Creating transplant tolerance by taming adverse intragraft innate immunity

D. Hanidziar,M. Koulmanda,T. Strom

Published 2010 in F1000 Biology Reports

ABSTRACT

Certain forms of inflammation of an allograft are highly detrimental to the induction and maintenance of transplant tolerance as they foster stable commitment to graft-destructive, not graft-protective, forms of T-cell immunity. Hence, a reduction in adverse tissue inflammation may prove crucial in facilitating the induction and maintenance of a long-lasting state of transplant tolerance.

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