Adenoviral E4orf3 and E4orf6 proteins, but not E1B55K, increase killing of cancer cells by radiotherapy in vivo.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  International Journal of Radiation Oncology, Biology, Physics

• Publication date

  2010-11-15

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/j.ijrobp.2010.05.037PMID 20832189
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Selective targeting of HPV-16 E6/E7 in cervical cancer cells with a potent oncolytic adenovirus and its enhanced effect with radiotherapy in vitro and vivo.

  2010cited by this paper
• Targeted Chemotherapy for Head and Neck Cancer with a Chimeric Oncolytic Adenovirus Coding for Bifunctional Suicide Protein FCU1

  2010cited by this paper
• Multimodal approach using oncolytic adenovirus, cetuximab, chemotherapy and radiotherapy in HNSCC low passage tumour cell cultures.

  2010cited by this paper
• Temporal Regulation of the Mre11-Rad50-Nbs1 Complex during Adenovirus Infection

  2009cited by this paper
• Mre11 inhibition by oncolytic adenovirus associates with autophagy and underlies synergy with ionizing radiation

  2009cited by this paper
• Effect of recombinant adenovirus-p53 combined with radiotherapy on long-term prognosis of advanced nasopharyngeal carcinoma.

  2009cited by this paper
• Mislocalization of the MRN complex prevents ATR signaling during adenovirus infection

  2009cited by this paper
• Higher-than-conventional radiation doses in localized prostate cancer treatment: a meta-analysis of randomized, controlled trials.

  2009cited by this paper
• Double E1B 19 kDa- and E1B 55 kDa-deleted oncolytic adenovirus in combination with radiotherapy elicits an enhanced anti-tumor effect

  2009cited by this paper
• E1B 55k-independent dissociation of the DNA ligase IV/XRCC4 complex by E4 34k during adenovirus infection.

  2008cited by this paper
• γ-H2AX - A Novel Biomarker for DNA Double-strand Breaks

  2008cited by this paper
• Control of mRNA Export by Adenovirus E4orf6 and E1B55K Proteins during Productive Infection Requires E4orf6 Ubiquitin Ligase Activity

  2008cited by this paper
• Early events in the mammalian response to DNA double-strand breaks.

  2008cited by this paper
• Distinct Requirements of Adenovirus E1b55K Protein for Degradation of Cellular Substrates

  2008cited by this paper
• Gamma-H2AX - a novel biomarker for DNA double-strand breaks.

  2008cited by this paper
• Systematic Review: Comparative Effectiveness and Harms of Treatments for Clinically Localized Prostate Cancer

  2008cited by this paper
• Oncolytic adenovirus Ad5/3-delta24 and chemotherapy for treatment of orthotopic ovarian cancer.

  2008cited by this paper
• Mre11-Rad50-Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin template.

  2007cited by this paper
• Treatment of metastatic renal cancer with capsid-modified oncolytic adenoviruses

  2007cited by this paper
• Clinical trials with oncolytic adenovirus in China.

  2007cited by this paper
• Clinical experience with gene therapy for the treatment of prostate cancer.

  2007cited by this paper
• Using or abusing: viruses and the cellular DNA damage response.

  2007cited by this paper
• The Adenoviral E4orf6 Protein Induces Atypical Apoptosis in Response to DNA Damage*

  2007cited by this paper
• Noninvasive imaging for evaluation of the systemic delivery of capsid‐modified adenoviruses in an orthotopic model of advanced lung cancer

  2006cited by this paper
• China approves world's first oncolytic virus therapy for cancer treatment.

  2006cited by this paper
• Signaling via ErbB2 and ErbB3 Associates with Resistance and Epidermal Growth Factor Receptor (EGFR) Amplification with Sensitivity to EGFR Inhibitor Gefitinib in Head and Neck Squamous Cell Carcinoma Cells

  2006cited by this paper
• Histone H2AX Phosphorylation after Cell Irradiation with UV-B: Relationship to Cell Cycle Phase and Induction of Apoptosis

  2005cited by this paper
• Adenovirus Type 5 E4orf3 Protein Targets the Mre11 Complex to Cytoplasmic Aggresomes

  2005cited by this paper
• Serotype-Specific Reorganization of the Mre11 Complex by Adenoviral E4orf3 Proteins

  2005cited by this paper
• Relocalization of the Mre11-Rad50-Nbs1 Complex by the Adenovirus E4 ORF3 Protein Is Required for Viral Replication

  2005cited by this paper
• The Adenovirus E4orf6 Protein Inhibits DNA Double Strand Break Repair and Radiosensitizes Human Tumor Cells in an E1B-55K-independent Manner*

  2005cited by this paper
• Use of Replicating Oncolytic Adenoviruses in Combination Therapy for Cancer

  2004cited by this paper
• Expression of the adenovirus E4 34k oncoprotein inhibits repair of double strand breaks in the cellular genome of a 293-based inducible cell line.

  2004cited by this paper
• The Mre11 complex is required for ATM activation and the G2/M checkpoint

  2003cited by this paper
• Phase I study of replication-competent adenovirus-mediated double-suicide gene therapy in combination with conventional-dose three-dimensional conformal radiation therapy for the treatment of newly diagnosed, intermediate- to high-risk prostate cancer.

  2003cited by this paper
• Double Modification of Adenovirus Fiber with RGD and Polylysine Motifs Improves Coxsackievirus–Adenovirus Receptor-Independent Gene Transfer Efficiency

  2002cited by this paper
• Targeting adenovirus to the serotype 3 receptor increases gene transfer efficiency to ovarian cancer cells.

  2002cited by this paper
• Adenovirus oncoproteins inactivate the Mre11–Rad50–NBS1 DNA repair complex

  2002cited by this paper
• Gene transfer to ovarian cancer versus normal tissues with fiber-modified adenoviruses.

  2002cited by this paper
• Efficacy and toxicity of replication-competent adenovirus-mediated double suicide gene therapy in combination with radiation therapy in an orthotopic mouse prostate cancer model.

  2002cited by this paper
• Induction of apoptosis and G2/M arrest by infection with replication-deficient adenovirus at high multiplicity of infection

  1999cited by this paper
• The adenovirus type 5 E1b 55K and E4 Orf3 proteins associate in infected cells and affect ND10 components.

  1999cited by this paper
• Adenovirus E4 34k and E4 11k inhibit double strand break repair and are physically associated with the cellular DNA-dependent protein kinase.

  1999cited by this paper
• DNA Double-stranded Breaks Induce Histone H2AX Phosphorylation on Serine 139*

  1998cited by this paper
• Regulation of p53 levels by the E1B 55-kilodalton protein and E4orf6 in adenovirus-infected cells

  1997cited by this paper
• Expression of p53 in Saos-2 osteosarcoma cells induces apoptosis which can be inhibited by Bcl-2 or the adenovirus E1B-55 kDa protein.

  1996cited by this paper
• Adenovirus early region 4 encodes two gene products with redundant effects in lytic infection

  1989cited by this paper

• MRE11 as a molecular signature and therapeutic target for cancer treatment with radiotherapy.

  2021cites this paper
• ONCOLYTIC ADENOVIRUS CODING FOR GM-CSF IN TREATMENT OF CANCER

  2015cites this paper
• Oncolytic Immunotherapy: Where Are We Clinically?

  2014cites this paper
• Experimental adenovirus gene therapy for cancer patients with advanced tumors : Translational medicine from basic research to the patient's bedside

  2013cites this paper
• International Evaluation of Research and Doctoral Training at the University of Helsinki 2005-2010: RC-Specific Evaluation of ID-TM - Inflammatory Diseases-towards Translational Medicine

  2012cites this paper
• r ole of Mre 11 in cell Proliferation, t umor i nvasion, and DNA r epair in Breast c ancer

  2012cites this paper
• Role of MRE11 in cell proliferation, tumor invasion, and DNA repair in breast cancer.

  2012cites this paper