Toxicological Effects of Aqueous Extract From African Walnut (Tetracarpidium conophorum) Leaves in Rats

Tetracarpidium conophorum leaves are used in traditional medicine for the treatment of male infertility, without considering its toxicity and side effects. In this study, we investigated the effects of T conophorum leaves on some biochemical parameters such as alanine aminotransferase, aspartate aminotransferase, bilirubin, albumin, creatinine, and uric acid. Histology of the liver and kidney were also assessed. The result revealed that the alanine aminotransferase and aspartate aminotransferase levels of the control group were not significantly different from the experimental groups. There was no significant difference in the albumin and bilirubin levels of the control and experimental groups. Similarly, the uric acid and creatinine levels of the experimental rats were not significantly different from the control. The examination of liver and kidney sections did not show any morphological changes and inflammatory cell infiltrations. These findings suggest that the leaves did not induce any pathological changes at the doses tested.

• Publication year

  2017

• Venue

  Journal of Evidence-Based Complementary & Alternative Medicine

• Publication date

  2017-07-18

• Fields of study

  Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1177/2156587217718979PMID 28719975PMCID 5871301
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2015influential reference
• Nutritional Properties and Toxicological Assessment of High Nutrient Biscuit Developed from Blends of Some Cereals and Legume

  2015cited by this paper
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  2014cited by this paper
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  2011cited by this paper
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  2010cited by this paper
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  2010cited by this paper
• Advances in selected medicinal and aromatic plants indigenous to Africa.

  2009cited by this paper
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  2007cited by this paper
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  2007cited by this paper
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  2006cited by this paper
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  2006cited by this paper
• Determination of the total phenolic, flavonoid and proline contents in Burkina Fasan honey, as well as their radical scavenging activity.

  2005influential reference
• Ethnobotanical knowledge of local Arab practitioners in the Middle Eastern region.

  2003cited by this paper
• Sub-chronic Toxicity Studies of the Aqueous Extract of Boerhavia diffusa Leaves

  2003cited by this paper
• Special considerations in interpreting liver function tests.

  1999cited by this paper
• Analysis of total phenols and other oxidation substrates and antioxidants by means of Folin-Ciocalteu reagent

  1999influential reference
• Albumin standards and the measurement of serum albumin with bromcresol green.

  1997cited by this paper
• Adverse reactions and interactions with herbal medicines. Part 1. Adverse reactions.

  1991cited by this paper
• Adverse reactions and interactions with herbal medicines. Part 1. Adverse reactions.

  1991cited by this paper
• [Determination of uric acid].

  1976cited by this paper
• Reduction of ferric phenanthroline--a procedure for determining serum uric acid.

  1973cited by this paper
• [Uric acid].

  1967cited by this paper
• Clinical Chemistry: Principles and Technics

  1964cited by this paper
• 2,4,6-Tripyridyl-s-triazine as Reagent for Iron. Determination of Iron in Limestone, Silicates, and Refractories

  1959cited by this paper
• Liver function tests and their interpretation.

  1958cited by this paper
• A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases.

  1957cited by this paper
• Protein measurement with the Folin phenol reagent.

  1951cited by this paper
• A Textbook of Pharmacognosy

  1945cited by this paper

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