Torso RTK controls Capicua degradation by changing its subcellular localization

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Development

• Publication date

  2012-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1242/dev.084327PMID 23048183PMCID PMC3472588
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The Capicua repressor – a general sensor of RTK signaling in development and disease

  2012cited by this paper
• ATXN1 protein family and CIC regulate extracellular matrix remodeling and lung alveolarization.

  2011cited by this paper
• Mutations in CIC and FUBP1 Contribute to Human Oligodendroglioma

  2011cited by this paper
• Measurement and perturbation of morphogen lifetime: effects on gradient shape.

  2011cited by this paper
• Exercise and Genetic Rescue of SCA1 via the Transcriptional Repressor Capicua

  2011influential reference
• Capicua DNA-binding sites are general response elements for RTK signaling in Drosophila

  2011influential reference
• ERK/p90RSK/14-3-3 signalling has an impact on expression of PEA3 Ets transcription factors via the transcriptional repressor capicúa

  2010cited by this paper
• A compartmental model for the bicoid gradient.

  2010cited by this paper
• Shuttling of SOX proteins.

  2010cited by this paper
• Gene regulation by MAPK substrate competition.

  2010cited by this paper
• MAPK substrate competition integrates patterning signals in the Drosophila embryo.

  2010cited by this paper
• Antagonistic action of Bicoid and the repressor Capicua determines the spatial limits of Drosophila head gene expression domains

  2009influential reference
• Dynamics of the Dorsal morphogen gradient

  2009cited by this paper
• Mechanical stimulation by osmotic and hydrostatic pressure activates Drosophila oocytes in vitro in a calcium-dependent manner.

  2008cited by this paper
• Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1

  2008cited by this paper
• Nuclear trapping shapes the terminal gradient in the Drosophila embryo.

  2008cited by this paper
• Stability and nuclear dynamics of the bicoid morphogen gradient.

  2007cited by this paper
• The HMG-box: a versatile protein domain occurring in a wide variety of DNA-binding proteins

  2007cited by this paper
• Nucleocytoplasmic shuttling mediates the dynamic maintenance of nuclear Dorsal levels during Drosophila embryogenesis

  2007cited by this paper
• A MAPK docking site is critical for downregulation of Capicua by Torso and EGFR RTK signaling

  2007influential reference
• ATAXIN-1 interacts with the repressor Capicua in its native complex to cause SCA1 neuropathology.

  2006cited by this paper
• Fusion between CIC and DUX4 up-regulates PEA3 family genes in Ewing-like sarcomas with t(4;19)(q35;q13) translocation.

  2006cited by this paper
• Regulated Fast Nucleocytoplasmic Shuttling Observed by Reversible Protein Highlighting

  2004cited by this paper
• In and out of Torso RTK signalling

  2003cited by this paper
• CRM1-mediated nuclear export and regulated activity of the Receptor Tyrosine Kinase antagonist YAN require specific interactions with MAE

  2003cited by this paper
• Ste11p, a High-Mobility-Group Box DNA-Binding Protein, Undergoes Pheromone- and Nutrient-Regulated Nuclear-Cytoplasmic Shuttling

  2003cited by this paper
• A variant of yellow fluorescent protein with fast and efficient maturation for cell-biological applications

  2002influential reference
• CIC, a member of a novel subfamily of the HMG-box superfamily, is transiently expressed in developing granule neurons.

  2002cited by this paper
• EGFR signalling inhibits Capicua-dependent repression during specification of Drosophila wing veins.

  2002influential reference
• Drosophila Pin1 prolyl isomerase Dodo is a MAP kinase signal responder during oogenesis

  2001cited by this paper
• Relief of gene repression by torso RTK signaling: role of capicua in Drosophila terminal and dorsoventral patterning.

  2000influential reference
• Down-regulation of transcription factor CF2 by Drosophila Ras/MAP kinase signaling in oogenesis: cytoplasmic retention and degradation.

  1998cited by this paper
• Yan functions as a general inhibitor of differentiation and is negatively regulated by activation of the Ras1/MAPK pathway.

  1995cited by this paper
• Torso receptor activity is regulated by a diffusible ligand produced at the extracellular terminal regions of the Drosophila egg.

  1992cited by this paper
• Female sterile mutations on the second chromosome of Drosophila melanogaster. I. Maternal effect mutations.

  1989cited by this paper
• Isolation and characterization of dominant female sterile mutations of Drosophila melanogaster. II. Mutations on the second chromosome.

  1989cited by this paper
• Mobility measurement by analysis of fluorescence photobleaching recovery kinetics.

  1976cited by this paper
• Supplementary Material Supplementary File Title Supplementary Text Mathematical Model

  year unknowncited by this paper

• Oncogenic signaling in the Drosophila prostate-like accessory gland activates a pro-tumorigenic program in the absence of proliferation

  2025cites this paper
• Transcriptional repressor Capicua is a gatekeeper of cell-intrinsic interferon responses.

  2025cites this paper
• O-GlcNAc transferase congenital disorder of glycosylation (OGT-CDG): Potential mechanistic targets revealed by evaluating the OGT interactome

  2024cites this paper
• ERK inhibits Cic repressor function via multisite phosphorylation

  2024cites this paper
• Both the transcriptional activator, Bcd, and repressor, Cic, form small mobile oligomeric clusters.

  2024cites this paper
• Oncogenic signaling in the adult Drosophila prostate-like accessory gland leads to activation of a conserved pro-tumorigenic program, in the absence of proliferation

  2024cites this paper
• Both the transcriptional activator, Bcd, and transcriptional repressor, Cic, form small mobile oligomeric clusters in early fly embryo nuclei

  2024cites this paper
• A guide to ERK dynamics, part 2: downstream decoding

  2023cites this paper
• Dynamics of Drosophila endoderm specification

  2022cites this paper
• Noncanonical function of Capicua as a growth termination signal in Drosophila oogenesis

  2022cites this paper
• Control of DUX4 Expression in Facioscapulohumeral Muscular Dystrophy and Cancer.

  2021cites this paper
• Antagonism between germ cell-less and Torso receptor regulates transcriptional quiescence underlying germline/soma distinction

  2021cites this paper
• Capicua suppresses YAP1 to limit tumorigenesis and maintain drug sensitivity in human cancer

  2021cites this paper
• From complex datasets to predictive models of embryonic development

  2021cites this paper
• Using FCS to accurately measure protein concentration in the presence of noise and photobleaching.

  2021cites this paper
• Collective oscillations of coupled cell cycles.

  2021cites this paper
• Capicua is a fast-acting transcriptional brake.

  2021cites this paper
• Modeling the role for nuclear import dynamics in the early embryonic cell cycle.

  2021cites this paper
• From heterogeneous datasets to predictive models of embryonic development

  2021cites this paper
• Capicua suppresses colorectal cancer progression via repression of ETV4 expression

  2020cites this paper
• Extracellular signal-regulated kinase mediates chromatin rewiring and lineage transformation in lung cancer

  2020cites this paper
• Capicua in Human Cancer.

  2020cites this paper
• Negative MAPK-ERK regulation sustains CIC-DUX4 oncoprotein expression in undifferentiated sarcoma

  2020cites this paper
• Optogenetic Rescue of a Patterning Mutant.

  2020cites this paper
• The design and logic of terminal patterning in Drosophila.

  2020cites this paper
• Rapid Dynamics of Signal-Dependent Transcriptional Repression by Capicua.

  2020influential citation
• Lighting up the central dogma for predictive developmental biology.

  2020cites this paper
• Activation-induced substrate engagement in ERK signaling

  2020influential citation
• Capicua regulates neural stem cell proliferation and lineage specification through control of Ets factors

  2019cites this paper
• Functional divergence caused by mutations in an energetic hotspot in ERK2

  2019cites this paper
• Rat ERK2 E320K

  2019cites this paper
• Self-Similar Dynamics of Nuclear Packing in the Early Drosophila Embryo.

  2019cites this paper
• Fly-on-a-Chip: Microfluidics for Drosophila melanogaster Studies.

  2019cites this paper
• Signaling Dynamics Control Cell Fate in the Early Drosophila Embryo.

  2019cites this paper
• Capicua suppresses hepatocellular carcinoma progression by controlling the ETV4–MMP1 axis

  2018cites this paper
• Toward deciphering developmental patterning with deep neural network

  2018cites this paper
• Outstanding questions in developmental ERK signaling

  2018cites this paper
• A quantitative model of developmental RTK signaling.

  2018cites this paper
• The Capicua tumor suppressor: a gatekeeper of Ras signaling in development and cancer

  2018cites this paper
• Capicua regulates neural stem cell proliferation and lineage specification through control of Ets factors

  2018cites this paper
• Mecanismo de acción del factor represor Capicua, un sensor de señales Ras/MAPK

  2017cites this paper
• Quantitative biology of developmental Ras signaling: from molecules to morphologies

  2017influential citation
• CIC (capicua transcriptional repressor)

  2017cites this paper
• Parallel imaging of Drosophila embryos for quantitative analysis of genetic perturbations of the Ras pathway

  2017influential citation
• A double‐edged sword: The world according to Capicua in cancer

  2017cites this paper
• The Spatiotemporal Limits of Developmental Erk Signaling.

  2017cites this paper
• COP9 signalosome subunits protect Capicua from MAPK-dependent and -independent mechanisms of degradation

  2017influential citation
• Tracing Information Flow from Erk to Target Gene Induction Reveals Mechanisms of Dynamic and Combinatorial Control.

  2017cites this paper
• Minibrain and Wings apart control organ growth and tissue patterning through down-regulation of Capicua

  2016cites this paper
• Inactivation of Capicua drives cancer metastasis

  2016cites this paper
• Maternal AP determinants in the Drosophila oocyte and embryo

  2016cites this paper
• Mapping the binding interface of ERK and transcriptional repressor Capicua using photocrosslinking

  2015cites this paper
• EGFR/Ras Signaling Controls Drosophila Intestinal Stem Cell Proliferation via Capicua-Regulated Genes

  2015cites this paper
• Origins of Context-Dependent Gene Repression by Capicua

  2015cites this paper
• Dynamics of Inductive ERK Signaling in the Drosophila Embryo.

  2015influential citation
• A Systematic Ensemble Approach to Thermodynamic Modeling of Gene Expression from Sequence Data.

  2015cites this paper
• Epidermal Growth Factor Signalling Controls Myosin II Planar Polarity to Orchestrate Convergent Extension Movements during Drosophila Tubulogenesis

  2014cites this paper
• The regulation and functions of MAPK pathways in Drosophila.

  2014cites this paper
• Capturing embryonic development from metamorphosis: how did the terminal patterning signalling pathway of Drosophila evolve?

  2014cites this paper
• Kinetics of gene derepression by ERK signaling

  2013influential citation
• Context-dependent transcriptional interpretation of mitogen activated protein kinase signaling in the Drosophila embryo.

  2013cites this paper
• Canonical terminal patterning is an evolutionary novelty.

  2013cites this paper
• of Enzyme Kinetics in Cells ReviewERK as a Model for Systems Biology

  2013cites this paper
• Torso RTK controls Capicua degradation by changing its subcellular localization

  2012cites this paper