Exploring the GluR2 ligand‐binding core in complex with the bicyclical AMPA analogue (S)‐4‐AHCP

No abstract is available for this paper.

• Publication year

  2005

• Venue

  The FEBS Journal

• Publication date

  2005-04-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1111/j.1742-4658.2005.04583.xPMID 15794751
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Gaussian 03, Revision E.01.

  2007cited by this paper
• Structure and function of glutamate receptor ion channels.

  2004cited by this paper
• The Three-dimensional Structure of an Ionotropic Glutamate Receptor Reveals a Dimer-of-dimers Assembly.

  2004cited by this paper
• Glutamate receptor function in learning and memory.

  2003cited by this paper
• Three-dimensional structure of the ligand-binding core of GluR2 in complex with the agonist (S)-ATPA: implications for receptor subunit selectivity.

  2003cited by this paper
• (S)-2-Amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid, a potent and selective agonist at the GluR5 subtype of ionotropic glutamate receptors. Synthesis, modeling, and molecular pharmacology.

  2003cited by this paper
• Tuning activation of the AMPA-sensitive GluR2 ion channel by genetic adjustment of agonist-induced conformational changes

  2003cited by this paper
• Structural basis for partial agonist action at ionotropic glutamate receptors

  2003cited by this paper
• Competitive antagonism of AMPA receptors by ligands of different classes: crystal structure of ATPO bound to the GluR2 ligand-binding core, in comparison with DNQX.

  2003cited by this paper
• The selective activation of the glutamate receptor GluR5 by ATPA is controlled by serine 741.

  2003cited by this paper
• Multiple Molecular Determinants for Allosteric Modulation of Alternatively Spliced AMPA Receptors

  2003cited by this paper
• GluR2 ligand‐binding core complexes: importance of the isoxazolol moiety and 5‐substituent for the binding mode of AMPA‐type agonists

  2002cited by this paper
• Structural basis for AMPA receptor activation and ligand selectivity: crystal structures of five agonist complexes with the GluR2 ligand-binding core.

  2002cited by this paper
• Mechanism of glutamate receptor desensitization

  2002cited by this paper
• Functional Stoichiometry of Glutamate Receptor Desensitization

  2002cited by this paper
• Mechanism of activation and selectivity in a ligand-gated ion channel: structural and functional studies of GluR2 and quisqualate.

  2002cited by this paper
• Identification of Amino Acid Residues in GluR1 Responsible for Ligand Binding and Desensitization

  2001cited by this paper
• Heteromeric AMPA receptors assemble with a preferred subunit stoichiometry and spatial arrangement.

  2001cited by this paper
• Subunit Interactions and AMPA Receptor Desensitization

  2001cited by this paper
• Functional assembly of AMPA and kainate receptors is mediated by several discrete protein-protein interactions.

  2001cited by this paper
• Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2 ligand binding core.

  2000cited by this paper
• Stable expression of human homomeric and heteromeric AMPA receptor subunits in HEK293 cells.

  2000cited by this paper
• Heterogeneous Conductance Levels of Native AMPA Receptors

  2000cited by this paper
• Agonist discrimination between AMPA receptor subtypes

  2000cited by this paper
• Agonist-induced Isomerization in a Glutamate Receptor Ligand-binding Domain

  2000cited by this paper
• Ligands for glutamate receptors: design and therapeutic prospects.

  2000cited by this paper
• Automated protein model building combined with iterative structure refinement

  1999cited by this paper
• The glutamate receptor ion channels.

  1999cited by this paper
• Further additions to MolScript version 1.4, including reading and contouring of electron-density maps.

  1999cited by this paper
• A tetrameric subunit stoichiometry for a glutamate receptor–channel complex

  1998cited by this paper
• Probing the ligand binding domain of the GluR2 receptor by proteolysis and deletion mutagenesis defines domain boundaries and yields a crystallizable construct

  1998cited by this paper
• The tetrameric structure of a glutamate receptor channel.

  1998cited by this paper
• Pharmacological properties of homomeric and heteromeric GluR1o and GluR3o receptors.

  1998cited by this paper
• Processing of X-ray diffraction data collected in oscillation mode.

  1997cited by this paper
• Refinement of macromolecular structures by the maximum-likelihood method.

  1997cited by this paper
• Overexpression of a glutamate receptor (GluR2) ligand binding domain in Escherichia coli: application of a novel protein folding screen.

  1997cited by this paper
• Protein domain movements: detection of rigid domains and visualization of hinges in comparisons of atomic coordinates

  1997cited by this paper
• VMD: visual molecular dynamics.

  1996cited by this paper
• AMPA receptor heterogeneity in rat hippocampal neurons revealed by differential sensitivity to cyclothiazide.

  1996cited by this paper
• Phi/psi-chology: Ramachandran revisited.

  1996cited by this paper
• Molecular dissection of the agonist binding site of an AMPA receptor.

  1995cited by this paper
• AMoRe: an automated package for molecular replacement

  1994cited by this paper
• Raster3D Version 2.0. A program for photorealistic molecular graphics.

  1994cited by this paper
• The CCP4 suite: programs for protein crystallography.

  1994cited by this paper
• Subunit stoichiometry of a mammalian K+ channel determined by construction of multimeric cDNAs.

  1992cited by this paper
• A program to produce both detailed and schematic plots of protein structures

  1991cited by this paper
• Improved methods for building protein models in electron density maps and the location of errors in these models.

  1991cited by this paper
• Ibotenic acid analogues. Synthesis and biological and in vitro activity of conformationally restricted agonists at central excitatory amino acid receptors.

  1984cited by this paper

• Structural Mechanisms Underlying Activity Changes in an AMPA-type Glutamate Receptor Induced by Substitutions in Its Ligand-Binding Domain.

  2019cites this paper
• Population Shift Mechanism for Partial Agonism of AMPA Receptor.

  2019cites this paper
• Molecular interaction studies of green tea catechins as multitarget drug candidates for the treatment of Parkinson’s disease: computational and structural insights

  2015cites this paper
• Studies on an (S)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid (AMPA) receptor antagonist IKM-159: asymmetric synthesis, neuroactivity, and structural characterization.

  2013cites this paper
• Chemoenzymatic synthesis of new 2,4-syn-functionalized (S)-glutamate analogues and structure-activity relationship studies at ionotropic glutamate receptors and excitatory amino acid transporters.

  2013cites this paper
• Pharmacological and structural characterization of conformationally restricted (S)-glutamate analogues at ionotropic glutamate receptors.

  2012influential citation
• Size matters in activation/inhibition of ligand-gated ion channels.

  2012cites this paper
• Ionotropic Glutamate Receptors (iGluRs): Overview of iGluR2 ligand binding domain in complex with agonists and antagonists

  2011cites this paper
• Quantifying Water-Mediated Protein–Ligand Interactions in a Glutamate Receptor: A DFT Study

  2011cites this paper
• Lessons from more than 80 structures of the GluA2 ligand-binding domain in complex with agonists, antagonists and allosteric modulators.

  2011cites this paper
• Pharmacology of ionotropic glutamate receptors: A structural perspective.

  2010cites this paper
• Molecular structure of ionotropic glutamate receptors.

  2010cites this paper
• The Hidden Energetics of Ligand-Binding and Activation in a Glutamate Receptor

  2010cites this paper
• The glutamate receptor GluR5 agonist (S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid and the 8-methyl analogue: synthesis, molecular pharmacology, and biostructural characterization.

  2009cites this paper
• Subtype selective kainic acid receptor agonists: Discovery and approaches to rational design

  2009cites this paper
• Investigation of the structure and function of glutamate receptor GluR2 using solution NMR spectroscopy

  2009cites this paper
• Structural Correlates of Ionotropic Glutamate Receptor Function

  2008cites this paper
• Synthesis, binding affinity, and molecular docking analysis of new benzofuranone derivatives as potential antipsychotics.

  2008cites this paper
• Structures of the ligand-binding core of iGluR2 in complex with the agonists (R)- and (S)-2-amino-3-(4-hydroxy-1,2,5-thiadiazol-3-yl)propionic acid explain their unusual equipotency.

  2008cites this paper
• Structural aspects of AMPA receptor activation, desensitization and deactivation.

  2007cites this paper
• The structure of a mixed GluR2 ligand-binding core dimer in complex with (S)-glutamate and the antagonist (S)-NS1209.

  2006cites this paper