Inhibition of nitric oxide formation by aminoguanidine: an attempt to prevent insulin-dependent diabetes mellitus.

No abstract is available for this paper.

• Publication year

  1997

• Venue

  General Pharmacology

• Publication date

  1997-11-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/S0306-3623(97)00012-8PMID 9347312
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The harmony of the spheres: inducible nitric oxide synthase and related genes in pancreatic beta cells

  1996cited by this paper
• Inhibition of inducible nitric oxide synthase prevents myocardial and systemic vascular barrier dysfunction during early cardiac allograft rejection.

  1996cited by this paper
• Aminoguanidine ameliorates and L-arginine worsens brain damage from intraluminal middle cerebral artery occlusion.

  1996cited by this paper
• Selective inhibition of inducible nitric oxide synthase by aminoguanidine.

  1996cited by this paper
• Effects of aminoguanidine on rat pancreatic islets in culture and on the pancreatic islet blood flow of anaesthetized rats.

  1996cited by this paper
• The role of interleukin-1 in the pathogenesis of IDDM

  1996cited by this paper
• Nω-Nitro-L-Arginine Methyl Ester Reduces the Incidence of IDDM in BB/E Rats

  1995cited by this paper
• The blood flow in pancreatico-duodenal grafts in rats: inhibition of nitric oxide synthase preferentially decreases islet blood flow.

  1995cited by this paper
• Mechanisms of endotoxin-induced dilatation of cerebral arterioles.

  1995cited by this paper
• Aminoguanidine‐provoked leukocyte adherence to rat mesenteric venules: role of constitutive nitric oxide synthase inhibition

  1995cited by this paper
• Nitric oxide induces vascular permeability changes in the guinea pig conjunctiva.

  1995cited by this paper
• N omega-nitro-L-arginine methyl ester reduces the incidence of IDDM in BB/E rats.

  1995cited by this paper
• Increased nitric oxide synthase activity despite lack of response to endothelium-dependent vasodilators in postischemic acute renal failure in rats.

  1995cited by this paper
• Nitric Oxide Synthesis and the Effect of Aminoguanidine and NG-monomethyl-L-Arginine on the Onset of Diabetes in the Spontaneously Diabetic BB Rat

  1995cited by this paper
• Aminoguanidine is an isoform-selective, mechanism-based inactivator of nitric oxide synthase.

  1995cited by this paper
• Primary cultures of rat islet capillary endothelial cells. Constitutive and cytokine-inducible macrophagelike nitric oxide synthases are expressed and activities regulated by glucose concentration.

  1994cited by this paper
• Effects of aminoguanidine on insulin release from pancreatic islets.

  1994cited by this paper
• Effects of NG-methyl-L-arginine, NG-nitro-L-arginine, and aminoguanidine on constitutive and inducible nitric oxide synthase in rat aorta.

  1994cited by this paper
• Inhibition of nitric oxide synthase by NG-nitro-L-arginine causes a preferential decrease in pancreatic islet blood flow in normal rats and spontaneously diabetic GK rats.

  1994cited by this paper
• Requirement for transcription factor IRF-1 in NO synthase induction in macrophages.

  1994cited by this paper
• Cytokines suppress human islet function irrespective of their effects on nitric oxide generation.

  1994cited by this paper
• Aminoguanidine, an inhibitor of inducible nitric oxide synthase, ameliorates experimental autoimmune encephalomyelitis in SJL mice.

  1994cited by this paper
• Nitric Oxide: A Physiologic Messenger

  1994cited by this paper
• The regulation of pancreatic islet blood flow.

  1994cited by this paper
• Prevention of Diabetic Vascular Dysfunction by Guanidines: Inhibition of Nitric Oxide Synthase Versus Advanced Glycation End-Product Formation

  1993cited by this paper
• Aminoguanidine: a drug proposed for prophylaxis in diabetes inhibits catalase and generates hydrogen peroxide in vitro.

  1993cited by this paper
• Selective inhibition of the inducible nitric oxide synthase by aminoguanidine.

  1993cited by this paper
• Nitric oxide production in islets from nonobese diabetic mice: aminoguanidine-sensitive and -resistant stages in the immunological diabetic process.

  1993cited by this paper
• Aminoguanidine, an inhibitor of nitric oxide formation, fails to protect against insulitis and hyperglycemia induced by multiple low dose streptozotocin injections in mice.

  1993cited by this paper
• Does Nitric Oxide Mediate Autoimmune Destruction of β-Cells?: Possible Therapeutic Interventions in IDDM

  1992cited by this paper
• Nitric oxide and arginine-evoked insulin secretion.

  1992cited by this paper
• Insulin secretion from pancreatic B cells caused by L-arginine-derived nitrogen oxides.

  1992cited by this paper
• Effects of advanced glycation products and aminoguanidine upon insulin release

  1992cited by this paper
• Inhibition of nitric oxide generation affects the induction of diabetes by streptozocin in mice.

  1991cited by this paper
• Interleukin-1 beta-induced nitric oxide production in isolated rat pancreatic islets requires gene transcription and may lead to inhibition of the Krebs cycle enzyme aconitase.

  1991cited by this paper
• Biochemical and Molecular Actions of Interleukin-1 on Pancreatic β-Cells

  1991cited by this paper
• Suppression of low dose streptozotocin induced diabetes in mice by administration of a nitric oxide synthase inhibitor.

  1991cited by this paper
• Nitric oxide: physiology, pathophysiology, and pharmacology.

  1991cited by this paper
• Biochemical and molecular actions of interleukin-1 on pancreatic beta-cells.

  1991cited by this paper
• Nitric oxide synthesis in the CNS endothelium and macrophages differs in its sensitivity to inhibition by arginine analogues.

  1991cited by this paper
• Macrophage and endothelial cell nitric oxide synthesis: cell-type selective inhibition by NG-aminoarginine, NG-nitroarginine and NG-methylarginine.

  1990cited by this paper
• Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo

  1990cited by this paper
• Inhibition of insulin secretion by interleukin-1 beta and tumour necrosis factor-alpha via an L-arginine-dependent nitric oxide generating mechanism.

  1990cited by this paper
• Inhibition of insulin secretion by interleukin‐1β and tumour necrosis factor‐α via an L‐arginine‐dependent nitric oxide generating mechanism

  1990cited by this paper
• Immune hormones (cytokines); pathogenic role in autoimmune rheumatic and endocrine diseases.

  1989cited by this paper
• Low-Dose Streptozocin-Induced Diabetes in Mice: Electron Microscopy Reveals Single-Cell Insulitis Before Diabetes Onset

  1988cited by this paper
• Preferential Infiltration of Macrophages During Early Stages of Insulitis in Diabetes-Prone BB Rats

  1988cited by this paper
• The HLA-IDDM association: implications for etiology and pathogenesis of IDDM.

  1987cited by this paper
• Induction of nitrite/nitrate synthesis in murine macrophages by BCG infection, lymphokines, or interferon-gamma.

  1987cited by this paper
• Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

  1987cited by this paper
• Type I diabetes mellitus. A chronic autoimmune disease.

  1986cited by this paper
• Aminoguanidine prevents diabetes-induced arterial wall protein cross-linking.

  1986cited by this paper
• Type I diabetes mellitus. A chronic autoimmune disease.

  1986cited by this paper

• Synthesis and reactivity of an osmium(iii) aminoguanidine complex.

  2019cites this paper
• Pancreatic Blood Flow with Special Emphasis on Blood Perfusion of the Islets of Langerhans.

  2019cites this paper
• COX-2 and survivin reduction may play a role in berberine-induced apoptosis in human ductal breast epithelial tumor cell line

  2012cites this paper
• Oxidative stress and nitrosative stress are involved in different stages of proteolytic pulmonary emphysema.

  2012cites this paper
• Berberine-induced apoptosis via decreasing the survivin protein in K562 cell line

  2011cites this paper
• Functional roles of nitric oxide signalling during zebrafish nervous system development

  2011cites this paper
• Aminoguanidine administered during the induction of oral tolerance alters the systemic response of the tolerised rats.

  2010cites this paper
• Suppression of bank vole pancreatic islet function by proinflammatory cytokines.

  2009cites this paper
• Metabolism of aminoguanidine, diaminoguanidine, and NG-amino-L-arginine by neuronal NO-synthase and covalent alteration of the heme prosthetic group.

  2005cites this paper
• Reversal by aminoguanidine of the age-related increase in glycoxidation and lipoxidation in the cardiovascular system of Fischer 344 rats.

  2005cites this paper
• Spatial distribution and temporal onset of NF-kB activation and inducible nitric oxide synthase within pancreatic islets in the pre-diabetic stage of genetic, diabetic-prone BB rats: Attenuation by drug intervention decreases inflammatory cell infiltration and incidence of diabetes

  2003cites this paper
• Antimonial-induced Increase in Intracellular Ca2+ through Non-selective Cation Channels in the Host and the Parasite Is Responsible for Apoptosis of Intracellular Leishmania donovani Amastigotes*

  2003cites this paper
• Aminoguanidine downregulates expression of cytokine-induced Fas and inducible nitric oxide synthase but not cytokine-enhanced surface antigens of rat islet cells.

  2003cites this paper
• EPR investigation of in vivo inhibitory effect of guanidine compounds on nitric oxide production in rat tissues.

  2003cites this paper
• Effect of age receptor blocker and/or anti-inflammatory coadministration in relation to glycation, oxidative stress and cytokine production in stz diabetic rats.

  2002cites this paper
• Effect of chronic aminoguanidine treatment on age-related glycation, glycoxidation, and collagen cross-linking in the Fischer 344 rat.

  2001cites this paper
• New issues about nitric oxide and its effects on the gastrointestinal tract.

  2001cites this paper
• Aminoguanidine-mediated Inactivation and Alteration of Neuronal Nitric-oxide Synthase*

  2000cites this paper
• Elevated, sustained peroxynitrite levels as the cause of chronic fatigue syndrome.

  2000cites this paper
• Involvement of nitric oxide in nickel-induced hyperglycemia in rats.

  2000cites this paper
• Suppression of the development of hypertension by the inhibitor of inducible nitric oxide synthase

  2000cites this paper
• Nitric Oxide in the Immunopathogenesis of Type 1 Diabetes

  2000cites this paper
• Cytotoxic Role of Nitric Oxide in Diabetes

  2000cites this paper
• Antioxidants, NFkappaB activation, and diabetogenesis.

  1999cites this paper
• Antioxidants, NFκB Activation, and Diabetogenesis (44445)

  1999cites this paper
• Supplementation of N‐acetylcysteine inhibits NFκB activation and protects against alloxan‐induced diabetes in CD‐1 mice

  1999cites this paper
• Exploiting glycation to stiffen and strengthen tissue equivalents for tissue engineering.

  1999cites this paper
• Cytotoxicity of advanced glycation endproducts is mediated by oxidative stress

  1998cites this paper
• [Nitric oxide and inflammatory bowel disease].

  1998cites this paper