Anti-PEG IgM and complement system are required for the association of second doses of PEGylated liposomes with splenic marginal zone B cells.

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Immunobiology

• Publication date

  2015-10-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/j.imbio.2015.06.005PMID 26095176
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Biodistribution, pharmacokinetics, and blood compatibility of native and PEGylated tobacco mosaic virus nano-rods and -spheres in mice.

  2014cited by this paper
• In vivo immune cell distribution of gold nanoparticles in naïve and tumor bearing mice.

  2014cited by this paper
• Generation, characterization and in vivo biological activity of two distinct monoclonal anti-PEG IgMs.

  2014cited by this paper
• Size-dependent biodistribution of carbon nanohorns in vivo.

  2013cited by this paper
• Transport of PEGylated liposomes from the splenic marginal zone to the follicle in the induction phase of the accelerated blood clearance phenomenon.

  2013cited by this paper
• Therapeutic efficacy of a lipid-based prodrug of mitomycin C in pegylated liposomes: studies with human gastro-entero-pancreatic ectopic tumor models.

  2012cited by this paper
• Visualization of splenic marginal zone B cell shuttling and follicular B cell egress

  2012cited by this paper
• Altered Ig levels and antibody responses in mice deficient for the Fc receptor for IgM (FcμR)

  2012cited by this paper
• Effect of the poly(ethylene glycol) (PEG) density on the access and uptake of particles by antigen-presenting cells (APCs) after subcutaneous administration.

  2012cited by this paper
• PEGylated cationic liposomes robustly augment vaccine-induced immune responses: Role of lymphatic trafficking and biodistribution.

  2012cited by this paper
• Phase I and pharmacokinetic study of IHL-305 (PEGylated liposomal irinotecan) in patients with advanced solid tumors

  2012cited by this paper
• IgM Promotes the Clearance of Small Particles and Apoptotic Microparticles by Macrophages

  2011cited by this paper
• Gemcitabine-loaded PEGylated unilamellar liposomes vs GEMZAR: biodistribution, pharmacokinetic features and in vivo antitumor activity.

  2010cited by this paper
• Uncoupling CD21 and CD19 of the B-cell coreceptor

  2009cited by this paper
• B Cell Receptor-Mediated Internalization of Salmonella: A Novel Pathway for Autonomous B Cell Activation and Antibody Production1

  2009cited by this paper
• The impact of size on tissue distribution and elimination by single intravenous injection of silica nanoparticles.

  2009cited by this paper
• Follicular shuttling of marginal zone B cells facilitates antigen transport

  2008cited by this paper
• Antigens take the shuttle

  2008cited by this paper
• PEGylated liposomes elicit an anti-PEG IgM response in a T cell-independent manner.

  2007cited by this paper
• Injection of PEGylated liposomes in rats elicits PEG-specific IgM, which is responsible for rapid elimination of a second dose of PEGylated liposomes.

  2006cited by this paper
• Spleen plays an important role in the induction of accelerated blood clearance of PEGylated liposomes.

  2006cited by this paper
• Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs.

  2005cited by this paper
• Marginal zone B cells transport and deposit IgM-containing immune complexes onto follicular dendritic cells.

  2004cited by this paper
• Impaired Antibody Response to Group B Streptococcal Type III Capsular Polysaccharide in C3- and Complement Receptor 2-Deficient Mice1

  2003cited by this paper
• Accelerated clearance of PEGylated liposomes in rats after repeated injections.

  2003cited by this paper
• Macrophages Control the Retention and Trafficking of B Lymphocytes in the Splenic Marginal Zone

  2003cited by this paper
• The dual function of the splenic marginal zone: essential for initiation of anti‐TI‐2 responses but also vital in the general first‐line defense against blood‐borne antigens

  2002cited by this paper
• Accelerated blood clearance and altered biodistribution of repeated injections of sterically stabilized liposomes.

  2000cited by this paper
• Preclinical and clinical evidence for disappearance of long-circulating characteristics of polyethylene glycol liposomes at low lipid dose.

  2000cited by this paper
• B cells on the front line

  2000cited by this paper
• Role of natural and immune IgM antibodies in immune responses.

  2000cited by this paper
• Splenic Trapping of Nanoparticles: Complementary Approaches for In Situ Studies

  1997cited by this paper
• B-1 cells: unique origins and functions.

  1996cited by this paper
• Regulation and targeting of T-cell immune responses by IgE and IgG antibodies.

  1995cited by this paper
• Natural antibody and complement-mediated antigen processing and presentation by B lymphocytes.

  1994cited by this paper
• Effect of liposome size on the circulation time and intraorgan distribution of amphipathic poly(ethylene glycol)-containing liposomes.

  1994cited by this paper
• Poly(ethylene glycol) on the liposome surface: on the mechanism of polymer-coated liposome longevity.

  1994cited by this paper
• Influence of surface hydrophilicity of liposomes on their interaction with plasma protein and clearance from the circulation: studies with poly(ethylene glycol)-coated vesicles.

  1991cited by this paper
• Liposomes containing synthetic lipid derivatives of poly(ethylene glycol) show prolonged circulation half-lives in vivo.

  1991cited by this paper
• Studies on the in vivo effects of antibody. Interaction of IgM antibody and complement in the immune clearance and destruction of erythrocytes in man.

  1974cited by this paper
• Role of antibody and complement in the immune clearance and destruction of erythrocytes. I. In vivo effects of IgG and IgM complement-fixing sites.

  1972cited by this paper
• The structure of the spleen and hemolysis.

  1969cited by this paper
• Colorimetric assay methods for free and phosphorylated glyceric acids.

  1959cited by this paper

• Liposomal Nanocarriers in Precision Oncology: Advances and Prospects.

  2026cites this paper
• The curious case of anti-PEG antibodies.

  2025cites this paper
• Emerging strategies against accelerated blood clearance phenomenon of nanocarrier drug delivery systems

  2025cites this paper
• Implications of Anaphylaxis Following mRNA-LNP Vaccines: It Is Urgent to Eliminate PEG and Find Alternatives

  2025cites this paper
• Revealing the Incidence of the Accelerated Blood Clearance Phenomenon of PEGylated Liposomes in Individuals Using a Drug‐Release Reporter Liposome

  2025cites this paper
• Long circulating liposomal platform utilizing hydrophilic polymer-based surface modification: preparation, characterisation, and biological evaluation.

  2024cites this paper
• Development of Lipid Nanoparticle Formulation for the Repeated Administration of mRNA Therapeutics

  2024cites this paper
• Impact of the Different Molecular Weights of Polyethylene Glycol (PEG) Coating Agents on the Magnetic Targeting Characteristics of Functionalized Magnetoresponsive Nanoclusters

  2024cites this paper
• The interplay between PEGylated nanoparticles and blood immune system.

  2023cites this paper
• Polysarcosine-Coated liposomes attenuating immune response induction and prolonging blood circulation.

  2023cites this paper
• Lipid nanoparticles (LNPs) for in vivo RNA delivery and their breakthrough technology for future applications.

  2023cites this paper
• Cleavable-Branched Polymer-Modified Liposomes Reduce Accelerated Blood Clearance and Enhance Photothermal Therapy.

  2023cites this paper
• Investigating Generation of Antibodies against the Lipid Nanoparticle Vector Following COVID-19 Vaccination with an mRNA Vaccine.

  2023cites this paper
• Poly(oxanorbornene)-Protein Conjugates Prepared by Grafting-to Romp as Alternatives for Peg.

  2023cites this paper
• Activation of CYP3A by Accelerated Blood Clearance Phenomenon Potentiates the Hepatocellular Carcinoma-Targeting Therapeutic Effects of PEGylated Anticancer Prodrug Liposomes

  2023cites this paper
• Treatment-induced and pre-existing anti-PEG antibodies: Prevalence, clinical implications, and future perspectives.

  2023cites this paper
• Polyethylene glycol: Properties, applications, and challenges

  2023cites this paper
• Cell-targeted vaccines: implications for adaptive immunity

  2023cites this paper
• Polymersome-based protein drug delivery – quo vadis?

  2022cites this paper
• PEGylated Gold Nanoparticles Target Age-Associated B Cells In Vivo

  2022cites this paper
• mRNA-LNP vaccines tuned for systemic immunization induce strong antitumor immunity by engaging splenic immune cells

  2022cites this paper
• Liposomes: An emerging carrier for targeting Alzheimer's and Parkinson's diseases

  2022cites this paper
• Development of an Antigen Delivery System for a B Cell-Targeted Vaccine as an Alternative to Dendritic Cell-Targeted Vaccines.

  2022cites this paper
• Re-directing nanomedicines to the spleen: A potential technology for peripheral immunomodulation.

  2022cites this paper
• Development of B cell-targeted vaccines utilizing immune responses against PEG

  2022cites this paper
• Anti-PEG antibodies compromise the integrity of PEGylated lipid-based nanoparticles via complement.

  2021cites this paper
• Anti-PEG IgM production and accelerated blood clearance phenomenon after the administration of PEGylated exosomes in mice.

  2021cites this paper
• Polyethylene Glycol Immunogenicity: Theoretical, Clinical, and Practical Aspects of Anti-Polyethylene Glycol Antibodies.

  2021cites this paper
• The fate of nanoparticles in vivo and the strategy of designing stealth nanoparticle for drug delivery.

  2021cites this paper
• Lymphoid follicle antigen (Ag) delivery and enhanced rodent humoral immune responses mediated by Ag-containing PEGylated liposomes.

  2021cites this paper
• Liposome induction of CD8+ T cell responses depends on CD169+ macrophages and Batf3-dependent dendritic cells and is enhanced by GM3 inclusion.

  2021cites this paper
• A Novel 89Zr-labeled DDS Device Utilizing Human IgG Variant (scFv): “Lactosome” Nanoparticle-Based Theranostics for PET Imaging and Targeted Therapy

  2021cites this paper
• Clinical Relevance of Pre-Existing and Treatment-Induced Anti-Poly(Ethylene Glycol) Antibodies

  2021cites this paper
• Polymeric Delivery of Therapeutic Nucleic Acids.

  2021cites this paper
• PEG shedding-rate-dependent blood clearance of PEGylated lipid nanoparticles in mice: faster PEG shedding attenuates anti-PEG IgM production.

  2020cites this paper
• Immunological responses to PEGylated proteins

  2020cites this paper
• [Induction of Anti-PEG Immune Responses by PEGylation of Proteins].

  2020cites this paper
• Immunogenicity of Polyethylene Glycol Based Nanomedicines: Mechanisms, Clinical Implications and Systematic Approach

  2020cites this paper
• Liposomes and PEGylated liposomes as drug delivery system

  2020cites this paper
• Hepatosplenic phagocytic cells indirectly contribute to anti-PEG IgM production in the accelerated blood clearance (ABC) phenomenon against PEGylated liposomes: Appearance of an unexplained mechanism in the ABC phenomenon.

  2020cites this paper
• Concentration of polymer nanoparticles through dialysis: Efficacy and comparison with lyophilization for PEGylated and zwitterionic systems.

  2020cites this paper
• Blood retention and antigenicity of polycarboxybetaine-modified liposomes.

  2020cites this paper
• Complement Activation: A Potential Threat on the Safety of Poly(ethylene glycol)-Coated Nanomedicines.

  2020cites this paper
• Opportunities and challenges for the clinical translation of structured DNA assemblies as gene therapeutic delivery and vaccine vectors

  2020cites this paper
• Anti-PEG antibodies: Properties, formation and role in adverse immune reactions to PEGylated nano-biopharmaceuticals.

  2020cites this paper
• An RNAi therapeutic, DFP-10825, for intraperitoneal and intrapleural malignant cancers.

  2020cites this paper
• Nanoparticle Toxicology.

  2020cites this paper
• Pegfilgrastim (PEG-G-CSF) Induces Anti-polyethylene Glycol (PEG) IgM via a T Cell-Dependent Mechanism.

  2020cites this paper
• Complement activation induced by PEG enhances humoral immune responses against antigens encapsulated in PEG-modified liposomes.

  2020cites this paper
• Anti-PEG scFv corona ameliorates accelerated blood clearance phenomenon of PEGylated nanomedicines.

  2020cites this paper
• Pseudo-Anaphylaxis to Polyethylene Glycol (PEG)-Coated Liposomes: Roles of Anti-PEG IgM and Complement Activation in a Porcine Model of Human Infusion Reactions.

  2019cites this paper
• Subchronic and Chronic Toxicity Evaluation of Inorganic Nanoparticles for Delivery Applications.

  2019cites this paper
• Anti-PEG IgM Production via a PEGylated Nanocarrier System for Nucleic Acid Delivery.

  2019cites this paper
• Induction of Cytochrome P450 Involved in the Accelerated Blood Clearance Phenomenon Induced by PEGylated Liposomes In Vivo

  2019cites this paper
• Short Peptide-Mediated Brain-Targeted Drug Delivery with Enhanced Immunocompatibility.

  2019cites this paper
• PEGylated liposomes: immunological responses

  2019cites this paper
• Accelerated Blood Clearance of Lipid Nanoparticles Entails a Biphasic Humoral Response of B-1 Followed by B-2 Lymphocytes to Distinct Antigenic Moieties

  2019cites this paper
• Liposome and immune system interplay: Challenges and potentials.

  2019cites this paper
• Toxicity and immunogenicity concerns related to PEGylated-micelle carrier systems: a review

  2019cites this paper
• Evaluating the Accelerated Blood Clearance Phenomenon of PEGylated Nanoemulsions in Rats by Intraperitoneal Administration

  2018cites this paper
• Polyethylene glycol in spinal cord injury repair: a critical review

  2018cites this paper
• Reactivity of IgM antibodies elicited by PEGylated liposomes or PEGylated lipoplexes against auto and foreign antigens

  2018cites this paper
• Zwitterionic Polyester-Based Nanoparticles with Tunable Size, Polymer Molecular Weight, and Degradation Time.

  2018cites this paper
• Enhanced Opsonization-Independent Phagocytosis and High Response Ability to Opsonized Antigen-Antibody Complexes: A New Role of Kupffer Cells in the Accelerated Blood Clearance Phenomenon upon Repeated Injection of PEGylated Emulsions.

  2018cites this paper
• A Promising Biocompatible Platform: Lipid-Based and Bio-Inspired Smart Drug Delivery Systems for Cancer Therapy

  2018cites this paper
• A Novel Platform for Cancer Vaccines: Antigen-Selective Delivery to Splenic Marginal Zone B Cells via Repeated Injections of PEGylated Liposomes

  2018cites this paper
• Anti‐polyethylene glycol antibodies alter the protein corona deposited on nanoparticles and the physiological pathways regulating their fate in vivo

  2018cites this paper
• Cleavable PEGylation: a strategy for overcoming the “PEG dilemma” in efficient drug delivery

  2017cites this paper
• Anti-PEG Abs in the clinic 2 . 1 The case of PEG-uricase

  2017cites this paper
• Dendrimers Effects on the Immune System: Insights into Toxicity and Therapeutic Utility.

  2017cites this paper
• Inner ear barriers to nanomedicine-augmented drug delivery and imaging☆

  2016cites this paper
• Exploring and harnessing PEG-immune system interactions to engineer targeted stealth nanoparticles

  2016cites this paper
• Specific delivery of an immunosuppressive drug to splenic B cells by antigen-modified liposomes and its antiallergic effect

  2016cites this paper
• Anti-PEG antibodies in the clinic: Current issues and beyond PEGylation.

  2016cites this paper
• Cytocompatible and multifunctional polymeric nanoparticles for transportation of bioactive molecules into and within cells

  2016cites this paper
• Immunogenicity of long-lasting recombinant factor VIII products.

  2016cites this paper
• Analysis of Pre-existing IgG and IgM Antibodies against Polyethylene Glycol (PEG) in the General Population.

  2016cites this paper
• PEGylated cationic hybrid bicellar nanodisc for efficient siRNA delivery

  2016cites this paper