A p120-catenin–CK1ε complex regulates Wnt signaling

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Journal of Cell Science

• Publication date

  2010-08-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1242/jcs.067512PMID 20940130
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Interactions between Casein Kinase Iε (CKIε) and Two Substrates from Disparate Signaling Pathways Reveal Mechanisms for Substrate-Kinase Specificity

  2009cited by this paper
• Inhibition of GSK3 Phosphorylation of β-Catenin via Phosphorylated PPPSPXS Motifs of Wnt Coreceptor LRP6

  2009influential reference
• Wnt/beta-catenin signaling: components, mechanisms, and diseases.

  2009influential reference
• A p120 Catenin Isoform Switch Affects Rho Activity, Induces Tumor Cell Invasion, and Predicts Metastatic Disease*

  2008influential reference
• Gamma-Secretase-Dependent and -Independent Effects of Presenilin1 on β-Catenin·Tcf-4 Transcriptional Activity

  2008cited by this paper
• E-cadherin controls β-catenin and NF-κB transcriptional activity in mesenchymal gene expression

  2008cited by this paper
• Rac1 activation controls nuclear localization of beta-catenin during canonical Wnt signaling.

  2008cited by this paper
• N-Cadherin Interacts with Axin and LRP5 To Negatively Regulate Wnt/β-Catenin Signaling, Osteoblast Function, and Bone Formation

  2008cited by this paper
• Direct Inhibition of GSK3β by the Phosphorylated Cytoplasmic Domain of LRP6 in Wnt/β-Catenin Signaling

  2008influential reference
• Wnt Signaling, Stem Cells, and Cancer

  2008cited by this paper
• A combination of neutral loss and targeted product ion scanning with two enzymatic digestions facilitates the comprehensive mapping of phosphorylation sites

  2007cited by this paper
• Initiation of Wnt signaling: control of Wnt coreceptor Lrp6 phosphorylation/activation via frizzled, dishevelled and axin functions

  2007cited by this paper
• p120-ctn: A nexus for contextual signaling via Rho GTPases.

  2007influential reference
• Casein Kinase 1 Is a Novel Negative Regulator of E-Cadherin-Based Cell-Cell Contacts

  2007influential reference
• p120 catenin and phosphorylation: Mechanisms and traits of an unresolved issue.

  2007cited by this paper
• Wnt Induces LRP6 Signalosomes and Promotes Dishevelled-Dependent LRP6 Phosphorylation

  2007cited by this paper
• CKI, there's more than one: casein kinase I family members in Wnt and Hedgehog signaling.

  2006influential reference
• Specific Phosphorylation of p120-Catenin Regulatory Domain Differently Modulates Its Binding to RhoA

  2006cited by this paper
• Wnt signalling in stem cells and cancer

  2005cited by this paper
• A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation

  2005cited by this paper
• The casein kinase 1 family: participation in multiple cellular processes in eukaryotes.

  2005cited by this paper
• Casein kinase 1 γ couples Wnt receptor activation to cytoplasmic signal transduction

  2005cited by this paper
• Kaiso/p120-catenin and TCF/beta-catenin complexes coordinately regulate canonical Wnt gene targets.

  2005cited by this paper
• Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transduction.

  2005cited by this paper
• Regulation of Casein Kinase Iϵ Activity by Wnt Signaling*

  2004influential reference
• LDL receptor-related proteins 5 and 6 in Wnt/β-catenin signaling: Arrows point the way

  2004cited by this paper
• Serine and Threonine Phospho-Specific Antibodies to p120-Catenin

  2004cited by this paper
• Autoregulation of E-cadherin expression by cadherin–cadherin interactions

  2003cited by this paper
• Casein kinase I epsilon enhances the binding of Dvl-1 to Frat-1 and is essential for Wnt-3a-induced accumulation of beta-catenin.

  2003cited by this paper
• A core function for p120-catenin in cadherin turnover

  2003cited by this paper
• Casein Kinase Iε Enhances the Binding of Dvl-1 to Frat-1 and Is Essential for Wnt-3a-induced Accumulation of β-Catenin*

  2003cited by this paper
• A novel role for p120 catenin in E-cadherin function

  2002cited by this paper
• The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells.

  2002cited by this paper
• Control of -Catenin Phosphorylation/Degradation by a Dual-Kinase Mechanism

  2002influential reference
• The -Catenin/TCF-4 Complex Imposes a Crypt Progenitor Phenotype on Colorectal Cancer Cells

  2002cited by this paper
• Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism.

  2002influential reference
• Casein kinase I phosphorylates and destabilizes the β-catenin degradation complex

  2002cited by this paper
• Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway.

  2001cited by this paper
• Crystal Structure of a Conformation-selective Casein Kinase-1 Inhibitor*

  2000influential reference
• Casein kinase iepsilon in the wnt pathway: regulation of beta-catenin function.

  1999cited by this paper
• The Catenin p120ctnInteracts with Kaiso, a Novel BTB/POZ Domain Zinc Finger Transcription Factor

  1999cited by this paper
• Casein kinase I transduces Wnt signals

  1999cited by this paper
• Identification of c-MYC as a target of the APC pathway.

  1998cited by this paper
• The cytoplasmic tyrosine kinase FER is associated with the catenin-like substrate pp120 and is activated by growth factors

  1995cited by this paper

• Plasticity in cell adhesion during tumor progression.

  2025cites this paper
• Effect of Casein Kinase 1 epsilon on promoting cartilage degeneration in lumbar facet joint osteoarthritis.

  2025cites this paper
• Mechanism of trypsin-mediated differentiation of pancreatic progenitor cells into functional islet-like clusters

  2025cites this paper
• Outside-in engineering of cadherin endocytosis using a conformation strengthening antibody

  2025cites this paper
• Targeting allograft inflammatory factor 1 reprograms kidney macrophages to enhance repair

  2025cites this paper
• EIF4A3-negatively driven circular RNA β-catenin (circβ-catenin) promotes colorectal cancer progression via miR-197-3p/CTNND1 regulatory axis

  2024cites this paper
• Homocysteine‐potentiated Kelch‐like ECH‐associated protein 1 promotes senescence of neuroblastoma 2a cells via inhibiting ubiquitination of β‐catenin

  2024cites this paper
• TIM-3 signaling hijacks the canonical Wnt/β-catenin pathway to maintain cancer stemness in acute myeloid leukemia

  2023cites this paper
• Cadherins and catenins in cancer: connecting cancer pathways and tumor microenvironment

  2023influential citation
• Dephosphorylation of Y228 and Y217 and phosphorylation of Y335 in p120 catenin activate convergent extension during zebrafish gastrulation

  2022cites this paper
• Kinase domain autophosphorylation rewires the activity and substrate specificity of CK1 enzymes.

  2022cites this paper
• CTNND1 variants cause familial exudative vitreoretinopathy through the Wnt/cadherin axis

  2022cites this paper
• The Wnt pathway can stabilize hybrid phenotypes in the epithelial-mesenchymal transition: A logical modeling approach

  2022cites this paper
• Phosphorylation of serine residues S252, S268/S269, and S879 in p120 catenin activates migration of presomitic mesoderm in gastrulating zebrafish embryos

  2022influential citation
• Crosstalk Between β-CATENIN-Mediated Cell Adhesion and the WNT Signaling Pathway

  2022cites this paper
• New mechanism-based approaches to treating and evaluating the vasculopathy of scleroderma

  2021cites this paper
• Wnt/β‐catenin signaling: Structure, assembly and endocytosis of the signalosome

  2021cites this paper
• Casein kinase 1 epsilon facilitates cartilage destruction in osteoarthritis through JNK pathway

  2020cites this paper
• Autophosphorylation of the CK1 kinase domain regulates enzyme activity and function

  2019cites this paper
• Spatiotemporal regulation of the Dma1-mediated mitotic checkpoint coordinates mitosis with cytokinesis

  2019cites this paper
• Intracellular Signals Activated by Canonical Wnt Ligands Independent of GSK3 Inhibition and β-Catenin Stabilization

  2019cites this paper
• Src and Fyn define a new signaling cascade activated by canonical and non-canonical Wnt ligands and required for gene transcription and cell invasion

  2019cites this paper
• CK1ε and p120‐catenin control Ror2 function in noncanonical Wnt signaling

  2018influential citation
• Hsp90ab1 stabilizes LRP5 to promote epithelial–mesenchymal transition via activating of AKT and Wnt/β-catenin signaling pathways in gastric cancer progression

  2018cites this paper
• Haemorrhagic snake venom metalloproteases and human ADAMs cleave LRP5/6, which disrupts cell–cell adhesions in vitro and induces haemorrhage in vivo

  2017cites this paper
• CK1 in Developmental Signaling: Hedgehog and Wnt.

  2017cites this paper
• Activation of CK1ɛ by PP2A/PR61ɛ is required for the initiation of Wnt signaling

  2017cites this paper
• p120-catenin in canonical Wnt signaling

  2017cites this paper
• Central nervous system development-related microRNAs levels increase in the serum of gestational diabetic women during the first trimester of pregnancy.

  2017cites this paper
• Casein kinase 1‐epsilon or 1‐delta required for Wnt‐mediated intestinal stem cell maintenance

  2017cites this paper
• Phosphorylation and isoform use in p120-catenin during development and tumorigenesis.

  2016cites this paper
• Adherens Junction and E-Cadherin complex regulation by epithelial polarity

  2016cites this paper
• Upon Wnt stimulation, Rac1 activation requires Rac1 and Vav2 binding to p120-catenin

  2016cites this paper
• Modulation of Inflammatory Responses by Wnt/β-Catenin Signaling in Dendritic Cells: A Novel Immunotherapy Target for Autoimmunity and Cancer

  2016cites this paper
• Regulation of Endothelial Adherens Junctions by Tyrosine Phosphorylation

  2015cites this paper
• Therapeutic inhibition of PI3K/AKT and WNT/b-catenin pathways in colorectal cancer

  2015cites this paper
• Biochemical and Molecular Signaling of the Canonical Wnt Pathway

  2015cites this paper
• The role of adherens junctions in the developing neocortex

  2015cites this paper
• Nuclear signaling from cadherin adhesion complexes.

  2015cites this paper
• E-Cadherin/Catenin Complex Modulations in Human Oral Cancer

  2015cites this paper
• Wnt/β-catenin signaling in Alzheimer's disease.

  2014cites this paper
• Role of cell–cell adhesion complexes in embryonic stem cell biology

  2014influential citation
• Cross-talk between the circadian clock and the cell cycle in cancer

  2014cites this paper
• Methoxy-Poly(ethylene glycol) Modified Poly(L-lactide) Enhanced Cell Affinity of Human Bone Marrow Stromal Cells by the Upregulation of 1-Cadherin and Delta-2-catenin

  2014cites this paper
• Cross-species Proteomics Reveals Specific Modulation of Signaling in Cancer and Stromal Cells by Phosphoinositide 3-kinase (PI3K) Inhibitors*

  2014cites this paper
• Casein kinase 1 and Wnt/β-catenin signaling.

  2014cites this paper
• Multivesicular GSK3 sequestration upon Wnt signaling is controlled by p120-catenin/cadherin interaction with LRP5/6.

  2014cites this paper
• The circadian clock in cancer development and therapy.

  2013cites this paper
• p120catenin alteration in cancer and its role in tumour invasion

  2013cites this paper
• p120 Catenin Is Required for the Stress Response in Drosophila

  2013cites this paper
• AKT activation by N-cadherin regulates beta-catenin signaling and neuronal differentiation during cortical development

  2013cites this paper
• Beta-catenin versus the other armadillo catenins: assessing our current view of canonical Wnt signaling.

  2013cites this paper
• p120 catenin: an essential regulator of cadherin stability, adhesion-induced signaling, and cancer progression.

  2013cites this paper
• Protein Ser/Thr phosphatase-6 is required for maintenance of E-cadherin at adherens junctions

  2013cites this paper
• Wnt/beta-Catenin Signaling and Small Molecule Inhibitors

  2012cites this paper
• Functions of p120ctn in development and disease.

  2012cites this paper
• Association of paired box 6 with high myopia in Japanese

  2012cites this paper
• Functions of p120ctn isoforms in cell-cell adhesion and intracellular signaling.

  2012cites this paper
• A Screen for X-Linked Mutations Affecting Drosophila Photoreceptor Differentiation Identifies Casein Kinase 1α as an Essential Negative Regulator of Wingless Signaling

  2012cites this paper
• P-cadherin regulates human hair growth and cycling via canonical Wnt signaling and transforming growth factor-β2.

  2012cites this paper
• Down's-syndrome-related kinase Dyrk1A modulates the p120-catenin–Kaiso trajectory of the Wnt signaling pathway

  2012cites this paper
• Upon Wnt stimulation, Rac1 activation requires Rac1 and Vav2 binding to p120-catenin

  2012cites this paper
• Regulation and function of the E-cadherin/catenin complex in cells of the monocyte-macrophage lineage and DCs.

  2012cites this paper
• Regulation of Adherens Junction Dynamics by Phosphorylation Switches

  2012cites this paper
• Recent Advances in Wnt/β-Catenin Pathway Small-Molecule Inhibitors

  2012cites this paper
• DEVELOPMENTAL AND CELLULAR FUNCTIONS OF DELTA-CATENIN

  2011cites this paper
• Mechanisms regulating the p120-catenin/Kaiso pathway

  2011cites this paper
• Wnt controls the transcriptional activity of Kaiso through CK1ε-dependent phosphorylation of p120-catenin

  2011cites this paper
• Coordinated Action of CK1 Isoforms in Canonical Wnt Signaling

  2011cites this paper
• A Nuclear Function for the Presenilin 1 Neuronal Partner NPRAP/δ-Catenin

  2011cites this paper
• All Dact (Dapper/Frodo) scaffold proteins dimerize and exhibit conserved interactions with Vangl, Dvl, and serine/threonine kinases

  2011cites this paper
• DigitalCommons@Th e Texas Medical Center

  2011cites this paper
• Shared molecular mechanisms regulate multiple catenin proteins: canonical Wnt signals and components modulate p120-catenin isoform-1 and additional p120 subfamily members

  2010cites this paper