fibrillization and inhibits Abeta42-induced neurotoxicity.

  2009cited by this paper
• In vitro and in vivo antioxidant properties of ferulic acid: a comparative study with other natural oxidation inhibitors.

  2009cited by this paper
• Salvianolic acid B inhibits Abeta fibril formation and disaggregates preformed fibrils and protects against Abeta-induced cytotoxicty.

  2008cited by this paper
• Molecular structural basis for polymorphism in Alzheimer's β-amyloid fibrils

  2008cited by this paper
• Conversion of non-fibrillar beta-sheet oligomers into amyloid fibrils in Alzheimer's disease amyloid peptide aggregation.

  2007cited by this paper
• Targeting soluble Aβ peptide with Tramiprosate for the treatment of brain amyloidosis

  2007cited by this paper
• Methylene blue inhibits amyloid Abeta oligomerization by promoting fibrillization.

  2007cited by this paper
• Hydrophobic cooperativity as a mechanism for amyloid nucleation.

  2007cited by this paper
• Aβ Oligomers – a decade of discovery

  2007cited by this paper
• Generation of superoxide and singlet oxygen from alpha-tocopherolquinone and analogues.

  2007cited by this paper
• Soluble protein oligomers as emerging toxins in alzheimer's and other amyloid diseases

  2007cited by this paper
• Inhibition of Amyloid Fibril Formation by Polyphenols: Structural Similarity and Aromatic Interactions as a Common Inhibition Mechanism

  2006cited by this paper
• The ups and downs of Abeta.

  2006cited by this paper
• High-resolution atomic force microscopy of soluble Abeta42 oligomers.

  2006cited by this paper
• The ups and downs of Aβ

  2006cited by this paper
• Molecular structure of amyloid fibrils: insights from solid-state NMR

  2006cited by this paper
• Ferulic acid, a natural protector against carbon tetrachloride‐induced toxicity

  2005cited by this paper
• Curcumin Inhibits Formation of Amyloid β Oligomers and Fibrils, Binds Plaques, and Reduces Amyloid in Vivo*

  2005cited by this paper
• Ferulic acid ethyl ester protects neurons against amyloid β‐ peptide(1–42)‐induced oxidative stress and neurotoxicity: relationship to antioxidant activity

  2005cited by this paper
• Ferulic acid destabilizes preformed beta-amyloid fibrils in vitro.

  2005cited by this paper
• Analysis of the secondary structure of beta-amyloid (Abeta42) fibrils by systematic proline replacement.

  2004cited by this paper
• Curcumin has potent anti‐amyloidogenic effects for Alzheimer's β‐amyloid fibrils in vitro

  2004cited by this paper
• Analysis of the Secondary Structure of (cid:1) -Amyloid (A (cid:1) 42) Fibrils by Systematic Proline Replacement*

  2004cited by this paper
• Kinetic studies of amyloid beta-protein fibril assembly. Differential effects of alpha-helix stabilization.

  2002cited by this paper
• FA15, a hydrophobic derivative of ferulic acid, suppresses inflammatory responses and skin tumor promotion: comparison with ferulic acid.

  2002cited by this paper
• Ferulic acid antioxidant protection against hydroxyl and peroxyl radical oxidation in synaptosomal and neuronal cell culture systems in vitro: structure-activity studies.

  2002cited by this paper
• Protection against β‐amyloid peptide toxicity in vivo with long‐term administration of ferulic acid

  2001cited by this paper
• Approaches to discovery and characterization of inhibitors of amyloid beta-peptide polymerization.

  2000cited by this paper

• Plant-Based Inhibitors of Protein Aggregation

  2025cites this paper
• Alzheimer’s Disease, β-Amyloid Peptides, and Ubiquitin-Proteasome System: Nutritherapeutic Insights

  2025cites this paper
• Unlocking ferulic acid for neurological diseases and tailoring of nanoformulations to advance its brain delivery.

  2025cites this paper
• Integrating molecular imaging with near-infrared theranostics to improve early detection and therapy of Alzheimer's disease.

  2025cites this paper
• Unravelling Anti-Glycation, Anti-Amyloid, Anti-Inflammatory, and Antioxidant Properties of Selected Medicinal Plant Extracts: A Multifaceted Novel Anti-Aging Approach

  2025cites this paper
• Development of dietary small molecules as multi-targeting treatment strategies for Alzheimer's disease

  2024cites this paper
• Natural polyphenol: Their pathogenesis-targeting therapeutic potential in Alzheimer's disease.

  2024cites this paper
• Diet–gut microbiome interaction and ferulic acid bioavailability: implications on neurodegenerative disorders

  2023cites this paper
• Cellular Stress Response (Hormesis) in Response to Bioactive Nutraceuticals with Relevance to Alzheimer Disease

  2023cites this paper
• Natural Compounds as Inhibitors of Aβ Peptide and Tau Aggregation.

  2023cites this paper
• Synergetic effect of matrine on the catalytic scFv antibody HS72 in vitro and in mice with Alzheimer disease pathology.

  2023cites this paper
• [Alzheimer's disease, amyloid-b peptides and ubiquitin-proteasome system: Therapeutic perspectives].

  2023cites this paper
• The Use of Bioactive Compounds in Hyperglycemia- and Amyloid Fibrils-Induced Toxicity in Type 2 Diabetes and Alzheimer’s Disease

  2022cites this paper
• Neuroprotective properties of Ferulic acid in preclinical models of Alzheimer's disease: A systematic literature review.

  2022cites this paper
• Plant Terpenoids as the Promising Source of Cholinesterase Inhibitors for Anti-AD Therapy

  2022cites this paper
• Small phenolic and indolic gut-dependent molecules in the primate central nervous system: levels vs. bioactivity

  2022cites this paper
• Destabilization of the Alzheimer's amyloid-β protofibrils by THC: A molecular dynamics simulation study.

  2021cites this paper
• A Review on Potential Footprints of Ferulic Acid for Treatment of Neurological Disorders

  2021cites this paper
• High-throughput screening for amyloid-β binding natural small-molecules based on the combinational use of biolayer interferometry and UHPLC−DAD-Q/TOF-MS/MS

  2021cites this paper
• Amyloid β fibrils disruption by kolaviron: Molecular docking and extended molecular dynamics simulation studies

  2021cites this paper
• Valorization of Apple Peels through the Study of the Effects on the Amyloid Aggregation Process of κ-Casein

  2021cites this paper
• Antioxidant ferulic acid prevents the aggregation of bovine β-lactoglobulin in vitro

  2020cites this paper
• Oral administration of ferulic acid or ethyl ferulate attenuates retinal damage in sodium iodate-induced retinal degeneration mice

  2020cites this paper
• Ferulic acid delayed amyloid β-induced pathological symptoms by autophagy pathway via a fasting-like effect in Caenorhabditis elegans.

  2020cites this paper
• Lipophilic ferulic acid derivatives protect PC12 cells against oxidative damage via modulating β-amyloid aggregation and activating Nrf2 enzymes.

  2020cites this paper
• Nonlinear and mixed inhibitory effect of matrine on the cytotoxicity of oligomeric amyloid-β protein.

  2020cites this paper
• Effects of Ferulic Acid and Angelica archangelica Extract (Feru-guard ®) on Mild Cognitive Impairment: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Prospective Trial

  2020cites this paper
• Natural and Synthetic Derivatives of Hydroxycinnamic Acid Modulating the Pathological Transformation of Amyloidogenic Proteins

  2020cites this paper
• An outlook on the role of decaffeinated coffee in neurodegenerative diseases

  2020influential citation
• Nanotechnology to improve the Alzheimer’s disease therapy with natural compounds

  2019cites this paper
• Natural Compounds for Alzheimer’s Disease Therapy: A Systematic Review of Preclinical and Clinical Studies

  2019cites this paper
• Insights into the inhibitory mechanism of a resveratrol and clioquinol hybrid against Aβ42 aggregation and protofibril destabilization: A molecular dynamics simulation study

  2019cites this paper
• Biophenols: Impacts and Prospects in Anti-Alzheimer Drug Discovery

  2018cites this paper
• Ferulic acid, a natural phenolic compound, as a potential inhibitor for collagen fibril formation and its propagation.

  2018cites this paper
• Application of Ferulic Acid for Alzheimer’s Disease: Combination of Text Mining and Experimental Validation

  2018cites this paper
• The relevance of natural compounds in the Alzheimer´s Disease

  2018influential citation
• Molecular Docking and Molecular Dynamics Simulation to Evaluate Compounds That Avoid the Amyloid Beta 1-42 Aggregation

  2018cites this paper
• Chapter 10 Structure and Function of Stefin B Oligomers – Important Role in

  2017cites this paper
• A review on the hybrids of hydroxycinnamic acid as multi-target-directed ligands against Alzheimer's disease.

  2017cites this paper
• Effects of Newly Synthesized Recombinant Human Amyloid-β Complexes and Poly-Amyloid-β Fibers on Cell Apoptosis and Cognitive Decline.

  2017cites this paper
• New insights into the ameliorative effects of ferulic acid in pathophysiological conditions.

  2017cites this paper
• Molecular insights into Aβ42 protofibril destabilization with a fluorinated compound D744: A molecular dynamics simulation study

  2017cites this paper
• Ferulic Acid and Naturally Occurring Compounds Bearing a Feruloyl Moiety: A Review on Their Structures, Occurrence, and Potential Health Benefits.

  2017cites this paper
• Biophenols pharmacology against the amyloidogenic activity in Alzheimer's disease.

  2017cites this paper
• Enzymatic synthesis of water-soluble ferulic acid derivatives and their improving effects for Alzheimer's disease.

  2017cites this paper
• A Novel, Multi-Target Natural Drug Candidate, Matrine, Improves Cognitive Deficits in Alzheimer’s Disease Transgenic Mice by Inhibiting Aβ Aggregation and Blocking the RAGE/Aβ Axis

  2016cites this paper
• Ferulic acid attenuated acetaminophen-induced hepatotoxicity though down-regulating the cytochrome P 2E1 and inhibiting toll-like receptor 4 signaling-mediated inflammation in mice.

  2016cites this paper
• Danggui-Shaoyao-San: New Hope for Alzheimer's Disease.

  2016cites this paper
• A Fluorescent Oligothiophene-Bis-Triazine ligand interacts with PrP fibrils and detects SDS-resistant oligomers in human prion diseases

  2016cites this paper
• Novel Therapeutic Strategies for Dementia.

  2016cites this paper
• The protective effects and underlying mechanism of an anti-oligomeric Aβ42 single-chain variable fragment antibody.

  2015cites this paper
• Natural Compounds as Therapeutic Agents for Amyloidogenic Diseases

  2015cites this paper
• Ferulic Acid: A Hope for Alzheimer’s Disease Therapy from Plants

  2015cites this paper
• Natural Phenolic Compounds as Therapeutic and Preventive Agents for Cerebral Amyloidosis.

  2015cites this paper
• Virtual and In Vitro Screens Reveal a Potential Pharmacophore that Avoids the Fibrillization of Aβ1–42

  2015cites this paper
• Cognitive Enhancers (Nootropics). Part 3: Drugs Interacting with Targets other than Receptors or Enzymes. Disease-Modifying Drugs. Update 2014

  2014cites this paper
• Erratum to: Functional Characteristics and Molecular Mechanism of a New scFv Antibody Against Aβ42 Oligomers and Immature Protofibrils

  2014cites this paper
• Pharmacogenomics of Alzheimer's disease: novel therapeutic strategies for drug development.

  2014cites this paper
• Structure and Function of Stefin B Oligomers – Important Role in Amyloidogenesis

  2014cites this paper
• Pharmacogenomics in Drug Discovery and Development

  2014cites this paper
• Functional Characteristics and Molecular Mechanism of a New scFv Antibody Against Aβ42 Oligomers and Immature Protofibrils

  2014cites this paper
• Inhibition of insulin amyloid fibril formation by ferulic acid, a natural compound found in many vegetables and fruits

  2014cites this paper
• β-Amyloid amorphous aggregates induced by the small natural molecule ferulic acid.

  2013cites this paper