NADPH oxidases 1 and 4 mediate cellular senescence induced by resveratrol in human endothelial cells.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Free Radical Biology & Medicine

• Publication date

  2009-06-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.freeradbiomed.2009.03.013PMID 19328228
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2006influential reference
• In vino veritas: a tale of two sirt1s?

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• Separation of biologically active lipids from red wine.

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• A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

  1995cited by this paper
• THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS.

  1965cited by this paper

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