Electrophysiological characterization of the first Tityus serrulatus alpha-like toxin, Ts5: Evidence of a pro-inflammatory toxin on macrophages.

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Biochimie

• Publication date

  2015-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.biochi.2015.04.010PMID 25906692
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Electrophysiological Characterization of Ts6 and Ts7, K+ Channel Toxins Isolated through an Improved Tityus serrulatus Venom Purification Procedure

  2014cited by this paper
• TLR2, TLR4 and CD14 Recognize Venom-Associated Molecular Patterns from Tityus serrulatus to Induce Macrophage-Derived Inflammatory Mediators

  2014cited by this paper
• Macrophage alteration induced by inflammatory toxins isolated from Tityus discrepans scorpion venom. The role of Na(+)/Ca(2+) exchangers.

  2014cited by this paper
• Molecular, Immunological, and Biological Characterization of Tityus serrulatus Venom Hyaluronidase: New Insights into Its Role in Envenomation

  2014cited by this paper
• The synergy in cytokine production through MyD88‐TRIF pathways is co‐ordinated with ERK phosphorylation in macrophages

  2013cited by this paper
• Two peptides, TsAP-1 and TsAP-2, from the venom of the Brazilian yellow scorpion, Tityus serrulatus: evaluation of their antimicrobial and anticancer activities.

  2013cited by this paper
• Ts6 and Ts2 from Tityus serrulatus venom induce inflammation by mechanisms dependent on lipid mediators and cytokine production.

  2013cited by this paper
• Isolation and Characterization of an Anti-Insect β-Toxin from the Venom of the Scorpion Isometrus maculatus

  2013cited by this paper
• Isolation, homology modeling and renal effects of a C-type natriuretic peptide from the venom of the Brazilian yellow scorpion (Tityus serrulatus).

  2013cited by this paper
• Investigation of the relationship between the structure and function of Ts2, a neurotoxin from Tityus serrulatus venom

  2012cited by this paper
• Transcriptome analysis of the Tityus serrulatus scorpion venom gland

  2012cited by this paper
• Novo método de fracionamento da peçonha do escorpião Tityus serrulatus e caracterização eletrofisiológica das toxinas Ts6 e Ts7

  2012cited by this paper
• Platinum(IV)-chlorotoxin (CTX) conjugates for targeting cancer cells.

  2012cited by this paper
• New Tricks of an Old Pattern

  2012cited by this paper
• A portable device for the electrical extraction of scorpion venom.

  2011cited by this paper
• The human macrophage sodium channel NaV1.5 regulates mycobacteria processing through organelle polarization and localized calcium oscillations.

  2011cited by this paper
• Macrophages in Injured Skeletal Muscle: A Perpetuum Mobile Causing and Limiting Fibrosis, Prompting or Restricting Resolution and Regeneration

  2011cited by this paper
• Tityus serrulatus venom and toxins Ts1, Ts2 and Ts6 induce macrophage activation and production of immune mediators.

  2011cited by this paper
• Purification and characterization of Ts15, the first member of a new α-KTX subfamily from the venom of the Brazilian scorpion Tityus serrulatus.

  2011cited by this paper
• Toll-like receptor, RIG-I-like receptors and the NLRP3 inflammasome: key modulators of innate immune responses to double-stranded RNA viruses.

  2011cited by this paper
• Regulation of innate and adaptive immunity by the commensal microbiota.

  2011cited by this paper
• Immune cells recruitment and activation by Tityus serrulatus scorpion venom.

  2011cited by this paper
• Pathogen Recognition by the Innate Immune System

  2011cited by this paper
• Neurotoxins and Their Binding Areas on Voltage-Gated Sodium Channels

  2011cited by this paper
• Nucleic acid recognition by the innate immune system.

  2011cited by this paper
• Voltage-gated potassium channels as therapeutic targets

  2009cited by this paper
• Expression and function of Na+/Ca2+ exchangers 1 and 3 in human macrophages and monocytes

  2009cited by this paper
• Tityus serrulatus scorpion venom and toxins: an overview.

  2009cited by this paper
• Macrophage activation, phagocytosis and intracellular calcium oscillations induced by scorpion toxins from Tityus serrulatus

  2008cited by this paper
• Electrophysiological characterization of BmK I, an alpha-like scorpion toxin, on rNav1.5 expressed in HEK293t cells.

  2008cited by this paper
• With a little help from my friends: modulation of phagocytosis through TLR activation

  2008cited by this paper
• Voltage-gated sodium channel modulation by scorpion alpha-toxins.

  2007cited by this paper
• Recognition of microorganisms and activation of the immune response

  2007cited by this paper
• Expression of the Voltage-Gated Sodium Channel NaV1.5 in the Macrophage Late Endosome Regulates Endosomal Acidification1

  2007cited by this paper
• Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis

  2007cited by this paper
• The unique pharmacology of the scorpion alpha-like toxin Lqh3 is associated with its flexible C-tail.

  2007cited by this paper
• The unique pharmacology of the scorpion α‐like toxin Lqh3 is associated with its flexible C‐tail

  2007cited by this paper
• Effects of Tityus serrulatus scorpion venom and its toxin TsTX-V on neurotransmitter uptake in vitro.

  2006cited by this paper
• Sodium channels contribute to microglia/macrophage activation and function in EAE and MS

  2005cited by this paper
• Effects of voltage-gated Na+ channel toxins from Tityus serrulatus venom on rat arterial blood pressure and plasma catecholamines.

  2005cited by this paper
• Toll-like receptors in innate immunity.

  2004cited by this paper
• Extracellular ATP induces oscillations of intracellular Ca2+ and membrane potential and promotes transcription of IL-6 in macrophages.

  2004cited by this paper
• Structural mechanism governing cis and trans isomeric states and an intramolecular switch for cis/trans isomerization of a non-proline peptide bond observed in crystal structures of scorpion toxins.

  2004cited by this paper
• Participation of Na(+) channels in the potentiation by Tityus serrulatus alpha-toxin TsTx-V of glucose-induced electrical activity and insulin secretion in rodent islet beta-cells.

  2003cited by this paper
• Participation of Na+ channels in the potentiation by Tityus serrulatus α-toxin TsTx-V of glucose-induced electrical activity and insulin secretion in rodent islet β-cells

  2003cited by this paper
• Importance of the conserved aromatic residues in the scorpion alpha-like toxin BmK M1: the hydrophobic surface region revisited.

  2003cited by this paper
• Increased plasma levels of IL-1beta, IL-6, IL-8, IL-10 and TNF-alpha in patients moderately or severely envenomed by Tityus serrulatus scorpion sting.

  2003cited by this paper
• Increased plasma levels of IL-1β, IL-6, IL-8, IL-10 and TNF-α in patients moderately or severely envenomed by Tityus serrulatus scorpion sting

  2003cited by this paper
• The selectivity of scorpion alpha-toxins for sodium channel subtypes is determined by subtle variations at the interacting surface.

  2003cited by this paper
• Time course of acute-phase response induced by Tityus serrulatus venom and TsTX-I in mice.

  2003cited by this paper
• Exploration of the functional site of a scorpion alpha-like toxin by site-directed mutagenesis.

  2003cited by this paper
• Differential sensitivity of sodium channels from the central and peripheral nervous system to the scorpion toxins Lqh‐2 and Lqh‐3

  2002cited by this paper
• Effect of Tityus serrulatus venom on cytokine production and the activity of murine macrophages.

  2002cited by this paper
• Electrophysiological characterization of BmK M1, an α‐like toxin from Buthus martensi Karsch venom

  2001cited by this paper
• Scorpion toxins specific for Na+-channels.

  1999cited by this paper
• Serum levels of cytokines in patients envenomed by Tityus serrulatus scorpion sting.

  1999cited by this paper
• Crystal structures of two alpha-like scorpion toxins: non-proline cis peptide bonds and implications for new binding site selectivity on the sodium channel.

  1999cited by this paper
• Structure and function of scorpion toxins affecting K+-channels

  1999cited by this paper
• Functional Anatomy of Scorpion Toxins Affecting Sodium Channels

  1998cited by this paper
• Lysosomal Enzyme Trafficking between Phagosomes, Endosomes, and Lysosomes in J774 Macrophages

  1998cited by this paper
• Immunologic Dissonance: A Continuing Evolution in Our Understanding of the Systemic Inflammatory Response Syndrome (SIRS) and the Multiple Organ Dysfunction Syndrome (MODS)

  1996cited by this paper
• Scorpion Toxins Affecting Sodium Current Inactivation Bind to Distinct Homologous Receptor Sites on Rat Brain and Insect Sodium Channels (*)

  1996cited by this paper
• Simultaneous Detection of Free Radical Release and Membrane Current during Phagocytosis (*)

  1995cited by this paper
• Isolation and characterization of TsTX-V, a new neurotoxin from Tityus serrulatus scorpion venom which delays the inactivation of Na+ channels.

  1994cited by this paper
• Subunit stoichiometry of a mammalian K+ channel determined by construction of multimeric cDNAs.

  1992cited by this paper
• A simplified procedure for the fractionation of Tityus serrulatus venom: isolation and partial characterization of TsTX-IV, a new neurotoxin.

  1989cited by this paper
• Internalization and processing of Bacillus anthracis lethal toxin by toxin-sensitive and -resistant cells.

  1989cited by this paper
• Nitrate biosynthesis in man.

  1981cited by this paper
• Comparison of Tetrodotoxin and Procaine in Internally Perfused Squid Giant Axons

  1967cited by this paper
• A protein sequenator.

  1967cited by this paper
• Cellular and Molecular Life Sciences the Insecticidal Potential of Venom Peptides

  year unknowncited by this paper

• Properties and Pharmacology of Scorpion Toxins and Their Biotechnological Potential in Agriculture and Medicine

  2025cites this paper
• The complex repertoire of Tityus spp. venoms: Advances on their composition and pharmacological potential of their toxins.

  2024cites this paper
• Scorpion Neurotoxin BeM9 Derivative Uncovers Unique Interaction Mode with Nav1.5 Sodium Channel Isoform

  2024cites this paper
• The nociceptive response induced by different classes of Tityus serrulatus neurotoxins: The important role of Ts5 in venom-induced nociception

  2023cites this paper
• Biphasic Hormetic-like Effect of Lebecetin, a C-type Lectin of Snake Venom, on Formalin-induced Inflammation in Mice

  2023cites this paper
• Effect of animal venom toxins on the main links of the homeostasis of mammals (Review)

  2023cites this paper
• Ts17, a Tityus serrulatus β-toxin structurally related to α-scorpion toxins.

  2022cites this paper
• Unraveling the structure and function of CdcPDE: A novel phosphodiesterase from Crotalus durissus collilineatus snake venom.

  2021cites this paper
• Current Knowledge on Snake Dry Bites

  2020cites this paper
• Scorpion Venom: Detriments and Benefits

  2020cites this paper
• Pioneering Study on Rhopalurus crassicauda Scorpion Venom: Isolation and Characterization of the Major Toxin and Hyaluronidase

  2020cites this paper
• Spider Knottin Pharmacology at Voltage-Gated Sodium Channels and Their Potential to Modulate Pain Pathways

  2019cites this paper
• Scorpion envenomation and inflammation: Beyond neurotoxic effects.

  2019cites this paper
• Peptides ToAP3 and ToAP4 decrease release of inflammatory cytokines through TLR-4 blocking.

  2019cites this paper
• An Immunological Stairway to Severe Tissue Complication Assembly in Bothrops atrox Snakebites

  2019cites this paper
• Effects of Brazilian scorpion venoms on the central nervous system

  2018cites this paper
• A global accounting of medically significant scorpions: Epidemiology, major toxins, and comparative resources in harmless counterparts

  2018cites this paper
• Differential effect of Androctonus australis hector venom components on macrophage KV channels: electrophysiological characterization

  2018cites this paper
• Expanding biological activities of Ts19 Frag‐II toxin: Insights into IL‐17 production

  2017cites this paper
• Investigating possible biological targets of Bj-CRP, the first cysteine-rich secretory protein (CRISP) isolated from Bothrops jararaca snake venom.

  2017cites this paper
• Tityus serrulatus envenoming in non-obese diabetic mice: a risk factor for severity

  2016cites this paper
• Immunosuppressive evidence of Tityus serrulatus toxins Ts6 and Ts15: insights of a novel K+ channel pattern in T cells

  2016cites this paper
• Ts8 scorpion toxin inhibits the Kv4.2 channel and produces nociception in vivo.

  2016cites this paper
• Non-disulfide-bridged peptides from Tityus serrulatus venom: Evidence for proline-free ACE-inhibitors.

  2016influential citation
• Tityus serrulatus venom--A lethal cocktail.

  2015cites this paper
• Revealing the Function and the Structural Model of Ts4: Insights into the “Non-Toxic” Toxin from Tityus serrulatus Venom

  2015cites this paper
• Partial purification and functional characterization of Ts19 Frag-I, a novel toxin from Tityus serrulatus scorpion venom

  2015cites this paper