Imaging brain activity during seizures in freely behaving rats using a miniature multi-modal imaging system.

We report on a miniature label-free imaging system for monitoring brain blood flow and blood oxygenation changes in awake, freely behaving rats. The device, weighing 15 grams, enables imaging in a ∼ 2 × 2 mm field of view with 4.4 μm lateral resolution and 1 - 8 Hz temporal sampling rate. The imaging is performed through a chronically-implanted cranial window that remains optically clear between 2 to > 6 weeks after the craniotomy. This imaging method is well suited for longitudinal studies of chronic models of brain diseases and disorders. In this work, it is applied to monitoring neurovascular coupling during drug-induced absence-like seizures 6 weeks following the craniotomy.

• Publication year

  2016

• Venue

  Biomedical Optics Express

• Publication date

  2016-09-01

• Fields of study

  Medicine, Engineering

• Identifiers
  DOI 10.1364/BOE.7.003596PMID 27699123PMCID PMC5030035
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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