In Vivo Evolution of X4 Human Immunodeficiency Virus Type 1 Variants in the Natural Course of Infection Coincides with Decreasing Sensitivity to CXCR4 Antagonists

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Journal of Virology

• Publication date

  2004-03-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/JVI.78.6.2722-2728.2004PMID 14990692PMCID PMC353738
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• HIV-1 entry inhibitors: new targets, novel therapies.

  2003cited by this paper
• Reduced Fitness of HIV-1 Resistant to Cxcr4 Antagonists

  2003cited by this paper
• Susceptibility of diverse primary HIV isolates with varying co‐receptor specificity's to CXCR4 antagonistic compounds

  2002cited by this paper
• Sensitivity of HIV-1 to entry inhibitors correlates with envelope/coreceptor affinity, receptor density, and fusion kinetics

  2002cited by this paper
• HIV-1 entry and entry inhibitors as therapeutic agents.

  2002cited by this paper
• Antigenically Distinct Conformations of CXCR4

  2001cited by this paper
• Biological and Genetic Characterization of a Human Immunodeficiency Virus Strain Resistant to CXCR4 Antagonist T134

  2001cited by this paper
• gp120: Biologic aspects of structural features.

  2001cited by this paper
• Cytopathic Effects of Non-Syncytium-Inducing and Syncytium-Inducing Human Immunodeficiency Virus Type 1 Variants on Different CD4+-T-Cell Subsets Are Determined Only by Coreceptor Expression

  2001cited by this paper
• No Selection for CCR5 Coreceptor Usage during Parenteral Transmission of Macrophagetropic Syncytium-Inducing Human Immunodeficiency Virus Type 1

  2001cited by this paper
• Viral Entry through CXCR4 Is a Pathogenic Factor and Therapeutic Target in Human Immunodeficiency Virus Type 1 Disease

  2000cited by this paper
• In vivo HIV-1 infection of CD45RA(+)CD4(+) T cells is established primarily by syncytium-inducing variants and correlates with the rate of CD4(+) T cell decline.

  2000cited by this paper
• Differential coreceptor expression allows for independent evolution of non-syncytium-inducing and syncytium-inducing HIV-1.

  2000cited by this paper
• Inhibitory Mechanism of the CXCR4 Antagonist T22 against Human Immunodeficiency Virus Type 1 Infection

  1999cited by this paper
• CCR5- and CXCR4-tropic HIV-1 are equally cytopathic for their T-cell targets in human lymphoid tissue

  1999cited by this paper
• T134, a Small-Molecule CXCR4 Inhibitor, Has No Cross-Drug Resistance with AMD3100, a CXCR4 Antagonist with a Different Structure

  1999cited by this paper
• HIV-1 entry inhibitors: Evading the issue

  1999cited by this paper
• Preferential coreceptor utilization and cytopathicity by dual-tropic HIV-1 in human lymphoid tissue ex vivo.

  1999cited by this paper
• Both Memory and CD45RA+/CD62L+ Naive CD4+ T Cells Are Infected in Human Immunodeficiency Virus Type 1-Infected Individuals

  1999cited by this paper
• Chemokine receptors as HIV-1 coreceptors: roles in viral entry, tropism, and disease.

  1999cited by this paper
• HIV entry and its inhibition.

  1998cited by this paper
• Evolution of Syncytium-Inducing and Non-Syncytium-Inducing Biological Virus Clones in Relation to Replication Kinetics during the Course of Human Immunodeficiency Virus Type 1 Infection

  1998cited by this paper
• Expression of chemokine receptors CXCR4 and CCR5 in HIV-1-infected and uninfected individuals.

  1998cited by this paper
• Determinants for Sensitivity of Human Immunodeficiency Virus Coreceptor CXCR4 to the Bicyclam AMD3100

  1998cited by this paper
• AMD3100, a small molecule inhibitor of HIV-1 entry via the CXCR4 co-receptor

  1998cited by this paper
• A conserved HIV gp120 glycoprotein structure involved in chemokine receptor binding.

  1998cited by this paper
• T-Cell-Line-Tropic Human Immunodeficiency Virus Type 1 That Is Made Resistant to Stromal Cell-Derived Factor 1α Contains Mutations in the Envelope gp120 but Does Not Show a Switch in Coreceptor Use

  1998cited by this paper
• Change in Coreceptor Use Correlates with Disease Progression in HIV-1–Infected Individuals

  1997cited by this paper
• A Small Molecule CXCR4 Inhibitor that Blocks T Cell Line–tropic HIV-1 Infection

  1997cited by this paper
• Coreceptor usage of primary human immunodeficiency virus type 1 isolates varies according to biological phenotype

  1997cited by this paper
• Inhibition of T-tropic HIV Strains by Selective Antagonization of the Chemokine Receptor CXCR4

  1997cited by this paper
• A Small-molecule Inhibitor Directed against the Chemokine Receptor CXCR4 Prevents its Use as an HIV-1 Coreceptor

  1997cited by this paper
• Role of the first and third extracellular domains of CXCR-4 in human immunodeficiency virus coreceptor activity

  1997cited by this paper
• In vivo evolution of HIV-1 co-receptor usage and sensitivity to chemokine-mediated suppression

  1997cited by this paper
• The molecular target of bicyclams, potent inhibitors of human immunodeficiency virus replication

  1996influential reference
• Relation between changes in cellular load, evolution of viral phenotype, and the clonal composition of virus populations in the course of human immunodeficiency virus type 1 infection.

  1996cited by this paper
• CC CKR5: a RANTES, MIP-1alpha, MIP-1beta receptor as a fusion cofactor for macrophage-tropic HIV-1.

  1996cited by this paper
• CC CKR5: A RANTES, MIP-1α, MIP-1ॆ Receptor as a Fusion Cofactor for Macrophage-Tropic HIV-1

  1996cited by this paper
• Primary, syncytium-inducing human immunodeficiency virus type 1 isolates are dual-tropic and most can use either Lestr or CCR5 as coreceptors for virus entry

  1996cited by this paper
• HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5

  1996cited by this paper
• HIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein-Coupled Receptor

  1996cited by this paper
• Synthesis and structure-activity relationships of phenylenebis(methylene)-linked bis-tetraazamacrocycles that inhibit HIV replication. Effects of macrocyclic ring size and substituents on the aromatic linker.

  1995cited by this paper
• Macrophage-tropic variants initiate human immunodeficiency virus type 1 infection after sexual, parenteral, and vertical transmission.

  1994cited by this paper
• Prognostic Value of HIV-1 Syncytium-Inducing Phenotype for Rate of CD4+ Cell Depletion and Progression to AIDS

  1993cited by this paper
• Genotypic and phenotypic characterization of HIV-1 patients with primary infection.

  1993cited by this paper
• HIV‐1 biological phenotype in long‐term infected individuals evaluated with an MT‐2 cocultivation assay

  1992cited by this paper
• Biological phenotype of human immunodeficiency virus type 1 clones at different stages of infection: progression of disease is associated with a shift from monocytotropic to T-cell-tropic virus population

  1992cited by this paper
• Monocytotropic human immunodeficiency virus type 1 (HIV-1) variants detectable in all stages of HIV-1 infection lack T-cell line tropism and syncytium-inducing ability in primary T-cell culture

  1991cited by this paper

• Mechanisms of HIV-1 evasion to the antiviral activity of chemokine CXCL12 indicate potential links with pathogenesis

  2021cites this paper
• CCR5 Revisited: How Mechanisms of HIV Entry Govern AIDS Pathogenesis.

  2018cites this paper
• HIV-1 subtype CRF01_AE and B differ in utilization of low levels of CCR5, Maraviroc susceptibility and potential N-glycosylation sites.

  2017cites this paper
• Guidelines for cloning, expression, purification and functional characterization of primary HIV-1 envelope glycoproteins.

  2016cites this paper
• Quantifying the Sensitivity of HIV-1 Viral Entry to Receptor and Coreceptor Expression.

  2016cites this paper
• HIV-1 adaptation to low levels of CCR5 results in V3 and V2 loop changes that increase envelope pathogenicity, CCR5 affinity and decrease susceptibility to Maraviroc.

  2016cites this paper
• Defining the fitness of HIV-1 isolates with dual/mixed co-receptor usage

  2015cites this paper
• Short report Open Access

  2015cites this paper
• Evolution of HIV-1 Coreceptor Usage and Coreceptor Switching During Pregnancy

  2014cites this paper
• Herpes simplex virus type 2 infection increases human immunodeficiency virus type 1 entry into human primary macrophages

  2011cites this paper
• Neutralizing antibody responses and viral evolution in a longitudinal cohort of HIV subtype C infected antiretroviral-naïve individuals.

  2011cites this paper
• Clinical significance of HIV-1 coreceptor usage

  2011cites this paper
• Up-regulation of the Neuronal Nicotinic Receptor α7 by HIV Glycoprotein 120

  2011cites this paper
• R5X4 HIV-1 coreceptor use in primary target cells: implications for coreceptor entry blocking strategies

  2011cites this paper
• HIV-1 neutralizing humoral immunity, viral evolution and disease progression

  2010cites this paper
• Anti-HIV-1 activity of the neurokinin-1 receptor antagonist aprepitant and synergistic interactions with other antiretrovirals

  2010cites this paper
• UvA-DARE ( Digital Academic Repository ) Within-host HIV-1 evolution in relation to viral coreceptor use and host environment

  2010cites this paper
• Evolution of the human immunodeficiency virus type 1 envelope glycoprotein during chronic infection

  2010cites this paper
• STUDIES TO UNDERSTAND THE MECHANISM OF HORIZONTAL AND VERTICAL TRANSMISSION OF HUMAN IMMUNODEFICIENCY VIRUS

  2010cites this paper
• Major Coexisting Human Immunodeficiency Virus Type 1 env Gene Subpopulations in the Peripheral Blood Are Produced by Cells with Similar Turnover Rates and Show Little Evidence of Genetic Compartmentalization

  2009cites this paper
• Characterization of a chemokine receptor CCR5‐negative T cell line and its use in determining human immunodeficiency virus type 1 phenotype

  2008cites this paper
• Entry Coreceptor Use and Fusion Inhibitor T20 Sensitivity of Dual-Tropic R5X4 HIV-1 in Primary Macrophage Infection

  2008cites this paper
• Chemokine (C-C motif) receptor 5-using envelopes predominate in dual/mixed-tropic HIV from the plasma of drug-naive individuals

  2008influential citation
• Functional diversity of HIV-1 envelope proteins expressed by contemporaneous plasma viruses

  2008cites this paper
• HIV-1 Sequence Diversity as a Window Into HIV-1 Biology

  2008cites this paper
• Autologous Neutralizing Humoral Immunity and Evolution of the Viral Envelope in the Course of Subtype B Human Immunodeficiency Virus Type 1 Infection

  2008cites this paper
• CHAPTER 5 – Viral and Host Determinants of HIV-1 Disease Progression

  2008cites this paper
• R5X4 Viruses Are Evolutionary, Functional, and Antigenic Intermediates in the Pathway of a Simian-Human Immunodeficiency Virus Coreceptor Switch

  2008cites this paper
• Altered sensitivity of an R5X4 HIV-1 strain 89.6 to coreceptor inhibitors by a single amino acid substitution in the V3 region of gp120.

  2008cites this paper
• Natural Variation in the V3 Crown of Human Immunodeficiency Virus Type 1 Affects Replicative Fitness and Entry Inhibitor Sensitivity

  2007cites this paper
• Potentials of phenolic molecules of natural origin and their derivatives as anti-HIV agents.

  2007cites this paper
• HIV-1 Env sequence and structure contribute to both coreceptor tropism and susceptibility to antibody neutralization

  2007cites this paper
• VARIATIONS IN THE V3 CROWN OF HIV-1 ENVELOPE IMPACT AFFINITY FOR CCR5 AND AFFECT ENTRY AND REPLICATIVE FITNESS

  2007cites this paper
• Inhibitors that target gp120 interactions with coreceptor

  2007cites this paper
• Purifying selection of CCR 5-tropic human immunodeficiency virus type 1 variants in AIDS subjects that have developed syncytium-inducing , CXCR 4-tropic viruses

  2006cites this paper
• Increased Neutralization Sensitivity of Recently Emerged CXCR4-Using Human Immunodeficiency Virus Type 1 Strains Compared to Coexisting CCR5-Using Variants from the Same Patient

  2006cites this paper
• Comparative studies on mucosal and intravenous transmission of simian immunodeficiency virus (SIVsm): evolution of coreceptor use varies with pathogenic outcome.

  2006cites this paper
• HIV-1 burden influences host response to co-infection with Neisseria gonorrhoeae in vitro.

  2006cites this paper
• Purifying selection of CCR5-tropic human immunodeficiency virus type 1 variants in AIDS subjects that have developed syncytium-inducing, CXCR4-tropic viruses.

  2006influential citation
• Thymic pathogenicity of an HIV-1 envelope is associated with increased CXCR4 binding efficiency and V5-gp41-dependent activity, but not V1/V2-associated CD4 binding efficiency and viral entry.

  2005cites this paper
• Vossiuspers UvA is een imprint van Amsterdam University Press. Deze uitgave is totstandgekomen onder auspiciën van de Universiteit van Amsterdam.

  2005cites this paper
• Sensitivity of Primary R5 HIV-1 to Inhibition by Rantes Correlates with Sensitivity to Small-Molecule R5 Inhibitors

  2005cites this paper
• Open Access Research

  2004cites this paper
• CXCR4-Dependent Infection of CD8+, but Not CD4+, Lymphocytes by a Primary Human Immunodeficiency Virus Type 1 Isolate

  2004cites this paper
• Determinants of host HIV-1 suspectibility and R5 HIV-1 evolution

  2004cites this paper