Skeletal unloading–induced insulin‐like growth factor 1 (IGF‐1) Nonresponsiveness is not shared by platelet‐derived growth factor: The selective role of integrins in IGF‐1 signaling

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Journal of Bone and Mineral Research

• Publication date

  2011-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/jbmr.511PMID 21932337PMCID PMC3222734
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The Direct Binding of Insulin-like Growth Factor-1 (IGF-1) to Integrin αvβ3 Is Involved in IGF-1 Signaling*

  2009cited by this paper
• Platelet-derived growth factor enhances demineralized bone matrix-induced cartilage and bone formation

  2007cited by this paper
• Imatinib Promotes Osteoblast Differentiation by Inhibiting PDGFR Signaling and Inhibits Osteoclastogenesis by Both Direct and Stromal Cell‐Dependent Mechanisms

  2007cited by this paper
• beta1A integrin expression is required for type 1 insulin-like growth factor receptor mitogenic and transforming activities and localization to focal contacts.

  2005cited by this paper
• Transforming growth factor-beta inhibits CCAAT/enhancer-binding protein expression and PPARgamma activity in unloaded bone marrow stromal cells.

  2005cited by this paper
• Transforming growth factor-β inhibits CCAAT/enhancer-binding protein expression and PPARγ activity in unloaded bone marrow stromal cells

  2005cited by this paper
• Fluid Shear Stress Synergizes with Insulin-like Growth Factor-I (IGF-I) on Osteoblast Proliferation through Integrin-dependent Activation of IGF-I Mitogenic Signaling Pathway*

  2005cited by this paper
• (alpha)v(beta)3 integrins and Pyk2 mediate insulin-like growth factor I activation of Src and mitogen-activated protein kinase in 3T3-L1 cells.

  2005cited by this paper
• Integrin Signaling

  2005cited by this paper
• αvβ3 Integrins and Pyk2 Mediate Insulin-Like Growth Factor I Activation of Src and Mitogen-Activated Protein Kinase in 3T3-L1 Cells

  2005cited by this paper
• Selective modulation of type 1 insulin-like growth factor receptor signaling and functions by β1 integrins

  2004cited by this paper
• Differential regulation of platelet‐derived growth factor stimulated migration and proliferation in osteoblastic cells

  2004cited by this paper
• Platelet-derived growth factor and bone morphogenetic protein in the healing of mandibular fractures in rats.

  2003cited by this paper
• Skeletal unloading induces resistance to insulin-like growth factor I on bone formation.

  2003cited by this paper
• Skeletal Unloading Induces Resistance to Insulin‐Like Growth Factor‐I (IGF‐I) by Inhibiting Activation of the IGF‐I Signaling Pathways

  2003cited by this paper
• Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions.

  2001cited by this paper
• Editorial: Insulin-Like Growth Factor I Receptor Signaling-Overlapping or Redundant Pathways?

  2000cited by this paper
• FAK integrates growth-factor and integrin signals to promote cell migration

  2000cited by this paper
• Focal Adhesion Kinase Facilitates Platelet-derived Growth Factor-BB-stimulated ERK2 Activation Required for Chemotaxis Migration of Vascular Smooth Muscle Cells*

  2000cited by this paper
• Translocation of Akt/PKB to the nucleus of osteoblast‐like MC3T3‐E1 cells exposed to proliferative growth factors

  2000cited by this paper
• Insulin-like growth factor I receptor signaling--overlapping or redundant pathways?

  2000cited by this paper
• Insulin-like growth factors and skeletal growth: possibilities for therapeutic interventions.

  1999cited by this paper
• Bone and hormonal changes induced by skeletal unloading in the mature male rat.

  1999cited by this paper
• Bone and hormonal changes induced by skeletal unloading in the mature male rat.

  1999cited by this paper
• Synthetic αVβ3 Antagonists Inhibit Insulin-Like Growth Factor-I-Stimulated Smooth Muscle Cell Migration and Replication1.

  1999cited by this paper
• The response of bone to unloading

  1999cited by this paper
• Skeletal Unloading Causes Resistance of Osteoprogenitor Cells to Parathyroid Hormone and to Insulin‐like Growth Factor‐I

  1999cited by this paper
• Synthetic alphaVbeta3 antagonists inhibit insulin-like growth factor-I-stimulated smooth muscle cell migration and replication.

  1999cited by this paper
• Integrin signaling.

  1999cited by this paper
• Structural requirements of echistatin for the recognition of alpha(v)beta(3) and alpha(5)beta(1) integrins.

  1999cited by this paper
• Structural Requirements of Echistatin for the Recognition of αvβ3 and α5β1Integrins*

  1999cited by this paper
• Blocking ligand occupancy of the alphaVbeta3 integrin inhibits insulin-like growth factor I signaling in vascular smooth muscle cells.

  1998cited by this paper
• Blocking ligand occupancy of the αVβ3 integrin inhibits insulin-like growth factor I signaling in vascular smooth muscle cells

  1998cited by this paper
• Effect of mechanical unloading and reloading on periosteal bone formation and gene expression in tail-suspended rapidly growing rats.

  1998cited by this paper
• p125Fak Focal Adhesion Kinase Is a Substrate for the Insulin and Insulin-like Growth Factor-I Tyrosine Kinase Receptors*

  1998cited by this paper
• Regional Responsiveness of the Tibia to Intermittent Administration of Parathyroid Hormone as Affected by Skeletal Unloading

  1997cited by this paper
• Regulation of Neuronal Survival by the Serine-Threonine Protein Kinase Akt

  1997cited by this paper
• Skeletal unloading inhibits the in vitro proliferation and differentiation of rat osteoprogenitor cells.

  1997cited by this paper
• PI3K: downstream AKTion blocks apoptosis.

  1997cited by this paper
• Integrin Expression and Function on Human Osteoblast‐like Cells

  1997cited by this paper
• Skeletal unloading inhibits the in vitro proliferation and differentiation of rat osteoprogenitor cells.

  1997cited by this paper
• The effect of systemically administered PDGF‐BB on the rodent skeleton

  1996cited by this paper
• Rat tail suspension reduces messenger RNA level for growth factors and osteopontin and decreases the osteoblastic differentiation of bone marrow stromal cells

  1995cited by this paper
• Skeletal unloading induces resistance to insulin‐like growth factor I

  1994cited by this paper
• Skeletal unloading decreases production of 1,25-dihydroxyvitamin D.

  1993cited by this paper
• Skeletal unloading in rat decreases proliferation of rat bone and marrow-derived osteoblastic cells.

  1993cited by this paper
• Integrin expression in human bone

  1993cited by this paper
• Effects of desamino-(1-3)-insulin-like growth factor I on bone cell function in rat calvarial cultures.

  1991cited by this paper
• Skeletal growth factor and other growth factors known to be present in bone matrix stimulate proliferation and protein synthesis in human bone cells

  1990cited by this paper
• Platelet-derived growth factor enhances deoxyribonucleic acid and collagen synthesis in osteoblast-enriched cultures from fetal rat parietal bone.

  1989cited by this paper
• Glucocorticoids and inhibition of bone formation induced by skeletal unloading.

  1988cited by this paper
• Isolation and characterization of insulin-like growth factor I (somatomedin-C) from cultures of fetal rat calvariae.

  1988cited by this paper
• Insulin-like growth factor I has independent effects on bone matrix formation and cell replication.

  1988cited by this paper
• The temporal response of bone to unloading.

  1986cited by this paper
• Effect of insulinlike growth factor I on DNA and protein synthesis in cultured rat calvaria.

  1980cited by this paper

• Integrated proteomics and metabolomics analysis of sclerosis-related proteins and femoral head necrosis following internal fixation of femoral neck fractures

  2024cites this paper
• DI-5-Cuffs: Bone Remodelling and Associated Metabolism Markers in Humans After Five Days of Dry Immersion to Simulate Microgravity

  2022cites this paper
• Dissociation of Bone Resorption and Formation in Spaceflight and Simulated Microgravity: Potential Role of Myokines and Osteokines?

  2022cites this paper
• The effects of locomotion on bone marrow mesenchymal stem cell fate: insight into mechanical regulation and bone formation

  2021cites this paper
• Growth Hormone Effects on Bone Loss-Induced by Mild Traumatic Brain Injury and/or Hind Limb Unloading

  2019cites this paper
• Separate and combined effects of hypobaric hypoxia and hindlimb suspension on skeletal homeostasis and hematopoiesis in mice

  2019cites this paper
• HP_A_195827 41..52

  2019cites this paper
• Roles of Irisin in the Linkage from Muscle to Bone During Mechanical Unloading in Mice

  2018cites this paper
• Roles of Irisin in the Linkage from Muscle to Bone During Mechanical Unloading in Mice

  2018cites this paper
• Osteoinduction of human adipose stem cells in 3D hydrogel culture using mechanical stimulation

  2017cites this paper
• IGF‐1 signaling mediated cell‐specific skeletal mechano‐transduction

  2017cites this paper
• The RhoGAP Myo9b Promotes Bone Growth by Mediating Osteoblastic Responsiveness to IGF‐1

  2017influential citation
• Skeletal effects of growth hormone and insulin-like growth factor-I therapy.

  2016cites this paper
• Rôle et régulation des intégrines et des cadhérines dans la transdifférenciation MUSCLE/OS en réponse à la BMP-2 : approche biomimétique

  2016cites this paper
• Regulation of Ligand and Shear Stress-induced Insulin-like Growth Factor 1 (IGF1) Signaling by the Integrin Pathway*

  2016cites this paper
• Metalloproteases Affecting Blood Coagulation, Fibrinolysis and Platelet Aggregation from Snake Venoms: Definition and Nomenclature of Interaction Sites

  2016cites this paper
• Chapter 21 – Insulin-Like Growth Factor-1 and Its Binding Proteins∗

  2016cites this paper
• UNIVERSITY OF MINNESOTA BY Jung Kim IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF DOCTOR OF PHILOSOPHY Adviser

  2015cites this paper
• Swimming Activity Prevents the Unloading Induced Loss of Bone Mass, Architecture, and Strength in Rats

  2015cites this paper
• Integrin αvβ3 mediates the synergetic regulation of core-binding factor α1 transcriptional activity by gravity and insulin-like growth factor-1 through phosphoinositide 3-kinase signaling.

  2014cites this paper
• Integrin and cadherin signaling in bone: role and potential therapeutic targets.

  2014cites this paper
• Anabolic effects of IGF-1 signaling on the skeleton

  2013cites this paper
• New insights into adhesion signaling in bone formation.

  2013cites this paper
• Applications of snake venom components to modulate integrin activities in cell-matrix interactions.

  2013cites this paper
• Effect of Whole-Body Vibration and Insulin-Like Growth Factor-I on Muscle Paralysis-Induced Bone Degeneration after Botulinum Toxin Injection in Mice

  2013cites this paper
• Impact de l'extinction génique de la sialoprotéine osseuse (BSP) sur la différenciation des ostéoblastes et l'ostéogenèse in vitro : développement et validation d'un bioréacteur pour la culture ostéoblastique en trois dimensions

  2013cites this paper
• Role of Insulin-like Growth Factor-1 in the Regulation of Skeletal Growth

  2012cites this paper
• Insulin-Like Growth Factor-1 and Its Binding Proteins

  2010cites this paper