Pyruvate potentiates inotropic effects of isoproterenol and Ca(2+) in rabbit cardiac muscle preparations.

No abstract is available for this paper.

• Publication year

  2000

• Venue

  American Journal of Physiology. Heart and Circulatory Physiology

• Publication date

  2000-08-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1152/AJPHEART.2000.279.2.H702PMID 10924069
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• the heart

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• Haemodynamic effects of intracoronary pyruvate in patients with congestive heart failure: an open study.

  1999cited by this paper
• Transient and sustained impacts of hydroxyl radicals on sarcoplasmic reticulum function: protective effects of nebivolol.

  1999cited by this paper
• Frequency-dependence of myocardial energetics in failing human myocardium as quantified by a new method for the measurement of oxygen consumption in muscle strip preparations.

  1998cited by this paper
• The trabecula culture system: a novel technique to study contractile parameters over a multiday time period.

  1998cited by this paper
• Pyruvate augments calcium transients and cell shortening in rat ventricular myocytes.

  1998cited by this paper
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  1998cited by this paper
• The trabecula culture system: a novel technique to study contractile parameters over a multiday time period.

  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1996cited by this paper
• Force, not sarcomere length, correlates with prolongation of isosarcometric contraction.

  1995cited by this paper
• Effect of substrate on mitochondrial NADH, cytosolic redox state, and phosphorylated compounds in isolated hearts.

  1995cited by this paper
• Effects of inorganic phosphate and ADP on calcium handling by the sarcoplasmic reticulum in rat skinned cardiac muscles.

  1995cited by this paper
• Is lactate-induced myocardial ischaemic injury mediated by decreased pH or increased intracellular lactate?

  1995cited by this paper
• The relationship between phosphorylation potential and redox state in the isolated working rabbit heart.

  1994influential reference
• Hemodynamic effects of intravenous pyruvate in the intact, anesthetized dog

  1994cited by this paper
• Energetic modulation of cardiac inotropism and sarcoplasmic reticular Ca2+ uptake.

  1994cited by this paper
• Transport of lactate and other monocarboxylates across mammalian plasma membranes.

  1993cited by this paper
• Effects of Calcium and EMD‐453998 on Oxygen Consumption in Isolated Canine Hearts

  1992cited by this paper
• Ventricular energetics.

  1990cited by this paper
• Effect of Pyruvate on Regional Ventricular Function in Normal and Stunned Myocardium

  1989cited by this paper
• Protection of Human Left Ventricular Myocardium From Cutting Injury With 2,3 -Butanedione Monoxime

  1989cited by this paper
• Pyruvate-enhanced phosphorylation potential and inotropism in normoxic and postischemic isolated working heart. Near-complete prevention of reperfusion contractile failure.

  1989cited by this paper
• Ryanodine and the calcium content of cardiac SR assessed by caffeine and rapid cooling contractures.

  1987influential reference
• Energetic aspects of inotropic interventions in rat myocardium.

  1987cited by this paper
• Substrate-induced alterations of high energy phosphate metabolism and contractile function in the perfused heart.

  1987cited by this paper
• The Heart: Physiology, Metabolism, Pharmacology and Therapy

  1986cited by this paper
• Comparison between the Sarcomere Length‐Force Relations of Intact and Skinned Trabeculae from Rat Right Ventricle: Influence of Calcium Concentrations on These Relations

  1986cited by this paper
• The effects of inorganic phosphate and creatine phosphate on force production in skinned muscles from rat ventricle.

  1986cited by this paper
• Relationships between the sarcoplasmic reticulum and sarcolemmal calcium transport revealed by rapidly cooling rabbit ventricular muscle

  1986cited by this paper
• Phosphorylation of troponin I and phospholamban during catecholamine stimulation of rabbit heart

  1982cited by this paper
• Tension Development and Sarcomere Length in Rat Cardiac Trabeculae: Evidence of Length‐Dependent Activation

  1980cited by this paper
• Phosphorylation of troponin I and the inotropic effect of adrenaline in the perfused rabbit heart

  1976cited by this paper
• Effects of Treatment with Pyruvate and Tromethamine in Experimental Myocardial Ischemia

  1976cited by this paper

• Investigating the inotropic effect of pyruvic acid on the isolated rat heart and its underlying mechanism.

  2019cites this paper
• Matrix Revisited: Mechanisms Linking Energy Substrate Metabolism to the Function of the Heart

  2014cites this paper
• Chapter 6 – Carbohydrates, Alcohols, and Organic Acids

  2014cites this paper
• The Positive Inotropic Effect of Pyruvate Involves an Increase in Myofilament Calcium Sensitivity

  2013cites this paper
• Intracoronary pyruvate in cardiogenic shock as an adjunctive therapy to catecholamines and intra-aortic balloon pump shows beneficial effects on hemodynamics

  2010cites this paper
• The effect of glucose on cardiac AMP-activated protein kinase

  2009cites this paper
• The role of amino acids in the modulation of cardiac metabolism during ischemia and heart failure.

  2008cites this paper
• In vivo assessment of pyruvate dehydrogenase flux in the heart using hyperpolarized carbon-13 magnetic resonance

  2008cites this paper
• Elevated Afterload, Neuroendocrine Stimulation, and Human Heart Failure Increase BNP Levels and Inhibit Preload-Dependent SERCA Upregulation

  2008cites this paper
• Influence of pyruvate on economy of contraction in isolated rabbit myocardium

  2007cites this paper
• Direct in vivo monitoring of sarcoplasmic reticulum Ca2+ and cytosolic cAMP dynamics in mouse skeletal muscle

  2006cites this paper
• Apoyo metabólico del corazón isquémico en cirugía cardíaca

  2006cites this paper
• Pyruvate improves cardiac electromechanical and metabolic recovery from cardiopulmonary arrest and resuscitation.

  2005cites this paper
• Metabolic Cardioprotection by Pyruvate: Recent Progress

  2005cites this paper
• Myocardial substrate metabolism in the normal and failing heart.

  2005cites this paper
• The intermediary metabolite pyruvate attenuates stunning and reduces infarct size in in vivo porcine myocardium.

  2004cites this paper
• Dose-dependent effects of ethyl pyruvate in mice subjected to mesenteric ischemia and reperfusion

  2003cites this paper
• Improved systolic and diastolic myocardial function with intracoronary pyruvate in patients with congestive heart failure

  2003cites this paper
• Antioxidant properties of myocardial fuels

  2003cites this paper
• Modulation of the positive inotropic effect of pyruvate by energetic substrate availability

  2003cites this paper
• Pyruvate Modulates Cardiac Sarcoplasmic Reticulum Ca2+ Release in Rats Via Mitochondria‐Dependent and ‐Independent Mechanisms

  2003cites this paper
• The Role of SR Ca2+-Content in Blunted Inotropic Responsiveness of Failing Human Myocardium

  2002cites this paper
• Potentiation of beta-adrenergic inotropic response by pyruvate in failing human myocardium.

  2002cites this paper
• The role of SR Ca(2+)-content in blunted inotropic responsiveness of failing human myocardium.

  2002cites this paper
• Energetic Stimulation of the Heart

  2001cites this paper
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  2001cites this paper