Metabolic Effect of 1-Deoxynojirimycin from Mulberry Leaves on db/db Diabetic Mice Using Liquid Chromatography-Mass Spectrometry Based Metabolomics.

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Journal of Agricultural and Food Chemistry

• Publication date

  2017-06-02

• Fields of study

  Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1021/acs.jafc.7b01766PMID 28541040
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The ameliorative effects of probiotic Lactobacillus fermentum strain RS-2 on alloxan induced diabetic rats

  2017cited by this paper
• Urine metabolomics of high‐fat diet induced obesity using UHPLC‐Q‐TOF‐MS

  2017cited by this paper
• Preliminary study of urine metabolism in type two diabetic patients based on GC-MS.

  2016cited by this paper
• Metabolic and biochemical changes in streptozotocin induced obese-diabetic rats treated with Phyllanthus niruri extract.

  2016cited by this paper
• Metabolic alteration in obese diabetes rats upon treatment with Centella asiatica extract.

  2016cited by this paper
• 1-Deoxynojirimycin Alleviates Liver Injury and Improves Hepatic Glucose Metabolism in db/db Mice

  2016cited by this paper
• Urinary metabolomic profiling in mice with diet-induced obesity and type 2 diabetes mellitus after treatment with metformin, vildagliptin and their combination.

  2016cited by this paper
• Mulberry 1-Deoxynojirimycin Inhibits Adipogenesis by Repression of the ERK/PPARγ Signaling Pathway in Porcine Intramuscular Adipocytes.

  2015cited by this paper
• A short review of applications of liquid chromatography mass spectrometry based metabolomics techniques to the analysis of human urine.

  2015cited by this paper
• Screening and verification of linearly dependent biomarkers with acute toxicity induced by Aconiti Radix based on liquid chromatography-mass spectrometry-based metabolite profiling

  2015cited by this paper
• Chronic adjunction of 1-deoxynojirimycin protects from age-related behavioral and biochemical changes in the SAMP8 mice

  2015cited by this paper
• 1-deoxynojirimycin isolated from Bacillus subtilis improves hepatic lipid metabolism and mitochondrial function in high-fat-fed mice.

  2015cited by this paper
• 1-Deoxynojirimycin Alleviates Insulin Resistance via Activation of Insulin Signaling PI3K/AKT Pathway in Skeletal Muscle of db/db Mice

  2015cited by this paper
• Salidroside ameliorates insulin resistance through activation of a mitochondria‐associated AMPK/PI3K/Akt/GSK3β pathway

  2015cited by this paper
• A systems view of type 2 diabetes-associated metabolic perturbations in saliva, blood and urine at different timescales of glycaemic control

  2015cited by this paper
• Metabolomic profiling of urinary changes in mice with monosodium glutamate-induced obesity

  2015cited by this paper
• Metabolic profiling study of early and late recurrence of hepatocellular carcinoma based on liquid chromatography-mass spectrometry.

  2014cited by this paper
• MeOx-TMS derivatization for GC-MS metabolic profiling of urine and application in the discrimination between normal C57BL/6J and type 2 diabetic KK-Ay mice

  2014cited by this paper
• Mulberry 1-deoxynojirimycin pleiotropically inhibits glucose-stimulated vascular smooth muscle cell migration by activation of AMPK/RhoB and down-regulation of FAK.

  2013cited by this paper
• Metabolic effect of an exogenous gene on transgenic Beauveria bassiana using liquid chromatography-mass spectrometry-based metabolomics.

  2013cited by this paper
• Comparison of urinary protein: creatinine index and dipsticks for detection of microproteinuria in diabetes mellitus patients.

  2013cited by this paper
• Dynamic Metabolic Profiling of Urine From Type 2 Diabetic KK-Ay Mice Treated with Repaglinide by GC-MS

  2012cited by this paper
• LRH-1-dependent glucose sensing determines intermediary metabolism in liver.

  2012cited by this paper
• Development of high 1-deoxynojirimycin (DNJ) content mulberry tea and use of response surface methodology to optimize tea-making conditions for highest DNJ extraction

  2012cited by this paper
• Emerging perspectives on essential amino acid metabolism in obesity and the insulin-resistant state.

  2011cited by this paper
• Discovery of early-stage biomarkers for diabetic kidney disease using ms-based metabolomics (FinnDiane study)

  2011cited by this paper
• Serum advanced glycation end products (AGEs) are associated with insulin resistance

  2011cited by this paper
• Comparison of 1-deoxynojirimycin and aqueous mulberry leaf extract with emphasis on postprandial hypoglycemic effects: in vivo and in vitro studies.

  2011cited by this paper
• Creatine metabolism and the urea cycle.

  2010cited by this paper
• Global metabolic profiling procedures for urine using UPLC–MS

  2010cited by this paper
• Comparison of absorption of 1-deoxynojirimycin from mulberry water extract in rats.

  2010cited by this paper
• Cellular organization of normal mouse liver: a histological, quantitative immunocytochemical, and fine structural analysis

  2009cited by this paper
• Phytochemical profiles of different mulberry (Morus sp.) species from China.

  2009cited by this paper
• Intake of 1-deoxynojirimycin suppresses lipid accumulation through activation of the beta-oxidation system in rat liver.

  2009cited by this paper
• Antiobesity effects and improvement of insulin sensitivity by 1-deoxynojirimycin in animal models.

  2008cited by this paper
• Occurrence of orally administered mulberry 1-deoxynojirimycin in rat plasma.

  2007cited by this paper
• A metabolomic comparison of urinary changes in type 2 diabetes in mouse, rat, and human.

  2007cited by this paper
• Food-grade mulberry powder enriched with 1-deoxynojirimycin suppresses the elevation of postprandial blood glucose in humans.

  2007cited by this paper
• Determination of 1-deoxynojirimycin in mulberry leaves using hydrophilic interaction chromatography with evaporative light scattering detection.

  2004cited by this paper
• Mulberry leaf extract inhibits the oxidative modification of rabbit and human low density lipoprotein.

  2000cited by this paper
• Proton nuclear magnetic resonance spectral profiles of urine in type II diabetic patients.

  1998cited by this paper
• Raised Blood Pyruvic Acid Level in Diabetic Acidosis

  1951cited by this paper

• Mulberry Leaf Alkaloids and Their Main Component 1-Deoxynojirimycin Mitigate CDAHFD-Induced Metabolic Dysfunction-Associated Steatohepatitis by Promoting Autophagy through the PI3K/AKT/mTOR Pathway.

  2026cites this paper
• Mulberry Leaf-Derived Bioactive Constituents on Diabetes: Structure, Extraction, Quality Analysis, and Hypoglycemic Mechanisms

  2026influential citation
• Characterization of Turkish mulberry genetic resources based on antioxidant capacity, biochemical composition, nutrient content, and morphological traits of leaves

  2025cites this paper
• The effects of exogenous GABA on the quality of processed mulberry leaf tea were investigated based on metabolomics

  2025cites this paper
• Brassica rapa L. Polysaccharides Alleviate T2D via Modulation of Gut Microbiota and Metabolites

  2025cites this paper
• Insights into the toxicity effects of indoxacarb against Spodoptera frugiperda using metabolomics combined with mass spectrometry imaging

  2025cites this paper
• Regulating the PI3K and AMPK pathway: the secret of 1-deoxynojirimycin's success in alleviating chronic diseases

  2025cites this paper
• Network Pharmacology Prediction and Metabolomics Validation of the Novel Targets of Morus alba L. against High-Fat Diet-Induced Diabetes Mellitus in C57/6J Mice

  2024cites this paper
• RECENT ADVANCES IN NETWORK PHARMACOLOGY OF FICUS: A REVIEW

  2024cites this paper
• Anthocyanin-rich black wheat as a functional food for managing type 2 diabetes mellitus: a study on high fat diet-streptozotocin-induced diabetic rats.

  2024cites this paper
• Flavonoids from Camellia oleifera flower ameliorate type 2 diabetes mellitus by regulating the p53 pathway.

  2024cites this paper
• 1‐Deoxynojirimycin attenuates pathological markers of Alzheimer's disease in the in vitro model of neuronal insulin resistance

  2024cites this paper
• Preparation and Characterization of Natural Deep Eutectic Solvents (NADESs): Application in the Extraction of Phenolic Compounds from Araza Pulp (Eugenia stipitata)

  2024cites this paper
• Protective effects of flavonoids in Coreopsis tinctoria Nutt. in a mouse model of type 2 diabetes.

  2023cites this paper
• Flavonoids from mulberry leaves inhibit fat production and improve fatty acid distribution in adipose tissue in finishing pigs

  2023cites this paper
• Anti-diabetic effects of natural and modified 'Ganzhou' navel orange peel pectin on type 2 diabetic mice via gut microbiota.

  2023cites this paper
• The Mechanism of Mori Folium and Eucommiae Cortex against Cyclophosphamide-Induced Immunosuppression Integrating Network Pharmacology, Molecular Docking, Molecular Dynamics Simulations, and Experimental Validation

  2023cites this paper
• Mulberry as a Valuable Resource for Food and Pharmaceutical Industries: A Review

  2023cites this paper
• Serum and urine metabolomics study revealed the amelioration of Gynura bicolor extract on high fat diet-fed and streptozotocin-induced type 2 diabetic mice based on UHPLC-MS/MS.

  2023cites this paper
• Effects of Rutin and Selenomethionine in Selenium-Enriched Tartary Buckwheat Roasted Grain Tea on Glucose and Lipid Metabolism in db/db Mice

  2023cites this paper
• Metallothionein–Kidney Bean Polyphenol Complexes Showed Antidiabetic Activity in Type 2 Diabetic Rats by Improving Insulin Resistance and Regulating Gut Microbiota

  2023cites this paper
• Low glycemic index potato biscuits alleviate physio-histological damage and gut dysbiosis in rats with type-2 diabetes mellitus induced by high-sugar and high-fat diet and streptozotocin.

  2023cites this paper
• Evaluation of mulberry leaves’ hypoglycemic properties and hypoglycemic mechanisms

  2023cites this paper
• Mulberry leaf extract reduces abdominal fat deposition via adenosine-activated protein kinase/sterol regulatory element binding protein-1c/acetyl-CoA carboxylase signaling pathway in female Arbor Acre broilers

  2023cites this paper
• Mulberry leaf extract reduces abdominal fat deposition via AMPK/SREBP-1c/ACC signaling pathway in female Arbor Acre broilers

  2023cites this paper
• Planting conditions can enhance the bioactivity of mulberry by affecting its composition

  2023cites this paper
• Integrated Gut Microbiota and Urine Metabolite Analyses of T2DM with NAFLD Rat Model

  2023cites this paper
• Functional And Nutraceutical Characterization of Mulberry Leaves

  2022cites this paper
• Protective Application of Morus and Its Extracts in Animal Production

  2022cites this paper
• Hypoglycemic Effects of Lycium barbarum Polysaccharide in Type 2 Diabetes Mellitus Mice via Modulating Gut Microbiota

  2022cites this paper
• Whey protein and xylitol complex alleviate type 2 diabetes in C57BL/6 mice by regulating the intestinal microbiota.

  2022cites this paper
• Mulberry plant as a source of functional food with therapeutic and nutritional applications: A review.

  2022cites this paper
• Interaction between Gelatin and Mulberry Leaf Polysaccharides in Miscible System: Physicochemical Characteristics and Rheological Behavior

  2022cites this paper
• Effect of 1-Deoxynojirimycin on insulin resistance in prediabetic mice based on next-generation sequencing and intestinal microbiota study.

  2022cites this paper
• Mass spectrometry-based serum lipidomics strategy to explore the mechanism of Eleutherococcus senticosus (Rupr. & Maxim.) Maxim. leaves in the treatment of ischemic stroke.

  2021cites this paper
• Differences in kinetic metabolomics in Eisenia fetida under single and dual exposure of imidacloprid and dinotefuran at environmentally relevant concentrations.

  2021cites this paper
• Component changes of mulberry leaf tea processed with honey and its application to in vitro and in vivo models of diabetes

  2021cites this paper
• Application of metabolomics for revealing the interventional effects of functional foods on metabolic diseases.

  2021cites this paper
• Quantitative determination of 1-deoxynojirimycin in 146 varieties of mulberry fruit

  2021cites this paper
• A comprehensive review on the production, pharmacokinetics and health benefits of mulberry leaf iminosugars: Main focus on 1-deoxynojirimycin, d-fagomine, and 2-O-ɑ-d-galactopyranosyl-DNJ

  2021cites this paper
• Formononetin reshapes the gut microbiota, prevents progression of obesity and improves host metabolism.

  2021cites this paper
• A polysaccharide isolated from Ganoderma lucidum ameliorates hyperglycemia through modulating gut microbiota in type 2 diabetic mice.

  2021cites this paper
• Sargassum fusiforme polysaccharide partly replaces acarbose against type 2 diabetes in rats.

  2020cites this paper
• Iminosugar 1-Deoxynojirimycin (DNJ) sebagai Antiviral Infeksi Virus Dengue

  2020cites this paper
• The application of metabolomics in investigating anti-diabetic activity of medicinal plants.

  2020cites this paper
• MMHub, a database for the mulberry metabolome

  2020cites this paper
• Antidiabetic effects of polysaccharide from azuki bean (Vigna angularis) in type 2 diabetic rats via insulin/PI3K/AKT signaling pathway

  2020cites this paper
• Flavonoids extracted from mulberry (Morus alba L.) leaf improve skeletal muscle mitochondrial function by activating AMPK in type 2 diabetes.

  2020cites this paper
• Mulberry 1-deoxynojirimycin (DNJ): an exemplary compound for therapeutics

  2020cites this paper
• Comparative Study of the Antioxidant and Anti-Inflammatory Effects of Leaf Extracts from Four Different Morus alba Genotypes in High Fat Diet-Induced Obesity in Mice

  2020cites this paper
• The Gut Microbiota-Produced Indole-3-Propionic Acid Confers the Antihyperlipidemic Effect of Mulberry-Derived 1-Deoxynojirimycin

  2020cites this paper
• 1-Deoxynojirimycin from mulberry leaves changes gut digestion and microbiota composition in geese

  2020cites this paper
• Serum metabolomic investigations of mulberry leaf powder supplementation in Chinese Erhualian pigs

  2020influential citation
• Advances in understanding of health‐promoting benefits of medicine and food homology using analysis of gut microbiota and metabolomics

  2020cites this paper
• Berberine compounds improves hyperglycemia via microbiome mediated colonic TGR5-GLP pathway in db/db mice.

  2020cites this paper
• Physicochemical properties of polysaccharide fractions from Sargassum fusiforme and their hypoglycemic and hypolipidemic activities in type 2 diabetic rats.

  2019cites this paper
• Polysaccharide from Rosa roxburghii Tratt fruit attenuates hyperglycemia, hyperlipidemia and regulates colon microbiota in diabetic db/db mice.

  2019cites this paper
• An overview of the biological production of 1-deoxynojirimycin: current status and future perspective

  2019cites this paper
• RNA-Seq analysis of the pathogenesis of STZ-induced male diabetic mouse liver.

  2019cites this paper
• Biosynthesis of metallic nanoparticles using mulberry fruit (Morus alba L.) extract for the preparation of antimicrobial nanocellulose film

  2019cites this paper
• Bioactive compounds, health benefits and utilisation of Morus spp.– a comprehensive review

  2019cites this paper
• A Novel Strategy to Regulate 1-Deoxynojirimycin Production Based on Its Biosynthetic Pathway in Streptomyces lavendulae

  2019cites this paper
• Metabolomic Study on Nude Mice Models of Gastric Cancer Treated with Modified Si Jun Zi Tang via HILIC UHPLC-Q-TOF/MS Analysis

  2019cites this paper
• 1-Deoxynojirimycin, its potential for management of non-communicable metabolic diseases

  2019cites this paper
• Preparation of 1-deoxynojirimycin controlled release matrix pellets of capsules and evaluation in vitro-in vivo to enhance bioavailability

  2019cites this paper
• Mass spectrometry-based urinary metabolomics for the investigation on the mechanism of action of Eleutherococcus senticosus (Rupr. & Maxim.) Maxim. leaves against ischemic stroke in rats.

  2019cites this paper
• Antidiabetic effects of different polysaccharide fractions from Artemisia sphaerocephala Krasch seeds in db/db mice

  2019cites this paper
• The chemical structure and biological activities of a novel polysaccharide obtained from Fructus Mori and its zinc derivative

  2019cites this paper
• Mulberry leaf active components alleviate type 2 diabetes and its liver and kidney injury in db/db mice through insulin receptor and TGF-β/Smads signaling pathway.

  2019cites this paper
• Effects of Mulberry (Morus alba) Leaf Tea on Blood Glucose and Satiety in Healthy Subjects

  2019cites this paper
• Protective effects of p-coumaric acid against oxidant and hyperlipidemia-an in vitro and in vivo evaluation.

  2019cites this paper
• Lycium barbarum L. leaves ameliorate type 2 diabetes in rats by modulating metabolic profiles and gut microbiota composition.

  2019cites this paper
• Enhanced phenolic compounds extraction from Morus alba L. leaves by deep eutectic solvents combined with ultrasonic-assisted extraction

  2018cites this paper
• Nutritional and functional components of mulberry leaves from different varieties: Evaluation of their potential as food materials

  2018cites this paper
• Safety evaluation of mulberry leaf extract: Acute, subacute toxicity and genotoxicity studies

  2018cites this paper
• Lethal Toxicity and Sublethal Metabolic Interference Effects of Sulfoxaflor on the Earthworm ( Eisenia fetida).

  2018cites this paper
• Synchronised determination of chlorogenic acid and five flavonoids in mulberry leaves using HPLC with photodiode array detection

  2018cites this paper
• Fecal Metabolomics of Type 2 Diabetic Rats and Treatment with Gardenia jasminoides Ellis Based on Mass Spectrometry Technique.

  2018cites this paper
• Metabolomics-based evidence of the hypoglycemic effect of Ge-Gen-Jiao-Tai-Wan in type 2 diabetic rats via UHPLC-QTOF/MS analysis.

  2018cites this paper
• Coating rice with mulberry leaves rich in deoxynojirimycin ameliorates hyperglycemia and dyslipidemia in C57BL/KsJ db/db mice

  2018influential citation
• Mulberry Leaf Regulates Differentially Expressed Genes in Diabetic Mice Liver Based on RNA-Seq Analysis

  2018cites this paper
• Analysis of mulberry leaf components in the treatment of diabetes using network pharmacology

  2018influential citation
• Patterns of chemical diversity in the marine ascidian Phallusia spp.: anti-tumor activity and metabolic pathway inhibiting steroid biosynthesis

  2018cites this paper
• 1-Deoxynojirimycin (DNJ) Ameliorates Indomethacin-Induced Gastric Ulcer in Mice by Affecting NF-kappaB Signaling Pathway

  2018cites this paper
• 1-Deoxynojirimycin from Bacillus subtilis improves antioxidant and antibacterial activities of juvenile Yoshitomi tilapia

  2017cites this paper
• Thermal and Antioxidant Properties of Polysaccharides Sequentially Extracted from Mulberry Leaves (Morus alba L.)

  2017cites this paper